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1. 发明授权

US06686360B2 N-benzylpiperazine compounds 失效
标题翻译： N-苄基哌嗪化合物
公开(公告)号：US06686360B2
公开(公告)日：2004-02-03
申请号：US10195948
申请日：2002-07-16
申请人： Serge Labidalle , Jean-Paul Tillement , Bernard Testa , Roméo Cecchelli , Alain Le Ridant , Catherine Harpey , Michael Spedding , Esther Schenker
发明人： Serge Labidalle , Jean-Paul Tillement , Bernard Testa , Roméo Cecchelli , Alain Le Ridant , Catherine Harpey , Michael Spedding , Esther Schenker
IPC分类号： A61K31495
CPC分类号： C07D239/42 , C07C2601/02 , C07C2601/14 , C07D295/096 , C07D295/15
摘要： The present invention relates to a compound selected from those of formula (I): wherein: R1 represents alkyl, R2 represents hydroxy, alkoxy, or amino, n represents an integer from 1 to 12 inclusive, R3 represents: hydrogen, optionally substituted alkyl, cycloalkyl, pyrimidinyl or optionally substituted phenyl, its isomers, and addition salts thereof with a pharmaceutically acceptable acid or base, medicinal products containing the same are useful in the prevention or treatment of acute and chronic cell ischaemia.
摘要翻译：本发明涉及一种选自式（I）的化合物：其中：R1代表烷基，R2代表羟基，烷氧基或氨基，n代表1至12的整数，其中R3代表氢，任意取代的烷基，环烷基，嘧啶基或任选取代的苯基，其异构体及其与药学上可接受的酸或碱的加成盐，含有它们的药物可用于预防或治疗急性和慢性细胞缺血。

2. 发明申请

US20090298813A1 USE OF NEUROPROTECTIVE COMPOUNDS IN OBTAINING MEDICAMENTS INTENDED FOR THE TREATMENT OF NEURODEGENERATING DISEASES 审中-公开
标题翻译：神经保护性化合物在获得治疗神经病变疾病药物中的应用
公开(公告)号：US20090298813A1
公开(公告)日：2009-12-03
申请号：US12448719
申请日：2008-01-04
申请人： Alain Le Ridant , Catherine Harpey
发明人： Alain Le Ridant , Catherine Harpey
IPC分类号： A61K31/4439 , A61K31/496 , A61K31/444 , A61K31/4545 , A61K31/551 , A61P25/00
CPC分类号： C07D487/06 , C07D401/12
摘要： Use of neuroprotective compounds in obtaining medicaments intended for the curative treatment of neurodegenerative disease and/or the prevention of the appearance of disorders ensuing from those diseases.
摘要翻译：使用神经保护性化合物获得用于治疗神经变性疾病的药物和/或预防由这些疾病引起的疾病的出现。

3. 发明申请

US20060063801A1 Novel 3-(4-oxo-4h-chromen-2-yl)-(1H)-quinolin-4-one derivatives, method for preparing same and pharmaceutical compositions containing same 失效
标题翻译：新的3-（4-氧代-4H-色烯-2-基） - （1H） - 喹啉-4-酮衍生物，其制备方法和含有它们的药物组合物
公开(公告)号：US20060063801A1
公开(公告)日：2006-03-23
申请号：US10519208
申请日：2003-06-18
申请人： Jean-Daniel Brion , Lucien Israel , Alain Le Ridant , Catherine Harpey , Cherif Rabhi , El Bachir Kaloun
发明人： Jean-Daniel Brion , Lucien Israel , Alain Le Ridant , Catherine Harpey , Cherif Rabhi , El Bachir Kaloun
IPC分类号： A61K31/4709 , C07D405/02
CPC分类号： C07D405/04 , C07D405/14
摘要： Compound of formula (I): wherein: R1, R2, R3, R4, R6, R8, R9 and R10, which may be the same or different, each represent a group selected from hydrogen, hydroxy, alkoxy, alkyl, arylalkoxy, alkoxycarbonylalkoxy and OR′ wherein R′ represents an ionised or ionisable group, R5 represents a group selected from alkyl, aryl and heteroaryl, R7 represents a group selected from hydrogen, hydroxy, alkoxy, alkyl and cycloalkyl, or R7 represents a nitrogen-containing or oxygen-containing heterocycle, its optical isomers, hydrates and solvates thereof and addition salts thereof, with a pharmaceutically acceptable acid or base. Medicinal products containing the same which are useful as anti-cancer agents.
摘要翻译：式（I）化合物：

4. 发明申请

US20090176794A1 1H-INDOL-1-YL-UREA COMPOUNDS 审中-公开
标题翻译： 1H-INDOL-1-YL-UREA化合物
公开(公告)号：US20090176794A1
公开(公告)日：2009-07-09
申请号：US12317904
申请日：2008-12-30
申请人： Jean-Daniel Brion , Abdallah Deyine , Alain Le Ridant , Catherine Harpey
发明人： Jean-Daniel Brion , Abdallah Deyine , Alain Le Ridant , Catherine Harpey
IPC分类号： A61K31/4439 , C07D401/02 , C07D403/02 , A61K31/454 , A61K31/506 , A61K31/501 , A61P25/28 , A61P25/16 , A61P25/22 , A61P25/24
CPC分类号： C07D401/12 , C07D209/08 , C07D403/12
摘要： Compounds of formula (I): wherein:R1 and R2, which may be the same or different, represent a hydrogen atom or a linear or branched (C1-C6)alkyl group,R3 represents a hydrogen or halogen atom, a linear or branched (C1-C6)alkyl group, or a linear or branched (C1-C6)alkoxy group,Het represents a pyridyl, pyrimidinyl or piperidyl group, which are optionally substituted by one or more groups selected from halogen, linear or branched (C1-C6)alkyl and linear or branched (C1-C6)alkoxy,—represents a single bond or a double bond,their enantiomers and diastereoisomers, and also addition salts thereof with a pharmaceutically acceptable acid or base.Medicinal products containing the same which are useful in the treatment of depression, anxiety, disorders of memory in the course of aging and/or neurodegenerative diseases, and in the palliative treatment of Parkinson's disease, and for adaptation to stress.
摘要翻译：式（I）化合物：其中：R1和R2可以相同或不同，表示氢原子或直链或支链（C1-C6）烷基，R3表示氢或卤素原子，直链或支链（C 1 -C 6）烷基，或直链或支链（C 1 -C 6）烷氧基，Het表示吡啶基，嘧啶基或哌啶基，其任选被一个或多个选自以下的基团取代：卤素，直链或支链（C1- C6）烷基和直链或支链（C1-C6）烷氧基， - 表示单键或双键，它们的对映体和非对映异构体，以及其与药学上可接受的酸或碱的加成盐。含有它们的药用产品，其可用于治疗抑郁症，焦虑症，老化和/或神经变性疾病过程中的记忆障碍，以及帕金森病的姑息治疗以及适应压力。

5. 发明授权

US07339061B2 3-(4-oxo-4H-chromen-2-yl)-(1H)-quinolin-4-one derivatives, method for preparing same and pharmaceutical compositions containing same 失效
标题翻译： 3-（4-氧代-4H-色烯-2-基） - （1H） - 喹啉-4-酮衍生物，其制备方法和含有它们的药物组合物
公开(公告)号：US07339061B2
公开(公告)日：2008-03-04
申请号：US10519208
申请日：2003-06-18
申请人： Jean-Daniel Brion , Lucien Israel , Alain Le Ridant , Catherine Harpey , Cherif Rabhi , El Bachir Kaloun
发明人： Jean-Daniel Brion , Lucien Israel , Alain Le Ridant , Catherine Harpey , Cherif Rabhi , El Bachir Kaloun
IPC分类号： C07D215/38
CPC分类号： C07D405/04 , C07D405/14
摘要： Compound of formula (I): wherein: R1, R2, R3, R4, R6, R8, R9 and R10, which may be the same or different, each represent a group selected from hydrogen, hydroxy, alkoxy, alkyl, arylalkoxy, alkoxycarbonylalkoxy and OR′ wherein R′ represents an ionised or ionisable group, R5 represents a group selected from alkyl, aryl and heteroaryl, R7 represents a group selected from hydrogen, hydroxy, alkoxy, alkyl and cycloalkyl, or R7 represents a nitrogen-containing or oxygen-containing heterocycle, its optical isomers, hydrates and solvates thereof and addition salts thereof, with a pharmaceutically acceptable acid or base. Medicinal products containing the same which are useful as anti-cancer agents.
摘要翻译：式（I）化合物：其中：R 1，R 2，R 3，R 4，R R 6，R 8，R 9和R 10可以相同或不同，各自表示选自氢，羟基，烷氧基，烷基，芳基烷氧基，烷氧基羰基烷氧基和OR'的基团，其中R'表示电离或可离子基团，R 5表示选自烷基，芳基和杂芳基的基团，R SUB > 7表示选自氢，羟基，烷氧基，烷基和环烷基的基团，或R 7表示含氮或含氧杂环，其光学异构体，水合物和溶剂合物和其加成盐与药学上可接受的酸或碱。含有该药物的药物可用作抗癌剂。

6. 发明申请

US20100105666A1 TRIAZABENZO (A)NAPHTHO(2,1,8-CDE) AZULENE COMPOUNDS. 审中-公开
标题翻译：三氮杂萘（A）萘（2,1,8-CDE）亚苄基化合物。
公开(公告)号：US20100105666A1
公开(公告)日：2010-04-29
申请号：US12448627
申请日：2008-01-04
申请人： Jean-Daniel Brion , Maud Hervet , Anne Moreau , Zafiarisoa Dolor Renko , Alain Le Ridant , Catherine Harpey
发明人： Jean-Daniel Brion , Maud Hervet , Anne Moreau , Zafiarisoa Dolor Renko , Alain Le Ridant , Catherine Harpey
IPC分类号： A61K31/551 , C07D487/22 , A61P25/22 , A61P25/16 , A61P25/24
CPC分类号： C07D471/22
摘要： Compounds of formula (I): wherein: R1 represents hydrogen, (C1-C6)alkyl, (C1-C6)aminoalkyl or (C1-C6)hydroxyalkyl, R2 represents hydrogen, or R1 and R2, together with the carbon atoms carrying them, form a carbon-carbon bond, R3 represents hydrogen, R4 represents hydrogen, methyl or (C3-C6)alkyl, (C1-C6)aminoalkyl, (C1-C6)hydroxyalkyl, aryl-(C1-C6)alkyl or heterocycloalkyl-(C1-C6)alkyl, or R3 and R4 together with the carbon atoms carrying them, form a carbon-carbon bond, R5, R6, R7 and R8 represent hydrogen, or a pair of geminal substituents (R5 and R6 and/or R7 and R8) form an oxo, thioxo or imino group, R9 represents hydrogen, halogen, (C1-C6)alkyl, (C1-C6)alkoxy, hydroxy, cyano, nitro, (C1-C6)polyhaloalkyl or optionally substituted amino, R10 and R11 represent hydrogen, halogen, (C1-C6)alkyl, (C1-C6)alkoxy, hydroxy, cyano, nitro, (C1-C6)polyhaloalkyl or optionally substituted amino, n represents an integer between 0 and 4 inclusive, m represents an integer between 0 and 2 inclusive, p represents an integer between 0 and 3 inclusive, X represents a group NR12, R12 represents hydrogen, (C1-C6)alkyl, (C2-C6)alkenyl, aryl-(C1-C6)alkyl or (C1-C6)polyhaloalkyl, their enantiomers, diastereoisomers and N-oxides, and also addition salts thereof with a pharmaceutically acceptable acid or base.
摘要翻译：式（I）化合物：其中：R1表示氢，（C1-C6）烷基，（C1-C6）氨基烷基或（C1-C6）羟基烷基，R2表示氢，或R1和R2以及携带它们的碳原子（C 1 -C 6）烷基，（C 1 -C 6）羟基烷基，芳基 - （C 1 -C 6）烷基或杂环烷基 - （C 1 -C 6）（C1-C6）烷基或R3和R4与携带它们的碳原子一起形成碳 - 碳键，R5，R6，R7和R8表示氢或一对偕取代基（R5和R6和/或R7 卤素，（C1-C6）烷基，（C1-C6）烷氧基，羟基，氰基，硝基，（C1-C6）多卤代烷基或任意取代的氨基，R10 并且R 11表示氢，卤素，（C 1 -C 6）烷基，（C 1 -C 6）烷氧基，羟基，氰基，硝基，（C 1 -C 6）多卤代烷基或任选取代的氨基，n表示0至4的整数， 0和2之间的整数，包括0和2， p表示0〜3的整数，X表示NR12，R12表示氢，（C1-C6）烷基，（C2-C6）烯基，芳基 - （C1-C6）烷基或（C1-C6）多卤代烷基，它们的对映异构体，非对映异构体和N-氧化物，以及其与药学上可接受的酸或碱的加成盐。

7. 发明申请

US20090258883A1 1H-Indole-Pyridinecarboxamide and 1H-Indole-Piperidinecarboxamide Compounds 审中-公开
标题翻译： 1H-吲哚 - 吡啶甲酰胺和1H-吲哚 - 哌啶甲酰胺化合物
公开(公告)号：US20090258883A1
公开(公告)日：2009-10-15
申请号：US11988424
申请日：2006-07-06
申请人： Jean-Daniel Brion , Fabrice Bintein , Rodolphe Razet , Patrick Razon , Zafiarisoa Dolor Renko , Eric Levoirier , Jean-Francois Pujol , Dinah Weissmann , Alain Le Ridant , Catherine Harpey
发明人： Jean-Daniel Brion , Fabrice Bintein , Rodolphe Razet , Patrick Razon , Zafiarisoa Dolor Renko , Eric Levoirier , Jean-Francois Pujol , Dinah Weissmann , Alain Le Ridant , Catherine Harpey
IPC分类号： A61K31/496 , C07D401/12 , A61K31/454 , A61P25/22 , A61P25/16 , A61P25/24 , A61P25/28 , A61K31/4439 , C07D401/14
CPC分类号： C07D401/12
摘要： Compounds of formula (I): wherein: A represents a divalent radical: wherein: Z represents an oxygen atom or a sulphur atom, R6 represents a hydrogen atom, an alkyl, alkenyl, arylalkyl or polyhaloalkyl group or a substituted, linear or branched alkyl chain, represents a single bond or a double bond, R1, R2, R3 and R4 represent a hydrogen or halogen atom, an alkyl, alkoxy, hydroxy, cyano, nitro, polyhaloalkyl or optionally substituted amino group, or a linear or branched alkyl chain substituted by one or more groups, R5 represents a hydrogen atom or an alkyl, aminoalkyl or hydroxyalkyl group, X and Y represent a hydrogen atom or an alkyl group, Ra, Rb, Rc and Rd represent a hydrogen or halogen atom, an alkyl, hydroxy, alkoxy, cyano, nitro, polyhaloalkyl, optionally substituted amino group, or a substituted, linear or branched alkyl chain, Re represents a hydrogen atom or an alkyl, arylalkyl or alkenyl group or a substituted, linear or branched alkyl chain, their enantiomers, diastereoisomers, and N-oxides, and also addition salts thereof with a pharmaceutically acceptable acid or base.
摘要翻译：式（I）化合物：其中：A表示二价基团：其中：Z表示氧原子或硫原子，R6表示氢原子，烷基，烯基，芳基烷基或多卤代烷基或取代的直链或支链烷基链接，表示单键或双键，R 1，R 2，R 3和R 4表示氢或卤素原子，烷基，烷氧基，羟基，氰基，硝基，多卤代烷基或任选取代的氨基，或直链或支链烷基链被一个或多个基团取代，R 5表示氢原子或烷基，氨基烷基或羟烷基，X和Y表示氢原子或烷基，R a，R b，R c和R d表示氢或卤素原子，烷基，羟基，烷氧基，氰基，硝基，多卤代烷基，任选取代的氨基或取代的直链或支链烷基链，表示氢原子或烷基，芳基烷基或烯基或取代的直链或支链烷基链，它们的对映异构体，非对映异构体和N-氧化物，以及其与药学上可接受的酸或碱的加成盐。

8. 发明授权

US5863925A Use of sulbutiamine in the treatment of Parkinson's disease, schizophrenia, alcoholism, and dysthymia 失效
标题翻译：使用苏木丁胺治疗帕金森病，精神分裂症，酒精中毒和精神郁闷
公开(公告)号：US5863925A
公开(公告)日：1999-01-26
申请号：US943564
申请日：1997-10-03
申请人： Helene Ollat , Alain Le Ridant , Laurent Perret
发明人： Helene Ollat , Alain Le Ridant , Laurent Perret
IPC分类号： C07D239/42 , A61K31/506 , A61K31/51 , A61P25/00 , A61P25/16 , A61P25/18 , A61P25/24 , A61P25/26
CPC分类号： A61K31/506
摘要： The invention relates to the use of sulbutiamine and pharmaceutical compositions thereof for the treatment of Parkinson's Disease, Schizophrenia, alcoholism, and dysthymia.
摘要翻译：本发明涉及舒巴坦及其药物组合物用于治疗帕金森病，精神分裂症，酒精中毒和精神抑郁症的用途。

9. 发明授权

US4765987A Artificial surfactants, pharmaceutical compositions containing them and use thereof 失效
标题翻译：人造表面活性剂，含有它们的药物组合物及其用途
公开(公告)号：US4765987A
公开(公告)日：1988-08-23
申请号：US899656
申请日：1986-08-25
申请人： Frederic Bonte , Michel Dehan , Alain Le Ridant , Francis Puisieux , Christiane C. Taupin
发明人： Frederic Bonte , Michel Dehan , Alain Le Ridant , Francis Puisieux , Christiane C. Taupin
IPC分类号： A61K31/685 , A61K9/00 , A61K9/127 , A61P11/00 , B01F17/14 , C11D1/88 , A61K37/22 , A61K9/42 , B01J13/02 , C07F9/10
CPC分类号： C11D1/886 , A61K31/685 , A61K9/0082 , A61K9/127 , Y10S436/829 , Y10S516/06 , Y10T428/2984
摘要： New artificial surfactants composed of dipalmitoylphosphatidylcholine, distearoylphosphatidylcholine and soya lecithin and pharmaceutical compositions containing them, which can be used to replace deficient endogenous pulmonary surfactant.
摘要翻译：由二棕榈酰磷脂酰胆碱，二硬脂酰磷脂酰胆碱和大豆卵磷脂组成的新型人造表面活性剂和含有它们的药物组合物，可用于代替缺乏内源性肺表面活性剂。

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