专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US4510168A Process for sealing body and cap of gelatin hard capsule and apparatus therefor 失效
标题翻译：明胶硬胶囊体和帽体的方法及其设备
公开(公告)号：US4510168A
公开(公告)日：1985-04-09
申请号：US589976
申请日：1984-03-15
申请人： Shigeru Sakashita , Takeshi Nakagawa , Takayuki Ohwaki , Yasuo Miyake
发明人： Shigeru Sakashita , Takeshi Nakagawa , Takayuki Ohwaki , Yasuo Miyake
IPC分类号： A61J3/07 , A61K9/48 , A01N25/00
CPC分类号： A61J3/072
摘要： This invention provides a process for sealing a body and a cap of a capsule which comprises successively dipping a gelatin hard capsule containing drugs one by one in a mixed solvent of water and ethanol whose volume ratio to water is 50-55%, thereafter taking said capsule out of this solvent and drying each capsule separately.
摘要翻译：本发明提供了一种密封胶囊的主体和盖子的方法，该方法包括将含有药物的明胶硬胶囊逐个浸入与水的体积比为50-55％的水和乙醇的混合溶剂中，然后将所述将胶囊从该溶剂中分离出来并分别干燥每个胶囊。

2. 发明授权

US4532881A Process for sealing body and cap of gelatin hard capsule and apparatus therefor 失效
标题翻译：明胶硬胶囊体和帽体的方法及其设备
公开(公告)号：US4532881A
公开(公告)日：1985-08-06
申请号：US631423
申请日：1984-07-16
申请人： Shigeru Sakashita , Takeshi Nakagawa , Takayuki Ohwaki , Yasuo Miyake
发明人： Shigeru Sakashita , Takeshi Nakagawa , Takayuki Ohwaki , Yasuo Miyake
IPC分类号： A61J3/07 , A61K9/48 , A23G3/20
CPC分类号： A61J3/072
摘要： This invention provides a process for sealing a body and a cap of a capsule which comprises successively dipping a gelatin hard capsule containing drugs one by one in a mixed solvent of water and ethanol whose volume ratio to water is 50-55%, thereafter taking said capsule out of this solvent and drying each capsule separately.

3. 发明授权

US4598070A Tripamide and cyclodextrin inclusion compound 失效
标题翻译：三酰胺和环糊精包合物
公开(公告)号：US4598070A
公开(公告)日：1986-07-01
申请号：US631997
申请日：1984-07-18
申请人： Takayuki Ohwaki , Shigeru Sakashita , Masahiro Kawahara , Aishin Shinoda , Yasuo Miyake
发明人： Takayuki Ohwaki , Shigeru Sakashita , Masahiro Kawahara , Aishin Shinoda , Yasuo Miyake
IPC分类号： C07D209/72 , A61K31/40 , A61K47/48 , C08B37/00 , A61K31/73
CPC分类号： B82Y5/00 , A61K31/40 , A61K47/48969 , C08B37/0015
摘要： An inclusion compound composed of tripamide and cyclodextrin markedly improves the solubility of tripamide which is effective for treatment of essential hypertension.
摘要翻译：由三酰胺和环糊精组成的包合物显着提高了对治疗原发性高血压有效的三酰胺的溶解度。

4. 发明授权

US4827062A Composition containing ubidecarenone with absorption promoted 失效
标题翻译：含有吸收促进的ubidecarenone的组合物
公开(公告)号：US4827062A
公开(公告)日：1989-05-02
申请号：US844025
申请日：1986-03-25
申请人： Yasuharu Saeki , Takeshi Watanabe , Takayuki Ohwaki , Masahiro Kawahara , Yasuo Miyake
发明人： Yasuharu Saeki , Takeshi Watanabe , Takayuki Ohwaki , Masahiro Kawahara , Yasuo Miyake
IPC分类号： A61K9/08 , A61K9/48 , A61K31/12 , A61K47/00 , A61K47/14 , A61K47/44
CPC分类号： A61K47/44 , A61K31/12 , A61K47/14 , Y10S514/975
摘要： A composition containing ubidecarenone, a glycerol mono-fatty acid ester and/or a propylene glycol mono-fatty acid ester, and a liquid oil. Oral administration of the composition provides a promoted absorption of ubidecarenone which is used for improving a coronary function.
摘要翻译：含有ubidecarenone，甘油单脂肪酸酯和/或丙二醇单脂肪酸酯和液体油的组合物。组合物的口服给药促进了用于改善冠状动脉功能的ubidecarenone的吸收。

5. 发明申请

US20100009003A1 PHARMACEUTICAL PREPARATION TO BE DISPERSED BEFORE ADMINISTRATION 审中-公开
标题翻译：在管理之前要分配的药物制剂
公开(公告)号：US20100009003A1
公开(公告)日：2010-01-14
申请号：US12561776
申请日：2009-09-17
申请人： Koji UKAI , Yasuyuki Asai , Yoshiteru Kato , Takayuki Ohwaki , Shigeru Aoki , Yasuhiro Zaima , Takehiro Yamaguchi
发明人： Koji UKAI , Yasuyuki Asai , Yoshiteru Kato , Takayuki Ohwaki , Shigeru Aoki , Yasuhiro Zaima , Takehiro Yamaguchi
IPC分类号： A61K31/4439 , A61K9/14
CPC分类号： A61K9/0095 , A61K9/5078 , A61K31/717 , A61K45/06
摘要： The present invention provides a pharmaceutical preparation to be dispersed before administration which has an adequate viscosity and a suitable flowability even when dispersed in a small amount of water and can be easily administered through an NG tube is provided. Specifically, the pharmaceutical preparation to be dispersed before administration contains active granules containing a pharmaceutically active substance having an average particle diameter of 5 mm or less and a thickening agent, and can be administered through an NG tube by dispersing in water before administration.
摘要翻译：本发明提供了即使分散在少量的水中也可以容易地通过NG管施用的具有足够的粘度和合适的流动性的在给药前分散的药物制剂。具体地说，给药前待分散的药物制剂含有含有平均粒径为5mm以下的药物活性物质和增稠剂的活性颗粒，并且可以通过NG管通过在给药前在水中分散来给药。

6. 发明授权

US5672364A Apparatus for manufacturing tablets 失效
标题翻译：片剂制造装置
公开(公告)号：US5672364A
公开(公告)日：1997-09-30
申请号：US494924
申请日：1995-06-26
申请人： Heizaburo Kato , Yuki Tsushima , Takayuki Ohwaki , Masaharu Nakajima , Yutaka Morita
发明人： Heizaburo Kato , Yuki Tsushima , Takayuki Ohwaki , Masaharu Nakajima , Yutaka Morita
IPC分类号： A61J1/10 , A61J3/10 , B30B11/10
CPC分类号： A61J3/10 , B30B11/027 , B30B11/10 , B30B15/302
摘要： A method and an apparatus for manufacturing tablets of moist powder which is produced by adding an additive agent such as an excipient or a binder to medical ingredients, further adding a solvent such as water, ethanol or the like, and kneading the mixture. The tablet manufacturing method comprises the steps of: preparing a first table and a second table which are intermittently rotated and driven relatively with respect to each other; supplying moist powder from a hopper into filling holes of the first table; filling the supplied moist powder into mold cavities of the second table under a pressurized condition by means of filling pins of a filling and pressurizing device at a location where the first table overlaps with the second table; relatively moving the first and second tables with respect to each other so as to level the surface of the moist powder in the mold cavities by removing the excessive powder; chamfering the surface of the moist powder by a finish-forming device; drying the moist powder by a dryer; and releasing the moist powder out of the mold cavities by a release device.
摘要翻译：通过向医药成分添加赋形剂或粘合剂等添加剂而进一步添加水，乙醇等溶剂，捏合该混合物而制造的湿粉状片剂的制造方法和装置。片剂制造方法包括以下步骤：制备相对于彼此间歇地旋转和驱动的第一工作台和第二工作台; 将料斗中的潮湿粉末装入第一台的填充孔; 在第一台与第二台重叠的位置处，通过填充和加压装置的填充销填充所供应的潮湿粉末到加压状态下的第二台的模腔中; 相对于彼此相对移动第一和第二台，以通过去除过量的粉末来平衡模具腔中的湿粉末的表面; 通过精整成形装置对潮湿粉末的表面进行倒角; 用干燥机干燥湿粉; 并通过释放装置将湿粉释放出模腔。

7. 发明申请

US20100015221A1 ORALLY RAPID DISINTEGRATING TABLET PREPARATION COMPRISING FAT-SOLUBLE ACTIVE INGREDIENTS 审中-公开
标题翻译：可快速消除包含脂肪可溶性活性成分的片剂制剂
公开(公告)号：US20100015221A1
公开(公告)日：2010-01-21
申请号：US12097867
申请日：2006-12-20
申请人： Norishige Takami , Shinsuke Nagira , Yasushi Okada , Noriko Okada , Takayuki Ohwaki , Reiko Nishijima
发明人： Norishige Takami , Shinsuke Nagira , Yasushi Okada , Noriko Okada , Takayuki Ohwaki , Reiko Nishijima
IPC分类号： A61K9/20 , A61K31/07 , A61K31/59 , A61K31/122 , A61K31/121 , A61K31/355 , A61P43/00
CPC分类号： A61K9/2054 , A61K9/0056 , A61K9/16 , A61K9/2018 , A61K9/2077 , A61K31/07 , A61K31/121 , A61K31/122 , A61K31/355 , A61K31/59
摘要： The present invention provides an orally rapid disintegrating tablet preparation that contains a high dose of a fat-soluble active ingredient, that exhibits excellent disintegration characteristics in the oral cavity, and that can be produced by a dry tabletting method. The present invention also provides a method of producing an orally rapid disintegrating tablet preparation. The present invention discloses an orally rapid disintegrating tablet preparation that is obtained by tabletting a uniform mixture prepared by mixing saccharide alcohol, crystalline cellulose, and a lubricant with a granule that has been produced by the adsorption of a fat-soluble active ingredient on a porous material.
摘要翻译：本发明提供一种口服快速崩解片剂，其含有高剂量的在口腔中具有优异的崩解特性的脂溶性活性成分，并且可以通过干燥压片法制造。本发明还提供一种口服快速崩解片剂的制备方法。本发明公开了一种口服快速崩解片剂，其通过将通过将脂溶性活性成分吸附在多孔性物质上制成的颗粒将糖醇，结晶纤维素和润滑剂混合而成的均匀混合物材料。

8. 发明授权

US06743443B1 Tablets immediately disintegrating in the oral cavity 失效
标题翻译：片剂立即在口腔内分解
公开(公告)号：US06743443B1
公开(公告)日：2004-06-01
申请号：US09806823
申请日：2001-04-05
申请人： Hisao Furitsu , Akira Kato , Takayuki Ohwaki , Masanobu Yasui
发明人： Hisao Furitsu , Akira Kato , Takayuki Ohwaki , Masanobu Yasui
IPC分类号： A61K920
CPC分类号： A61K9/0056 , A61K9/2095 , A61K31/4985 , A61K31/502 , A61K31/517 , A61K31/519
摘要： The present invention provides an intraoral quickly disintegrating tablet containing a phosphodiesterase inhibitor having an effect of improving the erectile dysfunction and a method for manufacturing the tablet. The present invention also provides an intraoral quickly disintegrating tablet containing a slightly soluble pharmaceutical agent having an improved solubility and a method for manufacturing the tablet. That is, it is an intraoral quickly disintegrating tablet containing a cyclic GMP phosphodiesterase inhibitor and a saccharide, and a method for manufacturing the tablet. Further, it is a method for manufacturing an intraoral quickly disintegrating tablet, which comprises dissolving a slightly soluble pharmaceutical agent in an organic solvent or an aqueous organic solvent together with a surfactant and/or a water-soluble polymer, coating the solution on a filler or granulating it with a filler to obtain molded products, mixing a saccharide with them, adding an organic solvent, water or an aqueous organic solvent thereto, followed by kneading, and subjecting it to a compression-molding.
摘要翻译：本发明提供含有具有改善勃起功能障碍的作用的磷酸二酯酶抑制剂的口腔内快速崩解片剂及其制造方法。本发明还提供了含有具有改善的溶解性的微溶性药剂和制造片剂的方法的口腔内快速崩解片剂。也就是说，它是含有环状GMP磷酸二酯酶抑制剂和糖类的口内快速崩解片及其制造方法。此外，它是一种制造口内快速崩解片的方法，其包括将微溶性药剂与表面活性剂和/或水溶性聚合物一起溶解在有机溶剂或含水有机溶剂中，将该溶液涂覆在填料上或者用填充剂造粒，得到成型品，与其混合，向其中加入有机溶剂，水或有机溶剂，然后捏合，并进行压缩成形。

9. 发明授权

US06227836B1 Apparatus for manufacturing tablets 失效
标题翻译：片剂制造装置
公开(公告)号：US06227836B1
公开(公告)日：2001-05-08
申请号：US09501012
申请日：2000-02-09
申请人： Heizaburo Kato , Yuki Tsushima , Takayuki Ohwaki , Masaharu Nakajima , Yutaka Morita
发明人： Heizaburo Kato , Yuki Tsushima , Takayuki Ohwaki , Masaharu Nakajima , Yutaka Morita
IPC分类号： B29C4306
CPC分类号： A61J3/10 , B30B11/027 , B30B11/10 , B30B15/302
摘要： A method and an apparatus for manufacturing tablets of moist powder which is produced by adding an additive agent such as an excipient or a binder to medical ingredients, further adding a solvent such as water, ethanol or the like, and kneading the mixture. The tablet manufacturing method comprises the steps of: preparing a first table and a second table which are intermittently rotated and driven relatively with respect to each other; supplying moist powder from a hopper into filling holes of the first table; filling the supplied moist powder into mold cavities of the second table under a pressurized condition by means of filling pins of a filling and pressurizing device at a location where the first table overlaps with the second table; relatively moving the first and second tables with respect to each other so as to level the surface of the moist powder in the mold cavities by removing the excessive powder; chamfering the surface of the moist powder by a finish-forming device; drying the moist powder by a dryer; and releasing the moist powder out of the mold cavities by a release device.
摘要翻译：通过向医药成分添加赋形剂或粘合剂等添加剂而进一步添加水，乙醇等溶剂，捏合该混合物而制造的湿粉状片剂的制造方法和装置。片剂制造方法包括以下步骤：制备相对于彼此间歇地旋转和驱动的第一工作台和第二工作台; 将料斗中的潮湿粉末装入第一台的填充孔; 在第一台与第二台重叠的位置处，通过填充和加压装置的填充销填充所供应的潮湿粉末到加压状态下的第二台的模腔中; 相对于彼此相对移动第一和第二台，以通过去除过量的粉末来平衡模具腔中的湿粉末的表面; 通过精整成形装置对潮湿粉末的表面进行倒角; 用干燥机干燥湿粉; 并通过释放装置将湿粉释放出模腔。

10. 发明授权

US5603880A Method and apparatus for manufacturing tablets 失效
标题翻译：制造片剂的方法和装置
公开(公告)号：US5603880A
公开(公告)日：1997-02-18
申请号：US494922
申请日：1995-06-26
申请人： Heizaburo Kato , Yuki Tsushima , Takayuki Ohwaki , Masaharu Nakajima , Yutaka Morita
发明人： Heizaburo Kato , Yuki Tsushima , Takayuki Ohwaki , Masaharu Nakajima , Yutaka Morita
IPC分类号： A61J3/07 , A61J3/00 , A61J3/06 , A61J3/10 , A61K9/20 , B01J2/22 , B30B11/02 , B30B11/10 , B30B11/14 , B29C43/06
CPC分类号： A61J3/10 , A61J3/005 , A61J3/06 , B30B11/10 , B30B11/14
摘要： It is an object of the present invention to realize a method and an apparatus for efficiently mass-producing tablets of high mechanical strength, accuracy and quality which are so excellent in solubility and collapsibility that they can be easily taken by persons of advanced ages and infants. By using a turn table and endless belt means to which a number of dies are connected, a part of which turn table contacts with the endless belt means, the turn table and the endless belt means being adapted to relatively move with respect to each other, receptacles are formed by pressing plastic polymer film in mold cavities of the dies. Moist powder supplied from a hopper into filling holes of the turn table is pressurizingly filled in the receptacles by means of a filling and pressurizing device in the region where the turn table is laid above the endless belt means. The surface of this pressurizingly-filled moist powder is leveled by removing the excessive powder when the endless belt means is relatively moved with respect to the turn table, thus forming a tablet. Then, the surface of the moist powder is chamfered, the mass of the moist powder is treated by a dryer, the receptacles are closed by a sealing unit, and they are cut by a predetermined number by a cutting device, thereby finishing tablet products.
摘要翻译：本发明的目的是实现一种方法和装置，用于高效地批量生产高机械强度，精度和质量的片剂，其溶解性和可折叠性非常优异，可以容易地由年龄和婴儿的人服用。通过使用多个模具连接的转台和环形带装置，其中一部分将转台与环形带装置接触，转台和环形带装置适于相对于彼此相对移动，通过在模具的模腔中挤压塑料聚合物膜形成容器。从料斗供给到转台的充填孔的潮湿粉末通过填充加压装置在转台上设置在环形带装置上方的区域中被加压地插入到容器中。当环形带装置相对于转台相对移动时，通过去除过量的粉末来调平该加压填充的湿粉末的表面，从而形成片剂。然后，将湿粉末的表面倒角，用干燥机处理湿粉的质量，通过密封单元封闭容器，并通过切割装置切割预定数量，从而制成片剂产品。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式