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1. 发明申请

US20100126650A1 PROCESS FOR PRODUCING PREPARATION FOR ORAL ADMINISTRATION 有权
标题翻译：生产口服药物制剂的方法
公开(公告)号：US20100126650A1
公开(公告)日：2010-05-27
申请号：US12593896
申请日：2007-12-14
申请人： Akio Kabuto , Yusaku Sugiura , Eiji Suzuki , Hideaki Okabe
发明人： Akio Kabuto , Yusaku Sugiura , Eiji Suzuki , Hideaki Okabe
IPC分类号： B32B38/00 , B32B37/00 , B32B38/08
CPC分类号： A61K9/0053 , A61J3/06 , A61K9/7007 , A61K31/426 , Y10T156/10 , Y10T156/1039 , Y10T156/1043
摘要： A process for producing an oral preparation containing a first water-swellable gel-forming layer and a second water-swellable gel-forming layer as outermost layers, a medicine being sealed in an inner space formed by bonding the periphery of the first water-swellable gel-forming layer and the periphery of the second water-swellable gel-forming layer either directly or via an adhesive layer, the process including (a) a step of forming a first water-swellable gel-forming layer, (b) a step of forming a recess in a predetermined area of the first water-swellable gel-forming layer, (c) a step of filling the recess with a medicine to obtain a medicine-containing body, and (d) a step of forming a second water-swellable gel-forming layer over the medicine-containing body directly or via an adhesive layer so that the first water-swellable gel-forming layer and the second water-swellable gel-forming layer are bonded around the recess, and a process for continuously producing the oral preparation are disclosed. According to the above process for producing an oral preparation, an oral preparation in which the medicine is completely masked so that the medicine can be administered without a problem of bitterness and odor of the medicine can be efficiently produced without causing the medicine to deteriorate due to heat history, without a loss of the medicine, and without a limitation to the amount of the medicine to be added.
摘要翻译：一种制备含有第一水溶胀性凝胶形成层和第二水溶胀性凝胶形成层作为最外层的口腔制剂的方法，药物密封在内部空间中，该内部空间通过将第一水溶胀性凝胶形成层凝胶形成层和第二水溶胀性凝胶形成层的周边直接或经由粘合剂层，该方法包括（a）形成第一水溶胀性凝胶形成层的步骤，（b）步骤在第一水溶胀性凝胶形成层的预定区域中形成凹部，（c）用药物填充凹部以获得含药体的步骤，（d）形成第二水的步骤直接或经由粘合剂层使药物含有体上的不透水凝胶形成层，使得第一水溶胀性凝胶形成层和第二水溶胀性凝胶形成层结合在凹部周围，并且连续地进行生产口服制剂被披露。根据上述口服制剂的制造方法，可以有效地制造药剂完全被掩蔽的口服制剂，从而能够在不引起药物的苦味和异味的情况下给药而不会导致药物劣化热病历史，没有药物的流失，而不限制药物的添加量。

2. 发明授权

US06830726B2 Method of sterilizing a radiation-resistant medical adhesive product 有权
标题翻译：消毒耐辐射医用胶粘剂产品的方法
公开(公告)号：US06830726B2
公开(公告)日：2004-12-14
申请号：US09963425
申请日：2001-09-27
申请人： Rui Saito , Eiji Suzuki , Hideaki Okabe
发明人： Rui Saito , Eiji Suzuki , Hideaki Okabe
IPC分类号： A61L208
CPC分类号： C09J133/06 , C08L2666/02 , C08L2666/28 , C09J7/385 , Y10T428/1452 , Y10T428/1462 , Y10T428/31786
摘要： This invention relates to a radiation-resistant acrylic adhesive composition with less reduction in the adhesion thereof upon irradiation with radiations, which composition comprises an acrylic polymer and a radiation-resistant agent, and a radiation-resistant adhesive product comprising the composition.
摘要翻译：本发明涉及一种耐辐照丙烯酸类粘合剂组合物，其辐射照射时粘合力降低较少，该组合物包含丙烯酸类聚合物和耐辐射剂，以及包含该组合物的防辐射粘合剂产品。

3. 发明授权

US5164416A Transdermal therapeutic formulation containing a limonene 失效
标题翻译：含有柠檬烯的透皮治疗剂型
公开(公告)号：US5164416A
公开(公告)日：1992-11-17
申请号：US700046
申请日：1991-05-08
申请人： Tsuneji Nagai , Kozo Takayama , Hideaki Okabe
发明人： Tsuneji Nagai , Kozo Takayama , Hideaki Okabe
IPC分类号： A61K31/19 , A61K31/405 , A61K31/415 , A61K31/515 , A61K31/60 , A61K47/06
CPC分类号： A61K31/415 , A61K31/19 , A61K31/405 , A61K31/515 , A61K31/60 , A61K47/06 , A61K9/0014 , Y10S514/817 , Y10S514/947
摘要： A transdermal therapeutic formulation comprising d-limonene and at least one pharmaceutically active substance wherein the content of the d-limonene is in the range from 0.1 to 2 weight percent, based on the total amount of the formulation. The transdermal therapeutic formulation has an excellent percutaneous absorption, is safe and is capable of delivering desired pharmaceutically active substances to a desired location of treatment or to the entire body of a patient through the circulatory system and is thus effective for curing various diseases.
摘要翻译：一种透皮治疗剂，其包含d-柠檬烯和至少一种药物活性物质，其中所述d-柠檬烯的含量基于所述制剂的总量为0.1至2重量％。透皮治疗制剂具有优异的经皮吸收，是安全的，并且能够通过循环系统将期望的药物活性物质递送到患者的期望的治疗位置或整个身体，因此有效地治愈各种疾病。

4. 发明申请

US20070275405A1 Member for producing a probe array and probe array producing method 审中-公开
标题翻译：用于生产探针阵列和探针阵列制造方法的成员
公开(公告)号：US20070275405A1
公开(公告)日：2007-11-29
申请号：US11826060
申请日：2007-07-12
申请人： Yuko Yamamoto , Hideaki Okabe , Hideo Tashiro , Yasumitsu Kondoh
发明人： Yuko Yamamoto , Hideaki Okabe , Hideo Tashiro , Yasumitsu Kondoh
IPC分类号： C12Q1/68 , G01N33/53 , C12M3/00
CPC分类号： B01J19/0046 , B01J2219/00387 , B01J2219/00475 , B01J2219/00511 , B01J2219/00538 , B01J2219/00585 , B01J2219/00596 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00662 , B01J2219/00677 , B01J2219/00722 , B82Y30/00 , C40B40/06 , C40B60/14
摘要： In order to provide a member for producing a probe array that allows producing desired probe arrays immediately once the probe arrangement is established, and to provide a probe array producing method that uses this member for producing a probe array, the pieces F1, F2 . . . Fn are produced by cutting the members M1, M2 . . . Mn for producing a probe array, and a predetermined number of pieces F1, F2 . . . Fn are detached from a release sheet 13 and are attached via the adhesive layer 12 onto the supporting member 2a at predetermined locations.
摘要翻译：为了提供用于制造探针阵列的构件，其可以在建立探针装置之后立即产生所需的探针阵列，并且提供使用该构件产生探针阵列的探针阵列产生方法，片F 1 ，F＆lt; 2＆lt; 2＆gt ;. 。。通过切割构件M 1，M 2 2产生F n N n。。。用于产生探针阵列的M＆lt; N＆gt;和预定数量的F 1，F 2 2。。。 F＆lt; N＆gt;从剥离片13分离，并且经由粘合剂层12附着到预定位置的支撑构件2a上。

5. 发明申请

US20050250140A1 Probe array 审中-公开
标题翻译：探头数组
公开(公告)号：US20050250140A1
公开(公告)日：2005-11-10
申请号：US11091718
申请日：2005-03-29
申请人： Yuko Yamamoto , Hideaki Okabe , Rui Saito
发明人： Yuko Yamamoto , Hideaki Okabe , Rui Saito
IPC分类号： G01N33/53 , B01J19/00 , C12M1/00 , C12M1/34 , C40B40/06 , C40B60/14 , G01N37/00 , C12Q1/68
CPC分类号： B01J19/0046 , B01J2219/00387 , B01J2219/00475 , B01J2219/00511 , B01J2219/00538 , B01J2219/00585 , B01J2219/00596 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00662 , B01J2219/00677 , B01J2219/00722 , B82Y30/00 , C40B40/06 , C40B60/14
摘要： In order to provide a probe array capable of detecting target substances with simple operation and a good reproducibility, the present invention provides a probe array 1 comprising a cylindrical first member 11, a columned second member 12 housed in the hollow portion of the first member 11 and probe groups P immobilized onto the outer face of the second member 12, wherein spacers 13a are provided on the outer face of the second member 12 for preventing contact between the inner face of the first member 11 and the outer face of the second member 12.
摘要翻译：为了提供能够以简单的操作和良好的再现性检测目标物质的探针阵列，本发明提供一种探针阵列1，其包括圆柱形第一构件11，容纳在第一构件11的中空部分中的柱状第二构件12 和固定在第二构件12的外表面上的探针组P，其中间隔件13a设置在第二构件12的外表面上，用于防止第一构件11的内表面和第二构件的外表面之间的接触 12。

6. 发明授权

US06562357B2 Blackhead removing sheet and method for producing blackhead removing sheet 失效
标题翻译：除黑头粉刺片及其制造除黑头粉刺片的方法
公开(公告)号：US06562357B2
公开(公告)日：2003-05-13
申请号：US09327031
申请日：1999-06-07
申请人： Masaru Hoshi , Hideaki Okabe
发明人： Masaru Hoshi , Hideaki Okabe
IPC分类号： A01N2534
CPC分类号： A61Q19/10 , A61K8/0208 , A61Q19/00
摘要： A blackhead removing agent, a blackhead removing sheet and a method for producing the blackhead removing sheet are disclosed. The blackhead removing sheet comprises a base layer which is composed of a nonwoven fabric having the fineness of 0.0001 denier or more but less than 0.1 denier, and a blackhead removing layer consisting of the blackhead removing agent that contains a water-soluble macromolecular compound as a primary component. The blackhead removing agent comprises a water-soluble macromolecular compound, a filler, and a plasticizer that is compatible with the water-soluble macromolecular compound. The amount of the plasticizer in the blackhead removing agent is less than 0.01 parts by weight with respect to 100 parts by weight of the water-soluble macromolecular compound. The water-soluble macromolecular compound preferably includes a copolymer of N-vinyl-2-pyrrolidone and vinyl acetate as a primary component.
摘要翻译：公开了一种除黑头粉刺剂，除黑头粉刺贴和生产除黑头粉刺头皮片的方法。除黑头粉刺剂片材包括由细度为0.0001旦尼尔以上但小于0.1旦尼尔的无纺布构成的基层，以及由除黑头粉刺剂构成的除黑头粉刺剂，其含有水溶性高分子化合物作为主要成分。除黑头粉刺剂包含水溶性高分子化合物，填充剂和与水溶性大分子化合物相容的增塑剂。相对于100重量份的水溶性大分子化合物，除黑头粉刺剂中的增塑剂的量小于0.01重量份。水溶性高分子化合物优选包含N-乙烯基-2-吡咯烷酮和乙酸乙烯酯作为主要成分的共聚物。

7. 发明申请

US20050251046A1 Probe array producing method 审中-公开
标题翻译：探头阵列制作方法
公开(公告)号：US20050251046A1
公开(公告)日：2005-11-10
申请号：US11091714
申请日：2005-03-29
申请人： Yuko Yamamoto , Hideaki Okabe , Hideo Tashiro , Yasumitsu Kondoh
发明人： Yuko Yamamoto , Hideaki Okabe , Hideo Tashiro , Yasumitsu Kondoh
IPC分类号： G01N33/53 , B01J19/00 , C12N15/09 , C40B40/06 , C40B60/14 , G01N37/00 , A61B8/12
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00387 , B01J2219/00475 , B01J2219/00511 , B01J2219/00538 , B01J2219/00585 , B01J2219/00596 , B01J2219/00608 , B01J2219/0061 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00662 , B01J2219/00677 , B01J2219/00722 , C40B40/06 , C40B60/14
摘要： In order to provide a method for producing easily a probe array with probes arranged in the hollow portion of a tubular member, the present invention provides a method for producing a probe array comprising a step of forming a flexible sheet member 11 having a probe-immobilizing surface 110 into a tubular member in such a way that the probe-immobilizing surface 110 constitutes the inner face of the tubular member.
摘要翻译：为了提供容易地制造具有布置在管状构件的中空部分中的探针的探针阵列的方法，本发明提供了一种用于制造探针阵列的方法，其包括形成具有探针固定的柔性片构件11的步骤表面110成为管状构件，使得探针固定表面110构成管状构件的内表面。

8. 发明申请

US20050250139A1 Member for producing a probe array and probe array producing method 审中-公开
标题翻译：用于生产探针阵列和探针阵列制造方法的成员
公开(公告)号：US20050250139A1
公开(公告)日：2005-11-10
申请号：US11091707
申请日：2005-03-29
申请人： Yuko Yamamoto , Hideaki Okabe , Hideo Tashiro , Yasumitsu Kondoh
发明人： Yuko Yamamoto , Hideaki Okabe , Hideo Tashiro , Yasumitsu Kondoh
IPC分类号： G01N33/53 , B01J19/00 , C12M1/00 , C12N15/09 , C40B40/06 , C40B60/14 , G01N37/00 , C12Q1/68 , C12P19/34
CPC分类号： B01J19/0046 , B01J2219/00387 , B01J2219/00475 , B01J2219/00511 , B01J2219/00538 , B01J2219/00585 , B01J2219/00596 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00662 , B01J2219/00677 , B01J2219/00722 , B82Y30/00 , C40B40/06 , C40B60/14
摘要： In order to provide a member for producing a probe array that allows producing desired probe arrays immediately once the probe arrangement is established, and to provide a probe array producing method that uses this member for producing a probe array, the pieces F1, F2 . . . Fn are produced by cutting the members M1, M2 . . . Mn for producing a probe array, and a predetermined number of pieces F1, F2 . . . Fn are detached from a release sheet 13 and are attached via the adhesive layer 12 onto the supporting member 2a at predetermined locations.
摘要翻译：为了提供用于制造探针阵列的构件，其可以在建立探针装置之后立即产生所需的探针阵列，并且提供使用该构件产生探针阵列的探针阵列产生方法，片F 1 F / 2。。。通过切割构件M 1，M 2 2来产生F / N。。。用于产生探针阵列的M＆lt; N＆gt;和预定数量的F 1，F 2 2。。。 F＆lt; N＆gt;从剥离片13分离，并且经由粘合剂层12附着到预定位置的支撑构件2a上。

9. 发明授权

US06190683B1 Blackhead-removing face pack sheet 失效
标题翻译：黑头去除面包片
公开(公告)号：US06190683B1
公开(公告)日：2001-02-20
申请号：US08919744
申请日：1997-08-28
申请人： Masaru Hoshi , Eiji Suzuki , Hideaki Okabe
发明人： Masaru Hoshi , Eiji Suzuki , Hideaki Okabe
IPC分类号： A61K970
CPC分类号： A61Q19/00 , A61K8/0208
摘要： A blackhead-removing face pack sheet with superior ease of use and blackhead-removing capacity is provided. The blackhead-removing face pack sheet 1 is formed from a laminate which comprises a gas-permeable and flexible base layer 2 and a pack material layer 3 the primary component of which is a copolymer of vinyl acetate and N-vinyl-2-pyrrolidone. The base layer 2 comprises a porous material such as a nonwoven fabric, and part of it is impregnated or embedded with the pack material constituting the pack material layer 3. This gives a high force of adhesion between the base layer 2 and the pack material layer 3.
摘要翻译：提供了具有优异的易用性和除黑头粉碎能力的除黑头粉刺的面包纸。除黑头粉刺面包纸1由层叠体形成，该层压体包括透气且柔性的基底层2和主要成分为乙酸乙烯酯和N-乙烯基-2-吡咯烷酮的共聚物的包装材料层3。基层2由无纺布等多孔质材料构成，其一部分浸渍或嵌入构成包装材料层3的包装材料。这样，在基层2和包装材料层之间产生较大的粘合力 3。

10. 再颁专利

USRE36138E Percutaneous absorption promoter, a tape plaster and a method of promoting percutaneous absorption 失效
标题翻译：经皮吸收促进剂，胶带膏和促进经皮吸收的方法
公开(公告)号：USRE36138E
公开(公告)日：1999-03-09
申请号：US854136
申请日：1997-05-08
申请人： Eiji Suzuki , Hideaki Okabe , Takanori Saito
发明人： Eiji Suzuki , Hideaki Okabe , Takanori Saito
IPC分类号： A61K9/70 , A61K47/18 , C07C229/56 , C07C233/54 , A61F13/00
CPC分类号： A61K9/7061 , A61K47/18 , A61K47/183 , A61K9/0014 , Y10S514/946 , Y10S514/947
摘要： A percutaneous absorption promoter comprises a derivative of amino acid in which the amino group has or does not have an acyl substituent or a hydrocarbon substituent, the carboxylic group has a hydrocarbon substituent and the part between the amino group and the carboxylic group has a specified structure. A tape plaster comprises the percutaneous absorption promoter described above. The method utilizes the the percutaneous absorption promoter described above. The percutaneous promoter of the invention has excellent ability of promoting the percutaneous absorption of pharmacologically active substances and excellent safety simultaneously, capable of delivering the desired pharmacologically active substances rapidly to the location of treatment or to all parts of the body through the circulating system and effective for curing various kinds of disease. The tape plaster comprising it and the method of promoting percutaneous absorption by utilizing it have the same advantages.
摘要翻译：经皮吸收促进剂包括其中氨基具有或不具有酰基取代基或烃取代基的氨基酸衍生物，羧基具有烃取代基，氨基和羧基之间的部分具有特定的结构。胶带包含上述经皮吸收促进剂。该方法利用上述经皮吸收促进剂。本发明的经皮促进剂具有优异的促进药理活性物质的经皮吸收和同时具有优异安全性的能力，能够通过循环系统快速将期望的药理活性物质快速递送至身体的所有部位，用于治疗各种疾病。包含它的胶带膏和利用它促进经皮吸收的方法具有相同的优点。

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