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1. 发明授权

US06794470B2 Process for producing a tetrafluoroethylene polymer 失效
标题翻译：四氟乙烯聚合物的制造方法
公开(公告)号：US06794470B2
公开(公告)日：2004-09-21
申请号：US10290371
申请日：2002-11-08
申请人： Shigeki Kobayashi , Jun Hoshikawa , Kazuo Kato , Hiroki Kamiya , Hiroyuki Hirai
发明人： Shigeki Kobayashi , Jun Hoshikawa , Kazuo Kato , Hiroki Kamiya , Hiroyuki Hirai
IPC分类号： C08F11418
CPC分类号： C08F114/26 , C08F14/26
摘要： A tetrafluoroethylene polymer is produced by polymerizing tetrafluoroethylene in the presence of an aqueous medium and a polymerization initiator, wherein the content of impurities (e.g. a saturated compound such as CH2F2 or CHF3 and an unsaturated compound such as CF2═CFH, CF2═CH2, CF2═CFCl or CF2═CHCl) in the tetrafluoroethylene is not more than 100 ppm. By this method, PTFE which is uniform and stretchable at a high stretch ratio and which is excellent in the fibrillation property and has a high break strength, can be obtained.
摘要翻译：通过在水性介质和聚合引发剂的存在下聚合四氟乙烯来制备四氟乙烯聚合物，其中杂质（例如饱和化合物如CH 2 F 2或CHF 3和不饱和化合物如CF 2 = CFH，CF 2 = CH 2，CF 2 = CFCl或CF2 = CHCl）不大于100ppm。通过这种方法，可以获得均匀且可拉伸的PTFE，其具有优异的起纤性能并且具有高的断裂强度。

2. 发明授权

US06646078B2 Method of producing paraffin wax for aqueous dispersion polymerization of tetrafluoroethylene and method of producing a polytetrafluoroethylene using the same 有权
公开(公告)号：US06646078B2
公开(公告)日：2003-11-11
申请号：US10022426
申请日：2001-12-20
申请人： Shigeki Kobayashi , Jun Hoshikawa , Kazuo Kato , Hiroki Kamiya , Hiroyuki Hirai
发明人： Shigeki Kobayashi , Jun Hoshikawa , Kazuo Kato , Hiroki Kamiya , Hiroyuki Hirai
IPC分类号： C08F200
CPC分类号： C08F114/26 , C08F14/26 , C08F2/44
摘要： A method of producing a paraffin wax for aqueous dispersion polymerization of TFE which allows high speed aqueous dispersion polymerization of TFE with excellent polymerization behavior such as excellent dispersion stability and consistent production of PTFE having excellent physical properties, and a method of producing PTFE using the paraffin wax. Aqueous dispersion polymerization of tetrafluoroethylene (hereinafter referred to as TFE) is conducted in the presence of a paraffin wax, a polymerization initiator and an emulsifier at least once and then the paraffin wax is recovered. The recovered paraffin wax is used for aqueous dispersion polymerization of TFE in the presence of a polymerization initiator and an emulsifier.

3. 发明授权

US06518381B2 Tetrafluoroethylene polymer for stretching 有权
标题翻译：用于拉伸的四氟乙烯聚合物
公开(公告)号：US06518381B2
公开(公告)日：2003-02-11
申请号：US09970674
申请日：2001-10-05
申请人： Shigeki Kobayashi , Jun Hoshikawa , Kazuo Kato , Hiroki Kamiya , Hiroyuki Hirai
发明人： Shigeki Kobayashi , Jun Hoshikawa , Kazuo Kato , Hiroki Kamiya , Hiroyuki Hirai
IPC分类号： C08F21418
CPC分类号： C08F214/26 , Y10T428/249953
摘要： A tetrafluoroethylene polymer having high stretchability, a fibrillatable character and a non-melt fabricable quality, which has a standard specific gravity of at most 2.160, and a tensile break strength of from 32.0N (3.26 kgf) to 49.0N (5.0 kgf) or an endothermic ratio of at most 0.15 as calculated from the measurement by differential thermal analysis. The tetrafluoroethylene polymer is suitable for stretching operation after paste extrusion.
摘要翻译：具有高伸缩性，可原纤化特性和不熔融可加工品质的四氟乙烯聚合物，其标准比重至多为2.160，拉伸断裂强度为32.0N（3.26kgf）至49.0N（5.0kgf）或通过差热分析计算出的吸热比至多为0.15。四氟乙烯聚合物适用于糊料挤出后的拉伸操作。

4. 发明授权

US06822060B2 Process for producing a tetrafluoroethylene polymer excellent in strength 有权
标题翻译：制造强度优异的四氟乙烯聚合物的方法
公开(公告)号：US06822060B2
公开(公告)日：2004-11-23
申请号：US10072995
申请日：2002-02-12
申请人： Shigeki Kobayashi , Jun Hoshikawa , Kazuo Kato , Hiroki Kamiya , Hiroyuki Hirai
发明人： Shigeki Kobayashi , Jun Hoshikawa , Kazuo Kato , Hiroki Kamiya , Hiroyuki Hirai
IPC分类号： C08F21418
CPC分类号： C08F14/26 , Y10S526/915 , Y10S526/919 , C08F2/16
摘要： A process for producing a tetrafluoroethylene polymer, which comprises polymerizing tetrafluoroethylene in an aqueous medium in the presence of a dispersant, a stabilizer and a polymerization initiator, wherein the polymerization initiator is a redox polymerization initiator comprising a halogen acid salt YXO3/a sulfite Z2SO3 wherein X is a chlorine atom, a bromine atom or an iodine atom, Y is a hydrogen atom, ammonium, an alkali metal or an alkaline earth metal, and Z is ammonium, an alkali metal or an alkaline earth metal. By this process, it is possible to obtain a tetrafluoroethylene polymer which is suitable for a stretching operation after paste extrusion.
摘要翻译：一种制备四氟乙烯聚合物的方法，其包括在分散剂，稳定剂和聚合引发剂存在下在水性介质中聚合四氟乙烯，其中聚合引发剂是包含卤酸盐YXO 3 /亚硫酸盐Z 2 SO 3的氧化还原聚合引发剂，其中 X是氯原子，溴原子或碘原子，Y是氢原子，铵，碱金属或碱土金属，Z是铵，碱金属或碱土金属。通过该方法，可以获得适合于糊料挤出后的拉伸操作的四氟乙烯聚合物。

5. 发明授权

US06803437B2 Process for producing a tetrafluoroethylene polymer having high strength 有权
标题翻译：具有高强度的四氟乙烯聚合物的制造方法
公开(公告)号：US06803437B2
公开(公告)日：2004-10-12
申请号：US10314992
申请日：2002-12-10
申请人： Shigeki Kobayashi , Jun Hoshikawa , Kazuo Kato , Hiroki Kamiya , Hiroyuki Hirai
发明人： Shigeki Kobayashi , Jun Hoshikawa , Kazuo Kato , Hiroki Kamiya , Hiroyuki Hirai
IPC分类号： C08F11418
CPC分类号： C08F14/26 , C08F2/16
摘要： A process for producing a tetrafluoroethylene polymer, which comprises polymerizing tetrafluoroethylene in an aqueous medium in the presence of a water-soluble initiator, wherein the water used for the polymerization is regulated to have a TOC of 100 ppb or lower and/or an electrical conductivity of 1.0 &mgr;S/cm or lower. When this process for producing a tetrafluoroethylene polymer is employed, a decrease or fluctuation in the polymerization rate during the polymerization of tetrafluoroethylene will be minimal, and a deterioration in the physical properties of the obtained tetrafluoroethylene polymer will be minimal.
摘要翻译：一种制备四氟乙烯聚合物的方法，其包括在水溶性引发剂存在下在水性介质中聚合四氟乙烯，其中用于聚合的水被调节为具有100ppb或更低的TOC和/或导电性为1.0μS/ cm以下。当采用四氟乙烯聚合物的制造方法时，四氟乙烯聚合时的聚合速度的降低或波动变小，所得到的四氟乙烯聚合物的物理性能下降最小。

6. 发明授权

US09580689B2 Induced pluripotent stem cells 有权
标题翻译：诱导多能干细胞
公开(公告)号：US09580689B2
公开(公告)日：2017-02-28
申请号：US13811572
申请日：2011-07-22
申请人： Nobuaki Kikyo , Hiroyuki Hirai
发明人： Nobuaki Kikyo , Hiroyuki Hirai
IPC分类号： C12N5/00 , C12N5/074 , C07K14/47 , C12N15/85
CPC分类号： C12N5/0696 , A01K2207/12 , A01K2227/105 , C07K14/4702 , C07K2319/71 , C12N15/8509 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606 , C12N2506/1307 , C12N2510/00 , C12N2740/15041
摘要： Described herein is a major breakthrough in nuclear reprogramming and induced pluripotent stem cell (iPSC) technology. Fusion of the powerful transcription activation domain (TAD) of MyoD to the Oct4 protein makes iPSCs generation faster, more efficient, purer, safer and feeder-free. Also, disclosed herein is the first report of the use of a TAD fused to a transcription factor as a method for making iPSCs. By combining transcription factors and TADs, this approach to nuclear reprogramming can have a range of applications from inducing pluriopotency to inducing transdifferentiation without transitioning through iPSCs.
摘要翻译：这里描述的是核重新编程和诱导多能干细胞（iPSC）技术的重大突破。将MyoD强大的转录激活结构域（TAD）融合到Oct4蛋白质中，使得iPSC生成更快，更有效，更纯净，更安全，更无饲料。此外，本文公开的是使用与转录因子融合的TAD作为制备iPSC的方法的第一个报告。通过组合转录因子和TAD，这种核重新编程方法可以具有诱导多能性诱导转分化而不通过iPSC过渡的应用范围。

7. 发明申请

US20130195812A1 INDUCED PLURIPOTENT STEM CELLS 有权
标题翻译：诱导的大脑干细胞
公开(公告)号：US20130195812A1
公开(公告)日：2013-08-01
申请号：US13811572
申请日：2011-07-22
申请人： Nobuaki Kikyo , Hiroyuki Hirai
发明人： Nobuaki Kikyo , Hiroyuki Hirai
IPC分类号： C12N5/071
CPC分类号： C12N5/0696 , A01K2207/12 , A01K2227/105 , C07K14/4702 , C07K2319/71 , C12N15/8509 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606 , C12N2506/1307 , C12N2510/00 , C12N2740/15041
摘要： Described herein is a major breakthrough in nuclear reprogramming and induced pluripotent stem cell (iPSC) technology. Fusion of the powerful transcription activation domain (TAD) of MyoD to the Oct4 protein makes iPSCs generation faster, more efficient, purer, safer and feeder-free. Also, disclosed herein is the first report of the use of a TAD fused to a transcription factor as a method for making iPSCs. By combining transcription factors and TADs, this approach to nuclear reprogramming can have a range of applications from inducing pluriopotency to inducing transdifferentiation without transitioning through iPSCs.
摘要翻译：这里描述的是核重新编程和诱导多能干细胞（iPSC）技术的重大突破。将MyoD强大的转录激活结构域（TAD）融合到Oct4蛋白质中，使得iPSC生成更快，更有效，更纯净，更安全，更无饲料。此外，本文公开的是使用与转录因子融合的TAD作为制备iPSC的方法的第一个报告。通过组合转录因子和TAD，这种核重新编程方法可以具有诱导多能性诱导转分化而不通过iPSC过渡的应用范围。

8. 发明申请

US20090130022A1 MRI CONTRAST MEDIUM CONTAINING LIPOSOMES 审中-公开
标题翻译： MRI对比中药含有脂质体
公开(公告)号：US20090130022A1
公开(公告)日：2009-05-21
申请号：US11916391
申请日：2006-06-06
申请人： Junji Nishigaki , Hiroyuki Hirai , Masayoshi Kojima , Kazuhiro Aikawa
发明人： Junji Nishigaki , Hiroyuki Hirai , Masayoshi Kojima , Kazuhiro Aikawa
IPC分类号： A61B5/055 , A61K9/127
CPC分类号： A61K49/1812
摘要： A liposome containing a phosphatidylcholine and a phosphatidylserine in combination as membrane components at a phosphatidylcholine:phosphatidylserine molar ratio of 3:1 to 1:2, and said liposome containing superparamagnetic particles having a mean particle size not less than 1 nm and not more than 50 nm. A means for selectively accumulating an MRI contrast medium in a lesion of a vascular disease caused by abnormal proliferation of vascular smooth muscle cells such as arteriosclerosis and restenosis after PTCA is provided.
摘要翻译：含有磷脂酰胆碱和磷脂酰丝氨酸的磷脂酰丝氨酸组合为磷脂酰胆碱的膜组分：磷脂酰丝氨酸摩尔比为3:1至1:2，所述脂质体含有平均粒度不小于1nm且不大于50的超顺磁性颗粒 nm。用于选择性地累积由血管平滑肌细胞的异常增殖引起的血管疾病的病变中的MRI造影剂的手段，所述血管病变由PTCA提供之后的动脉硬化和再狭窄引起。

9. 发明授权

US07462300B2 Doped-type metal sulfide phosphor nanoparticle, dispersion thereof, and method for producing the same 失效
标题翻译：掺杂型金属硫化物荧光体纳米颗粒及其分散体及其制造方法
公开(公告)号：US07462300B2
公开(公告)日：2008-12-09
申请号：US10982876
申请日：2004-11-08
申请人： Hiroyuki Hirai , Keiko Sugihara , Junji Nishigaki
发明人： Hiroyuki Hirai , Keiko Sugihara , Junji Nishigaki
IPC分类号： C09K11/56 , B82B1/00 , C01G9/08
CPC分类号： C09K11/574 , B82Y15/00 , C09K11/584 , G01N33/582 , G01N33/588 , Y10S977/773 , Y10S977/786 , Y10S977/813 , Y10S977/824 , Y10S977/834 , Y10T428/2991
摘要： A doped-type metal sulfide phosphor nanoparticle, whose surface is modified with a surface modifier, the surface modifier being a compound of formula [I]: HS-L-W Formula [I] wherein L is a divalent linking group; and W is COOM or NH2, in which M is a hydrogen atom, an alkali metal atom, or NX4, in which X is a hydrogen atom or an alkyl group; a dispersion containing the nanoparticle; and a method of producing the nanoparticle or the dispersion.
摘要翻译：掺杂型金属硫化物荧光体纳米颗粒，其表面用表面改性剂改性，表面改性剂为式[I]的化合物：<？in-line-formula description =“In-line Formulas”end =“lead” α> HS-LW式[I] <？in-line-formula description =“In-line formula”end =“tail”？>其中L是二价连接基团; W为COOM或NH 2，其中M为氢原子，碱金属原子或NX4，其中X为氢原子或烷基; 含有纳米颗粒的分散体; 以及制备纳米颗粒或分散体的方法。

10. 发明申请

US20080156736A1 Magnetic Composite Body, Production Method Thereof, Method for Removing Substance with Mannose on Its Surface, and Method for Concentrating Substance with Mannose on Its Surface 有权
标题翻译：磁性复合体及其制造方法，其表面用甘露糖去除物质的方法及其表面上用甘露糖浓缩物质的方法
公开(公告)号：US20080156736A1
公开(公告)日：2008-07-03
申请号：US11883742
申请日：2006-02-08
申请人： Hiroyuki Hirai , Masayoshi Kojima
发明人： Hiroyuki Hirai , Masayoshi Kojima
IPC分类号： B03C1/02 , H01F1/42
CPC分类号： B03C1/01 , B82Y25/00 , H01F1/0054
摘要： A magnetic composite body comprising magnetic nanoparticles having a number average particle diameter of 1 to 50 nm and having a compound represented by formula (I) fixed on their surfaces, and a method comprising bringing the magnetic composite body into contact with a test piece followed by magnetic separation: R1O—(CH(R2)CH2O)n-L-X Formula (I) wherein R1 represents a hydrogen atom, an alkyl or alkenyl group having a carbon chain length of 1 to 20, or a substituted or unsubstituted, aryl or heterocyclic group; R2 represents a hydrogen atom or a methyl group; L may be present or not present, and, when L is present, L represents an alkylene or alkenylene group having a carbon chain length of 1 to 10 which may have a branched chain or a substituent; X represents a hydrogen atom, a carboxylic acid group, a phosphoric acid group, or a sulfonic acid group; and n represents an integer of 1 to 10
摘要翻译：一种磁性复合体，其包含数均粒径为1〜50nm的磁性纳米颗粒，并且具有固定在其表面上的式（I）表示的化合物，以及包括使磁性复合体与试验片接触的方法，磁分离：<？in-line-formula description =“In-line Formulas”end =“lead”？> R O-（CH（R 2）2 CH 式（I）<？in-line-formula description =“In-line formula”end =“tail”？>其中R ^{1 表示氢原子，碳链长度为1-20的烷基或烯基，或取代或未取代的芳基或杂环基; R 2表示氢原子或甲基; L可以存在或不存在，并且当存在L时，L表示碳链长度为1至10的亚烷基或亚烯基，其可以具有支链或取代基; X表示氢原子，羧酸基，磷酸基或磺酸基; n表示1〜10的整数}

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