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1. 发明申请

US20090290150A1 LASER MICROSCOPE APPARATUS 有权
标题翻译：激光显微镜设备
公开(公告)号：US20090290150A1
公开(公告)日：2009-11-26
申请号：US12469007
申请日：2009-05-20
申请人： Shinichi Takimoto , Takeshi Hashimoto , Hirokazu Kubo , Tatsuo Nakata
发明人： Shinichi Takimoto , Takeshi Hashimoto , Hirokazu Kubo , Tatsuo Nakata
IPC分类号： G01J3/44
CPC分类号： G01N21/6458 , G01N21/65 , G01N2021/653 , G01N2021/656
摘要： To enable both observations of coherent anti-Stokes Raman scattering light and multiphoton fluorescence in a same apparatus so as to observe a specimen by various observation methods. There is provided a laser microscope apparatus comprising: two optical paths for guiding pulsed laser beams having two different frequencies whose frequency difference is approximately equal to a specific molecular vibration frequency in a specimen; a multiplexer for combining the pulsed laser beams guided through these two optical paths; and a frequency dispersion adjuster which is provided on at least one of these two optical paths, and is capable of adjustment to approximately equalize frequency dispersion quantities of the pulsed laser beams guided through the two optical paths.
摘要翻译：为了使相同装置中的相干反斯托克斯拉曼散射光和多光子荧光观察到，可以通过各种观察方法观察样品。提供了一种激光显微镜装置，包括：两个光路，用于引导具有两个不同频率的脉冲激光束，其频率差近似等于样本中的特定分子振动频率; 用于组合通过这两个光路引导的脉冲激光束的多路复用器; 以及频率分散调整器，其被设置在这两个光路中的至少一个上，并且能够调节近似均衡通过两个光路引导的脉冲激光束的频率分散量。

2. 发明授权

US08159663B2 Laser microscope apparatus having a frequency dispersion adjuster 有权
标题翻译：具有频率分散调节器的激光显微镜装置
公开(公告)号：US08159663B2
公开(公告)日：2012-04-17
申请号：US12469007
申请日：2009-05-20
申请人： Shinichi Takimoto , Takeshi Hashimoto , Hirokazu Kubo , Tatsuo Nakata
发明人： Shinichi Takimoto , Takeshi Hashimoto , Hirokazu Kubo , Tatsuo Nakata
IPC分类号： G01J3/44 , G01N21/64 , G01N21/65
CPC分类号： G01N21/6458 , G01N21/65 , G01N2021/653 , G01N2021/656
摘要： To enable both observations of coherent anti-Stokes Raman scattering light and multiphoton fluorescence in a same apparatus so as to observe a specimen by various observation methods. There is provided a laser microscope apparatus comprising: two optical paths for guiding pulsed laser beams having two different frequencies whose frequency difference is approximately equal to a specific molecular vibration frequency in a specimen; a multiplexer for combining the pulsed laser beams guided through these two optical paths; and a frequency dispersion adjuster which is provided on at least one of these two optical paths, and is capable of adjustment to approximately equalize frequency dispersion quantities of the pulsed laser beams guided through the two optical paths.
摘要翻译：为了使相同装置中的相干反斯托克斯拉曼散射光和多光子荧光观察到，可以通过各种观察方法观察样品。提供了一种激光显微镜装置，包括：两个光路，用于引导具有两个不同频率的脉冲激光束，其频率差近似等于样本中的特定分子振动频率; 用于组合通过这两个光路引导的脉冲激光束的多路复用器; 以及频率分散调整器，其被设置在这两个光路中的至少一个上，并且能够调节近似均衡通过两个光路引导的脉冲激光束的频率分散量。

3. 发明申请

US20080192339A1 Laser Microscope 有权
标题翻译：激光显微镜
公开(公告)号：US20080192339A1
公开(公告)日：2008-08-14
申请号：US12012980
申请日：2008-02-06
申请人： Hirokazu Kubo
发明人： Hirokazu Kubo
IPC分类号： G02B21/06
CPC分类号： G02B21/0032 , G02F2203/26
摘要： It is possible to reduce a drop in output power in a positive-dispersion element used as a pulse compressor, thus improving multiphoton-excitation efficiency. Also, reducing the size of the positive-dispersion element makes it easier to attach it to a microscope main body and to accommodate it therein, thus improving maneuverability. The invention provides a laser microscope including a laser light source for emitting ultrashort-pulsed laser light; a pulse expander for expanding the ultrashort-pulsed laser light emitted from the laser light source; a large-diameter single-mode fiber for transmitting the ultrashort-pulsed laser light expanded by the pulse expander; a pulse compressor for compressing the ultrashort-pulsed laser light transmitted by the single-mode fiber; and a microscope main body for irradiating a specimen with the ultrashort-pulsed laser light compressed by the pulse compressor.
摘要翻译：可以减少用作脉冲压缩机的正色散元件中的输出功率的下降，从而提高多光子激发效率。此外，减小正分散元件的尺寸使得更容易将其附着到显微镜主体并将其容纳在其中，从而提高机动性。本发明提供一种激光显微镜，其包括用于发射超短脉冲激光的激光光源; 用于扩展从激光光源发射的超短脉冲激光的脉冲扩展器; 用于传输由脉冲扩展器扩展的超短脉冲激光的大直径单模光纤; 用于压缩由单模光纤传输的超短脉冲激光的脉冲压缩器; 以及用脉冲压缩机压缩的超短脉冲激光照射样本的显微镜主体。

4. 发明授权

US07121144B2 Pressure sensor having a metal diaphragm responsive to pressure 有权
标题翻译：压力传感器具有响应于压力的金属隔膜
公开(公告)号：US07121144B2
公开(公告)日：2006-10-17
申请号：US11019264
申请日：2004-12-23
申请人： Michitoshi Onoda , Michihiro Makita , Takeshi Ninomiya , Hirokazu Kubo
发明人： Michitoshi Onoda , Michihiro Makita , Takeshi Ninomiya , Hirokazu Kubo
IPC分类号： G01F7/08
CPC分类号： G01L19/0645 , G01L19/143
摘要： A pressure sensor is composed of a cylindrical connector case firmly connected to a housing and a pressure-detecting chamber formed between the connector case and the housing. The pressure-detecting chamber is confined by a metal diaphragm, an outer peripheral portion of which is firmly held at a portion connecting the connector case and the housing. A relatively thick ring plate is connected to a mounting surface of the housing, and the outer peripheral portion of the metal diaphragm is sandwiched between the ring plate and a pushing plate placed on and connected to the ring plate. Thus, the pressure-detecting chamber containing a sensing element therein is surely sealed even if the housing is made of a material, such as aluminum, which is different from that of the metal diaphragm.
摘要翻译：压力传感器由牢固地连接到壳体的圆筒形连接器壳体和形成在连接器壳体和壳体之间的压力检测室组成。压力检测室被金属隔膜限制，金属隔膜的外周部牢固地保持在连接壳体和壳体的部分。相对厚的环板连接到壳体的安装表面，并且金属隔膜的外周部分夹在环板和放置在环板上并与环板连接的推板之间。因此，即使壳体由与金属隔膜的材料不同的材料制成，也可以确保密封容纳有感应元件的压力检测室。

5. 发明授权

US07869124B2 Laser microscope 有权
标题翻译：激光显微镜
公开(公告)号：US07869124B2
公开(公告)日：2011-01-11
申请号：US12469944
申请日：2009-05-21
申请人： Hirokazu Kubo
发明人： Hirokazu Kubo
IPC分类号： G02B21/06 , G02B21/00 , G02F1/33
CPC分类号： G02B21/0036
摘要： It is an object to perform high-precision observation by compensating group-velocity-delay dispersion and angular dispersion with a simple structure. The invention provides a laser microscope 1 including a light source; an acousto-optic deflector 7 that deflects ultrashort-pulse laser light L emitted from the light source; an angular-dispersion element 8, disposed in front of or after the acousto-optic deflector 7, that applies angular dispersion in a direction opposite to the acousto-optic deflector 7; and a group-velocity-delay dispersion-amount adjusting unit 10 that adjusts the amount of dispersion compensation by moving the angular-dispersion element 8 so as to vary the optical path length at each wavelength between the angular-dispersion element 7 and the acousto-optic deflector 8.
摘要翻译：本发明的目的是通过以简单的结构补偿组速度延迟色散和角度色散来进行高精度观察。本发明提供一种包括光源的激光显微镜1; 声光偏转器7，其偏转从光源发射的超短脉冲激光L; 设置在声光偏转器7之前或之后的角度分散元件8，其在与声光偏转器7相反的方向上施加角度色散; 以及组速度延迟色散量调整单元10，其通过移动角分散元件8来调整色散补偿量，以便改变角分散元件7和声分散元件7之间的每个波长处的光路长度，光学偏转器8。

6. 发明授权

US07196796B2 Wavelength detecting apparatus, laser apparatus, and wavelength detecting method 有权
标题翻译：波长检测装置，激光装置和波长检测方法
公开(公告)号：US07196796B2
公开(公告)日：2007-03-27
申请号：US10341364
申请日：2003-01-14
申请人： Masato Moriya , Tatsuo Enami , Hirokazu Kubo , Masashi Shinbori , Toru Suzuki
发明人： Masato Moriya , Tatsuo Enami , Hirokazu Kubo , Masashi Shinbori , Toru Suzuki
IPC分类号： G01B9/02
CPC分类号： G01J9/0246 , H01S5/0687
摘要： In a wavelength detecting apparatus using an etalon, a drift in wavelength measurement by the etalon is stabilized and an adverse influence of out gas is eliminated, so that correct wavelength measurement is realized. The wavelength detecting apparatus includes a housing equipped with a port for use of introducing replacement gas, an etalon set inside the housing, and a moisture-absorbing unit for absorbing at least moisture released inside the housing.
摘要翻译：在使用标准具的波长检测装置中，标准具的波长测量的漂移被稳定，并且消除了气体的不良影响，从而实现了正确的波长测量。波长检测装置包括：壳体，其具有用于引入替代气体的端口，在壳体内部设置的标准具;以及用于吸收至少吸收在壳体内部释放的水分的吸湿单元。

7. 发明授权

US08279521B2 Optical device and laser microscope 有权
标题翻译：光学装置和激光显微镜
公开(公告)号：US08279521B2
公开(公告)日：2012-10-02
申请号：US12255021
申请日：2008-10-21
申请人： Hirokazu Kubo , Makio Ueno
发明人： Hirokazu Kubo , Makio Ueno
IPC分类号： G02B21/00 , G02B21/06
CPC分类号： G02B21/06 , G02B21/0032 , G02B21/0068 , H01S5/0064
摘要： The present invention is low cost, does not exert a negative influence on the surroundings, has a small group-velocity delay dispersion, efficiently blocks reflected return light such that the laser light does not return to the laser light source, and allows properly polarized laser light to enter a polarization-dependent element in a subsequent stage. An optical device is provided which includes a laser light source, an optical system that transmits laser light emitted from the laser light source, and a polarization-dependent element into which the laser light transmitted by the optical system enters. The characteristics of outgoing light are changed according to a polarization state of the incident light. The optical system includes a reflected-light generator that reflects a part of the transmitted laser light, and λ/4 wave plates are disposed such that the reflected-light generator is disposed therebetween.
摘要翻译：本发明成本低，不会对周围环境产生负面影响，具有小的群速延迟色散，有效地阻挡反射回光，使得激光不会返回到激光光源，并且允许适当的偏振激光光在后续阶段进入偏振相关元件。提供一种光学装置，其包括激光源，透射从激光源发射的激光的光学系统和由光学系统透射的激光进入的偏振相关元件。出射光的特性根据入射光的偏振状态而改变。光学系统包括反射部分发射激光的反射光发生器，并且设置λ/ 4波片，使得反射光发生器设置在它们之间。

8. 发明申请

US20090122397A1 OPTICAL DEVICE AND LASER MICROSCOPE 有权
标题翻译：光学器件和激光显微镜
公开(公告)号：US20090122397A1
公开(公告)日：2009-05-14
申请号：US12255021
申请日：2008-10-21
申请人： Hirokazu Kubo , Makio Ueno
发明人： Hirokazu Kubo , Makio Ueno
IPC分类号： G02B21/06
CPC分类号： G02B21/06 , G02B21/0032 , G02B21/0068 , H01S5/0064
摘要： The present invention is low cost, does not exert a negative influence on the surroundings, has a small group-velocity delay dispersion, efficiently blocks reflected return light such that the laser light does not return to the laser light source, and allows properly polarized laser light to enter a polarization-dependent element in a subsequent stage. An optical device is provided which includes a laser light source, an optical system that transmits laser light emitted from the laser light source, and a polarization-dependent element into which the laser light transmitted by the optical system enters. The characteristics of outgoing light are changed according to a polarization state of the incident light. The optical system includes a reflected-light generator that reflects a part of the transmitted laser light, and λ/4 wave plates are disposed such that the reflected-light generator is disposed therebetween.
摘要翻译：本发明成本低，不会对周围环境产生负面影响，具有小的群速延迟色散，有效地阻挡反射回光，使得激光不会返回到激光光源，并且允许适当的偏振激光光在后续阶段进入偏振相关元件。提供一种光学装置，其包括激光源，透射从激光源发射的激光的光学系统和由光学系统透射的激光进入的偏振相关元件。出射光的特性根据入射光的偏振状态而改变。光学系统包括反射部分透射的激光的反射光发生器，并且λ/ 4波片被布置成使得反射光发生器位于它们之间。

9. 发明授权

US07329880B2 Multiphoton-excitation laser scanning microscope 有权
标题翻译：多光子激发扫描显微镜
公开(公告)号：US07329880B2
公开(公告)日：2008-02-12
申请号：US11407300
申请日：2006-04-19
申请人： Hirokazu Kubo
发明人： Hirokazu Kubo
IPC分类号： G01T1/20
CPC分类号： G01J3/4406 , G01J3/10 , G01N21/6458 , G01N2201/06113 , G01N2201/08 , G02B21/0076 , G02B21/0084
摘要： A compact and inexpensive multiphoton-excitation laser scanning microscope for observing fluorescence by multiphoton excitation having a plurality of wavelengths by irradiating a specimen with ultrashort pulsed laser light having a plurality of wavelengths is provided. A multiphoton-excitation laser scanning microscope includes a laser light source that emits ultrashort pulsed laser light with a single wavelength, an optical fiber into which the ultrashort pulsed laser light from the laser light source is introduced and which broadens the spectrum of the ultrashort pulsed laser light, a laser scanning unit that scans the spectrally broadened ultrashort pulsed laser light emitted from the optical fiber, an objective optical system that focuses the scanned ultrashort pulsed laser light onto a specimen, optical detectors that detect fluorescence by multiphoton excitation emitted from the focal position of the ultrashort pulsed laser light in the specimen, and a dispersion-compensating optical system that compensates for the group velocity dispersion of the entire microscope that influences the pulse width of the ultrashort pulsed laser light.
摘要翻译：提供了一种紧凑而廉价的多光子激发扫描显微镜，用于通过用具有多个波长的超短脉冲激光照射样本，通过具有多个波长的多光子激发来观察荧光。多光子激发激光扫描显微镜包括发射具有单一波长的超短脉冲激光的激光光源，引入来自激光光源的超短脉冲激光的光纤，并且扩展了超短脉冲激光的光谱光，激光扫描单元，其扫描从光纤发射的光谱扩大的超短脉冲激光，将扫描的超短脉冲激光聚焦到样本上的物镜光学系统，通过从聚焦位置发射的多光子激发来检测荧光的光学检测器的样品中的超短脉冲激光，以及补偿影响超短脉冲激光的脉冲宽度的整个显微镜的组速度色散的色散补偿光学系统。

10. 发明授权

US08294985B2 Laser microscope apparatus 有权
标题翻译：激光显微镜装置
公开(公告)号：US08294985B2
公开(公告)日：2012-10-23
申请号：US12568775
申请日：2009-09-29
申请人： Hiroshi Sasaki , Hirokazu Kubo
发明人： Hiroshi Sasaki , Hirokazu Kubo
IPC分类号： G02B21/06
CPC分类号： G02B21/16 , G02B2207/114
摘要： Observation is performed using bright, clear multiphoton fluorescence images produced by efficiently generating a multiphoton excitation effect, without the need for a complex interference film structure. The invention employs a laser microscope apparatus including a first dichroic mirror that reflects visible laser light guided via a first light path and that transmits IR pulsed laser light guided via a second light path to combine the first light path and the second light path; an XY galvanometer mirror that scans the laser light from the first dichroic mirror on a specimen; an objective lens that irradiates the specimen with the scanned laser light and that collects fluorescence produced in the specimen; a second dichroic mirror that reflects the visible laser light and transmits the fluorescence from the specimen; and a detection unit that detects the fluorescence transmitted through the second dichroic mirror.
摘要翻译：使用通过有效地产生多光子激发效应产生的明亮，清晰的多光子荧光图像进行观察，而不需要复杂的干涉膜结构。本发明采用的激光显微镜装置包括：第一分色镜，其反射经由第一光路引导的可见激光，并透射经由第二光路引导的IR脉冲激光，以组合第一光路和第二光路; 扫描来自样品上的第一分色镜的激光的XY电流计镜; 物镜，用扫描的激光照射样本并收集样品中产生的荧光; 反射可见激光并透射来自样品的荧光的第二分色镜; 以及检测单元，其检测透过所述第二分色镜的荧光。

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