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1. 发明授权

US08309119B2 Drug containing adhesive preparation 失效
标题翻译：药物含胶粘剂制剂
公开(公告)号：US08309119B2
公开(公告)日：2012-11-13
申请号：US12071867
申请日：2008-02-27
申请人： Masato Nishimura , Sachiko Terashi , Shiro Satoda , Keigo Inosaka , Kensuke Matsuoka
发明人： Masato Nishimura , Sachiko Terashi , Shiro Satoda , Keigo Inosaka , Kensuke Matsuoka
IPC分类号： A61K9/70 , A61K31/4468 , A61F13/02
CPC分类号： A61L24/0015 , A61L15/58 , A61L24/04 , A61L2300/402
摘要： The present invention aims at providing an adhesive preparation wherein a drug is sufficiently dissolved in an adhesive layer and is not easily separated from the adhesive layer even during preservation of the adhesive preparation.The present invention provides an adhesive preparation having an adhesive layer on at least one surface of a support, wherein the adhesive layer comprises a first synthetic rubber having a viscosity average molecular weight of 1,600,000-6,500,000, a drug, an organic liquid component and a tackifier. The present invention further provides the aforementioned adhesive preparation, wherein the organic liquid component is contained in the adhesive layer in a proportion of 20 wt % or above relative to the total weight of the adhesive layer.
摘要翻译：本发明的目的在于提供一种粘合剂制剂，其中药物在粘合剂层中充分溶解，并且即使在粘合剂制备过程中也不容易与粘合层分离。本发明提供一种在支撑体的至少一个表面上具有粘合剂层的粘合剂制剂，其中粘合剂层包括粘均分子量为1,600,000-6,500,000的第一合成橡胶，药物，有机液体组分和增粘剂。本发明还提供了上述粘合剂制剂，其中粘合剂层中的有机液体组分相对于粘合剂层的总重量为20重量％以上。

2. 发明申请

US20080206315A1 Drug containing adhesive preparation 失效
标题翻译：药物含胶粘剂制剂
公开(公告)号：US20080206315A1
公开(公告)日：2008-08-28
申请号：US12071867
申请日：2008-02-27
申请人： Masato Nishimura , Sachiko Terashi , Shiro Satoda , Keigo Inosaka , Kensuke Matsuoka
发明人： Masato Nishimura , Sachiko Terashi , Shiro Satoda , Keigo Inosaka , Kensuke Matsuoka
IPC分类号： A61K9/70
CPC分类号： A61L24/0015 , A61L15/58 , A61L24/04 , A61L2300/402
摘要： The present invention aims at providing an adhesive preparation wherein a drug is sufficiently dissolved in an adhesive layer and is not easily separated from the adhesive layer even during preservation of the adhesive preparation.The present invention provides an adhesive preparation having an adhesive layer on at least one surface of a support, wherein the adhesive layer comprises a first synthetic rubber having a viscosity average molecular weight of 1,600,000-6,500,000, a drug, an organic liquid component and a tackifier. The present invention further provides the aforementioned adhesive preparation, wherein the organic liquid component is contained in the adhesive layer in a proportion of 20 wt % or above relative to the total weight of the adhesive layer.
摘要翻译：本发明的目的在于提供一种粘合剂制剂，其中药物在粘合剂层中充分溶解，并且即使在粘合剂制备过程中也不容易与粘合层分离。本发明提供一种在支撑体的至少一个表面上具有粘合剂层的粘合剂制剂，其中粘合剂层包括粘均分子量为1,600,000-6,500,000的第一合成橡胶，药物，有机液体组分和增粘剂。本发明还提供了上述粘合剂制剂，其中粘合剂层中的有机液体组分相对于粘合剂层的总重量为20重量％以上。

3. 发明授权

US08506991B2 Nicotine transdermal preparation and production method thereof 失效
标题翻译：尼古丁透皮制剂及其制备方法
公开(公告)号：US08506991B2
公开(公告)日：2013-08-13
申请号：US11546302
申请日：2006-10-12
申请人： Shiro Satoda , Kazuhisa Ninomiya , Junichi Saito , Kensuke Matsuoka , Shunetsu Kikuchi
发明人： Shiro Satoda , Kazuhisa Ninomiya , Junichi Saito , Kensuke Matsuoka , Shunetsu Kikuchi
IPC分类号： A61L15/16 , A61K9/70 , A61K31/465 , A61K47/14
CPC分类号： A61K9/7061 , A61K31/465 , A61K47/14
摘要： The present invention provides a production method of a nicotine transdermal preparation, which is capable of producing a nicotine transdermal preparation conveniently and economically, while maintaining highly precise content uniformity, which is capable of producing a preparation simultaneously achieving fixedness and a soft feeling during adhesion, associated with reduced skin irritation upon peeling off and superior in adhesive property. The present invention provides a nicotine transdermal preparation superior in content uniformity, simultaneously achieving fixedness and a soft feeling during adhesion, and showing reduced skin irritation upon peeling off.The present invention provides a method of producing a preparation containing a support and an adhesive layer formed thereon, which adhesive layer containing nicotine and a liquid ingredient compatible with the adhesive, which method includes (1) providing the adhesive layer wherein a contact angle of nicotine with the adhesive layer before containing nicotine is 20-60°, and (2) applying nicotine to the adhesive layer to allow absorption of nicotine into the adhesive layer, as well as a preparation containing a support and an adhesive layer formed thereon, which adhesive layer including nicotine and a liquid ingredient compatible with the adhesive, wherein a contact angle of nicotine with the adhesive layer before containing nicotine is 20-60°.
摘要翻译：本发明提供了一种尼古丁透皮制剂的制备方法，其能够方便且经济地制备尼古丁透皮制剂，同时保持高精度的含量均匀性，其能够同时制备粘合期间的固定性和柔软感，与剥离时的皮肤刺激性降低，粘合性优异。本发明提供了含量均匀性优异的尼古丁透皮制剂，同时达到粘合时的固定性和柔软感，并且在剥离时显示出减少的皮肤刺激性。本发明提供一种制备含有载体和粘合剂层的制剂的方法，该粘合剂层含有尼古丁和与粘合剂相容的液体成分的粘合剂层，该方法包括（1）提供粘合剂层，其中尼古丁的接触角含尼古丁之前的粘合剂层为20-60°，和（2）向粘合剂层施加尼古丁以允许将尼古丁吸收到粘合剂层中，以及含有形成在其上的载体和粘合剂层的制剂，该粘合剂包括尼古丁和与粘合剂相容的液体成分的层，其中尼古丁与包含尼古丁之前的粘合剂层的接触角为20-60°。

4. 发明申请

US20070087043A1 Nicotine transdermal preparation and production method thereof 失效
标题翻译：尼古丁透皮制剂及其制备方法
公开(公告)号：US20070087043A1
公开(公告)日：2007-04-19
申请号：US11546302
申请日：2006-10-12
申请人： Shiro Satoda , Kazuhisa Ninomiya , Junichi Saito , Kensuke Matsuoka , Shunetsu Kikuchi
发明人： Shiro Satoda , Kazuhisa Ninomiya , Junichi Saito , Kensuke Matsuoka , Shunetsu Kikuchi
IPC分类号： A61K31/4439 , A61K9/70
CPC分类号： A61K9/7061 , A61K31/465 , A61K47/14
摘要： The present invention provides a production method of a nicotine transdermal preparation, which is capable of producing a nicotine transdermal preparation conveniently and economically, while maintaining highly precise content uniformity, which is capable of producing a preparation simultaneously achieving fixedness and a soft feeling during adhesion, associated with reduced skin irritation upon peeling off and superior in adhesive property. The present invention provides a nicotine transdermal preparation superior in content uniformity, simultaneously achieving fixedness and a soft feeling during adhesion, and showing reduced skin irritation upon peeling off. The present invention provides a method of producing a preparation containing a support and an adhesive layer formed thereon, which adhesive layer containing nicotine and a liquid ingredient compatible with the adhesive, which method includes (1) providing the adhesive layer wherein a contact angle of nicotine with the adhesive layer before containing nicotine is 20-60°, and (2) applying nicotine to the adhesive layer to allow absorption of nicotine into the adhesive layer, as well as a preparation containing a support and an adhesive layer formed thereon, which adhesive layer including nicotine and a liquid ingredient compatible with the adhesive, wherein a contact angle of nicotine with the adhesive layer before containing nicotine is 20-60°.
摘要翻译：本发明提供了一种尼古丁透皮制剂的制备方法，其能够方便且经济地制备尼古丁透皮制剂，同时保持高精度的含量均匀性，其能够同时制备粘合期间的固定性和柔软感，与剥离时的皮肤刺激性降低，粘合性优异。本发明提供了含量均匀性优异的尼古丁透皮制剂，同时达到粘合时的固定性和柔软感，并且在剥离时显示出减少的皮肤刺激性。本发明提供一种制备含有载体和粘合剂层的制剂的方法，该粘合剂层含有尼古丁和与粘合剂相容的液体成分的粘合剂层，该方法包括（1）提供粘合剂层，其中尼古丁的接触角含尼古丁之前的粘合剂层为20-60°，和（2）向粘合剂层施加尼古丁以允许将尼古丁吸收到粘合剂层中，以及含有形成在其上的载体和粘合剂层的制剂，该粘合剂包括尼古丁和与粘合剂相容的液体成分的层，其中尼古丁与包含尼古丁之前的粘合剂层的接触角为20-60°。

5. 发明授权

US08394404B2 Adhesive material and adhesive preparation 有权
标题翻译：胶粘材料和粘合剂制备
公开(公告)号：US08394404B2
公开(公告)日：2013-03-12
申请号：US11196936
申请日：2005-08-04
申请人： Hitoshi Akemi , Kazuhisa Ninomiya , Hidetoshi Kuroda , Kensuke Matsuoka , Yuji Saeki , Masato Nishimura
发明人： Hitoshi Akemi , Kazuhisa Ninomiya , Hidetoshi Kuroda , Kensuke Matsuoka , Yuji Saeki , Masato Nishimura
IPC分类号： A61L15/16 , C08F136/00
CPC分类号： A61K9/7053
摘要： The present invention provides an adhesive material to be adhered to the skin etc., which maintains, for a certain time period after adhesion thereof to the skin surface, suitable adhesiveness that does not allow easy peeling or cause irritation to the skin, and which permits, when it is to be peeled off from the skin surface after the lapse of a desired certain time period, easy peeling without causing pain or physical irritation, and an adhesive preparation containing the adhesive material and a percutaneously absorbable drug in the adhesive layer. Specifically, the present invention provides an adhesive material containing a support and an adhesive layer laminated on one surface of the support, wherein the adhesive layer has an apparent viscosity at 30° C. of 0.2×104 to 10×104 Pa·s and comprises two kinds of synthetic rubbers having different flowability.
摘要翻译：本发明提供粘附到皮肤等上的粘合剂材料，其在粘附到皮肤表面上一段时间后保持适合的粘合性，其不容易剥离或对皮肤产生刺激，并且允许当在期望的特定时间段之后要从皮肤表面剥离时，易于剥离而不引起疼痛或身体刺激，以及在粘合剂层中含有粘合剂材料和经皮吸收药物的粘合剂。具体地说，本发明提供了一种粘合剂材料，其包含层叠在载体的一个表面上的载体和粘合剂层，其中所述粘合剂层在30℃下的表观粘度为0.2×10 4至10×10 4 Pa·s，并且包含两种具有不同流动性的合成橡胶。

6. 发明授权

US09808609B2 Patch and patch preparation 有权
公开(公告)号：US09808609B2
公开(公告)日：2017-11-07
申请号：US13983510
申请日：2012-02-01
申请人： Masato Nishimura , Yoshihiro Iwao , Katsuhiro Okada , Kensuke Matsuoka
发明人： Masato Nishimura , Yoshihiro Iwao , Katsuhiro Okada , Kensuke Matsuoka
IPC分类号： A61M35/00 , A61L31/12 , A61K9/70 , A61K31/405 , A61K31/663
CPC分类号： A61M35/00 , A61K9/7053 , A61K31/405 , A61K31/663 , A61L31/129
摘要： The invention provides a patch and a patch preparation having an adhesive layer with a high adhesive force, wherein the hydrophobic adhesive layer does not bloom even when an organic fluid component having high polarity is contained therein. The patch contains a support and an adhesive layer on at least one surface of the support, wherein the adhesive layer contains a synthetic rubber having a viscosity average molecular weight of 500,000-1,600,000, an organic fluid component having high polarity, a tackifier, and magnesium aluminometasilicate. In the patch preparation, the above-mentioned adhesive layer further contains a drug.

7. 发明申请

US20060034901A1 Adhesive material and adhesive preparation 有权
标题翻译：胶粘材料和粘合剂制备
公开(公告)号：US20060034901A1
公开(公告)日：2006-02-16
申请号：US11196936
申请日：2005-08-04
申请人： Hitoshi Akemi , Kazuhisa Ninomiya , Hidetoshi Kuroda , Kensuke Matsuoka , Yuji Saeki , Masato Nishimura
发明人： Hitoshi Akemi , Kazuhisa Ninomiya , Hidetoshi Kuroda , Kensuke Matsuoka , Yuji Saeki , Masato Nishimura
IPC分类号： A61L15/16 , C08F136/00
CPC分类号： A61K9/7053
摘要： The present invention provides an adhesive material to be adhered to the skin etc., which maintains, for a certain time period after adhesion thereof to the skin surface, suitable adhesiveness that does not allow easy peeling or cause irritation to the skin, and which permits, when it is to be peeled off from the skin surface after the lapse of a desired certain time period, easy peeling without causing pain or physical irritation, and an adhesive preparation containing the adhesive material and a percutaneously absorbable drug in the adhesive layer. Specifically, the present invention provides an adhesive material containing a support and an adhesive layer laminated on one surface of the support, wherein the adhesive layer has an apparent viscosity at 30° C. of 0.2×104 to 10×104Pa.s and comprises two kinds of synthetic rubbers having different flowability.
摘要翻译：本发明提供粘附到皮肤等上的粘合剂材料，其在粘附到皮肤表面上一段时间后保持适合的粘合性，其不容易剥离或对皮肤产生刺激，并且允许当在期望的特定时间段之后要从皮肤表面剥离时，容易剥离而不引起疼痛或身体刺激，以及在粘合剂层中含有粘合剂材料和经皮吸收药物的粘合剂。具体而言，本发明提供了一种粘合剂材料，其包含层压在载体的一个表面上的载体和粘合剂层，其中粘合剂层在30℃下的表观粘度为0.2×10 4至10×10 6 包括两种具有不同流动性的合成橡胶。

8. 发明授权

US09351942B2 Patch and patch preparation 有权
标题翻译：补丁和补丁准备
公开(公告)号：US09351942B2
公开(公告)日：2016-05-31
申请号：US13983481
申请日：2012-02-01
申请人： Masato Nishimura , Yoshihiro Iwao , Katsuhiro Okada , Kensuke Matsuoka
发明人： Masato Nishimura , Yoshihiro Iwao , Katsuhiro Okada , Kensuke Matsuoka
IPC分类号： A61K9/70 , A61K31/405 , A61K31/663
CPC分类号： A61K9/7053 , A61K31/405 , A61K31/663 , Y10T428/2857
摘要： The invention provides a patch and a patch preparation having an adhesive layer with a high adhesive force, wherein the hydrophobic adhesive layer does not bloom even when an organic fluid component having high polarity is contained therein. The patch contains a support and an adhesive layer on at least one surface of the support, wherein the adhesive layer contains a synthetic rubber having a viscosity average molecular weight of 1,700,000-6,500,000, an organic fluid component having high polarity, a tackifier, and magnesium aluminometasilicate. In the patch preparation, the above-mentioned adhesive layer further contains a drug.
摘要翻译：本发明提供了具有粘合力高的贴剂和贴片制剂，其中即使含有高极性的有机流体组分，疏水性粘合剂层也不会起泡。该贴片在支撑体的至少一个表面上包含支撑体和粘合剂层，其中粘合剂层含有粘均分子量为170万至6,500,000的合成橡胶，具有高极性的有机流体组分，增粘剂和镁硅酸铝在贴片制剂中，上述粘合剂层还含有药物。

9. 发明申请

US20130315978A1 PATCH AND PATCH PREPARATION 有权
标题翻译：配对和配对准备
公开(公告)号：US20130315978A1
公开(公告)日：2013-11-28
申请号：US13983481
申请日：2012-02-01
申请人： Masato Nishimura , Yoshihiro Iwao , Katsuhiro Okada , Kensuke Matsuoka
发明人： Masato Nishimura , Yoshihiro Iwao , Katsuhiro Okada , Kensuke Matsuoka
IPC分类号： A61K9/70 , A61K31/663 , A61K31/405
CPC分类号： A61K9/7053 , A61K31/405 , A61K31/663 , Y10T428/2857
摘要： The invention provides a patch and a patch preparation having an adhesive layer with a high adhesive force, wherein the hydrophobic adhesive layer does not bloom even when an organic fluid component having high polarity is contained therein. The patch contains a support and an adhesive layer on at least one surface of the support, wherein the adhesive layer contains a synthetic rubber having a viscosity average molecular weight of 1,700,000-6,500,000, an organic fluid component having high polarity, a tackifier, and magnesium aluminometasilicate. In the patch preparation, the above-mentioned adhesive layer further contains a drug.
摘要翻译：本发明提供了具有粘合力高的贴剂和贴片制剂，其中即使含有高极性的有机流体组分，疏水性粘合剂层也不会起泡。该贴片在支撑体的至少一个表面上包含支撑体和粘合剂层，其中粘合剂层含有粘均分子量为170万至6,500,000的合成橡胶，具有高极性的有机流体组分，增粘剂和镁硅酸铝在贴片制剂中，上述粘合剂层还含有药物。

10. 发明授权

US08591939B2 Adhesive preparation containing fentanyl 有权
标题翻译：含芬太尼的粘合剂
公开(公告)号：US08591939B2
公开(公告)日：2013-11-26
申请号：US11196935
申请日：2005-08-04
申请人： Yuji Saeki , Masato Nishimura , Kensuke Matsuoka , Takateru Muraoka , Yoshifumi Hosaka , Mitsuhiko Hori , Kazuhisa Ninomiya , Hitoshi Akemi , Hidetoshi Kuroda
发明人： Yuji Saeki , Masato Nishimura , Kensuke Matsuoka , Takateru Muraoka , Yoshifumi Hosaka , Mitsuhiko Hori , Kazuhisa Ninomiya , Hitoshi Akemi , Hidetoshi Kuroda
IPC分类号： A61K31/445 , A61F13/02
CPC分类号： A61K9/7053 , A61K31/4468
摘要： The present invention provides a Fentanyl-containing percutaneously absorbable adhesive preparation, which is obtained from economic starting materials, has a constitution simpler than that of conventional ones, has sufficient skin permeability, and which permits control of skin permeability by changing the mixing ratio of two kinds of polyisobutylene having different molecular weights, a tackifier and an organic liquid. Specifically, the present invention provides a percutaneously absorbable adhesive preparation comprising a support and an adhesive layer laminated on one surface thereof, wherein the adhesive layer comprises Fentanyl, two kinds of polyisobutylene having different molecular weights, a tackifier and an organic liquid compatible with the aforementioned two kinds of polyisobutylene and the aforementioned tackifier.
摘要翻译：本发明提供了一种经济起始材料得到的含有芬太尼的经皮吸收性粘合剂制剂，其结构比以往更简单，具有足够的皮肤渗透性，并且通过改变两者的混合比可以控制皮肤渗透性种类具有不同分子量的聚异丁烯，增粘剂和有机液体。具体地说，本发明提供了一种经皮吸收性粘合剂制剂，其包含在其一个表面上层叠的载体和粘合剂层，其中所述粘合剂层包括芬太尼，两种具有不同分子量的聚异丁烯，增粘剂和与上述相容的有机液体两种聚异丁烯和上述增粘剂。

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