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1. 发明授权

US07368721B2 Imaging devices and methods employing masks with a non-uniform grid of pinhole apertures 有权
标题翻译：使用具有不均匀网格的针孔的成像装置和方法
公开(公告)号：US07368721B2
公开(公告)日：2008-05-06
申请号：US10951324
申请日：2004-09-27
申请人： Sharon Xiaorong Wang , James T. Chapman , Ronald E. Malmin , Trudy Dayle Rempel , Fred E. Macciocchi , James Frank Caruba
发明人： Sharon Xiaorong Wang , James T. Chapman , Ronald E. Malmin , Trudy Dayle Rempel , Fred E. Macciocchi , James Frank Caruba
IPC分类号： G01T1/161
CPC分类号： G01T1/295
摘要： In some preferred embodiments, an apparatus is provided that facilitates correction, such as, e.g., linearity correction, in imaging devices, such as, e.g., scintillation cameras. In preferred embodiments, a mask is implemented that can produce images for locating the actual position of a nuclear event based on its apparent position with high accuracy and reliability. In the preferred embodiments, the mask includes a non-uniform array of apertures that can achieve this goal.
摘要翻译：在一些优选实施例中，提供了一种在诸如闪烁照相机的成像装置中有助于校正，例如线性校正的装置。在优选实施例中，实现了可以以高精度和可靠性基于其表观位置产生用于定位核事件的实际位置的图像的掩模。在优选实施例中，掩模包括可以实现该目标的不均匀的孔阵列。

2. 发明授权

US07417232B2 Systems and methods for camera calibration 有权
标题翻译：相机校准的系统和方法
公开(公告)号：US07417232B2
公开(公告)日：2008-08-26
申请号：US11454320
申请日：2006-06-16
申请人： Sharon Xiaorong Wang , James Frank Caruba , James T. Chapman , Ronald E. Malmin , Joseph Fang
发明人： Sharon Xiaorong Wang , James Frank Caruba , James T. Chapman , Ronald E. Malmin , Joseph Fang
IPC分类号： G01T1/161 , G01D18/00 , G12B13/00
CPC分类号： G01T1/295 , G01T1/202 , G01T7/005
摘要： A method and system for calibrating a scintillation camera includes steps of constructing a pair of generic linearity coefficient (LC) matrices from a representative detector based on measurement of non-linearity; and transforming the pair of generic LC matrices according to measured pinhole locations from a lead mask to generate detector specific LC matrices.
摘要翻译：用于校准闪烁照相机的方法和系统包括基于非线性测量从代表性检测器构建一对通用线性系数（LC）矩阵的步骤; 以及根据测量的针孔位置从导线掩模变换一对通用LC矩阵，以产生检测器特定的LC矩阵。

3. 发明授权

US07449680B2 Non-uniformity energy correction method and apparatus 有权
标题翻译：不均匀性能量校正方法及装置
公开(公告)号：US07449680B2
公开(公告)日：2008-11-11
申请号：US11414092
申请日：2006-04-28
申请人： Sharon Xiaorong Wang , James Frank Caruba , Ronald E. Malmin , Anthony P. DelMedico
发明人： Sharon Xiaorong Wang , James Frank Caruba , Ronald E. Malmin , Anthony P. DelMedico
IPC分类号： G01D18/00
CPC分类号： G01T1/1642 , G01T7/005
摘要： A method and apparatus for acquiring total uniformity for a scintillation imaging apparatus are provided. A generic energy (Z) map is first obtained. The generic Zmap is then corrected for linearity by use of a dot pattern. The listmode data is used to construct an energy histogram matrix. A twin Zmap is then obtained by optimizing the lower and upper boundaries of the energy window for each pixel in relation to the average energy over the Center Field of View.
摘要翻译：提供了一种用于获取闪烁成像装置的全部均匀性的方法和装置。首先获得一般能量（Z）图。然后通过使用点阵图来校正通用Zmap的线性度。列表模式数据用于构建能量直方图矩阵。然后通过相对于中心视野的平均能量优化每个像素的能量窗口的下边界和上边界来获得双Zmap。

4. 发明授权

US07232990B2 Peak detection calibration for gamma camera using non-uniform pinhole aperture grid mask 有权
标题翻译：使用不均匀针孔孔径网格掩模的伽马相机的峰值检测校准
公开(公告)号：US07232990B2
公开(公告)日：2007-06-19
申请号：US11165786
申请日：2005-06-24
申请人： Sharon Xiaorong Wang , James T. Chapman , Ronald E. Malmin
发明人： Sharon Xiaorong Wang , James T. Chapman , Ronald E. Malmin
IPC分类号： G12B13/00
CPC分类号： G01T1/1648 , G01T1/1642
摘要： Point source responses of pinhole apertures in a non-uniform grid mask used to spatially calibrate a gamma camera can be modeled as a two-dimensional Gaussian function with a set of seven parameters. The Gaussian parameters can be measured using a surface-fitting algorithm that seeks minimum error in the least squares sense. The process is repeated for data from each pinhole location and the data are added together to generate a complete model of the flood image from the mask, which then can be used in a peak detection process for clinical images.
摘要翻译：用于空间校准伽马照相机的不均匀网格掩模中针孔的点源反应可以被建模为具有一组七个参数的二维高斯函数。高斯参数可以使用寻求最小二乘法中最小误差的表面拟合算法进行测量。对于来自每个针孔位置的数据重复该过程，并且将数据相加在一起以从掩模生成洪水图像的完整模型，然后可以将其用于临床图像的峰值检测过程。

5. 发明授权

US08822910B2 Method for collaborative tuning of gamma camera 有权
标题翻译：伽马相机协同调谐方法
公开(公告)号：US08822910B2
公开(公告)日：2014-09-02
申请号：US12560055
申请日：2009-09-15
申请人： Sharon Xiaorong Wang , James Frank Caruba , John Thomas Pawlak
发明人： Sharon Xiaorong Wang , James Frank Caruba , John Thomas Pawlak
IPC分类号： G12B13/00 , G01T1/164 , G01T1/00 , G01T7/00
CPC分类号： G01T1/00 , G01T1/1648 , G01T7/005 , G12B13/00
摘要： A system and tuning method to collaboratively calibrate high voltage DAC values and Photomultiplier Tube DAC values of photomultiplier tubes of a gamma camera so that the detector produces a valid energy spectrum over the entire detector surface. A method for tuning a gamma camera having a plurality of photosensors, exposes the photosensors to scintillation photons corresponding to nuclear radiation of known energy; measures an energy output corresponding to each specific photosensor; calculates an average enemy output of all photosensors in the camera; collaboratively adjusts a DAC value corresponding to a voltage applied to a specific photosensor and a DACHV value corresponding to a high voltage applied to the camera based on the calculated average energy, energy output of each photosensor, and a target energy value corresponding to said known energy; and repeats the calibration until convergence is achieved between the average energy, energy output, and target energy.
摘要翻译：一种用于协调校准伽马相机的光电倍增管的高电压DAC值和光电倍增管DAC值的系统和调谐方法，使得检测器在整个检测器表面上产生有效的能谱。用于调整具有多个光电传感器的伽马照相机的方法，将光电传感器暴露于对应于已知能量的核辐射的闪烁光子; 测量对应于每个特定光电传感器的能量输出; 计算相机中所有光电传感器的平均敌方输出; 基于所计算的平均能量，每个光传感器的能量输出和对应于所述已知能量的目标能量值，协调地调整对应于施加到特定光电传感器的电压的DAC值和对应于施加到照相机的高电压的DACHV值 ; 并重复校准，直到在平均能量，能量输出和目标能量之间达到收敛。

6. 发明授权

US07335889B2 PMT-based pattern matching calibration for gamma camera using non-uniform pinhole aperture grid mask 有权
标题翻译：基于PMT的模式匹配校准用于伽马相机使用不均匀的针孔孔径网格掩模
公开(公告)号：US07335889B2
公开(公告)日：2008-02-26
申请号：US11237427
申请日：2005-09-28
申请人： Sharon Xiaorong Wang , Ronald E. Malmin
发明人： Sharon Xiaorong Wang , Ronald E. Malmin
IPC分类号： G01T1/00
CPC分类号： G01T1/1642 , A61B6/4258 , G01T1/295
摘要： Point source responses of pinhole apertures in a non-uniform grid mask used to spatially calibrate a gamma camera can be modeled as a two-dimensional Gaussian model function. Pinhole data from each pinhole location are added together to generate a complete Gaussian model of the flood image from the mask. The Gaussian model then is subjected to global and PMT-based pattern matching with an actual input flood image obtained using the mask, to obtain a transformed Gaussian model that is more accurately aligned with actual pinhole locations of the mask. The transformed Gaussian model then can be used in a peak detection process for calibration images, which are used to develop LC coefficients for the camera.
摘要翻译：用于空间校准伽马相机的不均匀网格掩模中针孔的点源响应可以被建模为二维高斯模型函数。来自每个针孔位置的针孔数据被加在一起以从掩模生成洪水图像的完整高斯模型。然后将高斯模型与使用掩模获得的实际输入洪水图像进行基于全局和PMT的模式匹配，以获得更准确地与掩模的实际针孔位置对准的变换高斯模型。然后，变换的高斯模型可用于校准图像的峰值检测过程，用于开发相机的LC系数。

7. 发明申请

US20100148046A1 METHOD FOR COLLABORATIVE TUNING OF GAMMA CAMERA 有权
标题翻译：伽马相机协同调谐方法
公开(公告)号：US20100148046A1
公开(公告)日：2010-06-17
申请号：US12560055
申请日：2009-09-15
申请人： Sharon Xiaorong Wang , James Frank Caruba , John Thomas Pawlak
发明人： Sharon Xiaorong Wang , James Frank Caruba , John Thomas Pawlak
IPC分类号： G12B13/00 , G01T1/208
CPC分类号： G01T1/00 , G01T1/1648 , G01T7/005 , G12B13/00
摘要： A system and tuning method to collaboratively calibrate high voltage DAC values and Photomultiplier Tube DAC values of photomultiplier tubes of a gamma camera so that the detector produces a valid energy spectrum over the entire detector surface. A method for tuning a gamma camera having a plurality of photosensors, exposes the photosensors to scintillation photons corresponding to nuclear radiation of known energy; measures an energy output corresponding to each specific photosensor; calculates an average enemy output of all photosensors in the camera; collaboratively adjusts a DAC value corresponding to a voltage applied to a specific photosensor and a DACHV value corresponding to a high voltage applied to the camera based on the calculated average energy, energy output of each photosensor, and a target energy value corresponding to said known energy; and repeats the calibration until convergence is achieved between the average energy, energy output, and target energy.
摘要翻译：一种用于协调校准伽马相机的光电倍增管的高电压DAC值和光电倍增管DAC值的系统和调谐方法，使得检测器在整个检测器表面上产生有效的能谱。用于调整具有多个光电传感器的伽马照相机的方法，将光电传感器暴露于对应于已知能量的核辐射的闪烁光子; 测量对应于每个特定光电传感器的能量输出; 计算相机中所有光电传感器的平均敌方输出; 基于所计算的平均能量，每个光传感器的能量输出和对应于所述已知能量的目标能量值，协调地调整对应于施加到特定光电传感器的电压的DAC值和对应于施加到照相机的高电压的DACHV值 ; 并重复校准，直到在平均能量，能量输出和目标能量之间达到收敛。

8. 发明授权

US07075087B2 Multi-modality diagnostic imager 有权
标题翻译：多模式诊断成像仪
公开(公告)号：US07075087B2
公开(公告)日：2006-07-11
申请号：US10878883
申请日：2004-06-28
申请人： Sharon Xiaorong Wang , James Frank Caruba
发明人： Sharon Xiaorong Wang , James Frank Caruba
IPC分类号： G01T1/166
CPC分类号： A61B6/032 , A61B6/037 , A61B6/5235 , A61B6/541 , G01T1/1611 , G01T1/1648
摘要： According to some embodiments, a multimodality diagnostic imaging system having one or more gamma cameras and a flat panel x-ray detector mounted on a common gantry to perform simultaneous FPCT and SPECT studies. In other embodiments, such systems may included EKG devices to gate said studies.
摘要翻译：根据一些实施例，具有一个或多个伽马照相机和安装在公共台架上的平板x射线检测器以执行同时FPCT和SPECT研究的多模式诊断成像系统。在其他实施例中，这样的系统可以包括用于门禁所述研究的EKG设备。

9. 发明申请

US20090141852A1 Method For Generation of SPECT Trajectory Data From CT Data 失效
标题翻译： CT数据生成SPECT轨迹数据的方法
公开(公告)号：US20090141852A1
公开(公告)日：2009-06-04
申请号：US12240818
申请日：2008-09-29
申请人： Sharon Xiaorong Wang , John Thomas Pawlak , Govind Pai
发明人： Sharon Xiaorong Wang , John Thomas Pawlak , Govind Pai
IPC分类号： H05G1/60
CPC分类号： G06T11/005
摘要： A method for optimizing the scanning trajectory of a radiation detector device, e.g., a SPECT scanning device, about an object generally includes: obtaining object image data using a different imaging modality, e.g., a CT scanning device, determining a maximum object boundary based on the image data, calculating an optimal scan trajectory of the SPECT scanning device relative to the object based on the maximum object boundary, scanning the object with the SPECT scanning device along the optimal scan trajectory to detect gamma photons emanating from the object, from which an image can be reconstructed from the detected gamma photons. Preferably, the SPECT device includes at least two detectors arranged at a pre-selected angle relative to one another and the optimal scan trajectory minimizes the distance between the detectors and the object while maximizing the geometric efficiency of the detectors relative to the object.
摘要翻译：用于优化关于物体的辐射检测器装置（例如，SPECT扫描装置）的扫描轨迹的方法通常包括：使用不同的成像模式获取对象图像数据，例如CT扫描装置，基于图像数据，基于最大对象边界计算SPECT扫描装置相对于对象的最佳扫描轨迹，沿着最佳扫描轨迹用SPECT扫描装置扫描对象以检测从对象发出的伽马光子，可以从检测到的伽马光子重建图像。优选地，SPECT装置包括相对于彼此以预选角度布置的至少两个检测器，并且最佳扫描轨迹使检测器和物体之间的距离最小化，同时使检测器相对于物体的几何效率最大化。

10. 发明授权

US07408149B2 Detector head position correction for hybrid SPECT/CT imaging apparatus 有权
标题翻译：混合SPECT / CT成像装置的检测头位置校正
公开(公告)号：US07408149B2
公开(公告)日：2008-08-05
申请号：US11844901
申请日：2007-08-24
申请人： Sharon Xiaorong Wang , Joseph Fang
发明人： Sharon Xiaorong Wang , Joseph Fang
IPC分类号： G12B13/00
CPC分类号： G01T1/1648 , G01T1/1611 , G01T1/1612 , G01T1/169 , G01T7/005
摘要： A system and method provide for more accurate SPECT/CT image registration. CT data is utilized to establish a global spatial coordinate system of a common test phantom. The common test phantom is then used to obtain a set of point source nuclear images. Three-dimensional CT point source data is mapped to a two-dimensional image plane of corresponding point source data, to obtain a pair of intersecting projection cones that are used to obtain a set of detector head position correction parameters to correct detector head positioning in the CT coordinate system when obtaining SPECT projection images of the same object.
摘要翻译：系统和方法提供更准确的SPECT / CT图像配准。 CT数据用于建立通用测试体模的全局空间坐标系。然后使用常见的测试体模来获得一组点源核图像。将三维CT点源数据映射到相应点源数据的二维图像平面，以获得一对相交的投影锥，其用于获得一组检测器头位置校正参数，以校正检测器头位置校正参数获取同一物体的SPECT投影图像时的CT坐标系。

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