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    • 6. 发明授权
    • Method and apparatus for continuous heat sterilization of liquid
    • 液体连续加热灭菌的方法和装置
    • US06673311B1
    • 2004-01-06
    • US09529956
    • 2000-06-26
    • Kazuyoshi SotoyamaKeiji IwatsukiTeruhiko MizotaYuzo AsanoYasutatsu MizotaHiroaki MatsuiTetsushi Mori
    • Kazuyoshi SotoyamaKeiji IwatsukiTeruhiko MizotaYuzo AsanoYasutatsu MizotaHiroaki MatsuiTetsushi Mori
    • A61L200
    • A23L3/0155A23L3/16A23L3/18A23L3/22A61L2/04
    • A method for continuous heat sterilization of liquid includes a continuous pre-heating step of preheating the liquid, a final heating step of heating the preheated liquid to reach a predetermined sterilizing temperature, a holding step of holding the liquid which has reached the predetermined sterilizing temperature for a predetermined period of time, and a cooling step of cooling the held liquid. The final heating step comprises the following steps (a) and (b): (a) a step of continuously pressurizing the liquid by a high pressure pump; and (b) a step of releasing the liquid continuously to a normal pressure within a time period of less than 10 seconds after the pressurizing step to thereby make the liquid reach the predetermined sterilizing temperature. An apparatus for automatically carrying out the method is provided. According to the continuous heat sterilization method and apparatus, scorch during the final heating step is dispensed with and accordingly, a long period of continuous operation is feasible. Furthermore, denaturation of liquid caused by heating is inconsiderable, investment cost and running cost become inexpensive, and a large amount of liquid can be processed.
    • 一种液体的连续加热灭菌方法,包括对液体进行预热的连续预热工序,对预热液进行加热达到规定的灭菌温度的最终加热工序,保持达预定灭菌温度的液体的保持步骤 预定时间段,以及冷却保持液体的冷却步骤。 最终加热步骤包括以下步骤(a)和(b):(a)通过高压泵连续加压液体的步骤; 和(b)在加压步骤后的10秒以内的时间内将液体连续地释放到常压的步骤,使液体达到规定的灭菌温度。 提供一种用于自动执行该方法的装置。 根据连续加热灭菌方法和装置,省去了最终加热步骤期间的焦烧,因此长时间的连续操作是可行的。 此外,由加热引起的液体的变性是不可忽视的,因此投资成本和运行成本便宜,并且可以处理大量的液体。
    • 7. 发明授权
    • Lactoferrin tablets
    • 乳铁蛋白片
    • US06319895B1
    • 2001-11-20
    • US09341316
    • 1999-09-02
    • Mamoru TomitaRyo KatoYuzo AsanoKenji NishiYuriko IiyamaTsutomu Kudo
    • Mamoru TomitaRyo KatoYuzo AsanoKenji NishiYuriko IiyamaTsutomu Kudo
    • A61K3840
    • A61K9/2018A61K35/741A61K38/40Y10S435/822Y10S435/853Y10S435/885A61K2300/00
    • Lactoferrin tablets comprising as the active ingredients lactoferrin and lactulose and having a horizontal hardness of at least 4 kg and a vertical hardness of at least 3 kg; and lactoferrin tablets comprising as the active ingredients a microbial cell powder of at least one microorganism selected from among lactic acid bacteria, lactoferrin and lactulose and having a horizontal hardness of at least 4 kg and a vertical hardness of at least 3 kg. These tablets can be produced by using the conventional tableting apparatuses and yet have high hardness. Thus, they do not adhere to the inner wall of the oral cavity and have a favorable taste. Since no excessive tableting pressure is needed in the production process, moreover, these tablets can contain much viable cells of lactic acid bacteria, though they are in the form of rigid tablet.
    • 乳铁蛋白片剂包含作为活性成分的乳铁蛋白和乳果糖,并且具有至少4kg的水平硬度和至少3kg的垂直硬度; 以及乳铁蛋白片,其包含至少一种选自乳酸菌,乳铁蛋白和乳果糖中的微生物的微生物细胞粉末作为活性成分,并且具有至少4kg的水平硬度和至少3kg的垂直硬度。 这些片剂可以通过使用常规的压片装置制造,但是具有高的硬度。 因此,它们不粘附到口腔的内壁并具有良好的味道。 由于在生产过程中不需要过量的压片压力,所以这些片剂可以含有很多活细胞的乳酸菌,尽管它们是刚性片剂的形式。