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1. 发明授权

US5252395A Blister resistant pressure sensitive adhesive sheet 失效
标题翻译：防潮压敏胶片
公开(公告)号：US5252395A
公开(公告)日：1993-10-12
申请号：US792013
申请日：1991-11-13
申请人： Shigenobu Maruoka , Toshio Sugizaki , Kouji Irie , Ichiro Tsuchida , Takanori Saito
发明人： Shigenobu Maruoka , Toshio Sugizaki , Kouji Irie , Ichiro Tsuchida , Takanori Saito
IPC分类号： C09J7/02 , C09J133/00 , C09J133/08 , C09J143/04 , C09J155/00
CPC分类号： C09J133/08 , C09J143/04 , C09J155/005 , C09J7/0217 , C09J2201/606 , Y10T428/2891
摘要： A pressure sensitive adhesive sheet comprising a substrate and an adhesive composition which is coated on the surface of the substrate. The main components of the adhesive composition are (a) a copolymer comprising monomeric units of an acrylic ester, (b) monomeric units of a polar acrylic compound, (c) monomeric units of a high glass transition temperature (Tg) macromonomer having a Tg of 20.degree. C. or above, (d) monomeric units of a low Tg macromonomer having a Tg of below 20.degree. C. and (e) monomeric units of an oligomer having telechelic thiol functional groups. The pressure sensitive adhesive sheet has excellent adhesive strength, resistance against formation of blisters and removability upon heating.

2. 发明授权

US5229195A Composite body having a blister-free pressure-sensitive adhesive sheet attached thereto 失效
标题翻译：具有附着于其上的无水泡粘合片的复合体
公开(公告)号：US5229195A
公开(公告)日：1993-07-20
申请号：US899048
申请日：1992-06-16
申请人： Shigenobu Maruoka , Ichiro Tsuchida , Takanori Saito
发明人： Shigenobu Maruoka , Ichiro Tsuchida , Takanori Saito
IPC分类号： C09J7/02 , C09J133/08 , C09J155/00
CPC分类号： C09J133/08 , C09J155/005 , C09J7/0217 , C09J2201/606 , Y10T428/2887 , Y10T428/31507 , Y10T428/31928 , Y10T428/31935
摘要： The pressure-sensitive adhesive sheet of the invention is free from the troubles of forming blisters due to the gas emission from the substrate surface to which the adhesive sheet is applied and bonded by using a unique pressure-sensitive adhesive to form the adhesive layer on a base sheet. The principal ingredient of the pressure-sensitive adhesive used in the present invention is a copolymer having a specified molecular weight and a specified glass transition temperature and composed of (a) from 50 to 85% by weight of a first monomeric moiety of an acrylic ester, e.g., 2-ethylhexyl acrylate, (b) from 1 to 30% by weight of a second monomeric moiety of an acrylic compound having a polar group, e.g., acrylic acid, and (c) from 5 to 40% by weight of a third monomeric moiety of a macromonomer having a polymeric molecular chain of styrene units and/or methyl methacrylate units and having a polymerizable functional group, e.g., methacryloyl group, at the molecular chain end.
摘要翻译：本发明的压敏粘合片由于通过使用独特的压敏粘合剂在粘合剂层的基材表面上产生气泡而形成泡罩而形成粘合剂层，因此不存在基板。本发明中使用的压敏粘合剂的主要成分是具有特定分子量和规定的玻璃化转变温度的共聚物，由（a）50-85重量％的丙烯酸酯的第一单体部分，例如丙烯酸2-乙基己酯，（b）1至30重量％的具有极性基团的丙烯酸化合物（例如丙烯酸）的第二单体部分，和（c）5-40重量％在分子链末端具有苯乙烯单元和/或甲基丙烯酸甲酯单元的聚合物分子链和具有可聚合官能团例如甲基丙烯酰基的大分子单体的第三单体部分。

3. 发明授权

US5266447A Photochromic composition 失效
标题翻译：光致变色组合物
公开(公告)号：US5266447A
公开(公告)日：1993-11-30
申请号：US658072
申请日：1991-02-20
申请人： Kazuhiro Takahashi , Yasukazu Nakada , Shigenobu Maruoka , Ichiro Tsuchida , Takanori Saito
发明人： Kazuhiro Takahashi , Yasukazu Nakada , Shigenobu Maruoka , Ichiro Tsuchida , Takanori Saito
IPC分类号： C08K5/00 , C08K5/17 , C09K9/02 , G03C1/685 , G03C1/73
CPC分类号： C09K9/02 , C08K5/0041 , C08K5/17 , G03C1/685 , Y10S430/163
摘要： Disclosed is a photochromic composition comprising an organic photochromic compound and a specific tertiary amine compound which are dissolved or dispersed in a high-molecular compound. Also disclosed are a photochromic film composed of the above photochromic composition and a photochromic laminate having a photochromic layer composed of the above photochromic composition on a surface of a substrate.

4. 发明授权

US5744162A Transdermal therapeutic formulation and a method of administration thereof 失效
标题翻译：透皮治疗剂型及其施用方法
公开(公告)号：US5744162A
公开(公告)日：1998-04-28
申请号：US929044
申请日：1992-08-13
申请人： Hideaki Okabe , Ichiro Tsuchida , Takanori Saito
发明人： Hideaki Okabe , Ichiro Tsuchida , Takanori Saito
IPC分类号： A61K9/70 , A61K47/32 , A61K9/14
CPC分类号： A61K9/7061 , A61K47/32
摘要： A transdermal therapeutic formulation is made of a composition comprising a polymer and ingredients mixed with the polymer which are a pharmacologically active substance, an alcohol, a percutaneous absorption promoter utilized according to necessity and water utilized according to necessity. The polymer comprises lipophilic monomer units and hydrophilic monomer units in a specific ratio. The alcohol, the percutaneous absorption promoter and water are mixed with the polymer in specific amounts. The transdermal therapeutic formulation has excellent percutaneous absorption, has many kinds of applicable pharmacologically active substances, shows good stability of percutaneous absorption with time because of absence of crystallization of the pharmacologically active substance, has good adhesive strength and thus favorably utilized as transdermal therapeutic plaster.
摘要翻译：透皮治疗制剂由包含聚合物和与聚合物混合的成分组成的组合物制成，所述组合物是药理活性物质，醇，根据需要使用的经皮吸收促进剂和根据需要使用的水。聚合物包含亲脂性单体单元和具有特定比例的亲水性单体单元。将醇，经皮吸收促进剂和水与特定量的聚合物混合。透皮治疗剂具有优异的经皮吸收性，具有多种适用的药理活性物质，由于不存在药理活性物质的结晶，显示出良好的经皮吸收稳定性，具有良好的粘合强度，因此有利地用作透皮治疗膏药。

5. 发明授权

US09324591B2 Heat treatment apparatus and heat treatment method 有权
标题翻译：热处理设备及热处理方法
公开(公告)号：US09324591B2
公开(公告)日：2016-04-26
申请号：US13438234
申请日：2012-04-03
申请人： Koji Yoshii , Tatsuya Yamaguchi , Wenling Wang , Takanori Saito
发明人： Koji Yoshii , Tatsuya Yamaguchi , Wenling Wang , Takanori Saito
IPC分类号： F27D21/00 , H01L21/67
CPC分类号： H01L21/67109 , H01L21/67248
摘要： A heat treatment apparatus including: a processing container for processing wafers held in a boat; heaters for heating the processing container; and a control section for controlling the heaters. Heater temperature sensors are provided between the heaters and the processing container, in-container temperature sensors are provided in the processing container, and movable temperature sensors are provided in the boat. The temperature sensors are connected to a temperature estimation section. The temperature estimation section selects two of the three types of temperature sensors, e.g. the movable temperature sensors and the in-container temperature sensors, and determines the temperature of a wafer according to the following formula: T=T1×(1−α)+T2×α, α>1, where T1 and T2 represent detection temperatures of the selected temperature sensors, and α represents a mixing ratio.
摘要翻译：一种热处理设备，包括：处理容器，用于处理保存在船上的晶片; 用于加热处理容器的加热器; 以及用于控制加热器的控制部。加热器温度传感器设置在加热器和处理容器之间，容器内温度传感器设置在处理容器中，并且可移动的温度传感器设置在船上。温度传感器连接到温度估计部。温度估计部分选择三种类型的温度传感器中的两种，例如，可移动温度传感器和容器内温度传感器，并根据以下公式确定晶片的温度：T = T1×（1-α）+ T2×α，α> 1，其中T1和T2表示检测温度的选定温度传感器，α表示混合比。

6. 发明授权

US09273128B2 Pharmaceutical composition for treatment and/or prophylaxis of cancer 有权
标题翻译：用于治疗和/或预防癌症的药物组合物
公开(公告)号：US09273128B2
公开(公告)日：2016-03-01
申请号：US14236793
申请日：2012-08-03
申请人： Fumiyoshi Okano , Shinichi Kobayashi , Yoshitaka Minamida , Takanori Saito
发明人： Fumiyoshi Okano , Shinichi Kobayashi , Yoshitaka Minamida , Takanori Saito
IPC分类号： C07K16/30 , A61K39/395 , C07K16/18 , A61K45/06 , C07K16/28
CPC分类号： C07K16/18 , A61K39/39558 , A61K45/06 , C07K16/28 , C07K16/30 , C07K2317/24 , C07K2317/34 , C07K2317/73 , C07K2317/732
摘要： This invention provides an antibody targeting a cancer antigenic protein specifically expressed on the surface of cancer cells and use thereof as a therapeutic and/or preventive agent for cancer. More specifically, the present invention provides an antibody, or a fragment thereof which has immunological reactivity with a partial CAPRIN-1 polypeptide consisting of the amino acid sequence shown by SEQ ID NO: 5 or an amino acid sequence having 80% or higher sequence identity to the amino acid sequence, and a pharmaceutical composition for treatment and/or prevention of cancer comprising the same as an active ingredient.
摘要翻译：本发明提供靶向癌细胞表面特异性表达的癌抗原蛋白的抗体及其作为癌症治疗和/或预防剂的用途。更具体地，本发明提供了与由SEQ ID NO：5所示的氨基酸序列或具有80％以上序列同一性的氨基酸序列组成的部分CAPRIN-1多肽具有免疫学反应性的抗体或其片段和用于治疗和/或预防癌症的药物组合物，其包含其作为活性成分。

7. 发明授权

US09180188B2 Pharmaceutical composition for treatment and/or prophylaxis of cancer 有权
标题翻译：用于治疗和/或预防癌症的药物组合物
公开(公告)号：US09180188B2
公开(公告)日：2015-11-10
申请号：US14236795
申请日：2012-08-03
申请人： Shinichi Kobayashi , Fumiyoshi Okano , Yoshitaka Minamida , Takanori Saito
发明人： Shinichi Kobayashi , Fumiyoshi Okano , Yoshitaka Minamida , Takanori Saito
IPC分类号： C07K16/30 , A61K39/395 , A61K45/06 , C07K16/28 , A61K39/00
CPC分类号： A61K39/39558 , A61K45/06 , A61K2039/505 , C07K16/28 , C07K2317/24 , C07K2317/56 , C07K2317/732 , A61K2300/00
摘要： It is intended to identify a cancer antigenic protein specifically expressed on the surface of cancer cells and to provide an antibody targeting the antigenic protein and use of the antibody as a therapeutic and/or preventive agent for cancer. The present invention provides an antibody or a fragment thereof which has immunological reactivity with a CAPRIN-1 protein, the antibody comprising a heavy chain variable region comprising amino acid sequences of SEQ ID NOs: 5, 6, and 7 and a light chain variable region comprising amino acid sequences of SEQ ID NOs: 9, 10, and 11, and a pharmaceutical composition for treatment and/or prevention of cancer, comprising this antibody or fragment as an active ingredient.
摘要翻译：旨在鉴定在癌细胞表面上特异性表达的癌抗原蛋白，并提供靶向抗原蛋白的抗体和使用抗体作为癌症的治疗和/或预防剂。本发明提供了与CAPRIN-1蛋白具有免疫反应性的抗体或其片段，所述抗体包含包含SEQ ID NO：5,6和7的氨基酸序列的重链可变区和轻链可变区包含SEQ ID NO：9,10和11的氨基酸序列，和包含该抗体或片段作为活性成分的用于治疗和/或预防癌症的药物组合物。

8. 发明申请

US20140178373A1 PHARMACEUTICAL COMPOSITION FOR TREATMENT AND/OR PROPHYLAXIS OF CANCER 有权
公开(公告)号：US20140178373A1
公开(公告)日：2014-06-26
申请号：US14236665
申请日：2012-08-03
申请人： Shinichi Kobayashi , Fumiyoshi Okano , Takanori Saito
发明人： Shinichi Kobayashi , Fumiyoshi Okano , Takanori Saito
IPC分类号： C07K16/30 , A61K45/06 , A61K39/395
CPC分类号： C07K16/30 , A61K39/39558 , A61K45/06 , A61K47/6851 , A61K47/6855 , A61K47/6857 , A61K47/6861 , A61K47/6865 , A61K47/6869 , A61K2039/505 , C07K16/28 , C07K2317/24 , C07K2317/732
摘要： An object of the present invention is to prepare an antibody that targets CAPRIN-1 specifically expressed on the surface of cancer cells and is superior in antitumor activity to conventional antibodies and to provide use of the antibody as a therapeutic and/or preventive agent for cancer. The present invention provides use of an antibody targeting an identified cancer antigenic protein specifically expressed on the surface of cancer cells as a therapeutic and/or preventive agent for cancer, specifically, a pharmaceutical composition for treatment and/or prevention of cancer, comprising as an active ingredient an antibody or a fragment thereof which has immunological reactivity with a CAPRIN-1 protein, the antibody or the fragment thereof comprising a heavy chain variable region comprising amino acid sequences represented by SEQ ID NOs: 5, 6, and 7 and a light chain variable region comprising amino acid sequences represented by SEQ ID NOs: 9, 10, and 11.

9. 发明申请

US20120258415A1 HEAT TREATMENT APPARATUS AND HEAT TREATMENT METHOD 有权
标题翻译：热处理设备和热处理方法
公开(公告)号：US20120258415A1
公开(公告)日：2012-10-11
申请号：US13438234
申请日：2012-04-03
申请人： Koji YOSHII , Tatsuya Yamaguchi , Wenling Wang , Takanori Saito
发明人： Koji YOSHII , Tatsuya Yamaguchi , Wenling Wang , Takanori Saito
IPC分类号： F27D21/00 , F27D3/00
CPC分类号： H01L21/67109 , H01L21/67248
摘要： A heat treatment apparatus including: a processing container for processing wafers held in a boat; heaters for heating the processing container; and a control section for controlling the heaters. Heater temperature sensors are provided between the heaters and the processing container, in-container temperature sensors are provided in the processing container, and movable temperature sensors are provided in the boat. The temperature sensors are connected to a temperature estimation section. The temperature estimation section selects two of the three types of temperature sensors, e.g. the movable temperature sensors and the in-container temperature sensors, and determines the temperature of a wafer according to the following formula: T=T1×(1−α)+T2×α, α>1, where T1 and T2 represent detection temperatures of the selected temperature sensors, and α represents a mixing ratio.
摘要翻译：一种热处理设备，包括：处理容器，用于处理保存在船上的晶片; 用于加热处理容器的加热器; 以及用于控制加热器的控制部。加热器温度传感器设置在加热器和处理容器之间，容器内温度传感器设置在处理容器中，并且可移动的温度传感器设置在船上。温度传感器连接到温度估计部。温度估计部分选择三种类型的温度传感器中的两种，例如，可移动温度传感器和容器内温度传感器，并根据以下公式确定晶片的温度：T = T1×（1-α）+ T2×α，α> 1，其中T1和T2表示检测温度的选定温度传感器，α表示混合比。

10. 发明申请

US20110256144A1 PHARMACEUTICAL COMPOSITION FOR TREATMENT AND PREVENTION OF CANCERS 有权
标题翻译：用于治疗和预防癌症的药物组合物
公开(公告)号：US20110256144A1
公开(公告)日：2011-10-20
申请号：US13057709
申请日：2009-08-05
申请人： Fumiyoshi Okano , Takayoshi Ido , Takanori Saito , Shinichi Kobayashi
发明人： Fumiyoshi Okano , Takayoshi Ido , Takanori Saito , Shinichi Kobayashi
IPC分类号： A61K39/395 , A61P35/00 , A61P35/02 , C07K16/18
CPC分类号： C07K16/3015 , A61K39/39558 , A61K2039/505 , C07K16/30 , C07K16/3053 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/732 , C07K2317/734
摘要： The present invention relates to a pharmaceutical composition for treatment and/or prevention of cancer, which comprises, as an active ingredient, an antibody or fragment thereof having an immunological reactivity with a CAPRIN-1 protein or a fragment thereof comprising 7 or more consecutive amino acids.
摘要翻译：本发明涉及用于治疗和/或预防癌症的药物组合物，其包含与包含7个或更多个连续氨基酸的CAPRIN-1蛋白或其片段具有免疫学反应性的抗体或其片段作为活性成分酸。

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