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1. 发明授权

US06596403B2 Optionally crosslinkable coatings, compositions and methods of use 失效
标题翻译：可交联的涂料，组合物和使用方法
公开(公告)号：US06596403B2
公开(公告)日：2003-07-22
申请号：US09977187
申请日：2001-10-12
申请人： Sumita B. Mitra , Charles E. Shelburne , Sharon M. Rozzi , Brant L. Kedrowski
发明人： Sumita B. Mitra , Charles E. Shelburne , Sharon M. Rozzi , Brant L. Kedrowski
IPC分类号： B32B2738
CPC分类号： A61K8/895 , A61Q11/00 , Y10T428/31612 , Y10T428/31663 , A61K6/0017 , C08L51/085
摘要： Coatings for hard tissue and surfaces of the oral environment are provided that reduce adhesion of bacteria and proteinaceous substances to these surfaces. Methods of reducing adhesion of these materials to such surfaces, and polymers for incorporation into such coatings are also provided.
摘要翻译：提供用于硬组织和口腔环境表面的涂层，其减少细菌和蛋白质物质对这些表面的粘附。还提供了将这些材料粘附到这些表面上的方法以及用于掺入这种涂层的聚合物。

2. 发明授权

US5607663A Hydrocarbyl containing coatings, compositions and methods of use 失效
标题翻译：含有碳氢化合物的涂料，组合物和使用方法
公开(公告)号：US5607663A
公开(公告)日：1997-03-04
申请号：US348048
申请日：1994-12-01
申请人： Sharon M. Rozzi , Sumita B. Mitra , Brant L. Kedrowski , Charles E. Shelburne
发明人： Sharon M. Rozzi , Sumita B. Mitra , Brant L. Kedrowski , Charles E. Shelburne
IPC分类号： A61K6/02 , A61K6/083 , A61K7/16
CPC分类号： A61K6/0017
摘要： Coatings for hard tissue and surfaces of the oral environment are provided that reduce adhesion of bacteria and proteinaceous substances to these surfaces. Methods of reducing adhesion of these materials to such surfaces, and polymers for incorporation into such coatings are also provided.
摘要翻译：提供用于硬组织和口腔环境表面的涂层，其减少细菌和蛋白质物质对这些表面的粘附。还提供了将这些材料粘附到这些表面上的方法以及用于掺入这种涂层的聚合物。

3. 发明授权

US5888491A Optionally crosslinkable coatings, compositions and methods of use 失效
公开(公告)号：US5888491A
公开(公告)日：1999-03-30
申请号：US347861
申请日：1994-12-01
申请人： Sumita B. Mitra , Charles E. Shelburne , Sharon M. Rozzi , Brant L. Kedrowski
发明人： Sumita B. Mitra , Charles E. Shelburne , Sharon M. Rozzi , Brant L. Kedrowski
IPC分类号： A61K9/70 , A61K6/02 , A61K6/083 , A61K6/093 , A61K8/00 , A61K8/34 , A61K8/35 , A61K8/36 , A61K8/368 , A61K8/37 , A61K8/46 , A61K8/49 , A61K8/58 , A61K8/89 , A61K8/891 , A61K8/892 , A61K8/895 , A61K8/91 , A61L27/34 , A61Q11/00 , C08L83/08 , A61K31/74
CPC分类号： A61K8/895 , A61K6/0017 , A61Q11/00
摘要： Coatings for hard tissue and surfaces of the oral environment are provided that reduce adhesion of bacteria and proteinaceous substances to these surfaces. Methods of reducing adhesion of these materials to such surfaces, and polymers for incorporation into such coatings are also provided.

4. 发明授权

US06312668B2 Optionally crosslinkable coatings, compositions and methods of use 有权
标题翻译：可交联的涂料，组合物和使用方法
公开(公告)号：US06312668B2
公开(公告)日：2001-11-06
申请号：US09237870
申请日：1999-01-27
申请人： Sumita B. Mitra , Charles E. Shelburne , Sharon M. Rozzi , Brant L. Kedrowski
发明人： Sumita B. Mitra , Charles E. Shelburne , Sharon M. Rozzi , Brant L. Kedrowski
IPC分类号： A61K716
CPC分类号： A61K8/895 , A61Q11/00 , Y10T428/31612 , Y10T428/31663 , A61K6/0017 , C08L51/085
摘要： Coatings for hard tissue and surfaces of the oral environment are provided that reduce adhesion of bacteria and proteinaceous substances to these surfaces. Methods of reducing adhesion of these materials to such surfaces, and polymers for incorporation into such coatings are also provided.
摘要翻译：提供用于硬组织和口腔环境表面的涂层，其减少细菌和蛋白质物质对这些表面的粘附。还提供了将这些材料粘附到这些表面上的方法以及用于掺入这种涂层的聚合物。

5. 发明授权

US5866630A Optionally crosslinkable coatings compositions and methods of use 失效
标题翻译：任选的可交联涂料组合物和使用方法
公开(公告)号：US5866630A
公开(公告)日：1999-02-02
申请号：US472000
申请日：1995-06-06
申请人： Sumita B. Mitra , Charles E. Shelburne , Sharon M. Rozzi , Brant L. Kedrowski
发明人： Sumita B. Mitra , Charles E. Shelburne , Sharon M. Rozzi , Brant L. Kedrowski
IPC分类号： A61K9/70 , A61K6/02 , A61K6/083 , A61K6/093 , A61K8/00 , A61K8/34 , A61K8/35 , A61K8/36 , A61K8/368 , A61K8/37 , A61K8/46 , A61K8/49 , A61K8/58 , A61K8/89 , A61K8/891 , A61K8/892 , A61K8/895 , A61K8/91 , A61L27/34 , A61Q11/00 , C08L83/08 , A61K6/00 , C08F30/08
CPC分类号： A61K8/895 , A61K6/0017 , A61Q11/00
摘要： Coatings for hard tissue and surfaces of the oral environment are provided that reduce adhesion of bacteria and proteinaceous substances to these surfaces. Methods of reducing adhesion of these materials to such surfaces, and polymers for incorporation into such coatings are also provided.
摘要翻译：提供用于硬组织和口腔环境表面的涂层，其减少细菌和蛋白质物质对这些表面的粘附。还提供了将这些材料粘附到这些表面上的方法以及用于掺入这种涂层的聚合物。

6. 发明授权

US5662887A Fluorocarbon containing coatings, compositions and methods of use 失效
标题翻译：含氟碳涂料，组合物和使用方法
公开(公告)号：US5662887A
公开(公告)日：1997-09-02
申请号：US347717
申请日：1994-12-01
申请人： Sharon M. Rozzi , Sumita B. Mitra , Brant Lawrence Kedrowski , Charles E. Shelburne
发明人： Sharon M. Rozzi , Sumita B. Mitra , Brant Lawrence Kedrowski , Charles E. Shelburne
IPC分类号： A23G4/00 , A23G4/06 , A61K6/00 , A61K6/02 , A61K6/083 , A61K8/81 , A61Q11/00 , A61K7/16
CPC分类号： A23G4/06 , A61K6/0017 , A61K6/0029 , A61K6/0205 , A61K6/05 , A61K6/083 , A61K6/0835 , A61K8/8152 , A61Q11/00
摘要： Coatings for hard tissue and surfaces of the oral environment are provided that reduce adhesion of bacteria and proteinaceous substances to these surfaces. Methods of reducing adhesion of these materials to such surfaces, and polymers for incorporation into such coatings are also provided.
摘要翻译：提供用于硬组织和口腔环境表面的涂层，其减少细菌和蛋白质物质对这些表面的粘附。还提供了将这些材料粘附到这些表面上的方法以及用于掺入这种涂层的聚合物。

7. 发明授权

US07226928B2 Methods for the treatment of periodontal disease 失效
标题翻译：治疗牙周病的方法
公开(公告)号：US07226928B2
公开(公告)日：2007-06-05
申请号：US10479109
申请日：2002-06-14
申请人： Sumita B. Mitra , Charles E. Shelburne , Mark A. Tomai
发明人： Sumita B. Mitra , Charles E. Shelburne , Mark A. Tomai
IPC分类号： A61K31/535 , A61K31/44
CPC分类号： A61K9/0063 , A61K9/006 , A61K31/00 , A61K31/4745 , A61K45/06 , A61K2300/00
摘要： The disclosure provides methods for the treatment and prevention of periodontal disease. In preferred embodiments, the invention provides for local treatment of periodontal tissues with a pharmaceutical composition including an immune response modifier (IRM) selected from the group of immune response modifiers comprising imidazoquinoline amines, imidazopyridine amines, 6,7-fused cycloalkylimidazopyridine amines, imidazonaphtyridine amines, oxazoloquinoline amines, thiazoloquinoline amines and 1,2-bridged imidazopyridine amines.
摘要翻译：本公开提供了治疗和预防牙周病的方法。在优选实施方案中，本发明提供了用包含免疫应答调节剂（IRM）的药物组合物局部治疗牙周组织，所述免疫应答调节剂选自包含咪唑并喹啉胺，咪唑并吡啶胺，6,7-稠合的环烷基咪唑并吡啶胺，咪唑并吡啶胺，恶唑啉喹啉胺，噻唑并喹啉胺和1,2-桥连的咪唑并吡啶胺。

8. 发明授权

US4888276A Method and composition for the diagnosis of Lyme disease 失效
标题翻译：莱姆病的诊断方法和组成
公开(公告)号：US4888276A
公开(公告)日：1989-12-19
申请号：US879153
申请日：1986-06-26
申请人： Charles E. Shelburne
发明人： Charles E. Shelburne
IPC分类号： G01N33/569
CPC分类号： G01N33/56911 , G01N2800/52
摘要： A reliable, rapid, inexpensive and noninvasive method is provided for the diagnosis of Lyme disease by the detection of antigens of the spirochete responsible for that disease, Borrelia burgdorferi, in the urine of an affected individual.

9. 发明授权

US06248733B1 Method for limiting the growth of microorganisms using metal-containing compounds 失效
标题翻译：使用含金属化合物限制微生物生长的方法
公开(公告)号：US06248733B1
公开(公告)日：2001-06-19
申请号：US09004892
申请日：1998-01-09
申请人： Kevin D. Landgrebe , Charles E. Shelburne , Terrance P. Smith , Gregory D. Cuny
发明人： Kevin D. Landgrebe , Charles E. Shelburne , Terrance P. Smith , Gregory D. Cuny
IPC分类号： C07D22900
CPC分类号： C07F15/0093 , A01N55/02 , A01N59/16 , A01N59/20
摘要： This invention relates to the use of compounds having the general structure: wherein: Z1 and Z2 each independently represent an arene nucleus, which has from 5 to 14 ring atoms; G1 and G2 each independently represent a metal ligating group; R represents a hydrogen atom, a halogen atom, an alkyl group, an acylamino group, an alkoxy group, a sulfonamido group, an aryl group, a thiol group, an alkylthio group, an arylthio group, an alkylamino group, an arylamino group, an amino group, an alkoxycarbonyl group, an acyloxy group, a nitro group, a cyano group, an alkylsulfonyl group, an arylsulfonyl group, an alkylsulfoxyl group, an arylsulfoxyl group, an aryloxyl group, a hydroxyl group, a thioamido group, a carbamoyl group, a suffamoyl group, a formyl group, an acyl group, a ureido group, an aryloxycarbonyl group, a silyl group, or a sulfoalkoxy group; L1 represents a nitrogen heterocycle; L2 represents a monodentate or polydentate (e.g., bidentate) ligand; X represents nitrogen or a methine (CH) group; M is a divalent or polyvalent transition metal ion where the coordination number is at least 4; and k, m, and n are whole numbers less than or equal to 3 as antimicrobial agents to inhibit the growth or replication of microorganisms such as viruses, bacteria, and fungi.
摘要翻译：本发明涉及具有以下通式结构的化合物的用途：其中：Z 1和Z 2各自独立地表示具有5至14个环原子的芳烃核; G1和G2各自独立地表示金属结合基团; R表示氢原子，卤素原子，烷基，酰氨基，烷氧基，亚磺酰氨基，芳基，硫醇基，烷硫基，芳硫基，烷基氨基，芳基氨基，氨基，烷氧基羰基，酰氧基，硝基，氰基，烷基磺酰基，芳基磺酰基，烷基亚砜基，芳基亚砜基，芳氧基，羟基，硫代酰氨基，氨基甲酰基氨基，酰基，脲基，芳氧基羰基，甲硅烷基或磺基烷氧基; L1表示氮杂环; L2表示单齿或多齿（例如双齿）配体; X表示氮或次甲基（CH）基团; M是配位数至少为4的二价或多价过渡金属离子; 和k，m和n是小于或等于3的整数作为抑制微生物如病毒，细菌和真菌的生长或复制的抗微生物剂。

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