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1. 发明申请

US20050226867A1 IL-5R-specific antibody composition 审中-公开
标题翻译： IL-5R特异性抗体组成
公开(公告)号：US20050226867A1
公开(公告)日：2005-10-13
申请号：US10959326
申请日：2004-10-07
申请人： Shigeru Iida , Mitsuo Satoh , Miho Urakubo , Masako Wakitani , Kazuhisa Uchida , Rinpei Niwa , Kenya Shitara , Masamichi Koike
发明人： Shigeru Iida , Mitsuo Satoh , Miho Urakubo , Masako Wakitani , Kazuhisa Uchida , Rinpei Niwa , Kenya Shitara , Masamichi Koike
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： C07K16/2866 , C07K2317/24 , C07K2317/41 , C07K2317/732
摘要： The present invention provides an antibody composition comprising an antibody molecule which specifically binds to human interleukin-5 receptor α chain and has complex type N-glycoside-linked sugar chains in the Fc region, wherein the complex type N-glycoside-linked sugar chains have a structure in which fucose is not bound to N-acetylglucosamine in the reducing end in the sugar chains; a transformant which produces the antibody composition; a process for producing the antibody composition; and a pharmaceutical composition comprising the antibody composition.
摘要翻译：本发明提供一种抗体组合物，其包含特异性结合人白细胞介素-5受体α链并在Fc区具有复合型N-糖苷连接的糖链的抗体分子，其中复合型N-糖苷连接的糖链具有岩藻糖在糖链的还原端不与N-乙酰氨基葡萄糖结合的结构; 产生抗体组成的转化体; 制备抗体组合物的方法; 和包含该抗体组合物的药物组合物。

2. 发明申请

US20050287138A1 CCR4-specific antibody composition 审中-公开
标题翻译： CCR4特异性抗体组成
公开(公告)号：US20050287138A1
公开(公告)日：2005-12-29
申请号：US10959310
申请日：2004-10-07
申请人： Shigeru Iida , Mitsuo Satoh , Miho Urakubo , Masako Wakitani , Kazuhisa Uchida , Rinpei Niwa , Kenya Shitara
发明人： Shigeru Iida , Mitsuo Satoh , Miho Urakubo , Masako Wakitani , Kazuhisa Uchida , Rinpei Niwa , Kenya Shitara
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： C07K16/2866 , C07K2317/41 , C07K2317/732
摘要： The present invention provides an antibody composition comprising an antibody molecule which specifically binds to human CC chemokine receptor 4 (CCR4) and has complex type N-glycoside-linked sugar chains in the Fc region, wherein the complex type N-glycoside-linked sugar chains have a structure in which fucose is not bound to N-acetylglucosamine in the reducing end in the sugar chains; a transformant which produces the antibody composition; a process for producing the antibody composition; and a pharmaceutical composition comprising the antibody composition.
摘要翻译：本发明提供一种抗体组合物，其包含特异性结合人类CC趋化因子受体4（CCR4）的抗体分子，并且在Fc区具有复合型N-糖苷连接的糖链，其中复合型N-糖苷连接的糖链在糖链的还原端具有岩藻糖不与N-乙酰葡糖胺结合的结构; 产生抗体组成的转化体; 制备抗体组合物的方法; 和包含该抗体组合物的药物组合物。

3. 发明申请

US20080213266A1 Method for Treating CCR4-Related Diseases 审中-公开
标题翻译：治疗CCR4相关疾病的方法
公开(公告)号：US20080213266A1
公开(公告)日：2008-09-04
申请号：US11969555
申请日：2008-01-04
申请人： Shigeru Iida , Mitsuo Satoh , Miho Urakubo , Masako Wakitani , Kazuhisa Uchida , Rinpei Niwa , Kenya Shitara
发明人： Shigeru Iida , Mitsuo Satoh , Miho Urakubo , Masako Wakitani , Kazuhisa Uchida , Rinpei Niwa , Kenya Shitara
IPC分类号： A61K39/395 , A61P43/00
CPC分类号： C07K16/2866 , C07K2317/41 , C07K2317/732
摘要： The present invention provides an antibody composition comprising an antibody molecule which specifically binds to human CC chemokine receptor 4 (CCR4) and has complex type N-glycoside-linked sugar chains in the Fc region, wherein the complex type N-glycoside-linked sugar chains have a structure in which fucose is not bound to N-acetylglucosamine in the reducing end in the sugar chains; a transformant which produces the antibody composition; a process for producing the antibody composition; and a pharmaceutical composition comprising the antibody composition.
摘要翻译：本发明提供一种抗体组合物，其包含特异性结合人类CC趋化因子受体4（CCR4）的抗体分子，并且在Fc区具有复合型N-糖苷连接的糖链，其中复合型N-糖苷连接的糖链在糖链的还原端具有岩藻糖不与N-乙酰葡糖胺结合的结构; 产生抗体组成的转化体; 制备抗体组合物的方法; 和包含该抗体组合物的药物组合物。

4. 发明申请

US20090028877A1 Antibody Composition Specifically Binding to Ganglioside Gm 审中-公开
标题翻译：特异性结合神经节苷脂Gm的抗体组成
公开(公告)号：US20090028877A1
公开(公告)日：2009-01-29
申请号：US10575114
申请日：2004-10-08
申请人： Shigeru Iida , Mitsuo Satoh , Miho Takabe , Masako Wakitani , Kazuhisa Uchida , Rinpei Niwa , Kenya Shitara
发明人： Shigeru Iida , Mitsuo Satoh , Miho Takabe , Masako Wakitani , Kazuhisa Uchida , Rinpei Niwa , Kenya Shitara
IPC分类号： A61K39/395 , C07K16/18 , C12N5/06 , A61P31/00 , C12P21/04
CPC分类号： C07K16/3084 , A61K2039/505 , C07K2317/52 , C07K2317/732
摘要： An anti-ganglioside GM2 antibody composition having enhanced effector function which is useful as a medicament has been desired. The present invention provides an antibody composition comprising an antibody molecule which specifically binds to ganglioside GM2 and has complex type N-glycoside-linked sugar chains in the Fc region, wherein the complex type N-glycoside-linked sugar chains have a structure in which fucose is not bound to N-acetylglucosamine in the reducing end in the sugar chains; a transformant which produces the antibody composition; a process for producing the antibody composition; and a pharmaceutical composition comprising the antibody composition.
摘要翻译：已经需要可用作药物的具有增强的效应子功能的抗神经节苷脂GM2抗体组合物。本发明提供一种抗体组合物，其包含特异性结合神经节苷脂GM2并且在Fc区中具有复合型N-糖苷连接的糖链的抗体分子，其中复合型N-糖苷连接的糖链具有其中岩藻糖在糖链的还原末端不与N-乙酰氨基葡萄糖结合; 产生抗体组成的转化体; 制备抗体组合物的方法; 和包含该抗体组合物的药物组合物。

5. 发明申请

US20060021071A1 Cell in which genome is modified 审中-公开
标题翻译：基因组修饰的细胞
公开(公告)号：US20060021071A1
公开(公告)日：2006-01-26
申请号：US10959309
申请日：2004-10-07
申请人： Mitsuo Satoh , Shigeru Iida , Katsuhiro Mori , Miho Urakubo , Reiko Kamochi , Kazuya Yamano
发明人： Mitsuo Satoh , Shigeru Iida , Katsuhiro Mori , Miho Urakubo , Reiko Kamochi , Kazuya Yamano
IPC分类号： A01K67/027 , C07H21/04 , C12P21/06 , A61K39/395 , A01H1/00 , C12N5/06 , C12N5/04
CPC分类号： C12N9/88 , A01K2217/075 , C07K16/2866 , C07K2317/21 , C07K2317/24 , C07K2317/52 , C07K2317/732 , C12N2510/02
摘要： The present invention provides a cell capable of controlling the sugar chain structure of a glycoprotein which is a producing protein, that is, a cell capable of producing a glycoprotein having high physiological activity; a process for producing a glycoprotein using the cell; a glycoprotein produced by the process; and use thereof.
摘要翻译：本发明提供能够控制作为产生蛋白质的糖蛋白的糖链结构的细胞，即能够产生具有高生理活性的糖蛋白的细胞; 使用该细胞产生糖蛋白的方法; 通过该过程产生的糖蛋白; 及其用途。

6. 发明申请

US20070128691A1 Genomically modified cell neutralized to serum-free system 审中-公开
标题翻译：将基因修饰的细胞中和至无血清系统
公开(公告)号：US20070128691A1
公开(公告)日：2007-06-07
申请号：US10575253
申请日：2004-10-08
申请人： Ryosuke Nakano , Mitsuo Satoh , Shigeru Iida , Miho Inoue , Machi Kusunoki , Satoko Kinoshita , Naoko Ohnuki
发明人： Ryosuke Nakano , Mitsuo Satoh , Shigeru Iida , Miho Inoue , Machi Kusunoki , Satoko Kinoshita , Naoko Ohnuki
IPC分类号： C12P21/06 , C07H21/04 , C12N9/10 , C12N5/06
CPC分类号： C12N5/0018 , C12N2500/92 , C12N2500/95 , C12N2510/00 , C12N2510/02
摘要： Development of a host cell capable of producing a glycoprotein composition such as an antibody composition which is useful in development of medicaments is desired. The present invention provides a cell in which a genomic gene encoding an enzyme relating to a sugar chain modification in which 1-position of fucose is bound to 6-position of N-acetylglucosamine in the reducing end through α-bond in a complex type N-glycoside-linked sugar chain is knocked out, wherein the cell is naturalized in a serum-free medium and a process for producing a glycoprotein composition using the cell.
摘要翻译：需要开发能够产生可用于开发药物的糖蛋白组合物如抗体组合物的宿主细胞。本发明提供一种细胞，其中编码与糖链修饰相关的酶的基因组基因，其中岩藻糖的1位通过复合型N中的α-键与还原末端的N-乙酰葡糖胺的6-位结合 - 糖苷连接的糖链被敲除，其中细胞在无血清培养基中归化，以及使用该细胞产生糖蛋白组合物的方法。

7. 发明申请

US20050033654A1 Online shopping method and system 审中-公开
标题翻译：在线购物方式和系统
公开(公告)号：US20050033654A1
公开(公告)日：2005-02-10
申请号：US10680225
申请日：2003-10-08
申请人： Kenjiro Takagi , Nobuya Okayama , Shigeru Iida , Hiroko Nakagawa
发明人： Kenjiro Takagi , Nobuya Okayama , Shigeru Iida , Hiroko Nakagawa
IPC分类号： G06Q30/02 , G06Q30/06 , G06Q50/00 , G06F17/60
CPC分类号： G06Q30/06 , G06Q30/0226 , G06Q30/0641
摘要： If a commodity desired to purchase is selected in a purchaser terminal, a list of users (information providers) having a purchase history of the commodity at a shopping site is displayed. The purchaser terminal exchanges messages in real time with an information terminal of an information provider selected from the list, and obtains information concerning the commodity (information provision). In the case where the purchaser purchases the commodity, its commodity ID and a user ID of the information provider are associated with each other and stored in a shopping site operation apparatus. After the purchase of the commodity, a comment and/or evaluation concerning the information provision are input. On the basis of the comment and/or evaluation, privilege is granted to the information provider. The comment and/or evaluation are reflected in information of the information providers.
摘要翻译：如果在购买者终端中选择了要购买的商品，则显示在购物站点具有该商品的购买历史的用户（信息提供者）列表。购买者终端与从列表中选择的信息提供者的信息终端实时交换消息，并获得关于商品的信息（信息提供）。在购买者购买商品的情况下，其商品ID和信息提供者的用户ID相互关联并存储在购物场所操作装置中。购买商品后，输入有关信息提供的意见和/或评估。在评论和/或评估的基础上，授予信息提供者的特权。评论和/或评估反映在信息提供者的信息中。

8. 发明申请

US20080086307A1 Digital contents version management system 审中-公开
标题翻译：数字内容版本管理系统
公开(公告)号：US20080086307A1
公开(公告)日：2008-04-10
申请号：US11807698
申请日：2007-05-29
申请人： Nobuya Okayama , Osamu Hoshino , Shigeru Iida , Akiko Isono , Aya Onoyama
发明人： Nobuya Okayama , Osamu Hoshino , Shigeru Iida , Akiko Isono , Aya Onoyama
IPC分类号： G10L13/00
CPC分类号： G09B21/007 , G09B5/06 , G09B21/003 , G10L13/00
摘要： Preparation of Braille books and audio books by man has a problem that a great deal of costs including the work cost for recitation or translation (printing) of Braille, composition, examination and the like and the distribution cost are required as compared with general books. Further, there is a problem that books that visually handicapped people wish to read cannot be delivered immediately at an inexpensive price. The user (reader) himself participates in editing or correction in processing for producing an audio book which reads an electronic book aloud using the speech synthesis technique and pronunciation symbol text constituting the basis of the audio book to thereby reduce the cost required for the production processing of the audio book and the pronunciation symbol text and improve the quality of the audio book and the pronunciation symbol text.
摘要翻译：制作盲人书籍和有声读物的问题是，与一般书籍相比，需要大量费用，包括盲文，作文，考试等的诵读或翻译（印刷）工作成本和分发费用。此外，有视觉障碍的人希望阅读的书籍不能以便宜的价格立即交付。用户（读取器）本身参与编辑或校正处理，用于制作使用构成音频书的基础的语音合成技术和发音符号文本朗读电子书的音频书，从而降低生产处理所需的成本的音频书和发音符号文本，并提高音频书和发音符号文本的质量。

9. 发明申请

US20050066386A1 Method of modifying genome in higher plant 审中-公开
标题翻译：高等植物基因组修饰方法
公开(公告)号：US20050066386A1
公开(公告)日：2005-03-24
申请号：US10487869
申请日：2002-08-23
申请人： Shigeru Iida , Rie Terada , Yoshishige Inagaki
发明人： Shigeru Iida , Rie Terada , Yoshishige Inagaki
IPC分类号： C12N15/82 , C12N15/84 , A01H1/00 , C07H21/04
CPC分类号： C12N15/8205 , C12N15/8213
摘要： A genome-modification technique based on homologous recombination was established for partial modification of genomic sequences into desired sequences. The use of such a technique to achieve high efficiency and reproducibility in higher plants has been regarded as difficult. According to the present invention, endogenous genome sequences of higher plants can be targeted to efficiently and reproducibly yield homologous recombinants without changing their original loci. Moreover, the present invention enables the production of a transformed plant in which a specific gene is modified without any restrictions, and it can also contribute to the analysis of gene functions as well as to the analysis of gene expression mechanisms associated with changes in genome dynamics.
摘要翻译：建立基于同源重组的基因组修饰技术，将基因组序列部分修饰成所需序列。使用这种技术在高等植物中实现高效率和再现性已被认为是困难的。根据本发明，可以靶向高等植物的内源基因组序列以有效和可重复地产生同源重组体而不改变其原始基因座。此外，本发明能够生产其中特异性基因被修饰而没有任何限制的转化植物，并且还可以有助于基因功能的分析以及与基因组动力学变化相关的基因表达机制的分析。

10. 发明申请

US20060212961A1 Rice transposon gene 审中-公开
标题翻译：水稻转座子基因
公开(公告)号：US20060212961A1
公开(公告)日：2006-09-21
申请号：US10563051
申请日：2004-03-19
申请人： Shigeru Iida , Masahiko Maekawa , Kazuo Tsugane
发明人： Shigeru Iida , Masahiko Maekawa , Kazuo Tsugane
IPC分类号： A01H5/00 , C12N5/04 , C12N15/82 , A01H1/00
CPC分类号： C07K14/415
摘要： The present inventors identified the causative gene of pyl mutant, which is mutable and shows a lowered chlorophyll accumulation, and discovered that a new type of transposon classified to Ac/Ds type is involved in the mutation. It is confirmed for the first time that the Ac/Ds type transposon nDart (SEQ ID NO: 1) in rice has transposon activity under normal cultivation conditions. Furthermore, an autonomous element Dart was discovered by analyzing said Ac/Ds type transposon.
摘要翻译：本发明人确定了pyl突变体的可变基因，其可变性并且显示出降低的叶绿素积累，并且发现分类为Ac / Ds型的新型转座子参与突变。首次确认水稻中Ac / Ds型转座子nDart（SEQ ID NO：1）在正常培养条件下具有转座子活性。此外，通过分析所述Ac / Ds型转座子发现自主元件Dart。

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