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1. 发明申请

US20080199362A1 Microfluidics Package and Method of Fabricating the Same 审中-公开
标题翻译：微流体包装及其制造方法
公开(公告)号：US20080199362A1
公开(公告)日：2008-08-21
申请号：US11816396
申请日：2005-02-15
申请人： Ser Choong Chong , Ling Xie , Hongmiao Ji , Jing Li , Yu Chen , Levent Yobas
发明人： Ser Choong Chong , Ling Xie , Hongmiao Ji , Jing Li , Yu Chen , Levent Yobas
IPC分类号： B01L3/00
CPC分类号： B81B7/0061 , B01F5/0603 , B01F13/0059 , B01L3/502707 , B01L3/502715 , B01L9/527 , B01L2200/028 , B01L2200/12 , B01L2300/0816 , B01L2300/0887 , B81B2201/051 , B81B2201/058
摘要： A microfluidics package (1) comprising a substrate (6) having a top surface, said top surface comprises at least one fluid channel (11, 12), at least one fluidic chip (2) having a top surface, a bottom surface, at least one side surface, and at least one passage to allow a fluid to traverse from the top surface or any side surface to the bottom surface of the chip; sides are adhesive, wherein the first adhesive side of the sheet (4) is secured to the substrate (6), and the at least one fluidic chip (2) is secured by the second adhesive side of the sheet (4), said fluidic chip (2) being arranged such that the at least one passage of the fluidic chip is in fluid communication with the at least one fluid channel (11, 12) of the substrate.
摘要翻译：一种微流体封装（1），包括具有顶表面的衬底（6），所述顶表面包括至少一个流体通道（11,12），至少一个流体芯片（2），其具有顶表面，底表面，至少一个侧表面和至少一个通道，以允许流体从所述芯片的顶表面或任何侧表面到所述底表面横越; 侧面是粘合剂，其中片材（4）的第一粘合剂侧固定到基底（6），并且至少一个流体碎片（2）由片材（4）的第二粘合剂侧固定，所述流体芯片（2）布置成使得流体芯片的至少一个通道与衬底的至少一个流体通道（11,12）流体连通。

2. 发明申请

US20110104817A1 INTEGRATED MICRO DEVICE, A METHOD FOR DETECTING BIOMARKERS USING THE INTEGRATED MICRO DEVICE, A METHOD FOR MANUFACTURING AN INTEGRATED MICRO DEVICE, AND AN INTEGRATED MICRO DEVICE ARRANGEMENT 审中-公开
标题翻译：集成微型器件，使用集成微型器件检测生物标记的方法，一种用于制造集成微型器件的方法和集成的微型器件布置
公开(公告)号：US20110104817A1
公开(公告)日：2011-05-05
申请号：US12907191
申请日：2010-10-19
申请人： Tae Goo Kang , Ajay Agarwal , Hongmiao Ji , Guojun Zhang , Yu Chen
发明人： Tae Goo Kang , Ajay Agarwal , Hongmiao Ji , Guojun Zhang , Yu Chen
IPC分类号： G01N1/18 , H01L21/98 , B01L3/00 , C12M1/34 , G01N33/48
CPC分类号： G01N33/54366 , B01L3/502707 , B01L3/502753 , B01L2200/10 , B01L2300/0816 , B01L2300/0819 , B01L2300/087 , B01L2300/0887 , B01L2300/0896 , B01L2300/163 , B82Y10/00 , B82Y30/00 , Y10T436/25375
摘要： Embodiments provide an integrated micro device. The integrated micro device comprises a substrate, a first microfluidic device disposed over a first surface of the substrate, a second microfluidic device disposed over a second surface of the substrate, and at least one via hole through the substrate connecting the first microfluidic device and the second microfluidic device. The second surface of the substrate is opposite to the first surface of the substrate. The first microfluidic device is monolithically integrated with the substrate, and the second microfluidic device is monolithically integrated with the substrate.
摘要翻译：实施例提供了一种集成微型装置。集成的微器件包括衬底，设置在衬底的第一表面上的第一微流体器件，设置在衬底的第二表面上的第二微流体器件，以及穿过衬底的至少一个通孔，其连接第一微流体器件和第二微流体装置。衬底的第二表面与衬底的第一表面相对。第一微流体装置与衬底单片集成，并且第二微流体装置与衬底整体地集成。

3. 发明申请

US20110129910A1 COOLING DEVICE, AND ASSEMBLY, AND METHODS FOR LOWERING TEMPERATURE IN A CHEMICAL REACTION 审中-公开
标题翻译：冷却装置和装置以及用于在化学反应中降低温度的方法
公开(公告)号：US20110129910A1
公开(公告)日：2011-06-02
申请号：US12907214
申请日：2010-10-19
申请人： Tae Goo Kang , Cheng Fang , Siow Pin Melvin Tan , Hongmiao Ji , Xiaowu Zhang , Yu Chen
发明人： Tae Goo Kang , Cheng Fang , Siow Pin Melvin Tan , Hongmiao Ji , Xiaowu Zhang , Yu Chen
IPC分类号： C12M1/00 , F25D5/00
CPC分类号： B01L7/52 , B01L9/52 , B01L2300/1805 , B01L2300/1877 , B01L2300/1894
摘要： Embodiments provide a cooling device. The cooling device comprises a container configured as a heat sink. The container is at least partially made from heat conducting material. The cooling device further comprises endothermic chemical material which is contained in the container.
摘要翻译：实施例提供一种冷却装置。冷却装置包括构造为散热器的容器。容器至少部分地由导热材料制成。冷却装置还包括容纳在容器中的吸热化学材料。

4. 发明申请

US20110117577A1 MICROFLUIDIC SYSTEM FOR TRAPPING AND DETECTION OF A BIOLOGICAL ENTITY IN A SAMPLE 审中-公开
标题翻译：用于在样品中捕获和检测生物实体的微流感系统
公开(公告)号：US20110117577A1
公开(公告)日：2011-05-19
申请号：US12908553
申请日：2010-10-20
申请人： Julien Reboud , Hongmiao Ji , Kokchuan Lee , Huimin Lim
发明人： Julien Reboud , Hongmiao Ji , Kokchuan Lee , Huimin Lim
IPC分类号： G01N33/574 , C12M1/34 , H05K13/00
CPC分类号： B03C1/0332 , B01L3/502761 , B01L2200/0668 , B01L2300/0645 , B01L2300/0883 , B01L2400/0424 , B01L2400/043 , B01L2400/0487 , B03C1/01 , B03C1/288 , B03C5/026 , B03C2201/26 , G01N15/1031 , G01N15/1056 , Y10T29/49117
摘要： According to embodiments of the present invention, a microfluidic system for detecting a biological entity in a sample volume is provided. The microfluidic system includes: an inlet configured to receive the sample volume; at least one microchannel in fluid communication with the inlet; a magnetic trapping region comprising the at least one microchannel; at least one detection region in fluid communication with the magnetic trapping region for detecting the biological entity to be detected; and at least one outlet in fluid communication with the at least one detection region.
摘要翻译：根据本发明的实施例，提供了一种用于检测样品体积中的生物实体的微流体系统。微流体系统包括：入口，被配置为接收样品体积; 至少一个与入口流体连通的微通道; 包括所述至少一个微通道的磁捕获区域; 与磁捕获区域流体连通的至少一个检测区域，用于检测待检测的生物体; 以及与所述至少一个检测区域流体连通的至少一个出口。

5. 发明申请

US20050022888A1 Microfluidics chips and methods of using same 失效
标题翻译：微流体芯片及其使用方法
公开(公告)号：US20050022888A1
公开(公告)日：2005-02-03
申请号：US10631488
申请日：2003-07-31
申请人： Victor Samper , Lin Cong , Hongmiao Ji
发明人： Victor Samper , Lin Cong , Hongmiao Ji
IPC分类号： B01L3/00 , B81C3/00 , F15C1/04
CPC分类号： B81C3/001 , B01L3/502707 , B01L2200/0689 , B01L2200/12 , B01L2200/141 , B01L2300/0887 , B01L2300/1827 , B81B2201/058 , Y10T137/2196 , Y10T156/10
摘要： Microfluidics chips and methods of use are described, comprising a pair of wafers, at least one having a patterned surface, and two polymeric barrier films between the wafers conforming to the patterned surface. The polymeric barrier films allow the wafers of the inventive microfluidics chips to be reused without cleaning.
摘要翻译：描述了微流体芯片和使用方法，包括一对晶片，至少一个具有图案化表面的晶片，以及在与图案化表面一致的晶片之间的两个聚合物阻挡膜。聚合物阻挡膜允许本发明的微流体芯片的晶片在不进行清洁的情况下重复使用。

6. 发明申请

US20080073019A1 Microfluidics Chips and Methods of Using Same 审中-公开
标题翻译：微流控芯片及其使用方法
公开(公告)号：US20080073019A1
公开(公告)日：2008-03-27
申请号：US11945393
申请日：2007-11-27
申请人： Victor Samper , Lin Cong , Hongmiao Ji
发明人： Victor Samper , Lin Cong , Hongmiao Ji
IPC分类号： B29C65/00
CPC分类号： B81C3/001 , B01L3/502707 , B01L2200/0689 , B01L2200/12 , B01L2200/141 , B01L2300/0887 , B01L2300/1827 , B81B2201/058 , Y10T137/2196 , Y10T156/10
摘要： Microfluidics chips and methods of use are described, comprising a pair of wafers, at least one having a patterned surface, and two polymeric barrier films between the wafers conforming to the patterned surface. The polymeric barrier films allow the wafers of the inventive microfluidics chips to be reused without cleaning.
摘要翻译：描述了微流体芯片和使用方法，包括一对晶片，至少一个具有图案化表面的晶片，以及在与图案化表面一致的晶片之间的两个聚合物阻挡膜。聚合物阻挡膜允许本发明的微流体芯片的晶片在不进行清洁的情况下重复使用。

7. 发明授权

US07160025B2 Micromixer apparatus and methods of using same 有权
标题翻译：微混合器装置及其使用方法
公开(公告)号：US07160025B2
公开(公告)日：2007-01-09
申请号：US10459200
申请日：2003-06-11
申请人： Hongmiao Ji , Victor Samper
发明人： Hongmiao Ji , Victor Samper
IPC分类号： B01F5/00 , B81B1/00
CPC分类号： B01F13/0059 , B01F5/0646 , B01F5/0647 , B01F2215/0431 , B01F2215/0495 , B01J19/0093 , B01J2219/00783 , B01J2219/00819 , B01J2219/00835 , B01J2219/00889 , B01J2219/00952 , B01J2219/00984 , B01J2219/00995 , B01L3/5027 , Y10S366/03
摘要： Microfluidics mixing apparatus and methods of using same are disclosed for mixing fluids using increasing centrifugal force as the fluids being mixed traverse a mixing channel. One inventive apparatus comprises a generally planar substrate having a top major surface and a bottom major surface generally parallel to the top major surface, and a cover plate over the top major surface. The substrate has at least one inlet port that routes fluid to the top major surface, and at least one outlet port for mixed fluid. The substrate comprises a mixing channel having a depth measured from the top surface and a width, the mixing channel adapted to route fluids to be mixed therein in laminar flow and in a substantially spiral flow pattern that is parallel to the top surface. Apparatus of the invention can mix fluids flowing serially, or two or more fluids entering the device from different feed channels.
摘要翻译：公开了微流体混合装置及其使用方法，用于当混合的流体穿过混合通道时，使用增加的离心力混合流体。一种本发明的装置包括具有大体上平行于顶部主表面的顶部主表面和底部主表面的大致平面的基底，以及在顶部主表面上的盖板。衬底具有至少一个将流体输送到顶部主表面的入口端口和用于混合流体的至少一个出口端口。衬底包括具有从顶表面测量的深度和宽度的混合通道，混合通道适于在层流中引导待混合的流体并且以与顶表面平行的基本上螺旋形的流动图案。本发明的装置可以混合串联流动的流体，或混合从不同进料通道进入装置的两种或更多种流体。

8. 发明授权

US07357898B2 Microfluidics packages and methods of using same 失效
标题翻译：微流体包装及其使用方法
公开(公告)号：US07357898B2
公开(公告)日：2008-04-15
申请号：US10631478
申请日：2003-07-31
申请人： Victor Samper , Lin Cong , Hongmiao Ji
发明人： Victor Samper , Lin Cong , Hongmiao Ji
IPC分类号： G01N1/10 , G01N27/00
CPC分类号： B01L3/502707 , B01L7/52 , B01L2200/0689 , B01L2200/141 , B01L2300/0816 , B01L2300/0887 , B01L2300/123 , B01L2400/0655 , Y10T436/2575
摘要： Microfluidics packages and methods of use are described, comprising in one embodiment a substrate having a top surface and means to lower pressure on the top surface; a fluidics card having a bottom surface and means to allow fluids to traverse through the card; and a polymeric barrier film, the polymeric barrier film positioned between the top surface of the substrate and the bottom surface of the fluidics card.
摘要翻译：描述了微流体包装和使用方法，在一个实施方案中包括具有顶表面的基材和在顶表面上降低压力的装置; 具有底表面的流体卡和允许流体穿过卡的装置; 和聚合物阻挡膜，聚合物阻挡膜定位在基底的顶表面和流体卡的底表面之间。

9. 发明申请

US20060087918A1 Micromixer apparatus and methods of using same 审中-公开
标题翻译：微混合器装置及其使用方法
公开(公告)号：US20060087918A1
公开(公告)日：2006-04-27
申请号：US11301386
申请日：2005-12-13
申请人： Hongmiao Ji , Victor Samper
发明人： Hongmiao Ji , Victor Samper
IPC分类号： B01F5/00 , B81B1/00
CPC分类号： B01F13/0059 , B01F5/0646 , B01F5/0647 , B01F2215/0431 , B01F2215/0495 , B01J19/0093 , B01J2219/00783 , B01J2219/00819 , B01J2219/00835 , B01J2219/00889 , B01J2219/00952 , B01J2219/00984 , B01J2219/00995 , B01L3/5027 , Y10S366/03
摘要： Microfluidics mixing apparatus and methods of using same are disclosed for mixing fluids using increasing centrifugal force as the fluids being mixed traverse a mixing channel. One inventive apparatus comprises a generally planar substrate having a top major surface and a bottom major surface generally parallel to the top major surface, and a cover plate over the top major surface. The substrate has at least one inlet port that routes fluid to the top major surface, and at least one outlet port for mixed fluid. The substrate comprises a mixing channel having a depth measured from the top surface and a width, the mixing channel adapted to route fluids to be mixed therein in laminar flow and in a substantially spiral flow pattern that is parallel to the top surface. Apparatus of the invention can mix fluids flowing serially, or two or more fluids entering the device from different feed channels.
摘要翻译：公开了微流体混合装置及其使用方法，用于当混合的流体穿过混合通道时，使用增加的离心力混合流体。一种本发明的装置包括具有大体上平行于顶部主表面的顶部主表面和底部主表面的大致平面的基底，以及在顶部主表面上的盖板。衬底具有至少一个将流体输送到顶部主表面的入口端口和用于混合流体的至少一个出口端口。衬底包括具有从顶表面测量的深度和宽度的混合通道，混合通道适于在层流中引导待混合的流体并且以与顶表面平行的基本上螺旋形的流动图案。本发明的装置可以混合串联流动的流体，或混合从不同进料通道进入装置的两种或更多种流体。

10. 发明申请

US20100300978A1 DEVICE, SYSTEM AND METHOD FOR WASHING AND ISOLATING MAGNETIC PARTICLES IN A CONTINOUS FLUID FLOW 审中-公开
标题翻译：用于在连续流体流中洗涤和分离磁性颗粒的装置，系统和方法
公开(公告)号：US20100300978A1
公开(公告)日：2010-12-02
申请号：US12679013
申请日：2007-09-19
申请人： Qasem Ramadan , Liang Zhu , Hongmiao Ji , Wen-Tso Liu
发明人： Qasem Ramadan , Liang Zhu , Hongmiao Ji , Wen-Tso Liu
IPC分类号： B03C1/02
CPC分类号： G01N33/54326 , B01L9/52 , B01L13/00 , B03C1/0332 , B03C1/288 , B03C2201/18
摘要： A device for washing and isolating magnetic particles from a continuous fluid flow in at least one fluidic channel having an inlet at one end and an outlet at another end, said device comprising at least one magnetic source carrier arranged proximate to the at least one fluidic channel. The at least one magnetic source carrier is moveable between a first position and a second position. The at least one magnetic source carrier comprises at least one first magnetic source, wherein a movement of the at least one magnetic source carrier to the first position places the at least one first magnetic source at a first spatial location along the at least one fluidic channel such that said at least one first magnetic source generates a maxima magnetic field at said first spatial location that attracts the magnetic particles from the continuous fluid flow and assembles said magnetic particles at said first spatial location. A movement of the at least one magnetic source carrier to the second position places the at least one first magnetic source distal from the first spatial location such that said magnetic field at said first spatial location is at a minima and the magnetic particles disperse from said first spatial location.
摘要翻译：一种用于在至少一个具有一端的入口和另一端的出口的流体通道中从连续的流体流中洗涤和分离磁性颗粒的装置，所述装置包括至少一个靠近所述至少一个流体通道布置的磁源载体。所述至少一个磁源载体可在第一位置和第二位置之间移动。所述至少一个磁源载体包括至少一个第一磁源，其中所述至少一个磁源载体到所述第一位置的移动将所述至少一个第一磁源置于沿所述至少一个流体通道的第一空间位置使得所述至少一个第一磁源在所述第一空间位置产生最大磁场，其吸引来自连续流体流的磁性颗粒，并在所述第一空间位置组装所述磁性颗粒。至少一个磁源载体到第二位置的移动将至少一个第一磁源远离第一空间位置放置，使得所述第一空间位置处的所述磁场处于最小值，并且磁性颗粒从所述第一空间位置分散空间位置。

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