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1. 发明授权

US5582697A Biosensor, and a method and a device for quantifying a substrate in a sample liquid using the same 失效
标题翻译：生物传感器，以及使用其进行样品液体中的基板的定量的方法和装置
公开(公告)号：US5582697A
公开(公告)日：1996-12-10
申请号：US425820
申请日：1995-04-20
申请人： Shin Ikeda , Toshihiko Yoshioka , Shiro Nankai , Haruhiro Tsutsumi , Hideyuki Baba , Yoshinobu Tokuno , Syoji Miyazaki
发明人： Shin Ikeda , Toshihiko Yoshioka , Shiro Nankai , Haruhiro Tsutsumi , Hideyuki Baba , Yoshinobu Tokuno , Syoji Miyazaki
IPC分类号： C12Q1/00 , G01N27/26
CPC分类号： C12Q1/005 , C12Q1/001 , Y10S435/817
摘要： The biosensor of this invention can quantify a substrate in a sample liquid by electrochemically measuring the amount of an electron acceptor that has been reduced by electrons generated in a reaction between the substrate and an oxidoreductase. The biosensor has an electrically insulating substrate and an electrode system formed on the substrate including a working electrode, a counter electrode and a third electrode used for detecting a liquid junction. The third electrode can be used merely for detecting a liquid junction, or can be used as both a reference electrode and a liquid junction detecting electrode.
摘要翻译：本发明的生物传感器可以通过电化学测量由底物和氧化还原酶之间的反应中产生的电子而减少的电子受体的量来量化样品液体中的底物。生物传感器具有电绝缘基板和形成在基板上的电极系统，该基板包括工作电极，对电极和用于检测液体接合点的第三电极。第三电极可以仅用于检测液体接点，也可以用作参考电极和液体接点检测电极。

2. 发明授权

US5650062A Biosensor, and a method and a device for quantifying a substrate in a sample liquid using the same 失效
标题翻译：生物传感器，以及使用其进行样品液体中的基板的定量的方法和装置
公开(公告)号：US5650062A
公开(公告)日：1997-07-22
申请号：US526557
申请日：1995-09-12
申请人： Shin Ikeda , Toshihiko Yoshioka , Shiro Nankai , Haruhiro Tsutsumi , Hideyuki Baba , Yoshinobu Tokuno , Syoji Miyazaki
发明人： Shin Ikeda , Toshihiko Yoshioka , Shiro Nankai , Haruhiro Tsutsumi , Hideyuki Baba , Yoshinobu Tokuno , Syoji Miyazaki
IPC分类号： C12Q1/00 , G01N27/26
CPC分类号： C12Q1/001 , Y10S435/817
摘要： The biosensor of this invention can quantify a substrate in a sample liquid by electrochemically measuring the amount of an electron acceptor that has been reduced by electrons generated in a reaction between the substrate and an oxidoreductase. The biosensor has an electrically insulating substrate and an electrode system formed on the substrate including a working electrode, a counter electrode and a third electrode used for detecting a liquid junction. The third electrode can be used merely for detecting a liquid junction, or can be used as both a reference electrode and a liquid junction detecting electrode.
摘要翻译：本发明的生物传感器可以通过电化学测量由底物和氧化还原酶之间的反应中产生的电子而减少的电子受体的量来量化样品液体中的底物。生物传感器具有电绝缘基板和形成在基板上的电极系统，该基板包括工作电极，对电极和用于检测液体接合点的第三电极。第三电极可以仅用于检测液体接点，也可以用作参考电极和液体接点检测电极。

3. 发明授权

US5565085A Method for quantifying specific compound 失效
标题翻译：定量化合物的方法
公开(公告)号：US5565085A
公开(公告)日：1996-10-15
申请号：US428040
申请日：1995-04-25
申请人： Shin Ikeda , Toshihiko Yoshioka , Shiro Nankai , Haruhiro Tsutsumi , Hideyuki Baba , Yoshinobu Tokuno
发明人： Shin Ikeda , Toshihiko Yoshioka , Shiro Nankai , Haruhiro Tsutsumi , Hideyuki Baba , Yoshinobu Tokuno
IPC分类号： G01N27/416 , C12Q1/00 , G01N27/30 , G01N27/327 , G01N27/26
CPC分类号： C12Q1/001 , Y10S435/817
摘要： A biosensor for quantifying a specific compound has a reaction layer containing at least an enzyme, and an electrode system having a working electrode and a counter electrode formed on an insulating base plate; the biosensor detects the specific compound contained in a sample on the basis of an electrochemical response. In quantifying, the working electrode and the counter electrode are short-circuited before the voltage is applied therebetween. The short-circuiting eliminates measuring errors that may occur due to nonuniform dissolution of the reaction layer in a sample, and achieves highly reliable quantification of a specific compound.
摘要翻译：用于定量特定化合物的生物传感器具有至少含有酶的反应层和在绝缘基板上形成有工作电极和对电极的电极系统; 生物传感器基于电化学响应来检测样品中包含的特定化合物。在量化之前，工作电极和对电极在施加电压之前短路。短路消除了由于反应层在样品中的不均匀溶解而可能发生的测量误差，并且实现了特定化合物的高度可靠的定量。

4. 发明授权

US5512159A Biosensor 失效
标题翻译：生物传感器
公开(公告)号：US5512159A
公开(公告)日：1996-04-30
申请号：US293131
申请日：1994-08-19
申请人： Toshihiko Yoshioka , Mariko Kawaguri , Shiro Nankai , Haruhiro Tsutsumi , Hideyuki Baba , Yoshinobu Tokuno , Shoji Miyazaki
发明人： Toshihiko Yoshioka , Mariko Kawaguri , Shiro Nankai , Haruhiro Tsutsumi , Hideyuki Baba , Yoshinobu Tokuno , Shoji Miyazaki
IPC分类号： G01N27/28 , C12M1/34 , C12M1/40 , C12Q1/00 , C12Q1/54 , G01N27/327 , G01N33/483
CPC分类号： C12Q1/001
摘要： A biosensor of the present invention is provided with an insulating base plate, an electrode system mainly consisting of a working electrode and a counter electrode formed on the insulating base plate, and a reaction layer on the electrode system. The counter electrode is partially a circular arc. A manufacturing method of the biosensor of the present invention is comprised of a step to form a base by arranging leads, an electrode system, and an insulating layer on an insulating base plate, and a step to form a reaction layer mainly composed of an enzyme on the electrode system. Since the counter electrode is partially in the shape of a circular arc, the reaction layer is easily formed and prevented from delaminating, whereby the measuring accuracy, preservative properties and reliability of the biosensor are improved. The present invention enables highly efficient biosensors to be mass produced at low cost.
摘要翻译：本发明的生物传感器设置有绝缘基板，主要由在绝缘基板上形成的工作电极和对电极组成的电极系统和电极系统上的反应层。对电极部分是圆弧。本发明的生物传感器的制造方法包括通过在绝缘基板上排列引线，电极系统和绝缘层形成基底的步骤，以及形成主要由酶组成的反应层的步骤在电极系统上。由于对电极部分为圆弧形状，反应层易于形成并防止分层，从而提高了生物传感器的测量精度，防腐性能和可靠性。本发明能够以低成本批量生产高效生物传感器。

5. 发明授权

US5320732A Biosensor and measuring apparatus using the same 失效
标题翻译：生物传感器和使用其的测量装置
公开(公告)号：US5320732A
公开(公告)日：1994-06-14
申请号：US75859
申请日：1993-06-11
申请人： Shiro Nankai , Mariko Kawaguri , Toshihiko Yoshioka , Haruhiro Tsutsumi , Minoru Fukuda
发明人： Shiro Nankai , Mariko Kawaguri , Toshihiko Yoshioka , Haruhiro Tsutsumi , Minoru Fukuda
IPC分类号： G01N27/28 , G01N33/487 , G01N27/26
CPC分类号： G01N27/3272
摘要： The subject invention provides a simple sensor and an easy to handle biosensor measuring apparatus for the purpose of making measurements easily, rapidly and with high accuracy for specific components within a biological specimen such as blood.The biosensor of the subject invention is provided with a protrusion or a depression in a portion of a base having at least a measurement electrode and an opposing electrode. Also, the biosensor measuring apparatus is so configurated to have a mating means in the main body of the measuring apparatus freely supporting this biosensor to contact the said sensor's protrusion or depression, and further having the activating switch of the driving power supply located in this mating means.By means of these, it is possible to prevent wasteful measuring operations, as noted in the prior art biosensors, such as inserting the sensor backwards and making measurements with the sensor inserted backwards.
摘要翻译：本发明提供了一种简单的传感器和易于处理的生物传感器测量装置，用于容易，快速且高度精确地测量诸如血液的生物样本内的特定组分的目的。本发明的生物传感器在至少具有测量电极和相对电极的基部的一部分中设置有突起或凹陷。此外，生物传感器测量装置被配置为具有在测量装置的主体中具有自由支撑该生物传感器的配合装置以接触所述传感器的突起或凹陷，并且还具有位于该配合中的驱动电源的启动开关手段。通过这些，可以防止浪费的测量操作，如现有技术的生物传感器中所述，例如向后插入传感器并且使传感器向后插入进行测量。

6. 发明授权

US5266179A Quantitative analysis method and its system using a disposable sensor 失效
标题翻译：定量分析方法及其使用一次性传感器的系统
公开(公告)号：US5266179A
公开(公告)日：1993-11-30
申请号：US733130
申请日：1991-07-19
申请人： Shiro Nankai , Mariko Kawaguri , Toshihiko Yoshioka , Haruhiro Tsutsumi , Kyozo Terao , Naoki Tanimoto , Masahiro Yoshioka , Hiroshi Hyodo , Takatoshi Uchigaki
发明人： Shiro Nankai , Mariko Kawaguri , Toshihiko Yoshioka , Haruhiro Tsutsumi , Kyozo Terao , Naoki Tanimoto , Masahiro Yoshioka , Hiroshi Hyodo , Takatoshi Uchigaki
IPC分类号： G01N27/26 , G01N27/28 , G01N27/416 , G01N27/49
CPC分类号： G01N33/48771 , G01N2035/009
摘要： A sensor 13 is inserted into a connector 14. A constant voltage required to obtain a response current is applied across the connector 14 by a voltage applying source 15 at timings required. A response current of the sensor 13 inserted into the connector 14 is converted into a voltage by a current-to-voltage converter 16, and the amount thereof is determined by a microcomputer, the analysis results being displayed onto a display unit.

7. 发明授权

US06773564B1 Glucose sensor 有权
标题翻译：葡萄糖传感器
公开(公告)号：US06773564B1
公开(公告)日：2004-08-10
申请号：US09406832
申请日：1999-09-28
申请人： Keiko Yugawa , Toshihiko Yoshioka , Shiro Nankai , Junko Iwata , Shoji Miyazaki , Hideyuki Baba , Seiji Takeshima
发明人： Keiko Yugawa , Toshihiko Yoshioka , Shiro Nankai , Junko Iwata , Shoji Miyazaki , Hideyuki Baba , Seiji Takeshima
IPC分类号： G01N27327
CPC分类号： C12Q1/006
摘要： The present invention provides a high performance glucose sensor which can demonstrate high stability against preservation and produces only a low blank value. The glucose sensor comprises an electrically insulating base plate, an electrode system formed on the base plate, and a reaction layer which is formed in contact with or in the vicinity of the electrode system and contains at least a glucose dehydrogenase whose coenzyme is pyrrolo-quinoline quinone, the reaction layer further containing an additive such as phthalic acid.
摘要翻译：本发明提供了一种高性能葡萄糖传感器，其可以显示对保存的高稳定性并且仅产生低的空白值。葡萄糖传感器包括电绝缘基板，形成在基板上的电极系统和与电极系统接触或附近形成的反应层，并且至少含有辅酶是吡咯并喹啉的葡萄糖脱氢酶醌，反应层还含有邻苯二甲酸等添加剂。

8. 发明授权

US07005048B1 Glucose sensor 有权
标题翻译：葡萄糖传感器
公开(公告)号：US07005048B1
公开(公告)日：2006-02-28
申请号：US09807692
申请日：2000-10-02
申请人： Motokazu Watanabe , Keiko Yugawa , Toshihiko Yoshioka , Shiro Nankai , Junko Nakayama , Shoji Miyazaki , Hideyuki Baba
发明人： Motokazu Watanabe , Keiko Yugawa , Toshihiko Yoshioka , Shiro Nankai , Junko Nakayama , Shoji Miyazaki , Hideyuki Baba
IPC分类号： G01N27/327
CPC分类号： C12Q1/006
摘要： The present invention provides a high-performance glucose sensor having excellent storage stability and an improved response characteristic. This sensor comprises: an electrically insulating base plate; an electrode system including at least a working electrode and a counter electrode formed on the base plate; and a reaction layer containing at least pyrrolo-quinoline quinone dependent glucose dehydrogenase, formed in contact with or in the vicinity of the electrode system, and the reaction layer contains at least one kind of additive selected from the group consisting of gluconic acid and salts thereof.
摘要翻译：本发明提供一种具有优异的储存稳定性和改善的响应特性的高性能葡萄糖传感器。该传感器包括：电绝缘基板; 电极系统，其至少包括形成在所述基板上的工作电极和对电极; 和至少含有与电极体系接触或附近形成的吡咯并喹啉醌依赖型葡萄糖脱氢酶的反应层，反应层含有选自葡萄糖酸及其盐的至少一种添加剂。

9. 发明授权

US06547954B2 Biosensor and method for quantitating biochemical substrate using the same 有权
标题翻译：生物传感器和使用其生物化学底物的定量方法
公开(公告)号：US06547954B2
公开(公告)日：2003-04-15
申请号：US09232320
申请日：1999-01-18
申请人： Shin Ikeda , Tomohiro Yamamoto , Toshihiko Yoshioka , Shiro Nankai , Shigeki Joko , Junko Iwata
发明人： Shin Ikeda , Tomohiro Yamamoto , Toshihiko Yoshioka , Shiro Nankai , Shigeki Joko , Junko Iwata
IPC分类号： G01N27327
CPC分类号： C12Q1/004 , Y10S435/817
摘要： A biosensor includes: an insulating substrate; an electrode system formed on the insulating substrate which has a working electrode and a counter electrode; and a reaction layer formed on the insulating substrate which contains an oxidoreductase and an electron acceptor. The electron acceptor is ferricinium ion derived from ferrocene electrolyte.
摘要翻译：生物传感器包括：绝缘基板; 形成在具有工作电极和对电极的绝缘基板上的电极系统; 以及形成在包含氧化还原酶和电子受体的绝缘基板上的反应层。电子受体是衍生自二茂铁电解质的三价铁离子。

10. 发明授权

US06340428B1 Device and method for determining the concentration of a substrate 有权
标题翻译：用于确定底物浓度的装置和方法
公开(公告)号：US06340428B1
公开(公告)日：2002-01-22
申请号：US09424715
申请日：1999-11-29
申请人： Shin Ikeda , Toshihiko Yoshioka , Shiro Nankai
发明人： Shin Ikeda , Toshihiko Yoshioka , Shiro Nankai
IPC分类号： G01N2726
CPC分类号： C12Q1/004
摘要： A method for determining the concentration of a substrate in a sample solution using an electrode system comprising a working electrode, a counter electrode, and a reaction layer which contains at least an oxidoreductase and an electron mediator and is formed on the electrode system to electrochemically measure a reduced amount of the electron mediator resulting from enzyme reaction in the reaction layer, wherein a third electrode is formed as an interfering substance detecting electrode. A current flowing between the counter electrode and the third electrode is measured which is taken as a positive error. Subsequently, voltage application between the counter electrode and the third electrode is released and a voltage for oxidizing the reduced form electron mediator is applied between the working electrode and the counter electrode to measure a current flowing between the two electrodes.
摘要翻译：一种使用包括工作电极，对电极和至少包含氧化还原酶和电子介体的反应层的电极系统来确定样品溶液中的衬底的浓度的方法，并且形成在电极系统上以电化学测量在反应层中由酶反应产生的电子介体的量减少，其中形成第三电极作为干扰物质检测电极。测量在对电极和第三电极之间流动的电流，其被认为是正误差。随后，释放对电极和第三电极之间的电压施加，并且在工作电极和对电极之间施加用于氧化还原形式的电子介体的电压，以测量在两个电极之间流动的电流。

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