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1. 发明申请

US20050164286A1 Nucleic acid concentration quantitative analysis chip, nucleic acid concentration quantitative analysis apparatus, and nucleic acid concentration quantitative analysis method 审中-公开
标题翻译：核酸浓度定量分析芯片，核酸浓度定量分析仪器和核酸浓度定量分析方法
公开(公告)号：US20050164286A1
公开(公告)日：2005-07-28
申请号：US11082877
申请日：2005-03-18
申请人： Shin-ichi O'uchi , Hideyuki Funaki , Sadato Hongo , Koji Hashimoto , Nobuhiro Gemma , Jun Okada , Masayoshi Takahashi
发明人： Shin-ichi O'uchi , Hideyuki Funaki , Sadato Hongo , Koji Hashimoto , Nobuhiro Gemma , Jun Okada , Masayoshi Takahashi
IPC分类号： G01N33/53 , B01L3/00 , C12M1/00 , C12M1/34 , C12N15/09 , C12Q1/68 , C40B40/06 , G01N27/327 , G01N27/416 , G01N27/49 , G01N33/566 , G01N37/00
CPC分类号： C12M1/34 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00653 , B01J2219/00657 , B01J2219/00659 , B01J2219/00677 , B01J2219/00691 , B01J2219/00722 , B01L3/502715 , B01L2200/143 , B01L2200/148 , B01L2300/024 , B01L2300/0636 , B01L2300/0645 , B01L2300/087 , B01L2300/0883 , B01L2400/0487 , C12Q1/68 , C12Q1/6837 , C40B40/06
摘要： The present invention includes a plurality of working electrodes on which the same type of nucleic acid probes each having a nucleic acid complementary to a target nucleic acid are immobilized and which have different sensor areas and a normalization circuit which normalizes detection signals obtained by the working electrodes with respect to the respective sensor areas.
摘要翻译：本发明包括多个工作电极，其上固定有与靶核酸互补的核酸的相同类型的核酸探针，并且具有不同的传感器区域，以及归一化电路，其对由工作电极获得的检测信号进行归一化相对于各个传感器区域。

2. 发明申请

US20070227885A1 NUCLEIC ACID DETECTION DEVICE 有权
标题翻译：核酸检测装置
公开(公告)号：US20070227885A1
公开(公告)日：2007-10-04
申请号：US11682484
申请日：2007-03-06
申请人： Jun Okada , Sadato Hongo , Nobuhiro Gemma
发明人： Jun Okada , Sadato Hongo , Nobuhiro Gemma
IPC分类号： G01N33/487
CPC分类号： B01L3/5027 , B01L2300/0636 , B01L2300/0645 , B01L2300/0883 , G01N27/3275
摘要： A nucleic acid detection device includes a flow channel through which a solution containing a nucleic acid recognition body flows, probe electrodes having immobilized nucleic acid probes, and a counter electrode used to measure an electrochemical response of the nucleic acid recognition body. The flow channel includes a curved portion and a straight portion continued from and located downstream of the curved portion. The probe electrodes are arranged at intervals along the straight portion, avoiding an upstream end of the straight portion that is located within a distance L from the curved portion. The distance L is given by L=0.065×Re×D, Re=ρuD/μ, and D=4 S/Lp where ρ, u, and μ are a concentration, a flow velocity, and a viscosity of the solution, and S and Lp are a sectional area and a wall peripheral perimeter of the flow channel, respectively.
摘要翻译：核酸检测装置包括含有核酸识别体的溶液流过的流路，具有固定化的核酸探针的探针电极和用于测定核酸识别体的电化学响应的对极。流动通道包括弯曲部分和从弯曲部分连续并位于弯曲部分下游的直线部分。探针电极沿着直线部分间隔设置，避免了直线部分的距弯曲部分的距离L内的上游端。距离L由L = 0.065xRexD，Re = rhouD / mu和D = 4S / Lp给出，其中rho，u和μ是溶液的浓度，流速和粘度，S和Lp 分别是流动通道的截面积和壁周边周长。

3. 发明申请

US20070215466A1 NUCLEIC ACID DETECTION DEVICE AND NUCLEIC ACID DETECTION APPARATUS 审中-公开
标题翻译：核酸检测装置和核酸检测装置
公开(公告)号：US20070215466A1
公开(公告)日：2007-09-20
申请号：US11555936
申请日：2006-11-02
申请人： Jun Okada , Sadato Hongo , Nobuhiro Gemma
发明人： Jun Okada , Sadato Hongo , Nobuhiro Gemma
IPC分类号： G01N33/487
CPC分类号： G01N27/4473
摘要： A nucleic acid detection device includes a flow channel which allows a solution containing a nucleic acid recognition body to flow therethrough, at least two first electrode portions including a probe electrode to which at least one nucleic acid probe is immobilized, and at least two second electrode portions including a reference electrode to be used for measuring a reference value. The first and second electrode portions are arranged in the flow channel to form a row along the flow channel. One of the second electrode portions is adjacent to one of the first electrode portions.
摘要翻译：核酸检测装置包括允许含有核酸识别体的溶液流过其中的流动通道，至少两个第一电极部分，包括固定有至少一个核酸探针的探针电极和至少两个第二电极包括用于测量参考值的参考电极的部分。第一和第二电极部分布置在流动通道中以沿着流动通道形成一排。第二电极部分中的一个与第一电极部分中的一个相邻。

4. 发明授权

US07851206B2 Nucleic acid detection device 有权
标题翻译：核酸检测装置
公开(公告)号：US07851206B2
公开(公告)日：2010-12-14
申请号：US11682484
申请日：2007-03-06
申请人： Jun Okada , Sadato Hongo , Nobuhiro Gemma
发明人： Jun Okada , Sadato Hongo , Nobuhiro Gemma
IPC分类号： C12M1/34 , C12M3/00
CPC分类号： B01L3/5027 , B01L2300/0636 , B01L2300/0645 , B01L2300/0883 , G01N27/3275
摘要： A nucleic acid detection device includes a flow channel through which a solution containing a nucleic acid recognition body flows, probe electrodes having immobilized nucleic acid probes, and a counter electrode used to measure an electrochemical response of the nucleic acid recognition body. The flow channel includes a curved portion and a straight portion continued from and located downstream of the curved portion. The probe electrodes are arranged at intervals along the straight portion, avoiding an upstream end of the straight portion that is located within a distance L from the curved portion. The distance L is given by L=0.065×Re×D, Re=ρuD/μ, and D=4S/Lp where ρ, u, and μ are a concentration, a flow velocity, and a viscosity of the solution, and S and Lp are a sectional area and a wall peripheral perimeter of the flow channel, respectively.
摘要翻译：核酸检测装置包括含有核酸识别体的溶液流过的流路，具有固定化的核酸探针的探针电极和用于测定核酸识别体的电化学响应的对极。流动通道包括弯曲部分和从弯曲部分连续并位于弯曲部分下游的直线部分。探针电极沿着直线部分间隔设置，避免了直线部分的距弯曲部分的距离L内的上游端。距离L由L = 0.065×Re×D，Re =＆rgr; uD /μ和D = 4S / Lp给出，其中＆rgr，u和μ是溶液的浓度，流速和粘度，S和Lp分别是流动通道的截面面积和壁周长。

5. 发明申请

US20100032319A1 DIAGNOSTIC CASSETTE FOR ELECTROCHEMICAL MEASURING APPARATUS AND METHOD OF DIAGNOSING ELECTROCHEMICAL MEASURING APPARATUS 审中-公开
标题翻译：电化学测量仪器诊断仪器及诊断电化学测量仪器的方法
公开(公告)号：US20100032319A1
公开(公告)日：2010-02-11
申请号：US12408980
申请日：2009-03-23
申请人： Jun Okada , Nobuhiro Gemma , Sadato Hongo , Tetsuya Kuwabara
发明人： Jun Okada , Nobuhiro Gemma , Sadato Hongo , Tetsuya Kuwabara
IPC分类号： G01N27/26
CPC分类号： G01N27/3277 , G01N27/4163
摘要： A diagnostic cassette for diagnosing an electrochemical measuring apparatus is disclosed. The electrochemical measuring apparatus is to perform electrochemical measurement on a sample in a sample cassette, which is attachable to and detachable from the electrochemical measuring apparatus, and includes a first working electrode interface, a first counter electrode interface, and a first reference electrode interface. The diagnostic cassette is attachable to and detachable from the electrochemical measuring apparatus like the sample cassette, and includes a second working electrode interface connectable to the first working electrode interface, a second counter electrode interface connectable to the first counter electrode interface, a second reference electrode interface connectable to the first reference electrode interface, and one of a capacitor and a resistor including one terminal connected to the second working electrode interface and the other terminal connected to the second counter electrode interface and the second reference electrode interface.
摘要翻译：公开了一种用于诊断电化学测量装置的诊断盒。电化学测量装置是对可附着到电化学测量装置上并可从电化学测量装置拆卸的样品盒中的样品进行电化学测量，并且包括第一工作电极界面，第一对电极界面和第一参考电极界面。诊断盒可以像样品盒一样安装到电化学测量装置上并可拆卸，并且包括可连接到第一工作电极接口的第二工作电极接口，可连接到第一对电极接口的第二对电极接口，第二参比电极接口，其可连接到第一参考电极接口，以及电容器和电阻器中的一个，包括连接到第二工作电极接口的一个端子和连接到第二对电极接口和第二参考电极接口的另一端子。

6. 发明申请

US20080233634A1 NUCLEIC ACID DETECTION DEVICE 审中-公开
标题翻译：核酸检测装置
公开(公告)号：US20080233634A1
公开(公告)日：2008-09-25
申请号：US12048690
申请日：2008-03-14
申请人： Jun OKADA , Sadato Hongo , Keiko Ito , Kenji Ooki , Nobuhiro Gemma
发明人： Jun OKADA , Sadato Hongo , Keiko Ito , Kenji Ooki , Nobuhiro Gemma
IPC分类号： C12M1/00
CPC分类号： G01N35/085
摘要： A nucleic acid detection device is provided with a closed channel formed of a first channel portion, through which a washing reagent storage section for storing a washing reagent for washing a detection section for nucleic acid detection communicates with the detection section, and a second channel portion through which a pretreatment section for nucleic acid treatment communicates with the detection section. The closed channel is connected with a gas inlet/outlet path for communication with the outside. The gas inlet/outlet path is blocked by a sealing mechanism before nucleic acid detection. In storing a pretreatment reagent and the washing reagent frozen, the gas inlet/outlet path is kept open and connected to the channel. Thus, there is provided a nucleic acid detection device having a structure for preventing leakage of nucleic acid samples to the outside and which can be stored for a long period of time with the reagents therein.
摘要翻译：核酸检测装置设置有由第一通道部分形成的封闭通道，用于存储用于清洗用于核酸检测的检测部分的洗涤剂的洗涤剂存储部分与检测部分通信，第二通道部分用于核酸处理的预处理部分与检测部分通信。封闭通道与用于与外部连通的气体入口/出口路径连接。在核酸检测之前，气体入口/出口路径被密封机构堵塞。在储存预处理试剂和洗涤剂冻结时，气体入口/出口路径保持打开并连接到通道。因此，提供了一种核酸检测装置，其具有防止核酸样品向外部泄漏的结构，并且可以用其中的试剂长时间储存。

7. 发明申请

US20070240985A1 DEVICE USED TO DETECT NUCLEIC ACID 审中-公开
标题翻译：用于检测核酸的装置
公开(公告)号：US20070240985A1
公开(公告)日：2007-10-18
申请号：US11734074
申请日：2007-04-11
申请人： Jun Okada , Sadato Hongo , Nobuhiro Gemma
发明人： Jun Okada , Sadato Hongo , Nobuhiro Gemma
IPC分类号： G01N33/487
CPC分类号： G01N27/3275 , B01L3/5027
摘要： A device includes a flow channel through which a solution containing at least one of a target nucleic acid and a nucleic acid recognition body flows. The flow channel includes a flat bottom surface parallel to the flowing direction of the solution and an inclined surface gradually projecting from the bottom surface in the flowing direction. The device also includes a probe electrode provided on the inclined surface. The probe electrode is formed of an exposed portion of a metal film through an opening of a passivation film stacked on the metal film. An angle θ that the probe electrode forms with respect to the bottom surface, a maximal width R of the opening in the flowing direction, and a thickness d of the passivation film satisfy tan θ>d/R.
摘要翻译：一种装置包括流动通道，含有至少一种靶核酸和核酸识别体的溶液通过该通道流动。流动通道包括平行于溶液的流动方向的平坦底表面和从流动方向上从底部表面逐渐突出的倾斜表面。该装置还包括设置在倾斜表面上的探针电极。探针电极通过层叠在金属膜上的钝化膜的开口由金属膜的暴露部分形成。探针电极相对于底面形成的角度θ，开口在流动方向上的最大宽度R以及钝化膜的厚度d满足tanθd / R。

8. 发明申请

US20090023201A1 NUCLEIC ACID DETECTING CASSETTE AND NUCLEIC ACID DETECTING APPARATUS 审中-公开
标题翻译：核酸检测CASSETTE和核酸检测装置
公开(公告)号：US20090023201A1
公开(公告)日：2009-01-22
申请号：US12175978
申请日：2008-07-18
申请人： Sadato Hongo , Takahiro Kokubo , Hideki Horiuchi , Koji Hashimoto , Jun Okada
发明人： Sadato Hongo , Takahiro Kokubo , Hideki Horiuchi , Koji Hashimoto , Jun Okada
IPC分类号： C12M1/00
CPC分类号： B01L3/502738 , B01L3/502 , B01L3/50273 , B01L7/52 , B01L2200/0621 , B01L2200/10 , B01L2200/12 , B01L2200/142 , B01L2300/06 , B01L2300/0627 , B01L2300/0645 , B01L2300/0816 , B01L2300/0867 , B01L2300/087 , B01L2300/0874 , B01L2300/0887 , B01L2300/123 , B01L2300/1805 , B01L2300/1827 , B01L2300/1883 , B01L2400/0487 , B01L2400/0655 , G01N2035/00366
摘要： In a nucleic acid detecting cassette in which a heating treatment chamber and a liquid delivery channel are constituted of a stationary member and flexible members, the heating treatment chamber is held by convex heating sections from both sides, whereby the heat treatment chamber and the liquid delivery channel are spatially separated from each other. Thus, it is possible to automatically execute a consistent process including nucleic acid amplification and other required treatments of the object sample as well as detection of a target nucleic acid.
摘要翻译：在其中加热处理室和液体输送通道由固定部件和柔性部件构成的核酸检测盒中，加热处理室由两侧由凸形加热部保持，由此热处理室和液体输送通道在空间上彼此分离。因此，可以自动执行包括对象样品的核酸扩增和其他所需处理以及靶核酸的检测的一致的过程。

9. 发明授权

US07745203B2 Base sequence detection apparatus and base sequence automatic analyzing apparatus 有权
标题翻译：基序检测装置和基序自动分析装置
公开(公告)号：US07745203B2
公开(公告)日：2010-06-29
申请号：US11045646
申请日：2005-01-31
申请人： Sadato Hongo , Minoru Ishikawa , Takiji Ishimura , Shigeru Wakayama , Shinji Yanaga , Kenji Oki , Jun Okada
发明人： Sadato Hongo , Minoru Ishikawa , Takiji Ishimura , Shigeru Wakayama , Shinji Yanaga , Kenji Oki , Jun Okada
IPC分类号： C12M1/00 , C12M1/34 , C12M3/00
CPC分类号： G01N33/5438
摘要： A base sequence detection apparatus is provided with a channel formed on a base sequence detection chip. Working electrodes are formed along the channel and include a probe immobilized thereon, counter electrodes are formed on the inner surface of the channel and, reference electrodes are formed on the inner surface of the channel. An introduction port introduces solution or air from the upstream side of the channel, a delivery port delivers the solution or air in the channel, and the sample is injected into the channel through a sample injection port.
摘要翻译：碱基序列检测装置具有形成在基序列检测芯片上的信道。沿通道形成工作电极，并且包括固定在其上的探针，在通道的内表面上形成相对电极，并且在通道的内表面上形成参考电极。引入端口从通道的上游侧引入溶液或空气，输送口将溶液或空气输送到通道中，并且样品通过样品注入口注入通道。

10. 发明授权

US07482153B2 Nucleic acid detection cassette and nucleic acid detection device 有权
标题翻译：核酸检测盒和核酸检测装置
公开(公告)号：US07482153B2
公开(公告)日：2009-01-27
申请号：US11384506
申请日：2006-03-21
申请人： Jun Okada , Sadato Hongo , Kenji Ooki
发明人： Jun Okada , Sadato Hongo , Kenji Ooki
IPC分类号： C12M3/00
CPC分类号： B01L3/502715 , B01L3/502738 , B01L2200/027 , B01L2200/04 , B01L2200/10 , B01L2200/16 , B01L2300/044 , B01L2300/0636 , B01L2300/0645 , B01L2300/0809 , B01L2300/0861 , B01L2300/0874 , B01L2400/0478 , B01L2400/0481 , B01L2400/0487
摘要： A nucleic acid detection cassette includes a cassette body, a nucleic acid detection region disposed in the cassette body, a first channel disposed in the cassette body, a second channel disposed in the cassette body. The nucleic acid detection region, in which a nucleic acid probe is immobilized, has a reagent inflow port, to which the first channel is connected, and a reagent outflow port, to which the second channel is connected. The nucleic acid detection cassette further includes a reagent injection portion which injects a reagent into the first channel, and a nucleic acid pretreatment region which is disposed in the first channel and which performs pretreatment for the detection of a nucleic acid. The first channel, the second channel, the nucleic acid detection region, the nucleic acid pretreatment region, and the reagent injection portion are sealed.
摘要翻译：核酸检测盒包括盒体，设置在盒主体中的核酸检测区域，设置在盒体中的第一通道，设置在盒体中的第二通道。其中固定有核酸探针的核酸检测区具有与第一通道连接的试剂流入口和连接第二通道的试剂流出口。核酸检测盒还包括向第一信道注入试剂的试剂注入部，以及配置在第一信道中并进行核酸检测的预处理的核酸预处理区域。第一通道，第二通道，核酸检测区域，核酸预处理区域和试剂注入部分被密封。

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