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1. 发明申请

US20100209408A1 Remodeling of Tissues and Organs 审中-公开
标题翻译：组织和器官的重塑
公开(公告)号：US20100209408A1
公开(公告)日：2010-08-19
申请号：US12716828
申请日：2010-03-03
申请人： Livesey Stephen A. , David J. McQuillan , Herbert Daniel Beniker , Lawrence E. Boerboom
发明人： Livesey Stephen A. , David J. McQuillan , Herbert Daniel Beniker , Lawrence E. Boerboom
IPC分类号： A61K35/14 , A61K35/12 , A61K35/48 , A61K35/44 , A61K35/32 , A61K35/36 , A61K35/34 , A61P19/04 , A61P19/00
CPC分类号： A61K35/32 , A61K35/36 , A61K38/00 , A61L27/3608 , A61L27/362 , A61L27/3804 , A61L27/54 , A61L2430/02
摘要： The invention provides methods of repairing damage to, or defects in, mammalian tissues or organs. In these methods, a particulate or non-particulate acellular matrix made from a tissue or organ other than the tissue or organ being repaired is placed in or on the organ or tissue that is being repaired.
摘要翻译：本发明提供修复对哺乳动物组织或器官的损伤或缺陷的方法。在这些方法中，将由被修复的组织或器官以外的组织或器官制成的颗粒状或非微粒状脱细胞基质置于被修复的器官或组织中或上。

2. 发明授权

US07358284B2 Particulate acellular tissue matrix 有权
标题翻译：颗粒无细胞组织基质
公开(公告)号：US07358284B2
公开(公告)日：2008-04-15
申请号：US11040127
申请日：2005-01-20
申请人： Edward S. Griffey , Stephen A. Livesey , Charles M. Schiff , Lawrence E. Boerboom
发明人： Edward S. Griffey , Stephen A. Livesey , Charles M. Schiff , Lawrence E. Boerboom
IPC分类号： A61K35/34
CPC分类号： A61L27/3804 , A61K9/0024 , A61K9/19 , A61K35/28 , A61K35/32 , A61K35/36 , A61K38/18 , A61K47/42 , A61L27/24 , A61L27/3604 , A61L27/3683 , A61L31/005 , A61L2430/40 , Y10S514/801
摘要： A method of processing an acellular tissue matrix to give a particulate acellular tissue matrix includes: cutting sheets of dry acellular tissue matrix into strips; cryofracturing the dry acellular tissue matrix strips at cryogenic temperatures; separating the resulting particles by size at cryogenic temperatures; and freeze drying the fraction of particles desired size to remove any moisture that may have been absorbed to give a dry particulate acellular tissue matrix. Rehydration of the dry particulate acellular tissue matrix may take place just prior to use. The particulate acellular tissue may be applied to a recipient site, by way of injection, spraying, layering, packing, in-casing or combinations thereof. The particulate acellular tissue may further include growth and stimulating agents selected from epidermal growth factor, fibroblast growth factor, nerve growth factor, keratinocyte growth factor, platelet derived growth factor, vasoactive intestinal peptide, stem cell factor, bone morphogetic proteins, chondrocyte growth factor and combinations thereof. Other pharmaceutically active compounds may be combined with the rehydrated particulate material including: analgesic drugs; hemostatic drugs; antibiotic drugs; local anesthetics and the like to enhance the acceptance of the implanted particulate material. The particulate material product may also be combined with stem cells selected from mesenchymal stem cells, epidermal stem cells, cartilage stem cells, hematopoietic stem cells and combinations thereof.
摘要翻译：一种处理无细胞组织基质以产生颗粒状无细胞组织基质的方法包括：将干燥的无细胞组织基质的片材切成条带; 在低温下对干燥的无细胞组织基质条进行冷冻干燥; 将所得颗粒在低温下分离大小; 并冷冻干燥所需尺寸的颗粒级分以除去可能被吸收的任何水分，以产生干燥的无细胞组织基质。干燥颗粒状无细胞组织基质的再水合可以在使用前进行。颗粒状脱细胞组织可以通过注射，喷雾，分层，包装，套管或其组合施用于受体部位。颗粒细胞组织还可以包括生长和刺激剂，其选自表皮生长因子，成纤维细胞生长因子，神经生长因子，角质形成细胞生长因子，血小板衍生生长因子，血管活性肠肽，干细胞因子，骨形态蛋白，软骨细胞生长因子和其组合。其他药物活性化合物可以与再水合的颗粒材料组合，包括：止痛药; 止血药; 抗生素药物; 局部麻醉剂等，以增强植入颗粒物质的接受性。颗粒材料产品还可以与选自间充质干细胞，表皮干细胞，软骨干细胞，造血干细胞及其组合的干细胞组合。

3. 发明授权

US06933326B1 Particulate acellular tissue matrix 有权
标题翻译：颗粒无细胞组织基质
公开(公告)号：US06933326B1
公开(公告)日：2005-08-23
申请号：US09762174
申请日：1999-06-18
申请人： Edward S. Griffey , Stephen A. Livesey , Charles M. Schiff , Lawrence E. Boerboom
发明人： Edward S. Griffey , Stephen A. Livesey , Charles M. Schiff , Lawrence E. Boerboom
IPC分类号： A61K9/00 , A61K9/19 , A61K35/12 , A61K35/28 , A61K35/32 , A61K35/36 , A61K38/18 , A61K47/42 , A61L27/24 , A61L27/36 , A61L27/38 , A61L31/00 , A61K35/34
CPC分类号： A61L27/3804 , A61K9/0024 , A61K9/19 , A61K35/28 , A61K35/32 , A61K35/36 , A61K38/18 , A61K47/42 , A61L27/24 , A61L27/3604 , A61L27/3683 , A61L31/005 , A61L2430/40 , Y10S514/801
摘要： A method of processing an acellular tissue matrix to give a particulate acellular tissue matrix includes: cutting sheets of dry acellular tissue matrix into strips; cryofracturing the dry acellular tissue matrix strips at cryogenic temperatures; separating the resulting particles by size at cryogenic temperatures; and freeze drying the fraction of particles desired size to remove any moisture that may have been absorbed to give a dry particulate acellular tissue matrix. Rehydration of the dry particulate acellular tissue matrix may take place just prior to use. The particulate acellular tissue may be applied to a recipient site, by way of injection, spraying, layering, packing, in-casing or combinations thereof. The particulate acellular tissue may further include growth and stimulating agents selected from epidermal growth factor, fibroblast growth factor, nerve growth factor, keratinocyte growth factor, platelet derived growth factor, vasoactive intestinal peptide, stem cell factor, bone morphogetic proteins, chondrocyte growth factor and combinations thereof. Other pharmaceutically active compounds may be combined with the rehydrated particulate material including: analgesic drugs; hemostatic drugs; antibiotic drugs; local anesthetics and the like to enhance the acceptance of the implanted particulate material. The particulate material product may also be combined with stem cells selected from mesenchymal stem cells, epidermal stem cells, cartilage stem cells, hematopoietic stem cells and combinations thereof.
摘要翻译：一种处理无细胞组织基质以产生颗粒状无细胞组织基质的方法包括：将干燥的无细胞组织基质的片材切成条带; 在低温下对干燥的无细胞组织基质条进行冷冻干燥; 将所得颗粒在低温下分离大小; 并冷冻干燥所需尺寸的颗粒级分以除去可能被吸收的任何水分，以产生干燥的无细胞组织基质。干燥颗粒状无细胞组织基质的再水合可以在使用前进行。颗粒状脱细胞组织可以通过注射，喷雾，分层，包装，套管或其组合施用于受体部位。颗粒细胞组织还可以包括生长和刺激剂，其选自表皮生长因子，成纤维细胞生长因子，神经生长因子，角质形成细胞生长因子，血小板衍生生长因子，血管活性肠肽，干细胞因子，骨形态蛋白，软骨细胞生长因子和其组合。其他药物活性化合物可以与再水合的颗粒材料组合，包括：止痛药; 止血药; 抗生素药物; 局部麻醉剂等，以增强植入颗粒物质的接受性。颗粒材料产品还可以与选自间充质干细胞，表皮干细胞，软骨干细胞，造血干细胞及其组合的干细胞组合。

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