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1. 发明授权

US09513407B2 Photochromic composition and optical article using photochromic composition 有权
标题翻译：光致变色组合物和使用光致变色组合物的光学制品
公开(公告)号：US09513407B2
公开(公告)日：2016-12-06
申请号：US14112255
申请日：2012-04-16
申请人： Toshimitsu Hiraren , Katsuhiro Mori , Yasutomo Shimizu
发明人： Toshimitsu Hiraren , Katsuhiro Mori , Yasutomo Shimizu
IPC分类号： G02B1/04 , C09K9/02 , G02B5/23 , G02C7/10 , C08K5/00 , C08G18/10 , C08G18/08 , C08G18/12
CPC分类号： G02B1/041 , C08G18/0809 , C08G18/0823 , C08G18/10 , C08G18/12 , C08K5/0041 , C09K9/02 , C09K2211/1007 , C09K2211/1011 , C09K2211/1029 , C09K2211/1033 , C09K2211/1088 , G02B5/23 , G02C7/102 , G02F2202/14 , Y10T156/10
摘要： To provide a photochromic composition which functions as an adhesive layer for bonding two optical sheets that are formed of a polycarbonate resin or the like, so that a laminate that is obtained by bonding two optical sheets with the composition being sandwiched therebetween has excellent adhesion, heat resistance and photochromic properties. In particular, to provide a photochromic composition which is capable of forming an adhesive layer that is not decreased in the adhesion between the optical sheets even in cases where the adhesive layer is in contact with hot water. Provided is a photochromic composition which contains a urethane polymer having a polymerizable group (component A) and a photochromic compound (component B).
摘要翻译：为了提供一种光致变色组合物，其用作用于粘合由聚碳酸酯树脂等形成的两个光学片的粘合剂层，使得通过粘合具有夹在其间的组合物的两个光学片而获得的层压体具有优异的粘附性，热性电阻和光致变色性质。特别是，为了提供即使在粘合剂层与热水接触的情况下也能够形成粘合剂层的光致变色组合物，其即使在光学片之间的粘合力也不会降低。本发明提供含有具有聚合性基团（A成分）和光致变色化合物（B成分）的聚氨酯聚合物的光致变色组合物。

2. 发明授权

US09234984B2 Photochromic composition 有权
标题翻译：光致变色组合物
公开(公告)号：US09234984B2
公开(公告)日：2016-01-12
申请号：US13814254
申请日：2011-08-04
申请人： Toshimitsu Hiraren , Katsuhiro Mori , Yasutomo Shimizu
发明人： Toshimitsu Hiraren , Katsuhiro Mori , Yasutomo Shimizu
IPC分类号： G02F1/07 , G02B1/04 , C09K9/02 , G02B5/23
CPC分类号： G02B1/04 , C09K9/02 , C09K2211/1007 , C09K2211/1011 , C09K2211/1033 , C09K2211/1088 , G02B5/23
摘要： A photochromic composition, which can function as an adhesive layer for bonding optical sheets made from a polycarbonate resin, may include a polyurethane-urea resin (A) obtained by reacting a polyol compound (A1), a polyisocyanate compound (A2) that has two or more isocyanato groups in the molecule, and an amino-containing compound (A3) that contains two or more isocyanato-reactive groups in the molecule, with at least one of the isocyanato-reactive groups being an amino group; and a photochromic compound (B).
摘要翻译：作为用于粘合由聚碳酸酯树脂制成的光学片的粘合剂层的光致变色组合物可以包括通过多元醇化合物（A1），多异氰酸酯化合物（A2）与二或更多的分子中的异氰酸根合基团，和分子中含有两个或多个异氰酸酯基反应性基团的含氨基化合物（A3），其中至少一个异氰酸酯基反应性基团是氨基; 和光致变色化合物（B）。

3. 发明授权

US09023999B2 Anti-CD27 antibody 有权
标题翻译：抗CD27抗体
公开(公告)号：US09023999B2
公开(公告)日：2015-05-05
申请号：US12494827
申请日：2009-06-30
申请人： Katsuhiro Mori , Naoko Hiura , Tsuguo Kubota , Akiko Furuya , Yutaka Kanda , Mitsuo Satoh
发明人： Katsuhiro Mori , Naoko Hiura , Tsuguo Kubota , Akiko Furuya , Yutaka Kanda , Mitsuo Satoh
IPC分类号： C07K16/00 , C12P19/00 , G01N33/53 , G01N33/574 , C07K16/28 , C12R1/91 , G01N33/68
CPC分类号： G01N33/57484 , C07K16/2878 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/734 , C07K2317/92 , C12R1/91 , G01N33/6863 , G01N2333/70578 , G01N2400/02 , G01N2800/347
摘要： The present invention provides a monoclonal antibody which specifically recognizes CD27 containing an O-linked sugar chain to which galactose is not bound and binds to its extracellular region, or a method for using the same.The present invention can provide a monoclonal antibody or an antibody fragment thereof, which specifically recognizes a polypeptide encoded by CD27 gene containing an O-linked sugar chain to which galactose is not bound, and binds to its extracellular region; a hybridoma which produces the antibody; a DNA which encodes the antibody; a vector which comprises the DNA; a transformant obtainable by transforming the vector; a process for producing an antibody or an antibody fragment thereof using the hybridoma or the transformant; and a diagnostic agent or a therapeutic agent comprising the antibody or the antibody fragment thereof as an active ingredient.
摘要翻译：本发明提供一种单克隆抗体，其特异性识别含有O-连接的糖链的CD27，其中半乳糖不结合并结合到其胞外区域，或其使用方法。本发明可以提供一种单克隆抗体或其抗体片段，该单克隆抗体或其抗体片段特异性识别由含有O-连接的糖链的CD27基因编码的多肽，其中半乳糖未结合到其上并结合其胞外区域; 产生抗体的杂交瘤; 编码抗体的DNA; 包含DNA的载体; 通过转化载体可获得的转化体; 使用杂交瘤或转化体生产抗体或其抗体片段的方法; 以及包含该抗体或其抗体片段作为有效成分的诊断剂或治疗剂。

4. 发明申请

US20140029079A1 Photocromic Composition 有权
标题翻译：光谱组成
公开(公告)号：US20140029079A1
公开(公告)日：2014-01-30
申请号：US14111393
申请日：2012-04-12
申请人： Toshimitsu Hiraren , Katsuhiro Mori , Yasutomo Shimizu
发明人： Toshimitsu Hiraren , Katsuhiro Mori , Yasutomo Shimizu
IPC分类号： G02F1/153 , G02B1/04
CPC分类号： G02F1/1533 , C08G18/022 , C08G18/4277 , C08G18/44 , C08G18/73 , C08G18/755 , C08G18/792 , C08K5/0041 , C08K5/1545 , C09K9/02 , C09K2211/1007 , C09K2211/1029 , C09K2211/1033 , C09K2211/1088 , G02B1/04 , G02B5/23 , C08L75/12 , C08G18/12 , C08G18/3234 , C08G18/1825
摘要： Provided is a photochromic composition which can function as an adhesive layer for bonding optical sheets made from a polycarbonate resin or the like and a laminated article using said composition exhibits excellent tight adhesion, heat resistance and photochromic properties. In particular, provided is a photochromic composition which can prevent an elution of the composition from the optical sheets when embedding and polymerizing in a polymerizable monomer. The photochromic composition comprises a polyurethane resin (A) having an isocyanurate structure and a photochromic compound (B).
摘要翻译：提供一种光致变色组合物，其可以用作用于粘合由聚碳酸酯树脂等制成的光学片的粘合剂层，并且使用所述组合物的层压制品表现出优异的紧密粘合性，耐热性和光致变色性能。特别地，提供了一种光致变色组合物，其可以防止组合物在嵌入和聚合在可聚合单体中时从光学片中的洗脱。光致变色组合物包含具有异氰脲酸酯结构的聚氨酯树脂（A）和光致变色化合物（B）。

5. 发明授权

US08557377B2 Photochromic optical element 失效
标题翻译：光致变色光学元件
公开(公告)号：US08557377B2
公开(公告)日：2013-10-15
申请号：US12223116
申请日：2007-01-19
申请人： Katsuhiro Mori , Yuichiro Kawabata , Ikumi Kawaguchi , Hironobu Nagoh
发明人： Katsuhiro Mori , Yuichiro Kawabata , Ikumi Kawaguchi , Hironobu Nagoh
IPC分类号： B32B9/04 , G02B1/10 , B05D5/06
CPC分类号： G02B5/23 , C09K9/02 , C09K2211/1011 , C09K2211/1033 , C09K2211/1088 , G02B1/105 , G02B1/113 , G02B1/14 , Y10T428/256 , Y10T428/257 , Y10T428/259 , Y10T428/263 , Y10T428/264 , Y10T428/265 , Y10T428/31511 , Y10T428/31663 , Y10T428/31667
摘要： A photochromic optical element comprising an optical substrate, a photochromic coat layer, and a hard coat layer that are laminated in this order, wherein (I) the photochromic coat layer comprising an alkylamino group-containing photochromic compound and/or a dialkylamino group-containing photochromic compound in a total amount of 0.1 to 10.0% by mass, and (II) the hard coat layer is obtained by curing a hard coat agent comprising metal oxide fine particles and an organosilicon compound, the hard coat agent containing as the organosilicon compound at least one selected from the group consisting of a tetraalkoxy silane, a methyl trialkoxy silane, and partial hydrolysates thereof in an amount of 10 to 60% by mass based on the total mass of the metal oxide fine particles and the organosilicon compound.
摘要翻译： 1.一种光致变色光学元件，其特征在于，含有依次层叠的光学基板，光致变色涂层和硬涂层，其中，（I）含有含有烷基氨基的光致变色化合物和/或含二烷基氨基的光致变色涂层光致变色化合物的总量为0.1〜10.0质量％，（II）硬涂层是通过将包含金属氧化物微粒和有机硅化合物的硬涂层固化而得到的，所述硬涂层包含作为有机硅化合物的硬涂层基于金属氧化物微粒和有机硅化合物的总质量，选自由四烷氧基硅烷，甲基三烷氧基硅烷及其部分水解产物组成的组中的至少一种为10〜60质量％。

6. 发明申请

US20120019888A1 PRIMER COMPOSITION FOR OPTICAL ARTICLES AND OPTICAL ARTICLES 有权
标题翻译：光学文章和光学文章的主要组成
公开(公告)号：US20120019888A1
公开(公告)日：2012-01-26
申请号：US13260600
申请日：2010-03-25
申请人： Katsuhiro Mori , Toshimitsu Hiraren
发明人： Katsuhiro Mori , Toshimitsu Hiraren
IPC分类号： G02B1/10 , C09D175/04 , C09D7/12
CPC分类号： G02B5/23 , C08K3/22 , C09D5/002 , C09D5/02 , C09D7/61 , G02B1/041 , Y10T428/24942 , Y10T428/269 , Y10T428/31507 , Y10T428/31551 , Y10T428/31598 , C08L75/00
摘要： A primer coating composition is provided for an optical article capable of forming a coating layer having excellent impact resistance, abrasion resistance, and adhesion to various kinds of plastic materials without occurring of appearance faulty for an optical base material, for example, a plastic lens for an eyeglass. A primer composition for an optical article comprises; (A) aqueous dispersion of urethane resin having a polycarbonate-derived skeleton and the elongation of 200˜1000%; (B) an organic solvent having 3˜9 carbon atoms and having an ether bond or carbonyl bond and one hydroxyl group in a molecule; and (C) lower alcohol having 1˜4 carbon atoms, wherein the weight ratio of said organic solvent to said lower alcohol is from 0.01 to less than 2.00.
摘要翻译：提供一种底漆涂料组合物，用于能够形成具有优异的耐冲击性，耐磨性和对各种塑料材料的粘附性的涂层的光学制品，而不会出现光学基材的外观缺陷，例如塑料透镜一个眼镜。用于光学制品的底漆组合物包括：（A）具有聚碳酸酯衍生骨架的聚氨酯树脂的水分散体，伸长率为200〜1000％。（B）分子中具有3〜9个碳原子并具有醚键或羰基键和1个羟基的有机溶剂; 和（C）具有1〜4个碳原子的低级醇，其中所述有机溶剂与所述低级醇的重量比为0.01至小于2.00。

7. 发明申请

US20100173324A1 ANTI-CD27 ANTIBODY 有权
标题翻译：抗CD27抗体
公开(公告)号：US20100173324A1
公开(公告)日：2010-07-08
申请号：US12494827
申请日：2009-06-30
申请人： Katsuhiro MORI , Naoko HIURA , Tsuguo KUBOTA , Akiko FURUYA , Yutaka KANDA , Mitsuo SATOH
发明人： Katsuhiro MORI , Naoko HIURA , Tsuguo KUBOTA , Akiko FURUYA , Yutaka KANDA , Mitsuo SATOH
IPC分类号： G01N33/53 , C07K16/18 , C12P21/08 , C12N5/16 , C07H21/04 , C12N15/63 , C12N5/10 , C12P21/06
CPC分类号： G01N33/57484 , C07K16/2878 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/734 , C07K2317/92 , C12R1/91 , G01N33/6863 , G01N2333/70578 , G01N2400/02 , G01N2800/347
摘要： The present invention provides a monoclonal antibody which specifically recognizes CD27 containing an O-linked sugar chain to which galactose is not bound and binds to its extracellular region, or a method for using the same.The present invention can provide a monoclonal antibody or an antibody fragment thereof, which specifically recognizes a polypeptide encoded by CD27 gene containing an O-linked sugar chain to which galactose is not bound, and binds to its extracellular region; a hybridoma which produces the antibody; a DNA which encodes the antibody; a vector which comprises the DNA; a transformant obtainable by transforming the vector; a process for producing an antibody or an antibody fragment thereof using the hybridoma or the transformant; and a diagnostic agent or a therapeutic agent comprising the antibody or the antibody fragment thereof as an active ingredient.
摘要翻译：本发明提供一种单克隆抗体，其特异性识别含有O-连接的糖链的CD27，其中半乳糖不结合并结合到其胞外区域，或其使用方法。本发明可以提供一种单克隆抗体或其抗体片段，该单克隆抗体或其抗体片段特异性识别由含有O-连接的糖链的CD27基因编码的多肽，其中半乳糖未结合到其上并结合其胞外区域; 产生抗体的杂交瘤; 编码抗体的DNA; 包含DNA的载体; 通过转化载体可获得的转化体; 使用杂交瘤或转化体生产抗体或其抗体片段的方法; 以及包含该抗体或其抗体片段作为有效成分的诊断剂或治疗剂。

8. 发明授权

US07749753B2 Cells in which activity of the protein involved in transportation of GDP-fucose is reduced or lost 有权
标题翻译：涉及GDP-岩藻糖运输的蛋白质活性降低或丧失的细胞
公开(公告)号：US07749753B2
公开(公告)日：2010-07-06
申请号：US10409600
申请日：2003-04-09
申请人： Yutaka Kanda , Mitsuo Satoh , Katsuhiro Mori
发明人： Yutaka Kanda , Mitsuo Satoh , Katsuhiro Mori
IPC分类号： C12P21/02 , C07H21/04
CPC分类号： C12N15/8245 , A61K2039/505 , C07K14/47 , C07K16/18 , C07K16/2866 , C07K2317/24 , C07K2317/732
摘要： A cell in which the activity of a protein relating to transport of an intracellular sugar nucleotide, GDP-fucose, to the Golgi body is more decreased or deleted than its parent cell; a process for producing an antibody composition using the cell; a transgenic non-human animal or plant or the progenies thereof, in which genome is modified so as to have a decreased or deleted activity of a protein relating to transport of an intracellular sugar nucleotide, GDP-fucose, to the Golgi body; a process for producing an antibody composition from the animal or plant; and a medicament comprising the antibody composition.
摘要翻译：与细胞内糖核苷酸GDP-岩藻糖转运到高尔基体相关的蛋白质的活性比其亲本细胞更多地减少或缺失的细胞; 使用该细胞产生抗体组合物的方法; 转基因非人动物或植物或其后代，其中基因组被修饰以具有与细胞内糖核苷酸GDP-岩藻糖转运到高尔基体相关的蛋白质的降低或缺失的活性; 从动物或植物制备抗体组合物的方法; 和包含该抗体组合物的药物。

9. 发明申请

US20100110521A1 COATING COMPOSITION AND PHOTOCHROMIC OPTICAL ARTICLE 有权
标题翻译：涂料组合物和光电光学制品
公开(公告)号：US20100110521A1
公开(公告)日：2010-05-06
申请号：US12519113
申请日：2008-02-21
申请人： Ikumi Kawaguchi , Hironobu Nagoh , Katsuhiro Mori
发明人： Ikumi Kawaguchi , Hironobu Nagoh , Katsuhiro Mori
IPC分类号： C09D4/00 , B32B9/00 , B32B27/00 , B05D5/06 , G02B5/23 , G02B1/10
CPC分类号： G02B5/23 , C08G77/14 , C08K3/36 , C08K5/5435 , C09D7/61 , C09D7/67 , C09D183/04 , C09D183/06 , G02B1/105 , G02B1/14 , Y10T428/25 , Y10T428/259 , Y10T428/31663
摘要： [Problem] To provide a coating composition capable of forming a hard coating on the surfaces of an optical base member such as a plastic lens featuring highly closely adhering property, excellent transparency and excellent scratch resistance.[Means for Solution] The coating composition comprise (a) a fine granular silica having a grain size of not larger than 30 nm; (b) organosilicon compound components containing an epoxy group-containing organosilicon compound (b1) and tetraalkoxysilane (b2) at a mass ratio (b1/b2) of 0.25 to 4.0; (c) water; and (d) a curing catalyst comprising a complex containing aluminum as a core metal, wherein the fine granular silica (a) is contained in an amount of 15 to 55 parts by mass, the water (c) is contained in an amount of 30 to 200 parts by mass and the curing catalyst (d) is contained in an amount of 0.1 to 5.0 parts by mass per the total amount of the fine granular silica (a) and the organosilicon compound components (b) of 100 parts by mass.
摘要翻译： [问题]提供一种能够在诸如塑料透镜的光学基底构件的表面上形成硬涂层的涂料组合物，其具有高密合性，优异的透明性和优异的耐刮擦性。 [解决方案]涂料组合物包含（a）粒径不大于30nm的细粒状二氧化硅; （b）质量比（b1 / b2）为0.25〜4.0的含有环氧基的有机硅化合物（b1）和四烷氧基硅烷（b2）的有机硅化合物成分; （c）水; 和（d）包含含有铝作为核心金属的络合物的固化催化剂，其中细粒状二氧化硅（a）的含量为15〜55质量份，水（c）的含量为30 相对于100质量份，相对于细颗粒状二氧化硅（a）和有机硅化合物成分（b）的总量，固化催化剂（d）的含量为0.1〜5.0质量份。

10. 发明申请

US20100086700A1 METHOD OF PRODUCING COATED LENSES 有权
标题翻译：生产涂层镜片的方法
公开(公告)号：US20100086700A1
公开(公告)日：2010-04-08
申请号：US12516740
申请日：2008-01-25
申请人： Naoto Takahashi , Katsuhiro Mori , Noriyuki Fukada
发明人： Naoto Takahashi , Katsuhiro Mori , Noriyuki Fukada
IPC分类号： G02B1/12 , C08F2/48
CPC分类号： B05D1/005 , B05D3/067 , B05D5/061
摘要： A method of coating without permitting the coating solution to flow onto the side surfaces or the back surfaces of the lenses in the operation for applying the coating solution onto the lenses. A lens 15 is spin-coated with the coating solution having a particular viscosity. A side edge portion 121 of a spatula 119 is brought into contact with an upper edge portion of a side surface 15a of the lens 15 before the coating solution fed onto the surface of the lens arrives at the peripheral edge portion of the lens. The side edge portion 121 of the spatula 119 is so arranged that the upper end side of the spatula is tilted toward the center side of the lens 15 at an angle of 5 to 35 degrees with the vertical line as a reference. The coating solution applied onto the lens 15 that is rotating adheres onto the spatula 119 but does not adhere onto the side surface of the lens 15.
摘要翻译：在涂布溶液到透镜的操作中，涂布方法不允许涂布溶液流到透镜的侧表面或背面。透镜15被涂覆有具有特定粘度的涂布溶液。刮刀119的侧边缘部分121与透镜15的侧表面15a的上边缘部分接触，然后将馈送到透镜表面的涂布溶液到达透镜的周缘部分。刮铲119的侧边缘部分121被布置成使得刮刀的上端侧以垂直线作为基准以5至35度的角度朝向透镜15的中心侧倾斜。施加到正在旋转的透镜15上的涂布溶液粘附到刮刀119上，但不粘附到透镜15的侧表面上。

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