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1. 发明授权

US07368721B2 Imaging devices and methods employing masks with a non-uniform grid of pinhole apertures 有权
标题翻译：使用具有不均匀网格的针孔的成像装置和方法
公开(公告)号：US07368721B2
公开(公告)日：2008-05-06
申请号：US10951324
申请日：2004-09-27
申请人： Sharon Xiaorong Wang , James T. Chapman , Ronald E. Malmin , Trudy Dayle Rempel , Fred E. Macciocchi , James Frank Caruba
发明人： Sharon Xiaorong Wang , James T. Chapman , Ronald E. Malmin , Trudy Dayle Rempel , Fred E. Macciocchi , James Frank Caruba
IPC分类号： G01T1/161
CPC分类号： G01T1/295
摘要： In some preferred embodiments, an apparatus is provided that facilitates correction, such as, e.g., linearity correction, in imaging devices, such as, e.g., scintillation cameras. In preferred embodiments, a mask is implemented that can produce images for locating the actual position of a nuclear event based on its apparent position with high accuracy and reliability. In the preferred embodiments, the mask includes a non-uniform array of apertures that can achieve this goal.
摘要翻译：在一些优选实施例中，提供了一种在诸如闪烁照相机的成像装置中有助于校正，例如线性校正的装置。在优选实施例中，实现了可以以高精度和可靠性基于其表观位置产生用于定位核事件的实际位置的图像的掩模。在优选实施例中，掩模包括可以实现该目标的不均匀的孔阵列。

2. 发明授权

US07417232B2 Systems and methods for camera calibration 有权
标题翻译：相机校准的系统和方法
公开(公告)号：US07417232B2
公开(公告)日：2008-08-26
申请号：US11454320
申请日：2006-06-16
申请人： Sharon Xiaorong Wang , James Frank Caruba , James T. Chapman , Ronald E. Malmin , Joseph Fang
发明人： Sharon Xiaorong Wang , James Frank Caruba , James T. Chapman , Ronald E. Malmin , Joseph Fang
IPC分类号： G01T1/161 , G01D18/00 , G12B13/00
CPC分类号： G01T1/295 , G01T1/202 , G01T7/005
摘要： A method and system for calibrating a scintillation camera includes steps of constructing a pair of generic linearity coefficient (LC) matrices from a representative detector based on measurement of non-linearity; and transforming the pair of generic LC matrices according to measured pinhole locations from a lead mask to generate detector specific LC matrices.
摘要翻译：用于校准闪烁照相机的方法和系统包括基于非线性测量从代表性检测器构建一对通用线性系数（LC）矩阵的步骤; 以及根据测量的针孔位置从导线掩模变换一对通用LC矩阵，以产生检测器特定的LC矩阵。

3. 发明授权

US07449680B2 Non-uniformity energy correction method and apparatus 有权
标题翻译：不均匀性能量校正方法及装置
公开(公告)号：US07449680B2
公开(公告)日：2008-11-11
申请号：US11414092
申请日：2006-04-28
申请人： Sharon Xiaorong Wang , James Frank Caruba , Ronald E. Malmin , Anthony P. DelMedico
发明人： Sharon Xiaorong Wang , James Frank Caruba , Ronald E. Malmin , Anthony P. DelMedico
IPC分类号： G01D18/00
CPC分类号： G01T1/1642 , G01T7/005
摘要： A method and apparatus for acquiring total uniformity for a scintillation imaging apparatus are provided. A generic energy (Z) map is first obtained. The generic Zmap is then corrected for linearity by use of a dot pattern. The listmode data is used to construct an energy histogram matrix. A twin Zmap is then obtained by optimizing the lower and upper boundaries of the energy window for each pixel in relation to the average energy over the Center Field of View.
摘要翻译：提供了一种用于获取闪烁成像装置的全部均匀性的方法和装置。首先获得一般能量（Z）图。然后通过使用点阵图来校正通用Zmap的线性度。列表模式数据用于构建能量直方图矩阵。然后通过相对于中心视野的平均能量优化每个像素的能量窗口的下边界和上边界来获得双Zmap。

4. 发明授权

US07232990B2 Peak detection calibration for gamma camera using non-uniform pinhole aperture grid mask 有权
标题翻译：使用不均匀针孔孔径网格掩模的伽马相机的峰值检测校准
公开(公告)号：US07232990B2
公开(公告)日：2007-06-19
申请号：US11165786
申请日：2005-06-24
申请人： Sharon Xiaorong Wang , James T. Chapman , Ronald E. Malmin
发明人： Sharon Xiaorong Wang , James T. Chapman , Ronald E. Malmin
IPC分类号： G12B13/00
CPC分类号： G01T1/1648 , G01T1/1642
摘要： Point source responses of pinhole apertures in a non-uniform grid mask used to spatially calibrate a gamma camera can be modeled as a two-dimensional Gaussian function with a set of seven parameters. The Gaussian parameters can be measured using a surface-fitting algorithm that seeks minimum error in the least squares sense. The process is repeated for data from each pinhole location and the data are added together to generate a complete model of the flood image from the mask, which then can be used in a peak detection process for clinical images.
摘要翻译：用于空间校准伽马照相机的不均匀网格掩模中针孔的点源反应可以被建模为具有一组七个参数的二维高斯函数。高斯参数可以使用寻求最小二乘法中最小误差的表面拟合算法进行测量。对于来自每个针孔位置的数据重复该过程，并且将数据相加在一起以从掩模生成洪水图像的完整模型，然后可以将其用于临床图像的峰值检测过程。

5. 发明授权

US07335889B2 PMT-based pattern matching calibration for gamma camera using non-uniform pinhole aperture grid mask 有权
标题翻译：基于PMT的模式匹配校准用于伽马相机使用不均匀的针孔孔径网格掩模
公开(公告)号：US07335889B2
公开(公告)日：2008-02-26
申请号：US11237427
申请日：2005-09-28
申请人： Sharon Xiaorong Wang , Ronald E. Malmin
发明人： Sharon Xiaorong Wang , Ronald E. Malmin
IPC分类号： G01T1/00
CPC分类号： G01T1/1642 , A61B6/4258 , G01T1/295
摘要： Point source responses of pinhole apertures in a non-uniform grid mask used to spatially calibrate a gamma camera can be modeled as a two-dimensional Gaussian model function. Pinhole data from each pinhole location are added together to generate a complete Gaussian model of the flood image from the mask. The Gaussian model then is subjected to global and PMT-based pattern matching with an actual input flood image obtained using the mask, to obtain a transformed Gaussian model that is more accurately aligned with actual pinhole locations of the mask. The transformed Gaussian model then can be used in a peak detection process for calibration images, which are used to develop LC coefficients for the camera.
摘要翻译：用于空间校准伽马相机的不均匀网格掩模中针孔的点源响应可以被建模为二维高斯模型函数。来自每个针孔位置的针孔数据被加在一起以从掩模生成洪水图像的完整高斯模型。然后将高斯模型与使用掩模获得的实际输入洪水图像进行基于全局和PMT的模式匹配，以获得更准确地与掩模的实际针孔位置对准的变换高斯模型。然后，变换的高斯模型可用于校准图像的峰值检测过程，用于开发相机的LC系数。

6. 发明授权

US08119980B2 Self-adaptive tuning of gamma camera 有权
标题翻译：伽马相机的自适应调谐
公开(公告)号：US08119980B2
公开(公告)日：2012-02-21
申请号：US12984029
申请日：2011-01-04
申请人： Ronald E. Malmin , James Frank Caruba
发明人： Ronald E. Malmin , James Frank Caruba
IPC分类号： G12B13/00
CPC分类号： G01T1/1648 , G01T1/40
摘要： An improved system and method for tuning individual sensors (e.g., photomultiplier tubes) of a multi-sensor imaging system such as e.g., a gamma camera having an array of photo-multiplier tubes is provided that produces a uniform response over the entire system. Individual sensors of a multi-sensor imaging system are tuned based explicitly or implicitly on gain characteristics of individual sensors of the multi-sensor imaging system so as to produce a uniform response over the system.
摘要翻译：提供了一种用于调整多传感器成像系统的单个传感器（例如，光电倍增管）的改进的系统和方法，所述多传感器成像系统例如具有光电倍增管阵列的伽马照相机，其在整个系统上产生均匀的响应。多传感器成像系统的各个传感器明确地或隐含地基于多传感器成像系统的各个传感器的增益特性进行调谐，以便在系统上产生均匀的响应。

7. 发明申请

US20110095172A1 Self-Adaptive Tuning Of Gamma Camera 有权
标题翻译：自适应调谐伽马相机
公开(公告)号：US20110095172A1
公开(公告)日：2011-04-28
申请号：US12984029
申请日：2011-01-04
申请人： Ronald E. Malmin , James Frank Caruba
发明人： Ronald E. Malmin , James Frank Caruba
IPC分类号： G12B13/00
CPC分类号： G01T1/1648 , G01T1/40
摘要： An improved system and method for tuning individual sensors (e.g., photomultiplier tubes) of a multi-sensor imaging system such as e.g., a gamma camera having an array of photo-multiplier tubes is provided that produces a uniform response over the entire system. Individual sensors of a multi-sensor imaging system are tuned based explicitly or implicitly on gain characteristics of individual sensors of the multi-sensor imaging system so as to produce a uniform response over the system.
摘要翻译：提供了一种用于调整多传感器成像系统的单个传感器（例如，光电倍增管）的改进的系统和方法，所述多传感器成像系统例如具有光电倍增管阵列的伽马照相机，其在整个系统上产生均匀的响应。多传感器成像系统的各个传感器明确地或隐含地基于多传感器成像系统的各个传感器的增益特性进行调谐，以便在系统上产生均匀的响应。

8. 发明授权

US08340386B2 System and method for measuring hole orientation for SPECT collimators 有权
标题翻译：用于测量SPECT准直仪孔取向的系统和方法
公开(公告)号：US08340386B2
公开(公告)日：2012-12-25
申请号：US12987376
申请日：2011-01-10
申请人： Ronald E. Malmin
发明人： Ronald E. Malmin
IPC分类号： G06K9/00 , A61B6/00
CPC分类号： G06T11/005 , A61B6/037
摘要： A method for measuring a SPECT collimator's hole orientation angles includes (a) providing a plurality of parallel spaced apart line radiation sources at a distance from a detector; (b) positioning a first collimator between the plurality of spaced apart line radiation sources and the detector; (c) obtaining a set of line images of the plurality of line radiation sources by scanning/stepping the plurality of line radiation sources across the first collimator in a first direction; (d) obtaining a second set of line images of the plurality of line radiation sources by scanning/stepping the plurality of line radiation sources across the first collimator in a second direction thai is perpendicular to the first direction; (c) repeating the steps (c) and (d) for a second collimator, wherein one of the two collimators is a reference collimator and the other of the two collimators is a collimator being measured.
摘要翻译：用于测量SPECT准直器的孔取向角的方法包括（a）在与检测器相距一定距离处提供多个平行间隔开的线辐射源; （b）将第一准直器定位在所述多个间隔开的线辐射源和所述检测器之间; （c）通过在第一方向跨越第一准直仪扫描/步进多条线辐射源来获得多条线辐射源的一组线图像; （d）通过在垂直于第一方向的第二方向跨越第一准直仪扫描/步进多条线辐射源来获得多条线辐射源的第二组线图像; （c）对于第二准直仪重复步骤（c）和（d），其中两个准直器中的一个是参考准直器，并且两个准直器中的另一个是被测量的准直器。

9. 发明申请

US20120177268A1 System and Method for Measuring Hole Orientation for SPECT Collimators 有权
标题翻译：用于测量SPECT准直器孔定位的系统和方法
公开(公告)号：US20120177268A1
公开(公告)日：2012-07-12
申请号：US12987376
申请日：2011-01-10
申请人： Ronald E. Malmin
发明人： Ronald E. Malmin
IPC分类号： G06K9/00
CPC分类号： G06T11/005 , A61B6/037
摘要： A method for measuring a SPECT collimator's hole orientation angles includes (a) providing a plurality of parallel spaced apart line radiation sources at a distance from a detector; (b) positioning a first collimator between the plurality of spaced apart line radiation sources and the detector; (c) obtaining a set of line images of the plurality of line radiation sources by scanning/stepping the plurality of line radiation sources across the first collimator in a first direction; (d) obtaining a second set of line images of the plurality of line radiation sources by scanning/stepping the plurality of line radiation sources across the first collimator in a second direction that is perpendicular to the first direction; (e) repeating the steps (c) and (d) for a second collimator, wherein one of the two collimators is a reference collimator and the other of the two collimators is a collimator being measured, whereby the line images obtained using the reference collimator are reference collimator line images and the line images obtained using the collimator being measured are measured collimator line images; (f) analyzing the reference collimator line images and the measured collimator line images and determining the offset distance dx between the reference collimator line images and the measured collimator line images in the first direction and the offset distance dy between the reference collimator line images and the measured collimator line images in the second direction, wherein dx is the offset distance in the first direction and dy is the offset distance in the second direction; and (g) calculating hole orientation angles θx, θy for each collimator hole in the collimator being measured.
摘要翻译：用于测量SPECT准直器的孔取向角的方法包括（a）在与检测器相距一定距离处提供多个平行间隔开的线辐射源; （b）将第一准直器定位在所述多个间隔开的线辐射源和所述检测器之间; （c）通过在第一方向跨越第一准直仪扫描/步进多条线辐射源来获得多条线辐射源的一组线图像; （d）通过在垂直于第一方向的第二方向跨越第一准直仪扫描/步进多条线辐射源来获得多条线辐射源的第二组线图像; （e）对于第二准直仪重复步骤（c）和（d），其中两个准直仪中的一个是参考准直仪，并且两个准直仪中的另一个是被测量的准直仪，由此使用参考准直仪是参考准直器线图像和使用被测量的准直器获得的线图像是测量准直器线图像; （f）分析参考准直器线图像和所测量的准直仪线图像，并且确定参考准直器线图像与第一方向上的测量准直仪线图像之间的偏移距离dx以及参考准直器线图像与参考准直器行图像之间的偏移距离dy 在第二方向上测量准直仪线图像，其中dx是第一方向上的偏移距离，dy是第二方向上的偏移距离; 和（g）计算待测量的准直器中的每个准直器孔的孔取向角度和角度; x，＆amp; t; y。

10. 发明授权

US08115172B2 Position-weighted location of scintillation events 有权
标题翻译：闪烁事件的位置加权位置
公开(公告)号：US08115172B2
公开(公告)日：2012-02-14
申请号：US12568432
申请日：2009-09-28
申请人： Ronald E. Malmin
发明人： Ronald E. Malmin
IPC分类号： G01T1/20
CPC分类号： G01T1/1644
摘要： Determining a scintillation event location bevent along an axis B of an array of photomultiplier tubes, each photomultiplier tube having a location bPMT and an output ZPMT. Determining a preliminary event location bprelim along the B axis as a centroid of the photomultiplier tube outputs. Determining a position-weighted characteristic (ZPMT·(bPMT−bprelim)2) of each of the photomultiplier tubes. Determining event location bevent along the B axis as a centroid of the outputs of those photomultiplier tubes characterized by a position-weighted characteristic less than or equal to a predetermined cutoff.
摘要翻译：确定沿着光电倍增管阵列的轴线B的闪烁事件位置，每个光电倍增管具有位置bPMT和输出ZPMT。确定沿B轴的初步事件位置bprelim作为光电倍增管输出的质心。确定每个光电倍增管的位置加权特性（ZPMT·（bPMT-bprelim）2）。确定沿着B轴的事件位置作为这些光电倍增管的输出的质心，其特征在于小于或等于预定截止点的位置加权特性。

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