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1. 发明授权

US09034850B2 Gonadotropin releasing hormone receptor antagonist, preparation method thereof and pharmaceutical composition comprising the same 有权
标题翻译：促性腺激素释放激素受体拮抗剂，其制备方法和包含其的药物组合物
公开(公告)号：US09034850B2
公开(公告)日：2015-05-19
申请号：US13511065
申请日：2010-11-19
申请人： Seon Mi Kim , Min Hee Lee , Jae Sun Kim , Hoe Chul Jung , So Young Lee , Soo Min Lee , Eun Jeong Kim , Eui Sun Park , Sung Hoon Park , Bong Yong Lee , Key An Um
发明人： Seon Mi Kim , Min Hee Lee , Jae Sun Kim , Hoe Chul Jung , So Young Lee , Soo Min Lee , Eun Jeong Kim , Eui Sun Park , Sung Hoon Park , Bong Yong Lee , Key An Um
IPC分类号： A01N57/00 , C07D239/545 , A61K31/506 , C07D239/46 , C07D401/04 , C07D403/04 , C07D405/14 , C07D213/74 , C07D253/075 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D487/04 , C07D491/048 , C07F9/6558
CPC分类号： C07D239/545 , A61K31/506 , C07D213/74 , C07D239/46 , C07D253/075 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D487/04 , C07D491/048 , C07F9/65583 , C07F9/65586
摘要： Disclosed are compounds useful as gonadotrophin-releasing hormone (“GnRH”) receptor antagonist.
摘要翻译：公开了可用作促性腺激素释放激素（“GnRH”）受体拮抗剂的化合物。

2. 发明申请

US20130137661A1 Gonadotropin Releasing Hormone Receptor Antagonist, Preparation Method Thereof And Pharmaceutical Composition Comprising The Same 有权
标题翻译：促性腺激素释放激素受体拮抗剂，其制备方法和药物组合物组成
公开(公告)号：US20130137661A1
公开(公告)日：2013-05-30
申请号：US13511065
申请日：2010-11-19
申请人： Seon Mi Kim , Min Hee Lee , Jae Sun Kim , Hoe Chul Jung , So Young Lee , Soo Min Lee , Eun Jeong Kim , Eui Sun Park , Sung Hoon Park , Bong Yong Lee , Key An Um
发明人： Seon Mi Kim , Min Hee Lee , Jae Sun Kim , Hoe Chul Jung , So Young Lee , Soo Min Lee , Eun Jeong Kim , Eui Sun Park , Sung Hoon Park , Bong Yong Lee , Key An Um
IPC分类号： C07D239/545 , C07D405/12 , C07D401/04 , C07D403/04 , C07D401/14 , C07D491/048 , C07D253/075 , C07D213/74 , C07D413/12 , C07D409/12 , C07D417/12 , C07D403/12 , C07D487/04 , C07D405/14 , C07D409/14 , C07F9/6558 , C07D403/06 , C07D401/12
CPC分类号： C07D239/545 , A61K31/506 , C07D213/74 , C07D239/46 , C07D253/075 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D487/04 , C07D491/048 , C07F9/65583 , C07F9/65586
摘要： Disclosed are compounds useful as gonadotrophin-releasing hormone (“GnRH”) receptor antagonist.
摘要翻译：公开了可用作促性腺激素释放激素（“GnRH”）受体拮抗剂的化合物。

3. 发明授权

US07723376B2 2-oxo-heterocyclic compounds and pharmaceutical compositions 失效
标题翻译： 2-氧杂环化合物和药物组合物
公开(公告)号：US07723376B2
公开(公告)日：2010-05-25
申请号：US10564653
申请日：2004-07-15
申请人： Hwan Mook Kim , Gyoon Hee Han , Song Kyu Park , Chang Woo Lee , Sang Bae Han , Ki Hoon Lee , Yung Hee Kho , Jin Hyuk Yang , Bum Woo Park , Hyang Woo Lee , Jeung Whan Han , Dong Kyu Ryu , Jin Ha Lee , Tae Gyu Chun , Yong Kee Kim , Hee Yoon Lee , Bong Yong Lee , Jeom Yong Kim , Ji Duck Kim , Kyunga Yu , Sun Young Kim
发明人： Hwan Mook Kim , Gyoon Hee Han , Song Kyu Park , Chang Woo Lee , Sang Bae Han , Ki Hoon Lee , Yung Hee Kho , Jin Hyuk Yang , Bum Woo Park , Hyang Woo Lee , Jeung Whan Han , Dong Kyu Ryu , Jin Ha Lee , Tae Gyu Chun , Yong Kee Kim , Hee Yoon Lee , Bong Yong Lee , Jeom Yong Kim , Ji Duck Kim , Kyunga Yu , Sun Young Kim
IPC分类号： A01N43/36
CPC分类号： A61K31/454 , A61K31/4015 , A61K31/4545 , C07D207/38 , C07D211/86 , C07D223/10 , C07D417/06
摘要： The present invention is related to novel use of 2-oxo-heterocyclic compounds having anticancer activity and the process for preparing them and a pharmaceutical composition comprising the same. The present invention provides a pharmaceutical composition for preventing and treating the cancer disease comprising lung cancer, bone cancer, pancreatic cancer, skin cancer, cancer of the head and neck, cutaneous or intraocular melanoma, uterine cancer, ovarian cancer, rectal cancer or cancer of the anal region, stomach cancer, colon cancer, breast cancer, gynecologic tumors, Hodgkin's disease, cancer of the esophagus, cancer of the small intestine, cancer of the endocrine system, sarcomas of soft tissues, cancer of the urethra, cancer of the penis, prostate cancer, chronic or acute leukemia, solid tumors of childhood, lymphocytic lymphonas, cancer of the bladder, cancer of the kidney or ureter, or neoplasms of the central nervous system, therefore, it can be used as the therapeutics for treating and preventing cancer diseases.
摘要翻译：本发明涉及具有抗癌活性的2-氧代杂环化合物及其制备方法的新用途以及包含其的药物组合物。本发明提供了用于预防和治疗包括肺癌，骨癌，胰腺癌，皮肤癌，头颈癌，皮肤或眼内黑素瘤，子宫癌，卵巢癌，直肠癌或癌症的癌症疾病的药物组合物肛门区域，胃癌，结肠癌，乳腺癌，妇科肿瘤，霍奇金病，食道癌，小肠癌，内分泌系统癌，软组织肉瘤，尿道癌，阴茎癌，前列腺癌，慢性或急性白血病，儿童实体瘤，淋巴细胞淋巴管，膀胱癌，肾或输尿管癌，或中枢神经系统肿瘤，因此可用作治疗和预防的治疗剂癌症疾病

4. 发明申请

US20110216602A1 FLASH MEMORY DEVICES WITH SELECTIVE BIT LINE DISCHARGE PATHS AND METHODS OF OPERATING THE SAME 有权
标题翻译：具有选择位线排放板的闪存存储器件及其操作方法
公开(公告)号：US20110216602A1
公开(公告)日：2011-09-08
申请号：US12813050
申请日：2010-06-10
申请人： Euido Kim , Bong Yong Lee , Haebum Lee , Sang-Youl Kwon , Jin-Young Kim , Hye Yeon Yun , Houng-kuk Jang
发明人： Euido Kim , Bong Yong Lee , Haebum Lee , Sang-Youl Kwon , Jin-Young Kim , Hye Yeon Yun , Houng-kuk Jang
IPC分类号： G11C16/06
CPC分类号： G11C16/06
摘要： Provided is a flash memory device that can include a memory cell configured to store data, a local bit line that is connected to the memory cell, a global bit line that is connected to the local bit line, a discharge transistor that is connected to the global bit line, and that is configured to selectively connect the global bit line to a reference level responsive to a discharge control signal, and a discharge control circuit, that is connected to the discharge transistor via the discharge control signal, and that is configured to selectively disable the discharge transistor during an erase interval occurring before a verify interval of an erase verification operation carried out by the flash memory device.
摘要翻译：提供了一种闪存器件，其可以包括被配置为存储数据的存储器单元，连接到存储单元的局部位线，连接到本地位线的全局位线，连接到本地位线的放电晶体管全局位线，并且被配置为响应于放电控制信号选择性地将全局位线连接到参考电平;以及放电控制电路，其通过放电控制信号连接到放电晶体管，并且被配置为在由闪速存储器件执行的擦除验证操作的验证间隔之前的擦除间隔期间，选择性地禁用放电晶体管。

5. 发明授权

US06545008B1 Pyrimidine derivatives and processes for the preparation thereof 失效
标题翻译：嘧啶衍生物及其制备方法
公开(公告)号：US06545008B1
公开(公告)日：2003-04-08
申请号：US09856048
申请日：2001-05-17
申请人： Jong Wook Lee , Bong Yong Lee , Chang Seop Kim , Seung Kyu Lee , Song Jin Lee
发明人： Jong Wook Lee , Bong Yong Lee , Chang Seop Kim , Seung Kyu Lee , Song Jin Lee
IPC分类号： C07D40104
CPC分类号： C07D401/04
摘要： The present invention relates to novel pyrimidine derivatives and pharmaceutically acceptable non-toxic salts thereof which possess an excellent inhibitory activity against gastric acid secretion, a pharmaceutical composition containing the same as an active ingredient, and a process for the preparation thereof.
摘要翻译：本发明涉及对胃酸分泌具有优异抑制活性的新型嘧啶衍生物及其药学上可接受的无毒性盐，其含有活性成分的药物组合物及其制备方法。

6. 发明授权

US07811786B1 Preparation method for the production of active and soluble proteins in prokaryotes and polycistronic vectors therefor 有权
标题翻译：用于在原核生物和多顺反子载体中生产活性和可溶性蛋白质的制备方法
公开(公告)号：US07811786B1
公开(公告)日：2010-10-12
申请号：US11579753
申请日：2004-06-11
申请人： Bong Yong Lee , Seung Kook Park , Shin Hye Park , Oh Byung Kwon , Chae Ha Yoon , Young Ju Kim , Song Young Kim , Kyung Hyun Min , Yoon Seok Lee , Tae Hee Lee , Tai Young Koo
发明人： Bong Yong Lee , Seung Kook Park , Shin Hye Park , Oh Byung Kwon , Chae Ha Yoon , Young Ju Kim , Song Young Kim , Kyung Hyun Min , Yoon Seok Lee , Tae Hee Lee , Tai Young Koo
IPC分类号： C12N15/00 , C12N1/20 , C12P21/06
CPC分类号： C12P21/02 , C12N15/70
摘要： Disclosed are a method of producing a target protein in a biologically-active, soluble form in prokaryotic cells and polycistronic vectors therefor.
摘要翻译：公开了在原核细胞和多顺反子载体中生产生物活性的可溶形式的靶蛋白的方法。

7. 发明授权

US07342027B2 1-phenylpiperidin-3-one derivatives and processes for the preparation thereof 失效
标题翻译： 1-苯基哌啶-3-酮衍生物及其制备方法
公开(公告)号：US07342027B2
公开(公告)日：2008-03-11
申请号：US10521752
申请日：2003-07-26
申请人： Jong Wook Lee , Bong Yong Lee , Chun Ho Lee , Yun Hur , Tae Dong Han , Hyun Kyoung Ko , Suk Won Yun , Jae Young Shim , Joong In Lim , Moon Ho Son , Jae Sung Yang , Mi Kyung Kim
发明人： Jong Wook Lee , Bong Yong Lee , Chun Ho Lee , Yun Hur , Tae Dong Han , Hyun Kyoung Ko , Suk Won Yun , Jae Young Shim , Joong In Lim , Moon Ho Son , Jae Sung Yang , Mi Kyung Kim
IPC分类号： A61K31/445 , C07D451/12 , C07D401/04
CPC分类号： C07D401/12 , C07D211/62 , C07D211/74 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/14 , C07D417/14
摘要： Provided are 1-phenylpiperidin-3-one derivatives and pharmaceutically acceptable salts thereof, having cysteine protease inhibitory activity, pharmaceutical compositions containing the same as an active ingredient, and processes for the preparation thereof.
摘要翻译：本发明提供了具有半胱氨酸蛋白酶抑制活性的1-苯基哌啶-3-酮衍生物及其药学上可接受的盐，其含有活性成分的药物组合物及其制备方法。

8. 发明授权

US06352993B1 Pyrimidine derivatives and processes for the preparation thereof 失效
标题翻译：嘧啶衍生物及其制备方法
公开(公告)号：US06352993B1
公开(公告)日：2002-03-05
申请号：US09381814
申请日：1999-09-24
申请人： Jong Wook Lee , Bong Yong Lee , Chang Seop Kim , Seung Kyu Lee , Keun Seog Song , Song Jin Lee , Woo Jeon Shim , Man Soon Hwang
发明人： Jong Wook Lee , Bong Yong Lee , Chang Seop Kim , Seung Kyu Lee , Keun Seog Song , Song Jin Lee , Woo Jeon Shim , Man Soon Hwang
IPC分类号： C07D40104
CPC分类号： C07D401/04 , C07D401/14 , C07D417/14
摘要： The present invention relates to novel pyrimidine derivatives of formula (I) or pharmaceutically acceptable salts thereof which possess an excellent anti-secretory activity, pharmaceutical compositions containing the same as an active ingredient, their novel intermediates, and processes for the preparation thereof wherein: when A is piperidin-1-yl or —NH—B, wherein B is C3-C4 alkyl, C3-C4 alkenyl, C3-C7 cycloalkyl, C1-C3 alkoxyethyl, phenylethl which may be substituted or unsubstituted, 3-trifluoromethylphenylmethyl, 1-naphthylmethyl, 4-methylthiazol-2-yl or 4-phenylthiazol-2-yl, R1 is hydrogen or methyl; and R2, R3, R4 and R5 are hydrogen; or when A is a group of formula (II); when R1 is hydroxymethyl or C1-C3 alkoxymethyl, R2, R3, R4, R5 and R6 are hydrogen; and R7 is hydrogen or halogen; or when R1 is hydrogen or methyl, R7 is hydrogen or halogen; and one or two of R2, R3, R4, R5 and R6 is hydroxy, methoxy, or a group of formula (III) wherein Z is C1-C4 alkyl, substituted or unsubstituted C1-C4 alkenyl, cyloalkyl, benzyloxyalkyl, alkoxycarbonylalkyl, morpholinomethyl, piperidinomethyl, 4-substituted-piperazinomethyl, substituted or unsubstituted phenyl, naphthyl, substituted or unsubstituted benzyl, thiophen-2-yl-methyl, 1-substituted-pyrrolidin-2-yl or —CHR8NHR9, wherein R8 is hydrogen, methyl, isopropyl, benzyl, benzyloxymethyl, methylthioethyl, benzyloxycarbonylmethyl, carbamolymethyl, carbamoylethyl, or 1-benzylimidazol-4-ylmethyl and R9 is hydrogen or t-butoxycarbonyl; and the others are hydrogen or methyl.
摘要翻译：本发明涉及具有优异抗分泌活性的式（I）的新颖的嘧啶衍生物或其药学上可接受的盐，其含有与活性成分相同的药物组合物，其新颖的中间体及其制备方法，其中： A是哌啶-1-基或-NH-B，其中B是C 3 -C 4烷基，C 3 -C 4烯基，C 3 -C 7环烷基，C 1 -C 3烷氧基乙基，可以被取代或未取代的苯乙基，3-三氟甲基苯基甲基，萘基甲基，4-甲基噻唑-2-基或4-苯基噻唑-2-基，R 1是氢或甲基; R2，R3，R4和R5是氢; 或当A为式（II）的基团时; 当R 1是羟甲基或C 1 -C 3烷氧基甲基时，R 2，R 3，R 4，R 5和R 6是氢; 并且R 7是氢或卤素; 或当R 1为氢或甲基时，R 7为氢或卤素; R 2，R 3，R 4，R 5和R 6中的一个或两个是羟基，甲氧基或其中Z是C 1 -C 4烷基，取代或未取代的C 1 -C 4烯基，环烷基，苄氧基烷基，烷氧基羰基烷基，吗啉代甲基，哌啶基甲基，4-取代的哌嗪基甲基，取代或未取代的苯基，萘基，取代或未取代的苄基，噻吩-2-基 - 甲基，1-取代的吡咯烷-2-基或-CHR8NHR9，其中R8是氢，甲基，苄基，苄氧基甲基，甲硫基乙基，苄氧基羰基甲基，氨基甲酰基，氨基甲酰基乙基或1-苄基咪唑-4-基甲基，R9为氢或叔丁氧基羰基; 其他的是氢或甲基。

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