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1. 发明申请

US20110195850A1 COMPACT NANOFABRICATION APPARATUS 审中-公开
标题翻译：紧凑的纳米装置
公开(公告)号：US20110195850A1
公开(公告)日：2011-08-11
申请号：US13088284
申请日：2011-04-15
申请人： Sergey V. ROZHOK , Michael Nelson , Nabil A. Amro , Joseph S. Fragala , Raymond Roger Shile , John Edward Bussan , Dirk N. vanMerkestyn
发明人： Sergey V. ROZHOK , Michael Nelson , Nabil A. Amro , Joseph S. Fragala , Raymond Roger Shile , John Edward Bussan , Dirk N. vanMerkestyn
IPC分类号： C40B30/00 , C40B50/14
CPC分类号： G03F7/0002 , G01Q80/00 , G03F7/70383 , G03F9/00
摘要： An apparatus for use in fabricating structures and depositing materials from tips to surfaces for patterning in direct-write mode, providing ability to travel macroscopic distances and yet provide for nanoscale patterning. Useful in small scale fabrication and nanolithography. The instrument can be compact and used on a laboratory bench or desktop. An apparatus comprising: at least one multi-axis assembly comprising a plurality of nanopositioning stages, at least one pen assembly, wherein the pen assembly and the multi-axis assembly are adapted for delivery of material from the pen assembly to a substrate which is positioned by the multi-axis assembly, at least one viewing assembly, at least one controller. Nanopositioning by piezoelectric methods and devices and motors is particularly useful. The apparatus can include integrated environmental chambers and housings, as well as ink reservoirs for materials to be delivered. The viewing assembly can be a microscope with a long working distance. Particularly useful for fabrication of bioarrays or microarrays. The multi-axis assembly can be a five-axis assembly. Software can facilitate efficient usage.
摘要翻译：一种用于制造结构并从尖端到表面沉积材料的装置，用于以直写式模式进行图案化，提供行进宏观距离并提供纳米尺度图案化的能力。适用于小规模制造和纳米光刻。该仪器可以紧凑，并在实验台或台式机上使用。一种装置，包括：至少一个多轴组件，其包括多个纳米定位阶段，至少一个笔组件，其中所述笔组件和所述多轴组件适于将材料从所述笔组件传送到定位的衬底通过多轴组件，至少一个观察组件，至少一个控制器。通过压电方法和装置和电动机的定位是特别有用的。该设备可以包括集成的环境室和壳体，以及用于要输送的材料的油墨储存器。观察组件可以是具有长工作距离的显微镜。特别适用于制造生物芯片或微阵列。多轴组件可以是五轴组件。软件可以促进有效的使用。

2. 发明申请

US20090023607A1 COMPACT NANOFABRICATION APPARATUS 审中-公开
标题翻译：紧凑的纳米装置
公开(公告)号：US20090023607A1
公开(公告)日：2009-01-22
申请号：US12116908
申请日：2008-05-07
申请人： Sergey V. Rozhok , Michael Nelson , Nabil A. Amro , Joseph S. Fragala , Raymond Roger Shile , John Edward Bussan , Dirk N. vanMerkestyn
发明人： Sergey V. Rozhok , Michael Nelson , Nabil A. Amro , Joseph S. Fragala , Raymond Roger Shile , John Edward Bussan , Dirk N. vanMerkestyn
IPC分类号： C40B50/14 , C40B60/14
CPC分类号： G03F7/0002 , G01Q80/00 , G03F7/70383 , G03F9/00
摘要： An apparatus for use in fabricating structures and depositing materials from tips to surfaces for patterning in direct-write mode, providing ability to travel macroscopic distances and yet provide for nanoscale patterning. Useful in small scale fabrication and nanolithography. The instrument can be compact and used on a laboratory bench or desktop. An apparatus comprising: at least one multi-axis assembly comprising a plurality of nanopositioning stages, at least one pen assembly, wherein the pen assembly and the multi-axis assembly are adapted for delivery of material from the pen assembly to a substrate which is positioned by the multi-axis assembly, at least one viewing assembly, at least one controller. Nanopositioning by piezoelectric methods and devices and motors is particularly useful. The apparatus can include integrated environmental chambers and housings, as well as ink reservoirs for materials to be delivered. The viewing assembly can be a microscope with a long working distance. Particularly useful for fabrication of bioarrays or microarrays. The multi-axis assembly can be a five-axis assembly. Software can facilitate efficient usage.
摘要翻译：一种用于制造结构并从尖端到表面沉积材料的装置，用于以直写式模式进行图案化，提供行进宏观距离并提供纳米尺度图案化的能力。适用于小规模制造和纳米光刻。该仪器可以紧凑，并在实验台或台式机上使用。一种装置，包括：至少一个多轴组件，其包括多个纳米定位阶段，至少一个笔组件，其中所述笔组件和所述多轴组件适于将材料从所述笔组件传送到定位的衬底通过多轴组件，至少一个观察组件，至少一个控制器。通过压电方法和装置和电动机的定位是特别有用的。该设备可以包括集成的环境室和壳体，以及用于要输送的材料的油墨储存器。观察组件可以是具有长工作距离的显微镜。特别适用于制造生物芯片或微阵列。多轴组件可以是五轴组件。软件可以促进有效的使用。

3. 发明授权

US08235302B2 Identification features 有权
标题翻译：识别功能
公开(公告)号：US08235302B2
公开(公告)日：2012-08-07
申请号：US11109877
申请日：2005-04-20
申请人： Cedric Loiret-Bernal , Linette Demers , Bjoern Rosner , Michael Nelson , Ray Eby , Joseph S. Fragala , Raymond Roger Shile , Hua Zhang , John Edward Bussan , Sylvain Cruchon-Dupeyrat
发明人： Cedric Loiret-Bernal , Linette Demers , Bjoern Rosner , Michael Nelson , Ray Eby , Joseph S. Fragala , Raymond Roger Shile , Hua Zhang , John Edward Bussan , Sylvain Cruchon-Dupeyrat
IPC分类号： G06K19/06 , B30B15/34
CPC分类号： B30B15/065 , B30B15/34 , G06K19/06028
摘要： Methods for providing pharmaceutical compositions and objects with identification regions and identification features which are difficult to detect. Microlithography, nanolithography, and stamping methods are used. The identification features can be positive protrusions or negative indentations with respect to the surface. The identification regions can comprise bar codes and holograms. DPN printing or other lithographies such as electron beam lithography, optical lithography, or nanoimprint lithography can be used to prepare stamps, which are then used to prepare the identification features. Redundant patterns can be formed. The invention is useful for counterfeit prevention. An apparatus for stamping the identification features is also described.
摘要翻译：用于提供药物组合物和物体具有难以检测的识别区域和识别特征的方法。使用微光刻，纳米光刻和冲压方法。识别特征可以是相对于表面的正突起或负凹痕。识别区域可以包括条形码和全息图。可以使用DPN印刷或诸如电子束光刻，光刻或纳米压印光刻的其它平版印刷术来制备标记，然后将其用于制备识别特征。可以形成冗余图案。本发明可用于防伪。还描述了用于冲压识别特征的装置。

4. 发明申请

US20100297190A1 IDENTIFICATION FEATURES 审中-公开
标题翻译：识别功能
公开(公告)号：US20100297190A1
公开(公告)日：2010-11-25
申请号：US12536465
申请日：2009-08-05
申请人： Cedric Loiret-Bernal , Linette Demers , Bjoern Rosner , Michael Nelson , Ray Eby , Joseph S. Fragala , Raymond Roger Shile , Hua Zhang , John Edward Bussan , Sylvain Cruchon-Dupeyrat
发明人： Cedric Loiret-Bernal , Linette Demers , Bjoern Rosner , Michael Nelson , Ray Eby , Joseph S. Fragala , Raymond Roger Shile , Hua Zhang , John Edward Bussan , Sylvain Cruchon-Dupeyrat
IPC分类号： A61K9/00 , A61P43/00
CPC分类号： B30B15/065 , B30B15/34 , G06K19/06028
摘要： Methods for providing pharmaceutical compositions and objects with identification regions and identification features which are difficult to detect. Microlithography, nanolithography, and stamping methods are used. The identification features can be positive protrusions or negative indentations with respect to the surface. The identification regions can comprise bar codes and holograms. DPN printing or other lithographies such as electron beam lithography, optical lithography, or nanoimprint lithography can be used to prepare stamps, which are then used to prepare the identification features. Redundant patterns can be formed. The invention is useful for counterfeit prevention. An apparatus for stamping the identification features is also described.
摘要翻译：用于提供药物组合物和物体具有难以检测的识别区域和识别特征的方法。使用微光刻，纳米光刻和冲压方法。识别特征可以是相对于表面的正突起或负凹痕。识别区域可以包括条形码和全息图。可以使用DPN印刷或诸如电子束光刻，光刻或纳米压印光刻的其它平版印刷术来制备标记，然后将其用于制备识别特征。可以形成冗余图案。本发明可用于防伪。还描述了用于冲压识别特征的装置。

5. 发明申请

US20100294844A1 Identification features 有权
标题翻译：识别功能
公开(公告)号：US20100294844A1
公开(公告)日：2010-11-25
申请号：US11109877
申请日：2005-04-20
申请人： Cedric Loiret-Bernal , Linette Demers , Bjoern Rosner , Michael Nelson , Ray Eby , Joseph S. Fragala , Raymond Roger Shile , Hua Zhang , John Edward Bussan , Sylvain Cruchon-Dupeyrat
发明人： Cedric Loiret-Bernal , Linette Demers , Bjoern Rosner , Michael Nelson , Ray Eby , Joseph S. Fragala , Raymond Roger Shile , Hua Zhang , John Edward Bussan , Sylvain Cruchon-Dupeyrat
IPC分类号： G06K19/06 , B30B15/34
CPC分类号： B30B15/065 , B30B15/34 , G06K19/06028
摘要： Methods for providing pharmaceutical compositions and objects with identification regions and identification features which are difficult to detect. Microlithography, nanolithography, and stamping methods are used. The identification features can be positive protrusions or negative indentations with respect to the surface. The identification regions can comprise bar codes and holograms. DPN printing or other lithographies such as electron beam lithography, optical lithography, or nanoimprint lithography can be used to prepare stamps, which are then used to prepare the identification features. Redundant patterns can be formed. The invention is useful for counterfeit prevention. An apparatus for stamping the identification features is also described.
摘要翻译：用于提供药物组合物和物体具有难以检测的识别区域和识别特征的方法。使用微光刻，纳米光刻和冲压方法。识别特征可以是相对于表面的正突起或负凹痕。识别区域可以包括条形码和全息图。可以使用DPN印刷或诸如电子束光刻，光刻或纳米压印光刻的其它平版印刷术来制备标记，然后将其用于制备识别特征。可以形成冗余图案。本发明可用于防伪。还描述了用于冲压识别特征的装置。

6. 发明申请

US20110014378A1 LEVELING DEVICES AND METHODS 审中-公开
标题翻译：水平设备和方法
公开(公告)号：US20110014378A1
公开(公告)日：2011-01-20
申请号：US12838384
申请日：2010-07-16
申请人： John Edward BUSSAN , Sergey V. Rozhok , Vadim Val-Khvalabov , Joseph S. Fragala , Jason R. Haaheim , Michael R. Nelson , Edward R. Solheim , Javad M. Vakil
发明人： John Edward BUSSAN , Sergey V. Rozhok , Vadim Val-Khvalabov , Joseph S. Fragala , Jason R. Haaheim , Michael R. Nelson , Edward R. Solheim , Javad M. Vakil
IPC分类号： B05D3/12 , G01Q70/02 , G01Q70/00 , G01Q80/00 , G01Q20/02 , F16M13/00
CPC分类号： G03F7/0002 , G01Q80/00 , G03F9/7034 , G03F9/7053
摘要： Devices for leveling an object for patterning a substrate surface, including an array of scanning probe tips, are provided. A device may include a support structure adapted to mount an object, the object having a plurality of protrusions adapted to form a pattern on a surface of a substrate upon contact of the object to the surface; and at least one flexible joint assembly mounted to the support structure and adapted to allow the object to achieve a parallel orientation with respect to the surface upon contact of the object to the surface. Also provided are apparatuses and kits incorporating the devices and methods of making and using the devices and apparatuses.
摘要翻译：提供了用于调整用于图案化衬底表面的对象的设备，包括扫描探针尖端的阵列。装置可以包括适于安装物体的支撑结构，所述物体具有适于在物体与表面接触时在基底的表面上形成图案的多个突起; 以及至少一个柔性接头组件，其安装到所述支撑结构并且适于允许所述物体在所述物体与所述表面接触时相对于所述表面实现平行取向。还提供了结合设备的装置和套件以及制造和使用设备和装置的方法。

7. 发明申请

US20120295030A1 HIGH DENSITY, HARD TIP ARRAYS 审中-公开
标题翻译：高密度，硬尖端阵列
公开(公告)号：US20120295030A1
公开(公告)日：2012-11-22
申请号：US13473533
申请日：2012-05-16
申请人： Albert K. HENNING , Raymond Roger Shile , Joseph S. Fragala , Nabil A. Amro , Jason R. Haaheim
发明人： Albert K. HENNING , Raymond Roger Shile , Joseph S. Fragala , Nabil A. Amro , Jason R. Haaheim
IPC分类号： B05C1/00 , B05D5/00 , B32B37/02 , B32B37/14 , B32B38/10
CPC分类号： B81C99/009 , B82Y10/00 , B82Y40/00 , G03F7/0002 , Y10T156/10 , Y10T156/1052
摘要： Improved high density, hard tip arrays for use in patterning are provided. An article comprises a handle chip; and a silicon nitride membrane bonded to at least a portion of the handle chip. The silicon nitride membrane comprises an array of a plurality of silicon nitride tips extending directly from a surface of the silicon nitride membrane. Another article comprises an elastomeric backing member; and an array of tips disposed on the elastomeric backing member. The tips of the array comprise a refractory material. Methods of making such articles are also provided.
摘要翻译：提供了用于图案化的改进的高密度硬尖端阵列。一种制品包括手柄芯片; 以及结合到手柄芯片的至少一部分的氮化硅膜。氮化硅膜包括直接从氮化硅膜的表面延伸的多个氮化硅尖端的阵列。另一制品包括弹性体背衬构件; 以及布置在弹性体背衬构件上的尖端阵列。阵列的尖端包括耐火材料。还提供制造这种制品的方法。

8. 发明授权

US08261662B1 Active pen nanolithography 失效
标题翻译：活性笔纳米光刻
公开(公告)号：US08261662B1
公开(公告)日：2012-09-11
申请号：US11268740
申请日：2005-11-08
申请人： Raymond Roger Shile , Terrisa Duenas , John Edward Bussan , Gregory J. Athas , Joseph S. Fragala , Jason R. Haaheim , Sylvain Cruchon-Dupeyrat , Jeffrey R. Rendlen
发明人： Raymond Roger Shile , Terrisa Duenas , John Edward Bussan , Gregory J. Athas , Joseph S. Fragala , Jason R. Haaheim , Sylvain Cruchon-Dupeyrat , Jeffrey R. Rendlen
IPC分类号： H01L21/02
CPC分类号： G02B21/0008 , G02B21/002
摘要： Improved actuated probes suitable for scanning probe lithography or microscopy, and especially direct-write nanolithography and method of fabrication thereof. In one embodiment, thermomechanically actuated cantilevers with oxide-sharpened microcast tips are inexpensively fabricated by a process that comprises low-temperature wafer bonding, such as (gold) thermocompressive bonding, eutectic or adhesive bonding. Also provided is a flexcircuit that electrically interconnects the actuated probes to external circuitry and mechanically couples them to the instrument actuator. An improved scanning probe lithography instrument, hardware and software, can be built around the actuated cantilevers and the flexcircuit. Finally, provided is an improved microfluidic circuit to deliver chemical compounds to the tips of (actuated) probes and a fabrication method for tall, high-aspect-ratio tips.
摘要翻译：改进的适用于扫描探针光刻或显微镜的致动探针，特别是直写式纳米光刻及其制造方法。在一个实施例中，通过包括低温晶片接合（例如（金））热压接合，共晶或粘合粘合的方法廉价地制造具有氧化物锐化的微型天线的热机械致动悬臂。还提供了将致动的探针电连接到外部电路并将它们机械耦合到仪器致动器的挠性电路。可以围绕致动的悬臂和柔性电路构建改进的扫描探针光刻仪器，硬件和软件。最后，提供了一种改进的微流体电路，用于将化学化合物递送到（致动的）探针的尖端，以及用于高，高纵横比尖端的制造方法。

9. 发明申请

US20110274839A1 Cantilevers for deposition 审中-公开
标题翻译：用于沉积的悬臂
公开(公告)号：US20110274839A1
公开(公告)日：2011-11-10
申请号：US13064766
申请日：2011-04-13
申请人： Joseph S. Fragala , R. Roger Shile , Sergey V. Rozhok
发明人： Joseph S. Fragala , R. Roger Shile , Sergey V. Rozhok
IPC分类号： B05C5/00 , B05D1/36 , C23F1/00 , B05D5/00
CPC分类号： G03F7/0002 , B81B2203/0118 , B81C1/00031 , B81C99/0025 , B82B3/00 , B82Y10/00 , B82Y40/00 , G03F7/2049
摘要： Cantilever design for patterning from a cantilever tip can be improved with, for example, a recessed area surrounding the cantilever tip. A device for printing nanoscopic and microscopic patterns includes at least one cantilever having a front surface, a first side edge, a second side edge, and a first end which is a free end and a second end which is a non-free end. The front surface includes at least one first sidewall disposed at the first cantilever side edge and at least one second sidewall disposed at the second cantilever side edge opposing the first cantilever side edge, at least one channel, adapted to hold a fluid, disposed between the first and second sidewalls, wherein the channel, the first sidewall, and the second sidewall extend toward the cantilever free end but do not reach the free end, and a base region having a boundary defined by the first edge, the second edge, and the cantilever free end and also the first sidewall, second sidewall, and the channel, wherein the base region comprises a tip extending away from the cantilever front surface. Improved deposition can result. Fluidic inks comprising biomolecules can be patterned successfully.
摘要翻译：例如可以通过围绕悬臂尖端的凹陷区域来改善从悬臂尖端进行图案化的悬臂设计。用于印刷纳米尺度和微观图案的装置包括至少一个具有前表面，第一侧边缘，第二侧边缘以及作为自由端的第一端和作为非自由端的第二端的悬臂。前表面包括设置在第一悬臂侧边缘处的至少一个第一侧壁和设置在与第一悬臂侧边缘相对的第二悬臂侧边缘处的至少一个第二侧壁，至少一个适于保持流体的通道，第一和第二侧壁，其中，所述通道，所述第一侧壁和所述第二侧壁朝向所述悬臂自由端延伸，但是不到达所述自由端，并且具有由所述第一边缘，所述第二边缘和所述第二边缘限定的边界的基底区域悬臂自由端以及第一侧壁，第二侧壁和通道，其中基部区域包括远离悬臂前表面延伸的尖端。可以改善沉积。可以成功地构图包含生物分子的流体油墨。

10. 发明申请

US20100294146A1 Stamps with micrometer-and nanometer-scale features and methods of fabrication thereof 有权
标题翻译：具有微米和纳米尺度特征的印模及其制造方法
公开(公告)号：US20100294146A1
公开(公告)日：2010-11-25
申请号：US11305326
申请日：2005-12-19
申请人： Joseph S. Fragala , Cedric Loiret-Bernal , Hua Zhang , Raymond Roger Shile , Bjoern Rosner , Sylvain Cruchon-Dupeyrat
发明人： Joseph S. Fragala , Cedric Loiret-Bernal , Hua Zhang , Raymond Roger Shile , Bjoern Rosner , Sylvain Cruchon-Dupeyrat
IPC分类号： B44B5/02
CPC分类号： B44B5/02 , G06K1/12
摘要： Stamps and methods of making stamps for applications in anti-counterfeiting and authentication. The stamps are relatively small in size and feature nanoscale and microscale identification regions and features. High throughput manufacturing and high resolution methods are used to make the stamps including electron beam lithography and optical lithography. Anti-fouling coatings can be applied.
摘要翻译：邮票和制作邮票的方法，用于防伪和认证。邮票的尺寸相对较小，具有纳米尺度和微尺度识别区域和特征。使用高通量制造和高分辨率方法来制作邮票，包括电子束光刻和光刻。可以应用防污涂料。

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