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1. 发明申请

US20090118602A1 Disease Diagnosis Support System 有权
标题翻译：疾病诊断支援系统
公开(公告)号：US20090118602A1
公开(公告)日：2009-05-07
申请号：US11916892
申请日：2006-06-08
申请人： Shingo Kawasaki , Noriyoshi Ichikawa , Fumio Kawaguchi , Hideo Kawaguchi , Naoki Tanaka , Masahiko Mikuni , Masato Fukuda
发明人： Shingo Kawasaki , Noriyoshi Ichikawa , Fumio Kawaguchi , Hideo Kawaguchi , Naoki Tanaka , Masahiko Mikuni , Masato Fukuda
IPC分类号： A61B5/1455
CPC分类号： A61B5/145 , A61B5/14546 , A61B5/14553 , G06F19/00 , G16H50/70
摘要： There is provided a system for supporting the assessment as to which disease group the subject to be examined falls in or what position in the whole disease group the subject is in. This support system comprises the data storage part which stores feature values of optical bio-measurement data of many subjects including patients in multiple disease groups, the analysis part which extracts plural kinds of feature values from the optical bio-measurement data and the display part which displays the results of analysis in the analysis part associated with the dictionary data, wherein the display part produces a scatter diagram on which features values of the dictionary data are plotted, with one of the two feature values being plotted along the axis of abscissa and the other along the axis of ordinate, and displays the positions of the subject to be assessed on the scatter diagram superimposed on the scatter diagram. With this scatter diagram, the relationship between the features of the subject and the feature of the disease group can be known in one glance.
摘要翻译：提供了一种系统，用于支持被检查对象的哪一个疾病组属于被检者所在的整个疾病组中的哪一个或多个位置。该支持系统包括存储光学生物学特征值的数据存储部分，包括多个疾病组中的患者的许多受试者的测量数据，从光学生物测量数据中提取多种特征值的分析部分和显示与字典数据相关联的分析部分中的分析结果的显示部分，其中显示部分产生一个散点图，绘制了字典数据的特征值，其中两个特征值中的一个沿着横坐标轴绘制，另一个是沿着纵坐标轴绘制，并将主体的位置显示为在散点图上进行评估，叠加在散点图上。利用该散点图，可以一目了然地了解该受试者的特征与疾病组特征之间的关系。

2. 发明申请

US20070055118A1 Optical measurement apparatus for living body 有权
标题翻译：生物体光学测量装置
公开(公告)号：US20070055118A1
公开(公告)日：2007-03-08
申请号：US10571430
申请日：2004-09-09
申请人： Shingo Kawasaki , Noriyoshi Ichikawa , Fumio Kawaguchi , Naoki Tanaka , Hideo Kawaguchi , Masahiko Mikuni , Masato Fukuda
发明人： Shingo Kawasaki , Noriyoshi Ichikawa , Fumio Kawaguchi , Naoki Tanaka , Hideo Kawaguchi , Masahiko Mikuni , Masato Fukuda
IPC分类号： A61B5/00
CPC分类号： A61B5/14553 , A61B5/14551 , A61B5/165
摘要： An apparatus which can objectively assess and display to what extent and to which disease the subject belongs based on the signals of changes in hemoglobin amount measured by the optical measurement apparatus is provided. The disease assessment apparatus comprises the feature extraction unit 15 for extracting features of the hemoglobin waveform, the feature analysis unit 16 and the storage unit 12 for storing features by each disease as database. The disease is assessed by extracting various kinds of feature amounts from the hemoglobin signals of the subject measured by the optical measurement apparatus in the feature extraction unit 15 and by applying multivariate analysis of similarities between feature amounts extracted and feature amounts stored by disease in the storage unit 12. Results of assessment are shown as scores expressing similarity with each disease group in a bar graph.
摘要翻译：提供了一种可以根据由光学测量装置测量的血红蛋白量变化的信号来客观地评估和显示受试者属于什么程度和哪种疾病所属的装置。疾病评估装置包括用于提取血红蛋白波形的特征的特征提取单元15，特征分析单元16和用于将每种疾病的特征存储为数据库的存储单元12。通过从特征提取单元15中的光学测量装置测量的对象的血红蛋白信号中提取各种特征量来评估疾病，并且通过在存储的特征量和特征量之间的相似性的多变量分析中应用多变量分析，单位12.评估结果以条形图表示与各疾病组相似度的分数。

3. 发明授权

US07353054B2 Optical measurement apparatus for living body 有权
标题翻译：生物体光学测量装置
公开(公告)号：US07353054B2
公开(公告)日：2008-04-01
申请号：US10571430
申请日：2004-09-09
申请人： Shingo Kawasaki , Noriyoshi Ichikawa , Fumio Kawaguchi , Naoki Tanaka , Hideo Kawaguchi , Masahiko Mikuni , Masato Fukuda
发明人： Shingo Kawasaki , Noriyoshi Ichikawa , Fumio Kawaguchi , Naoki Tanaka , Hideo Kawaguchi , Masahiko Mikuni , Masato Fukuda
IPC分类号： A61B5/00
CPC分类号： A61B5/14553 , A61B5/14551 , A61B5/165
摘要： An apparatus which can objectively assess and display to what extent and to which disease the subject belongs based on the signals of changes in hemoglobin amount measured by the optical measurement apparatus is provided. The disease assessment apparatus comprises the feature extraction unit 15 for extracting features of the hemoglobin waveform, the feature analysis unit 16 and the storage unit 12 for storing features by each disease as database. The disease is assessed by extracting various kinds of feature amounts from the hemoglobin signals of the subject measured by the optical measurement apparatus in the feature extraction unit 15 and by applying multivariate analysis of similarities between feature amounts extracted and feature amounts stored by disease in the storage unit 12. Results of assessment are shown as scores expressing similarity with each disease group in a bar graph.
摘要翻译：提供了一种可以根据由光学测量装置测量的血红蛋白量变化的信号来客观地评估和显示受试者属于什么程度和哪种疾病所属的装置。疾病评估装置包括用于提取血红蛋白波形的特征的特征提取单元15，特征分析单元16和用于将每种疾病的特征存储为数据库的存储单元12。通过从特征提取单元15中的光学测量装置测量的对象的血红蛋白信号中提取各种特征量来评估该疾病，并且通过应用提取的特征量和存储在存储器中的特征量的特征量之间的相似性的多变量分析来评估疾病单位12.评估结果以条形图表示与各疾病组相似度的分数。

4. 发明授权

US08386192B2 Disease diagnosis support system 有权
标题翻译：疾病诊断支持系统
公开(公告)号：US08386192B2
公开(公告)日：2013-02-26
申请号：US11916892
申请日：2006-06-08
申请人： Shingo Kawasaki , Noriyoshi Ichikawa , Fumio Kawaguchi , Hideo Kawaguchi , Naoki Tanaka , Masahiko Mikuni , Masato Fukuda
发明人： Shingo Kawasaki , Noriyoshi Ichikawa , Fumio Kawaguchi , Hideo Kawaguchi , Naoki Tanaka , Masahiko Mikuni , Masato Fukuda
IPC分类号： G01N33/48
CPC分类号： A61B5/145 , A61B5/14546 , A61B5/14553 , G06F19/00 , G16H50/70
摘要： There is provided a system for supporting the assessment as to which disease group the subject to be examined falls in or what position in the whole disease group the subject is in. This support system comprises the data storage part which stores feature values of optical bio-measurement data of many subjects including patients in multiple disease groups, the analysis part which extracts plural kinds of feature values from the optical bio-measurement data and the display part which displays the results of analysis in the analysis part associated with the dictionary data, wherein the display part produces a scatter diagram on which features values of the dictionary data are plotted, with one of the two feature values being plotted along the axis of abscissa and the other along the axis of ordinate, and displays the positions of the subject to be assessed on the scatter diagram superimposed on the scatter diagram. With this scatter diagram, the relationship between the features of the subject and the feature of the disease group can be known in one glance.
摘要翻译：提供了一种系统，用于支持被检查对象的哪一个疾病组属于被检者所在的整个疾病组中的哪一个或多个位置。该支持系统包括存储光学生物学特征值的数据存储部分，包括多个疾病组中的患者的许多受试者的测量数据，从光学生物测量数据中提取多种特征值的分析部分和显示与字典数据相关联的分析部分中的分析结果的显示部分，其中显示部分产生一个散点图，绘制了字典数据的特征值，其中两个特征值中的一个沿着横坐标轴绘制，另一个是沿着纵坐标轴绘制，并将主体的位置显示为在散点图上进行评估，叠加在散点图上。利用该散点图，可以一目了然地了解该受试者的特征与疾病组特征之间的关系。

5. 发明申请

US20120222470A1 WAY OF METHOD TRANSFER OF LIQUID CHROMATOGRAPH AND LIQUID CHROMATOGRAPH SYSTEM 审中-公开
标题翻译：方法转移液相色谱和液相色谱系统的方法
公开(公告)号：US20120222470A1
公开(公告)日：2012-09-06
申请号：US13472322
申请日：2012-05-15
申请人： Takaaki Suzuki , Masato Fukuda , Masahito Ito
发明人： Takaaki Suzuki , Masato Fukuda , Masahito Ito
IPC分类号： G01N30/02
CPC分类号： G01N30/8665 , G01N30/16 , G01N30/28 , G01N30/52 , G01N30/8658 , G01N30/8693 , G01N2030/027
摘要： Provided is a liquid chromatograph system and method configured to accurately obtain measurements by minimizing deviations in measurements due to a transfer from one measurement method to another measurement method. An aspect of the system and method includes minimizing deviations in measurements when a measurement method from a measurement system of a liquid chromatograph is transferred to measurement system under high pressure and high velocity. Such a transfer includes deviations due to differences in analysis conditions. The present subject matter uses a dwell volume value so as to minimize a deviation of measurement result due to methods before and after transfer. Another aspect includes calculating a correction value when there is a deviation in the measurement result, and automatically reflecting the correction value for the method transfer.
摘要翻译：提供了一种液相色谱系统和方法，其被配置为通过使由于从一种测量方法转移到另一种测量方法的测量中的偏差最小化来精确地获得测量。该系统和方法的一个方面包括当来自液相色谱仪的测量系统的测量方法在高压和高速下传递到测量系统时，测量的偏差最小化。这种转移包括由于分析条件的差异导致的偏差。本主题使用停留体积值，以便最小化由于传送之前和之后的方法导致的测量结果的偏差。另一方面包括当测量结果存在偏差时计算校正值，并自动反映方法传送的校正值。

6. 发明授权

US08205485B2 Way of method transfer of liquid chromatograph and liquid chromatograph system 有权
标题翻译：液相色谱仪和液相色谱系统的方法转移方式
公开(公告)号：US08205485B2
公开(公告)日：2012-06-26
申请号：US12470164
申请日：2009-05-21
申请人： Takaaki Suzuki , Masato Fukuda , Masahito Ito
发明人： Takaaki Suzuki , Masato Fukuda , Masahito Ito
IPC分类号： G01N30/00
CPC分类号： G01N30/8665 , G01N30/16 , G01N30/28 , G01N30/52 , G01N30/8658 , G01N30/8693 , G01N2030/027
摘要： Provided is a liquid chromatograph system and method configured to accurately obtain measurements by minimizing deviations in measurements due to a transfer from one measurement method to another measurement method. An aspect of the system and method includes minimizing deviations in measurements when a measurement method from a measurement system of a liquid chromatograph is transferred to measurement system under high pressure and high velocity. Such a transfer includes deviations due to differences in analysis conditions. The present subject matter uses a dwell volume value so as to minimize a deviation of measurement result due to methods before and after transfer. Another aspect includes calculating a correction value when there is a deviation in the measurement result, and automatically reflecting the correction value for the method transfer.
摘要翻译：提供了一种液相色谱系统和方法，其被配置为通过使由于从一种测量方法转移到另一种测量方法的测量中的偏差最小化来精确地获得测量。该系统和方法的一个方面包括当来自液相色谱仪的测量系统的测量方法在高压和高速下传递到测量系统时，测量的偏差最小化。这种转移包括由于分析条件的差异导致的偏差。本主题使用停留体积值，以便最小化由于传送之前和之后的方法导致的测量结果的偏差。另一方面包括当测量结果存在偏差时计算校正值，并自动反映方法传送的校正值。

7. 发明授权

US08871088B2 Liquid delivery device, liquid chromatograph, and method for operation of liquid delivery device 有权
标题翻译：液体输送装置，液相色谱仪和液体输送装置的操作方法
公开(公告)号：US08871088B2
公开(公告)日：2014-10-28
申请号：US12938780
申请日：2010-11-03
申请人： Hironori Kaji , Hiroyuki Wada , Masato Fukuda
发明人： Hironori Kaji , Hiroyuki Wada , Masato Fukuda
IPC分类号： G01N30/32 , F04B11/00 , B01D15/16
CPC分类号： B01D15/163 , F04B11/0075 , F04B2205/03 , F04B2205/05 , G01N30/32 , G01N2030/324 , G01N2030/326 , G01N2030/328 , Y10T137/0324 , Y10T137/86131
摘要： The present invention provides a liquid delivery device for liquid chromatographs which, by performing liquid delivery at an accurate flow rate with limited pulsation, gives accurate results of analysis. The present invention, with a view to preventing erroneous operation due to errors in measurements at the time of judgment of completion of compression of liquid, establishes the judgment point before the pressure measured by a cylinder pressure detector agrees with the pressure measured by a discharge pressure detector and also calculates the point of completion of compression. Control in this manner prevents pressure fluctuation. It also calculates for control the point of completion of compression from the history of compression performed previously.
摘要翻译：本发明提供了一种用于液相色谱仪的液体输送装置，通过以有限的脉动以精确的流速进行液体输送，给出了精确的分析结果。本发明为了防止在液体压缩完成判定时的测量误差的错误操作，在气缸压力检测器测得的压力与由排气压力测量的压力一致之前确立了判断点检测器，并计算压缩完成点。以这种方式进行控制可防止压力波动。它还从先前执行的压缩历史计算控制压缩完成点。

8. 发明授权

US08375772B2 Liquid chromatography apparatus and liquid chromatography analysis method 失效
标题翻译：液相色谱仪和液相色谱分析方法
公开(公告)号：US08375772B2
公开(公告)日：2013-02-19
申请号：US12244846
申请日：2008-10-03
申请人： Masato Fukuda , Hiroyuki Wada , Masahito Ito , Hironori Kaji , Kosaku Toyosaki
发明人： Masato Fukuda , Hiroyuki Wada , Masahito Ito , Hironori Kaji , Kosaku Toyosaki
IPC分类号： G01N30/04
CPC分类号： G01N30/34
摘要： An object of the present invention is to improve the accuracy in analysis repeatability of a liquid chromatography apparatus that feeds different eluent by use of a plurality of pumps and achieves the mixture of eluent.Each of the pumps includes means for notifying an automatic sampler and a higher-level control unit that the specified timing of a liquid feeding cycle is reached. A pump whose liquid feeding cycle is the slowest transmits own information so that analysis is synchronized with a liquid feeding cycle. Moreover, a cycle position of a liquid feeding cycle at the end of analysis is expected, and the analysis time is automatically adjusted so that the wait time until the start of the next analysis becomes the shortest.
摘要翻译：本发明的目的是提高通过使用多个泵进料不同洗脱液的液相色谱仪的分析重复性的准确性，并实现洗脱液的混合。每个泵包括用于通知自动取样器和上位控制单元的装置，以达到给定循环的指定时间。送液周期最慢的泵传送自己的信息，使分析与液体供给循环同步。此外，期望在分析结束时的送液循环的循环位置，并且自动调整分析时间，使得直到下一次分析开始的等待时间变得最短。

9. 发明申请

US20110042283A1 LIQUID DELIVERY DEVICE, LIQUID CHROMATOGRAPH, AND METHOD FOR OPERATION OF LIQUID DELIVERY DEVICE 有权
标题翻译：液体输送装置，液体色谱和液体输送装置的操作方法
公开(公告)号：US20110042283A1
公开(公告)日：2011-02-24
申请号：US12938780
申请日：2010-11-03
申请人： Hironori KAJI , Hiroyuki Wada , Masato Fukuda
发明人： Hironori KAJI , Hiroyuki Wada , Masato Fukuda
IPC分类号： B01D15/10 , B01D15/08 , B67D7/70
CPC分类号： B01D15/163 , F04B11/0075 , F04B2205/03 , F04B2205/05 , G01N30/32 , G01N2030/324 , G01N2030/326 , G01N2030/328 , Y10T137/0324 , Y10T137/86131
摘要： The present invention provides a liquid delivery device for liquid chromatographs which, by performing liquid delivery at an accurate flow rate with limited pulsation, gives accurate results of analyses. The present invention, with a view to preventing erroneous operation due to errors in measurements at the time of judgment of completion of compression of liquid, establishes the judgment point before the pressure measured by a cylinder pressure detector agrees with the pressure measured by a discharge pressure detector and also calculates the point of completion of compression. Control in this manner prevents pressure fluctuation. It also calculates for control the point of completion of compression from the history of compression performed previously.
摘要翻译：本发明提供一种用于液相色谱仪的液体输送装置，其通过以有限的脉动以精确的流速进行液体输送，给出精确的分析结果。本发明为了防止在液体压缩完成判定时的测量误差的错误操作，在气缸压力检测器测得的压力与由排气压力测量的压力一致之前确立了判断点检测器，并计算压缩完成点。以这种方式进行控制可防止压力波动。它还从先前执行的压缩历史计算控制压缩完成点。

10. 发明申请

US20090288473A1 WAY OF METHOD TRANSFER OF LIQUID CHROMATOGRAPH AND LIQUID CHROMATOGRAPH SYSTEM 有权
标题翻译：方法转移液相色谱和液相色谱系统的方法
公开(公告)号：US20090288473A1
公开(公告)日：2009-11-26
申请号：US12470164
申请日：2009-05-21
申请人： Takaaki Suzuki , Masato Fukuda , Masahito Ito
发明人： Takaaki Suzuki , Masato Fukuda , Masahito Ito
IPC分类号： G01N30/16
CPC分类号： G01N30/8665 , G01N30/16 , G01N30/28 , G01N30/52 , G01N30/8658 , G01N30/8693 , G01N2030/027
摘要： When transfer a method from a measurement system of a liquid chromatograph to a measurement system under a condition of a high pressure and a high velocity, an influence due to analysis condition cannot be neglected. Further, since a transfer value obtained by calculation is a logical value, an improper result can be obtained in an actual measurement. Further, since conventional methods are optimized by such as know-how based on previous experiences, how to carry on these know-how to a new method is remained to be solved.One of the features of the present invention is to use a value of dwell volume so as to minimize a deviation of measurement result due to methods before and after transfer. Another is, when a deviation of the measurement result is caused, to calculate a correction value for correcting the deviation from analysis of measurement data and to automatically reflect the correction value for the method transfer.
摘要翻译：当在高压和高速条件下将方法从液相色谱仪的测量系统转移到测量系统时，不能忽视由分析条件引起的影响。此外，由于通过计算获得的转印值是逻辑值，因此在实际测量中可以获得不正确的结果。此外，由于常规方法通过诸如以往经验的专有技术进行优化，所以仍然需要解决如何进行这些专门知识的新方法。本发明的特征之一是使用驻留体积的值，以便最小化由于转移之前和之后的方法导致的测量结果的偏差。另一个原因是当测量结果偏离时，计算用于校正偏离分析测量数据的偏差的校正值，并自动反映方法传送的校正值。

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