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1. 发明授权

US09168327B2 Bone/collagen composites and uses thereof 有权
标题翻译：骨/胶原复合材料及其用途
公开(公告)号：US09168327B2
公开(公告)日：2015-10-27
申请号：US12744810
申请日：2008-12-12
申请人： Sherry Hsiu-Ying Wang , Michael Jaffe , Lawrence A. Shimp , Nels J. Lauritzen , Charles M. Schiff
发明人： Sherry Hsiu-Ying Wang , Michael Jaffe , Lawrence A. Shimp , Nels J. Lauritzen , Charles M. Schiff
IPC分类号： A61F2/28 , A61L27/36 , A61L27/46 , A61F2/46
CPC分类号： A61L27/3691 , A61F2/28 , A61F2/4644 , A61F2002/2835 , A61F2210/0004 , A61F2210/0076 , A61F2250/0067 , A61F2310/00359 , A61F2310/00371 , A61L27/3608 , A61L27/365 , A61L27/3687 , A61L27/46 , A61L2400/06 , A61L2430/02 , A61L2430/40 , C08L89/06
摘要： A composition includes bone and collagen, wherein the collagen has been acid treated, and cross-linked via dehydrothermal treatment or by a cross-linking agent (e.g., a citric acid derivative) under a compressive force of at least approximately 40 MPa.
摘要翻译：组合物包括骨和胶原，其中胶原蛋白已被酸处理，并通过脱水热处理或通过交联剂（例如柠檬酸衍生物）在至少约40MPa的压缩力下进行交联。

2. 发明申请

US20100256774A1 BONE/COLLAGEN COMPOSITES AND USES THEREOF 有权
标题翻译：骨/胶原蛋白复合物及其用途
公开(公告)号：US20100256774A1
公开(公告)日：2010-10-07
申请号：US12744810
申请日：2008-12-12
申请人： Sherry Hsiu-Ying Wang , Michael Jaffe , Lawrence A. Shimp , Nels J. Lauritzen , Charles M. Schiff
发明人： Sherry Hsiu-Ying Wang , Michael Jaffe , Lawrence A. Shimp , Nels J. Lauritzen , Charles M. Schiff
IPC分类号： A61F2/28
CPC分类号： A61L27/3691 , A61F2/28 , A61F2/4644 , A61F2002/2835 , A61F2210/0004 , A61F2210/0076 , A61F2250/0067 , A61F2310/00359 , A61F2310/00371 , A61L27/3608 , A61L27/365 , A61L27/3687 , A61L27/46 , A61L2400/06 , A61L2430/02 , A61L2430/40 , C08L89/06
摘要： A composition includes bone and collagen, wherein the collagen has been acid treated, and cross-linked via dehydrothermal treatment or by a cross-linking agent (e.g., a citric acid derivative) under a compressive force of at least approximately 40 MPa.
摘要翻译：组合物包括骨和胶原，其中胶原蛋白已被酸处理，并通过脱水热处理或通过交联剂（例如柠檬酸衍生物）在至少约40MPa的压缩力下进行交联。

3. 发明授权

US4287868A Retracting arrow rest 失效
标题翻译：撤回箭头休息
公开(公告)号：US4287868A
公开(公告)日：1981-09-08
申请号：US159877
申请日：1980-06-16
申请人： Charles M. Schiff
发明人： Charles M. Schiff
IPC分类号： F41B5/22 , F41B5/00
CPC分类号： F41B5/143
摘要： An arrow rest, movable to clear fletching on an arrow released from a bow includes a pivotal arrow rest pivoting to an upright arrow holding position for drawing the bow, and lowered to arrow clearing position, having a triggering control attached to an end portion of the bow responsive to movement of the bow limb after arrow release for moving the arrow holding assembly from the upright position to the lowered position. The triggering control includes a controllable counterweight, for adjusting the timing of arrow holding release.
摘要翻译：可移动以在从弓上释放的箭头上移动以清除fletching的箭头，包括枢转的枢转箭头，其枢转到用于拉弓的直立箭头保持位置，并且降低到箭头清除位置，具有附接到所述弓的端部的触发控制弓箭头在箭头释放后响应于弓形肢的运动，以将箭头保持组件从直立位置移动到降低位置。触发控制包括一个可控的配重，用于调节箭头保持释放的时间。

4. 发明授权

US06933326B1 Particulate acellular tissue matrix 有权
标题翻译：颗粒无细胞组织基质
公开(公告)号：US06933326B1
公开(公告)日：2005-08-23
申请号：US09762174
申请日：1999-06-18
申请人： Edward S. Griffey , Stephen A. Livesey , Charles M. Schiff , Lawrence E. Boerboom
发明人： Edward S. Griffey , Stephen A. Livesey , Charles M. Schiff , Lawrence E. Boerboom
IPC分类号： A61K9/00 , A61K9/19 , A61K35/12 , A61K35/28 , A61K35/32 , A61K35/36 , A61K38/18 , A61K47/42 , A61L27/24 , A61L27/36 , A61L27/38 , A61L31/00 , A61K35/34
CPC分类号： A61L27/3804 , A61K9/0024 , A61K9/19 , A61K35/28 , A61K35/32 , A61K35/36 , A61K38/18 , A61K47/42 , A61L27/24 , A61L27/3604 , A61L27/3683 , A61L31/005 , A61L2430/40 , Y10S514/801
摘要： A method of processing an acellular tissue matrix to give a particulate acellular tissue matrix includes: cutting sheets of dry acellular tissue matrix into strips; cryofracturing the dry acellular tissue matrix strips at cryogenic temperatures; separating the resulting particles by size at cryogenic temperatures; and freeze drying the fraction of particles desired size to remove any moisture that may have been absorbed to give a dry particulate acellular tissue matrix. Rehydration of the dry particulate acellular tissue matrix may take place just prior to use. The particulate acellular tissue may be applied to a recipient site, by way of injection, spraying, layering, packing, in-casing or combinations thereof. The particulate acellular tissue may further include growth and stimulating agents selected from epidermal growth factor, fibroblast growth factor, nerve growth factor, keratinocyte growth factor, platelet derived growth factor, vasoactive intestinal peptide, stem cell factor, bone morphogetic proteins, chondrocyte growth factor and combinations thereof. Other pharmaceutically active compounds may be combined with the rehydrated particulate material including: analgesic drugs; hemostatic drugs; antibiotic drugs; local anesthetics and the like to enhance the acceptance of the implanted particulate material. The particulate material product may also be combined with stem cells selected from mesenchymal stem cells, epidermal stem cells, cartilage stem cells, hematopoietic stem cells and combinations thereof.
摘要翻译：一种处理无细胞组织基质以产生颗粒状无细胞组织基质的方法包括：将干燥的无细胞组织基质的片材切成条带; 在低温下对干燥的无细胞组织基质条进行冷冻干燥; 将所得颗粒在低温下分离大小; 并冷冻干燥所需尺寸的颗粒级分以除去可能被吸收的任何水分，以产生干燥的无细胞组织基质。干燥颗粒状无细胞组织基质的再水合可以在使用前进行。颗粒状脱细胞组织可以通过注射，喷雾，分层，包装，套管或其组合施用于受体部位。颗粒细胞组织还可以包括生长和刺激剂，其选自表皮生长因子，成纤维细胞生长因子，神经生长因子，角质形成细胞生长因子，血小板衍生生长因子，血管活性肠肽，干细胞因子，骨形态蛋白，软骨细胞生长因子和其组合。其他药物活性化合物可以与再水合的颗粒材料组合，包括：止痛药; 止血药; 抗生素药物; 局部麻醉剂等，以增强植入颗粒物质的接受性。颗粒材料产品还可以与选自间充质干细胞，表皮干细胞，软骨干细胞，造血干细胞及其组合的干细胞组合。

5. 发明授权

US06381026B1 Method of measuring the contour of a biological surface 有权
标题翻译：测量生物表面轮廓的方法
公开(公告)号：US06381026B1
公开(公告)日：2002-04-30
申请号：US09268266
申请日：1999-03-15
申请人： Charles M. Schiff , Greg Abott
发明人： Charles M. Schiff , Greg Abott
IPC分类号： G01B1124
CPC分类号： A61B5/0064 , A61B5/0059 , A61B5/1077 , A61B5/445 , G01B11/24
摘要： A method of determining the dimensional characteristics of a biological object included: measuring without physical contact or disruption of sterility the length, width and height above or below a reference plane of the biological object with an optical distance measuring device thereby creating a data set; and processing the data set in a computer so as to determine the dimensional characteristics of the biological feature. Preferably the optical distance measuring means is a laser based distance measuring device and the storage of x axis values, y axis values and distance values is in the electronic memory of a computer. The biological surface may be a wound bed or a dermal surface, or alternatively the biological surface may be vascular tissue including heart valves, veins and arteries.
摘要翻译：一种确定生物体的尺寸特性的方法包括：用光学距离测量装置测量物理接触或无菌破坏生物体的参考平面上方或下方的长度，宽度和高度，从而产生数据集; 以及处理计算机中的数据集，以便确定生物特征的尺寸特征。优选地，光学距离测量装置是基于激光的距离测量装置，并且x轴值，y轴值和距离值的存储在计算机的电子存储器中。生物表面可以是伤口床或皮肤表面，或者生物表面可以是血管组织，包括心脏瓣膜，静脉和动脉。

6. 发明授权

US5944005A Retracting arrow rest 失效
标题翻译：撤回箭头休息
公开(公告)号：US5944005A
公开(公告)日：1999-08-31
申请号：US895554
申请日：1997-07-16
申请人： Charles M. Schiff
发明人： Charles M. Schiff
IPC分类号： F41B5/22
CPC分类号： F41B5/143
摘要： An arrow rest assembly attached to a bow is designed to be horizontally movable in order to clear the fletching on a released arrow. The arrow rest assembly incorporates a flexible positioner to position the arrow away from the handle of the bow, in line with the bow string and in clearance of the fletching. An arrow rest holds the arrow in position while the bow is drawn and the arrow is aimed. The arrow rest assembly has a triggering control which responds to the movement of the bow string after the arrow is released; such triggering control retracts the arrow rest from its extended holding position to its retracted clearing position before the fletching of the arrow passes by the arrow rest. The triggering control can be adjusted relative to the bow string in order to vary the timing of the arrow rest's retraction.
摘要翻译：附着在弓上的箭头休息组件被设计成水平移动，以便在释放的箭头上清除微动。箭头支架组件包括柔性定位器，以将箭头定位成远离弓弓的手柄，与弓弦线一致并且在快速清除中。当箭头被拉出并且箭头被瞄准时，箭头休息将箭头固定在适当位置。箭头休息组件具有触发控制，其在箭头被释放之后响应弓弦的运动; 这种触发控制在箭头通过箭头休息之前将箭头从其延伸的保持位置缩回到其缩回的清除位置。触发控制可以相对于弓弦进行调节，以便改变箭头休息的缩回的时间。

7. 发明授权

US07358284B2 Particulate acellular tissue matrix 有权
标题翻译：颗粒无细胞组织基质
公开(公告)号：US07358284B2
公开(公告)日：2008-04-15
申请号：US11040127
申请日：2005-01-20
申请人： Edward S. Griffey , Stephen A. Livesey , Charles M. Schiff , Lawrence E. Boerboom
发明人： Edward S. Griffey , Stephen A. Livesey , Charles M. Schiff , Lawrence E. Boerboom
IPC分类号： A61K35/34
CPC分类号： A61L27/3804 , A61K9/0024 , A61K9/19 , A61K35/28 , A61K35/32 , A61K35/36 , A61K38/18 , A61K47/42 , A61L27/24 , A61L27/3604 , A61L27/3683 , A61L31/005 , A61L2430/40 , Y10S514/801
摘要： A method of processing an acellular tissue matrix to give a particulate acellular tissue matrix includes: cutting sheets of dry acellular tissue matrix into strips; cryofracturing the dry acellular tissue matrix strips at cryogenic temperatures; separating the resulting particles by size at cryogenic temperatures; and freeze drying the fraction of particles desired size to remove any moisture that may have been absorbed to give a dry particulate acellular tissue matrix. Rehydration of the dry particulate acellular tissue matrix may take place just prior to use. The particulate acellular tissue may be applied to a recipient site, by way of injection, spraying, layering, packing, in-casing or combinations thereof. The particulate acellular tissue may further include growth and stimulating agents selected from epidermal growth factor, fibroblast growth factor, nerve growth factor, keratinocyte growth factor, platelet derived growth factor, vasoactive intestinal peptide, stem cell factor, bone morphogetic proteins, chondrocyte growth factor and combinations thereof. Other pharmaceutically active compounds may be combined with the rehydrated particulate material including: analgesic drugs; hemostatic drugs; antibiotic drugs; local anesthetics and the like to enhance the acceptance of the implanted particulate material. The particulate material product may also be combined with stem cells selected from mesenchymal stem cells, epidermal stem cells, cartilage stem cells, hematopoietic stem cells and combinations thereof.
摘要翻译：一种处理无细胞组织基质以产生颗粒状无细胞组织基质的方法包括：将干燥的无细胞组织基质的片材切成条带; 在低温下对干燥的无细胞组织基质条进行冷冻干燥; 将所得颗粒在低温下分离大小; 并冷冻干燥所需尺寸的颗粒级分以除去可能被吸收的任何水分，以产生干燥的无细胞组织基质。干燥颗粒状无细胞组织基质的再水合可以在使用前进行。颗粒状脱细胞组织可以通过注射，喷雾，分层，包装，套管或其组合施用于受体部位。颗粒细胞组织还可以包括生长和刺激剂，其选自表皮生长因子，成纤维细胞生长因子，神经生长因子，角质形成细胞生长因子，血小板衍生生长因子，血管活性肠肽，干细胞因子，骨形态蛋白，软骨细胞生长因子和其组合。其他药物活性化合物可以与再水合的颗粒材料组合，包括：止痛药; 止血药; 抗生素药物; 局部麻醉剂等，以增强植入颗粒物质的接受性。颗粒材料产品还可以与选自间充质干细胞，表皮干细胞，软骨干细胞，造血干细胞及其组合的干细胞组合。

8. 发明授权

US4345847A Automatic brake sequencing for overhead support arm assemblies 失效
标题翻译：架空支撑臂组件的自动制动顺序
公开(公告)号：US4345847A
公开(公告)日：1982-08-24
申请号：US105360
申请日：1979-12-19
申请人： Charles M. Schiff , Eric K. Maxon , Ronald E. West
发明人： Charles M. Schiff , Eric K. Maxon , Ronald E. West
IPC分类号： A61B6/00 , A61B6/10 , A61B8/00 , F16C11/00
CPC分类号： A61B8/4281 , A61B6/105 , A61B6/4429 , A61B8/4218 , Y10T403/32418
摘要： A roller-switch and cam, located at an intermediary joint of a plural arm overhead assembly, delays the unlocking of a brake at a next adjacent joint until the joint at which the cam and switch are located has diverged a predetermined angle from alignment.
摘要翻译：位于多臂架空组件的中间接头处的滚轮开关和凸轮延迟了下一相邻接头处的制动器的解锁，直到凸轮和开关所在的接头已经从对准偏离预定角度。

9. 发明授权

US3960032A Motion transmitting remote control assembly 失效
标题翻译：运动遥控装置
公开(公告)号：US3960032A
公开(公告)日：1976-06-01
申请号：US557078
申请日：1975-03-10
申请人： Charles M. Schiff
发明人： Charles M. Schiff
IPC分类号： F16C1/22 , F16H59/18 , F16H59/24 , F16C1/10
CPC分类号： F16H59/18 , F16C1/22 , F16H59/24 , Y10T74/20402
摘要： A modulator valve control assembly which is attached to an automatic transmission in an automotive vehicle to operate the modulator valve of the transmission in response to movement of the throttle linkage. The modulator valve modulates the shift point at which the transmission changes from one mode to another. The assembly includes a rectangular housing in which a bell crank lever is rotatably supported with one arm engaging a plunger which, in turn, is slidably disposed in a connection means for engaging the modulator valve of an automatic transmission. The other arm of the bell crank is connected through a helically coiled spring to a flexible core element of a motion transmitting remote control assembly which includes a conduit or guide means for slidably supporting the core element. The other end of the core element is attached to a threaded rod which, in turn, may be attached to the throttle linkage. The housing includes a stop against which the bell crank lever may be positioned as the core element is placed in tension to place the helically coiled spring in compression. The core element may move the bell crank against the stop and place the helically coiled spring in compression and a spacer is disposed between the guide or conduit and some portion of the core element to retain the core element in tension so that the assembly is preloaded. The assembly is then placed in connection with a transmission whereby the modulator valve places a force upon the plunger of the modulator control assembly to move the bell crank away from the stop and thereafter the connection means is tightened to prevent relative motion between the modulator assembly and the transmission housing so that the assembly is preloaded.
摘要翻译：调节阀控制组件，其附接到机动车辆中的自动变速器，以响应于节流连杆的运动来操作变速器的调节阀。调制阀调节变速器从一种模式转换到另一种模式的移动点。该组件包括一个矩形壳体，其中一个钟形曲柄杆可旋转地支撑，一个臂接合一个柱塞，该柱塞又滑动地设置在与自动变速器的调节阀接合的连接装置中。钟形曲柄的另一个臂通过螺旋螺旋弹簧连接到运动传递遥控组件的柔性芯元件，其包括用于可滑动地支撑芯元件的导管或引导装置。芯元件的另一端连接到螺杆，螺杆可以连接到节流连杆。壳体包括一个挡块，当该芯元件处于张紧状态时，该曲柄杆可以定位在该止挡件上，以将螺旋盘旋的弹簧压缩。芯元件可以将钟形曲柄移动抵靠止动件并将螺旋形螺旋弹簧放置在压缩中，并且间隔件设置在引导件或管道与芯元件的一些部分之间，以将芯元件保持在张力中，使得组件被预加载。然后将组件与传动装置连接，由此调节器阀将力施加到调节器控制组件的柱塞上以将钟形曲柄移动离开止动件，此后连接装置被拧紧以防止调制器组件和变速器壳体，使得组件被预加载。

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