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1. 发明申请

US20070010689A1 Optically active 3,3'-dithiobis(2-amino-2methylpropionic acid) derivative and process for producing optically active 2-amino-3-mercapto-2-methylpropionic acid derivative 审中-公开
标题翻译：光活性的3,3'-二硫代双（2-氨基-2-甲基丙酸）衍生物和光学活性2-氨基-3-巯基-2-甲基丙酸衍生物的制备方法
公开(公告)号：US20070010689A1
公开(公告)日：2007-01-11
申请号：US10570791
申请日：2004-08-18
申请人： Shingo Matsumoto , Hiroshi Murao , Takao Yamaguchi , Masashi Izumida , Yasuyoshi Ueda
发明人： Shingo Matsumoto , Hiroshi Murao , Takao Yamaguchi , Masashi Izumida , Yasuyoshi Ueda
IPC分类号： C07C323/50
CPC分类号： C07D403/12 , C07B2200/07 , C07C319/06 , C07C323/58 , C07D233/76 , C12P7/52 , C12P11/00 , C12P41/002
摘要： The present invention provides a useful novel intermediate and a novel synthetic process that can highly prevent contamination by various impurities to an optically active R or S isomer of a 2-amino-3-mercapto-2-methylpropionic acid derivative or salt thereof useful as an intermediate for pharmaceuticals and the like and provides a process for easily and efficiently producing a high purity optically active R or S isomer of a 2-amino-3-mercapto-2-methylpropionic acid derivative or salt thereof on an industrial production scale. A process of producing a high purity 2-amino-3-mercapto-2-methylpropionic acid derivative or salt thereof includes reductively cleaving a sulfur-sulfur bond of an intermediate, which is a high purity optically active 3,3′-dithiobis(2-amino-2-methylpropionic acid) derivative substantially free of impurities. Thus, a resulting optically active 2-amino-3-mercapto-2-methylpropionic acid derivative can be produced without generating impurities as by-products which are difficult to remove.
摘要翻译：本发明提供了一种有用的新型中间体和新型合成方法，其可以高度防止各种杂质污染2-氨基-3-巯基-2-甲基丙酸衍生物的光学活性R或S异构体或其盐，其用作药物等的中间体，并且以工业生产规模提供容易且有效地制备2-氨基-3-巯基-2-甲基丙酸衍生物或其盐的高纯度光学活性R或S异构体的方法。制备高纯度2-氨基-3-巯基-2-甲基丙酸衍生物或其盐的方法包括还原性地裂解作为高纯度光学活性3,3'-二硫代双（2）的中间体的硫 - 硫键 - 氨基-2-甲基丙酸）衍生物。因此，得到的光学活性2-氨基-3-巯基-2-甲基丙酸衍生物可以不产生作为难以除去的副产物的杂质。

2. 发明授权

US09776029B2 Fire extinguishing agent and fire extinguishing method using same 有权
公开(公告)号：US09776029B2
公开(公告)日：2017-10-03
申请号：US14234303
申请日：2012-07-23
申请人： Masashi Izumida , Satohiro Yanagisawa , Yasuyoshi Ueda
发明人： Masashi Izumida , Satohiro Yanagisawa , Yasuyoshi Ueda
IPC分类号： A62D1/00 , C07K14/785 , A62D1/02
CPC分类号： A62D1/0042 , A62D1/00 , A62D1/0014 , A62D1/0071 , C07K14/785
摘要： The objective of the present invention is to provide an extinguishing agent which has excellent fire-extinguishing property and which exhibits high safety to the environment and human body. The fire extinguishing agent of the present invention is characterized in comprising a biosurfactant.

3. 发明申请

US20140290970A1 FIRE EXTINGUISHING AGENT AND FIRE EXTINGUISHING METHOD USING SAME 有权
标题翻译：消防灭火剂和消防灭火方法
公开(公告)号：US20140290970A1
公开(公告)日：2014-10-02
申请号：US14234303
申请日：2012-07-23
申请人： Masashi Izumida , Satohiro Yanagisawa , Yasuyoshi Ueda
发明人： Masashi Izumida , Satohiro Yanagisawa , Yasuyoshi Ueda
IPC分类号： A62D1/00
CPC分类号： A62D1/0042 , A62D1/00 , A62D1/0014 , A62D1/0071 , C07K14/785
摘要： The objective of the present invention is to provide an extinguishing agent which has excellent fire-extinguishing property and which exhibits high safety to the environment and human body. The fire extinguishing agent of the present invention is characterized in comprising a biosurfactant.
摘要翻译：本发明的目的是提供一种具有优异的灭火性能，对环境和人体的安全性高的灭火剂。本发明的灭火剂的特征在于包含生物表面活性剂。

4. 发明申请

US20090326246A1 Method for Production of Optically Active 3-Amino-Nitrogenated Compound 失效
标题翻译：光学活性3-氨基氮化合物的制备方法
公开(公告)号：US20090326246A1
公开(公告)日：2009-12-31
申请号：US12375141
申请日：2007-07-23
申请人： Masatoshi Ohnuki , Masashi Izumida , Akira Nishiyama , Shingo Matsumoto
发明人： Masatoshi Ohnuki , Masashi Izumida , Akira Nishiyama , Shingo Matsumoto
IPC分类号： C07D207/04
CPC分类号： C07D207/14 , C07D207/10 , C07D207/12 , C07D207/27
摘要： Aiming at production of an optically active 3-amino nitrogen-containing compound which is useful as an intermediate in synthesis of medicines and pesticides, in particular, an optically active 1-protected-3-aminopyrrolidine derivative, from an inexpensive and readily available raw material by a process which is efficient and can be practiced industrially, an optically active 3-amino nitrogen-containing compound is produced by performing a reaction of an optically active 3-substituted nitrogen-containing compound with ammonia, methylamine, ethylamine or dimethylamine in the presence of water. In addition, a 1-protected-3-aminopyrrolidine derivative is produced by performing a reaction of an optically active 1-protected-3-(sulfonyloxy)pyrrolidine derivative with ammonia, methylamine, ethylamine, or dimethylamine in the presence of methanol, ethanol, n-propanol, or isopropanol under a pressure of less than 30 barr.
摘要翻译：本发明涉及一种光学活性3-氨基含氮化合物的制备，其可用作药物和农药合成中的中间体，特别是光学活性的1-保护的3-氨基吡咯烷衍生物，由廉价且容易获得的原料通过工业上有效且可以在工业上实践的方法，通过在存在下进行光学活性的3-取代的含氮化合物与氨，甲胺，乙胺或二甲胺的反应来制备光学活性的3-氨基含氮化合物的水。此外，通过在甲醇，乙醇，甲醇，乙醇等的存在下进行光学活性的1-保护的3-（磺酰氧基）吡咯烷衍生物与氨，甲胺，乙胺或二甲胺的反应来制备1-保护的3-氨基吡咯烷衍生物，正丙醇或异丙醇，压力小于30巴。

5. 发明申请

US20080207936A1 Method of Producing 3-Hydroxybutyraldehyde Derivative 审中-公开
标题翻译：生产3-羟基丁醛衍生物的方法
公开(公告)号：US20080207936A1
公开(公告)日：2008-08-28
申请号：US11886837
申请日：2006-03-20
申请人： Masashi Izumida , Shingo Matsumoto
发明人： Masashi Izumida , Shingo Matsumoto
IPC分类号： C07F7/08
CPC分类号： C07F7/1892 , C07B53/00 , C07C29/147 , C07C45/29 , C07C47/19 , C07C31/207
摘要： The present invention relates to a method of producing a 3-hydroxybutyraldehyde derivative, particularly an optically active 3-hydroxybutyraldehyde derivative, which is useful as an intermediate of a pharmaceutical agent and the like.The method of the present invention is characterized by converting the 3-hydroxybutyrate derivative to an alcohol derivative by a reduction reaction followed by converting it to a desired aldehyde derivative by an oxidation reaction using a nitroxyl compound and a co-oxidant. In accordance with the present invention, a 3-hydroxybutyraldehyde derivative having high qualities (a low content of alcohol derivatives) can be produced by an easy and convenient method without resorting to a reaction under an extremely low temperature condition.
摘要翻译：本发明涉及可用作药剂等的中间体的3-羟基丁醛衍生物，特别是光学活性3-羟基丁醛衍生物的制造方法。本发明的方法的特征在于通过还原反应将3-羟基丁酸酯衍生物转化为醇衍生物，然后通过使用硝酰化合物和共氧化剂的氧化反应将其转化为所需的醛衍生物。根据本发明，通过简单方便的方法可以制得具有高质量（醇衍生物含量低）的3-羟基丁醛衍生物，而不会在极低温条件下进行反应。

6. 发明授权

US08030501B2 Process for producing optically active 3-amino nitrogen-containing compounds 失效
标题翻译：光学活性3-氨基含氮化合物的制备方法
公开(公告)号：US08030501B2
公开(公告)日：2011-10-04
申请号：US12375141
申请日：2007-07-23
申请人： Masatoshi Ohnuki , Masashi Izumida , Akira Nishiyama , Shingo Matsumoto
发明人： Masatoshi Ohnuki , Masashi Izumida , Akira Nishiyama , Shingo Matsumoto
IPC分类号： C07D295/00
CPC分类号： C07D207/14 , C07D207/10 , C07D207/12 , C07D207/27
摘要： Aiming at production of an optically active 3-amino nitrogen-containing compound which is useful as an intermediate in synthesis of medicines and pesticides, in particular, an optically active 1-protected-3-aminopyrrolidine derivative, from an inexpensive and readily available raw material by a process which is efficient and can be practiced industrially, an optically active 3-amino nitrogen-containing compound is produced by performing a reaction of an optically active 3-substituted nitrogen-containing compound with ammonia, methylamine, ethylamine or dimethylamine in the presence of water. In addition, a 1-protected-3-aminopyrrolidine derivative is produced by performing a reaction of an optically active 1-protected-3-(sulfonyloxy)pyrrolidine derivative with ammonia, methylamine, ethylamine, or dimethylamine in the presence of methanol, ethanol, n-propanol, or isopropanol under a pressure of less than 30 barr.
摘要翻译：本发明涉及一种光学活性3-氨基含氮化合物的制备，其可用作药物和农药合成中的中间体，特别是光学活性的1-保护的3-氨基吡咯烷衍生物，由廉价且容易获得的原料通过工业上有效且可以在工业上实践的方法，通过在存在下进行光学活性的3-取代的含氮化合物与氨，甲胺，乙胺或二甲胺的反应来制备光学活性的3-氨基含氮化合物的水。此外，通过在甲醇，乙醇，甲醇，乙醇等的存在下进行光学活性的1-保护的3-（磺酰氧基）吡咯烷衍生物与氨，甲胺，乙胺或二甲胺的反应来制备1-保护的3-氨基吡咯烷衍生物，正丙醇或异丙醇，压力小于30巴。

7. 发明申请

US20060105435A1 Process for producing optically active alpha-methylcysteine derivative 审中-公开
标题翻译：光学活性α-甲基半胱氨酸衍生物的制备方法
公开(公告)号：US20060105435A1
公开(公告)日：2006-05-18
申请号：US10515658
申请日：2003-06-05
申请人： Takahiro Ohishi , Hirokazu Nanba , Masanobu Sugawara , Masashi Izumida , Tatsuya Honda , Kohei Mori , Satohiro Yanagisawa , Nobuo Nagashima , Kenji Inoue
发明人： Takahiro Ohishi , Hirokazu Nanba , Masanobu Sugawara , Masashi Izumida , Tatsuya Honda , Kohei Mori , Satohiro Yanagisawa , Nobuo Nagashima , Kenji Inoue
IPC分类号： C12P13/12 , C12P17/00
CPC分类号： C12P13/12 , C07C319/06 , C07D233/76 , C12P17/04 , C12P17/10 , C12P41/009 , C07C323/58
摘要： The present invention provides a simple industrial process for producing an L- or D-optically active α-methylcysteine derivative or its salt, which is a useful pharmaceutical intermediate, from readily available, inexpensive raw materials. In a process for producing an L- or D-optically active α-methylcysteine derivative or its salt, a racemic N-carbamoyl-α-methylcysteine derivative or its salt is D-selectively cyclized with hydantoinase to produce a D-5-methyl-5-thiomethylhydantoin derivative or its salt and an N-carbamoyl-α-methyl-L-cysteine derivative or its salt, which are then subjected to deprotection of the amino group and the sulfur atom, and hydrolysis.
摘要翻译：本发明提供了一种用于从容易得到的廉价原料生产L-或D-光学活性α-甲基半胱氨酸衍生物或其盐的简单工业方法，其是有用的药物中间体。在制备L-或D-光学活性α-甲基半胱氨酸衍生物或其盐的方法中，外消旋的N-氨基甲酰基-α-甲基半胱氨酸衍生物或其盐与乙内酰脲酶D选择性环化以产生D-5-甲基 - 5-硫代甲基乙内酰脲衍生物或其盐和N-氨基甲酰基-α-甲基-L-半胱氨酸衍生物或其盐，然后对氨基和硫原子进行脱保护和水解。

8. 发明申请

US20130197190A1 METHOD FOR PRODUCING SURFACTIN AND SALT THEREOF 有权
标题翻译：生产磺草胺及其盐的方法
公开(公告)号：US20130197190A1
公开(公告)日：2013-08-01
申请号：US13876734
申请日：2011-09-30
申请人： Masashi Izumida , Hiroaki Kawasaki , Tadashi Moroshima
发明人： Masashi Izumida , Hiroaki Kawasaki , Tadashi Moroshima
IPC分类号： C07K1/14 , C07K1/36
CPC分类号： C07K1/145 , C07K1/36 , C07K7/06
摘要： The method for producing a surfactin or a salt thereof according to the present invention comprises the steps of adding an organic solvent containing a branched alkyl alcohol to a culture fluid containing the surfactin or the salt thereof, or to a solution obtained by removing an insoluble component from the culture fluid, and extracting the surfactin or the salt thereof with the organic solvent,wherein the surfactin or the salt thereof is represented by the formula (1): wherein * indicates an optically active center; X is an amino acid selected from leucine, isoleucine and valine; R is a C9-13 alkyl group or a C9-13 branched alkyl group; and M is an alkali metal, an alkaline earth metal, an optionally-substituted amine or the like.
摘要翻译：本发明的表面活性素或其盐的制造方法包括将含有支链烷基醇的有机溶剂添加到含有所述表面活性素或其盐的培养液中的步骤，或者将除去不溶成分从所述培养液中提取所述表面活性素或其盐，其中所述表面活性素或其盐由式（1）表示：其中*表示光学活性中心; X是选自亮氨酸，异亮氨酸和缬氨酸的氨基酸; R为C 9-13烷基或C 9-13支链烷基; M是碱金属，碱土金属，任意取代的胺等。

9. 发明授权

US08883968B2 Method for producing surfactin and salt thereof 有权
标题翻译：表面活性素及其盐的制备方法
公开(公告)号：US08883968B2
公开(公告)日：2014-11-11
申请号：US13876734
申请日：2011-09-30
申请人： Masashi Izumida , Hiroaki Kawasaki , Tadashi Moroshima
发明人： Masashi Izumida , Hiroaki Kawasaki , Tadashi Moroshima
IPC分类号： C07K1/14 , C07K1/30 , C07K7/06 , C07K1/36
CPC分类号： C07K1/145 , C07K1/36 , C07K7/06
摘要： The method for producing a surfactin or a salt thereof according to the present invention comprises the steps of adding an organic solvent containing a branched alkyl alcohol to a culture fluid containing the surfactin or the salt thereof, or to a solution obtained by removing an insoluble component from the culture fluid, and extracting the surfactin or the salt thereof with the organic solvent,wherein the surfactin or the salt thereof is represented by the formula (1): wherein * indicates an optically active center; X is an amino acid selected from leucine, isoleucine and valine; R is a C9-13 alkyl group or a C9-13 branched alkyl group; and M is an alkali metal, an alkaline earth metal, an optionally-substituted amine or the like.
摘要翻译：本发明的表面活性素或其盐的制造方法包括将含有支链烷基醇的有机溶剂添加到含有所述表面活性素或其盐的培养液中的步骤，或者将除去不溶成分从所述培养液中提取所述表面活性素或其盐，其中所述表面活性素或其盐由式（1）表示：其中*表示光学活性中心; X是选自亮氨酸，异亮氨酸和缬氨酸的氨基酸; R为C 9-13烷基或C 9-13支链烷基; M是碱金属，碱土金属，任意取代的胺等。

10. 发明申请

US20100197934A1 PROCESS FOR PRODUCING OPTICALLY ACTIVE ALPHA-METHYLCYSTEINE DERIVATIVE 审中-公开
标题翻译：生产光学活性阿尔法 - 甲基蛋白衍生物的方法
公开(公告)号：US20100197934A1
公开(公告)日：2010-08-05
申请号：US12757947
申请日：2010-04-09
申请人： Takahiro Ohishi , Hirokazu Nanba , Masanobu Sugawara , Masashi Izumida , Tatsuya Honda , Kohei Mori , Satohiro Yanagisawa , Nobuo Nagashima , Kenji Inoue
发明人： Takahiro Ohishi , Hirokazu Nanba , Masanobu Sugawara , Masashi Izumida , Tatsuya Honda , Kohei Mori , Satohiro Yanagisawa , Nobuo Nagashima , Kenji Inoue
IPC分类号： C12P17/10 , C12P13/12 , C07C321/00 , C07D233/02
CPC分类号： C12P13/12 , C07C319/06 , C07D233/76 , C12P17/04 , C12P17/10 , C12P41/009 , C07C323/58
摘要： The present invention provides a simple industrial process for producing an L- or D-optically active α-methylcysteine derivative or its salt, which is a useful pharmaceutical intermediate, from readily available, inexpensive raw materials. In a process for producing an L- or D-optically active α-methylcysteine derivative or its salt, a racemic N-carbamoyl-α-methylcysteine derivative or its salt is D-selectively cyclized with hydantoinase to produce a D-5-methyl-5-thiomethylhydantoin derivative or its salt and an N-carbamoyl-α-methyl-L-cysteine derivative or its salt, which are then subjected to deprotection of the amino group and the sulfur atom, and hydrolysis.
摘要翻译：本发明提供了一种简单的工业方法，用于从容易获得的便宜的原料制备作为有用的药物中间体的L-或D-光学活性的α-甲基半胱氨酸衍生物或其盐。在制备L-或D-光学活性α-甲基半胱氨酸衍生物或其盐的方法中，外消旋的N-氨基甲酰基-α-甲基半胱氨酸衍生物或其盐与乙内酰脲酶D选择性环化以产生D-5-甲基 - 5-硫代甲基乙内酰脲衍生物或其盐和N-氨基甲酰基-α-甲基-L-半胱氨酸衍生物或其盐，然后进行氨基和硫原子的脱保护和水解。

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