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1. 发明专利

JP2004330188A Aerator with function of swirling, aeration and intermittent aeration, and advanced sewage treating method using the same 审中-公开
标题翻译：具有SWIRLING，AERATION和INTERMITTENT AERATION功能的AERATOR，以及使用该方法的高级地下水处理方法
公开(公告)号：JP2004330188A
公开(公告)日：2004-11-25
申请号：JP2004136174
申请日：2004-04-30
申请人： Sang Bae Han , 相培韓
发明人： HAN SANG BAE
IPC分类号： B01D53/38 , B01D19/02 , B01D53/77 , B01F3/04 , C02F1/74 , C02F3/02 , C02F3/14 , C02F3/20 , C02F3/22 , C02F3/30 , C02F3/34
CPC分类号： Y02A50/2358 , Y02W10/15
摘要： PROBLEM TO BE SOLVED: To provide an aerator used for sewage treatment, or the like, and an advanced sewage treating method using the same. SOLUTION: The aerator provided with functions of swirling, aeration and intermittent aeration is constituted of a stirrer 3a which is installed in deep depth of water in a reaction tank, an ejector 1 which is equipped with an air supply tube 11 and is installed in shallow depth of water, a pump 4 having a suction port and an jetting port and an aeration stream guiding pipe 2. In the aerator, air inhaled by using the ejector 1 is forcibly fed by the pump 4 through the aeration stream guiding pipe 2 to deep depth of water to increase amount of air inhalation, is jetted while colliding with rotary vanes of the stirrer 3a to perform aeration and agitation in the reaction tank. Thus, the aerator is equipped with an intermittent aeration function which enables alternate repetition between aeration and non-aeration swirling to be performed. In the advanced sewage treating method, an aerator of a conventional system and this aerator are applied in an advanced sewage treating process, thus various operation modes can be selected and are variably operated. Thereby variation of operation conditions can be coped with and nitrogen and phosphor can be removed with high efficiencies from the sewage of a low inflow C/N ratio. COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：提供用于污水处理的曝气机等，以及使用该曝气机的先进的污水处理方法。解决方案：具有旋转，曝气和间歇曝气功能的曝气器由安装在反应罐中的深深水中的搅拌器3a，装有供气管11的喷射器1构成安装在浅水深处，具有吸入口和喷射口的泵4和曝气流引导管2.在曝气器中，通过使用喷射器1吸入的空气被泵4强制地通过曝气流引导管 2到深深的水以增加空气吸入量，同时与搅拌器3a的旋转叶片碰撞而喷射，以在反应罐中进行曝气和搅拌。因此，曝气器配备有间歇曝气功能，其能够进行曝气和非曝气旋转之间的交替重复。在先进的污水处理方法中，常规系统的曝气器和这种曝气器应用于先进的污水处理工艺中，因此可以选择和可变的操作各种操作模式。从而可以应对来自低流入C / N比的污水的高效率的氮和磷的操作条件的变化。版权所有（C）2005，JPO＆NCIPI

2. 发明专利

JP2005059002A Submerged aerator with multi-step mixing and dispersing function 审中-公开
标题翻译：具有多级混合和分散功能的分体式空调机
公开(公告)号：JP2005059002A
公开(公告)日：2005-03-10
申请号：JP2004229867
申请日：2004-08-05
申请人： Sang Bae Han , 相培韓
发明人： HAN SANG BAE
IPC分类号： A01K63/04 , A01K61/00 , B01F1/00 , B01F3/04 , B01F7/16 , C02F3/08 , C02F3/16 , C02F3/20
CPC分类号： Y02A40/81 , Y02W10/15
摘要： PROBLEM TO BE SOLVED: To provide a submerged aerator with multi-step mixing and dispersing function having a high oxygen transfer ratio and an excellent aeration power efficiency. SOLUTION: This submerged aerator with the multi-step mixing and dispersing function is composed of an ejector equipped with a water stream inlet 11, an air suction port 12 and a gas-liquid mixed water stream outlet and a casing 3 equipped with a drive motor 4, a rotation vane 2 and an aeration water stream outlet 31. Therein, reaction liquid flowing into the water stream inlet 11 of the ejector by the rotation of the rotation vane 2 and supplied air are subjected to primary mixing dispersion by the ejector. The gas-liquid mixed water stream flowing out of the ejector is sucked into the casing 3, is brought into collision with the rotation vane 2 and is subjected to secondary mixing dispersion. The aeration water stream subjected to the secondary mixing dispersion is injected to the reaction vessel through the aeration water stream outlet 31 of the casing 3, thereafter, is subjected to further mixing dispersions of two times by means of the ejector and the rotation vane 2, and through the prolonging of gas-liquid contact time and the reclamation of gas-liquid contact interface, the oxygen transsibility is enhanced. COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：提供具有高氧传输比和优异曝气功率效率的多级混合分散功能的浸没式曝气机。解决方案：具有多步混合分散功能的这种浸没式曝气器由装有水流入口11，空气吸入口12和气液混合水流出口的喷射器和装有驱动电动机4，旋转叶片2和曝气水流出口31.其中，通过旋转叶片2的旋转和供给的空气流入喷射器的水流入口11的反应液体通过喷射器。从喷射器流出的气液混合水流被吸入壳体3，与旋转叶片2碰撞，进行二次混合分散。经过二次混合分散体的曝气水流通过壳体3的曝气水流出口31注入反应容器中，然后通过喷射器和旋转叶片2进一步混合分散两次，通过气液接触时间的延长和气 - 液接触界面的回收，提高了氧气的可转换性。版权所有（C）2005，JPO＆NCIPI

3. 发明专利

JP2004275176A Biomembrane carrier improved in specific surface area, biological affinity, and fluidity 审中-公开
公开(公告)号：JP2004275176A
公开(公告)日：2004-10-07
申请号：JP2003295503
申请日：2003-08-19
申请人： Sang Bae Han , 相培韓
发明人： HAN SANG BAE
IPC分类号： C12N11/02 , C02F3/10 , C12M1/14
CPC分类号： Y02W10/15
摘要： PROBLEM TO BE SOLVED: To provide a biomembrane carrier capable of being filled into a microorganism culture tank which is used in producing a food or a pharmaceutical or treating sewage/waste water therefrom. SOLUTION: The biomembrane carrier for a liquid phase is formed by inserting a microorganism-contacting material into a firm synthetic resin case, wherein the microorganism-contacting material comprises a fibrous or sponge-like material and is formed by covering its surface with powdered ceramic, adhering granulated ceramic to the surface or mixing the granulated ceramic into its inside, so that a specific surface area and biological affinity of the microorganism-contacting material is increased, and further, a specific gravity of the carrier is controlled, and fluidity thereof is excellent. Further, another biomembrane carrier for a solid phase is structured by inserting the material comprising the ceramic into a case having a fixation means and an installation means and fixing the material thereto, so that the carrier is easily applied to a reactor. These carriers are used in various manners other than the use of the biomembrane carriers, e.g., used as a filling material of a wash-column, or the like, for treating a noxious gas. COPYRIGHT: (C)2005,JPO&NCIPI

4. 发明专利

JP2004042040A Red tide control method 审中-公开
公开(公告)号：JP2004042040A
公开(公告)日：2004-02-12
申请号：JP2003179350
申请日：2003-06-24
申请人： Sang Bae Han , 韓相培
发明人： HAN SANG BAE
IPC分类号： A01K63/00 , A01K63/04 , B64D1/18 , C02F1/50 , C02F1/72
摘要： PROBLEM TO BE SOLVED: To provide a red tide control method capable of easily and simply exterminating red tide microorganisms and obstructing the growth thereof by minimizing the disturbance of the ocean ecology world.
SOLUTION: The red tide is controlled by spraying hydrogen peroxide water (H
2 O
2 ) to a water area and red tide zone of the ocean where the red tide microorganisms are densely proliferated and by exterminating the red tide microorganisms and obstructing the growth thereof by the oxidizing power of the hydrogen peroxide water. The means of spraying the hydrogen peroxide water to the red tide comprises mounting a water spraying machine composed of pipes provided with many nozzles on a transporting means, such as a ship or aircraft, spraying the hydrogen peroxide water into the water on the seawater surface or under the seawater surface by means of a pump, spraying the diluted hydrogen peroxide water mixed with the seawater to increase the flow rate of spraying of the hydrogen peroxide water in such a manner that the mixing and contact of the red tide microorganisms and the hydrogen peroxide are well performed, and spraying the hydrogen peroxide water together with a bivalent iron salt (Fe
++ ) to the red tide water area by a catalyst agent to increase oxidation reduction potential in order to increase the oxidizing power acting on the red tide microorganisms.
COPYRIGHT: (C)2004,JPO

5. 发明授权

US08975241B2 Composition for treating and preventing obesity including high water-soluble 2-hydroxypropyl-betacyclodextrin as effective component 有权
标题翻译：用于治疗和预防肥胖症的组合物，包括高水溶性2-羟丙基 - betacycextextrin作为有效成分
公开(公告)号：US08975241B2
公开(公告)日：2015-03-10
申请号：US13500843
申请日：2010-10-08
申请人： Gyoon-Hee Han , Yong Seok Choi , Sang-Bae Han , Jong-Ho Lee , Hwan-Mook Kim , Song-Kyu Park , Ki-Ho Lee , Jong-Soon Kang , Ki-Hoon Lee , Chang-Woo Lee
发明人： Gyoon-Hee Han , Yong Seok Choi , Sang-Bae Han , Jong-Ho Lee , Hwan-Mook Kim , Song-Kyu Park , Ki-Ho Lee , Jong-Soon Kang , Ki-Hoon Lee , Chang-Woo Lee
IPC分类号： A61K31/724 , A23L1/09 , A23L1/30
CPC分类号： A61K31/724 , A23L29/35 , A23L33/10 , A23V2002/00 , A23V2200/328 , A23V2200/332 , A23V2250/5112
摘要： There is provided a composition for preventing and treating obesity including high water-soluble β-cyclodextrin derivatives as an effective component. Specifically, the composition including the high water-soluble β-cyclodextrin derivatives, especially, 2-hydroxypropyl-β-cyclodextrin (HP-β-CD, HPBCD) has effects on suppressing an increase in body weight induced by a high fat diet, suppressing appetite through decreasing an amount of dietary intake, decreasing body fat, decreasing liver weight, and significantly decreasing a sharp increase of blood sugar induced by intaking glucose and maltose on an empty stomach so that it can be useful for preventing and treating obesity, preventing and treating various diseases induced by obesity, and suppressing a sharp increase of blood sugar after dinner.
摘要翻译：提供了用于预防和治疗包括高水溶性和环糊精衍生物作为有效成分的肥胖的组合物。具体地说，包含高水溶性β-环糊精衍生物，特别是2-羟丙基 - 环糊精（HP-＆bgr-CD，HPBCD）的组合物具有抑制高脂肪引起的体重增加的作用饮食，通过减少饮食摄入量，减少身体脂肪，减少肝脏重量并显着降低通过在空腹进食葡萄糖和麦芽糖而引起的血糖的急剧增加，从而抑制食欲，从而可用于预防和治疗肥胖预防和治疗肥胖引起的各种疾病，抑制晚饭后血糖急剧增加。

6. 发明授权

US07846963B2 2-oxo-heterocyclic compounds and the pharmaceutical compositions comprising the same 失效
标题翻译： 2-氧杂环化合物和包含它们的药物组合物
公开(公告)号：US07846963B2
公开(公告)日：2010-12-07
申请号：US10557085
申请日：2004-05-17
申请人： Yung Hee Kho , Gyoon Hee Han , Ho Jae Lee , Bum Woo Park , Hyo Kon Chun , Hwan Mook Kim , Song Kyu Park , Sang Bae Han , Dong Kyu Ryu , Tae Gyu Chun , Jin Ha Lee , Chang Woo Lee , Ki Hoon Lee , Hee Yoon Lee
发明人： Yung Hee Kho , Gyoon Hee Han , Ho Jae Lee , Bum Woo Park , Hyo Kon Chun , Hwan Mook Kim , Song Kyu Park , Sang Bae Han , Dong Kyu Ryu , Tae Gyu Chun , Jin Ha Lee , Chang Woo Lee , Ki Hoon Lee , Hee Yoon Lee
IPC分类号： A01N43/36 , A61K31/40 , C07D207/00 , C07D295/00 , C09B1/00
CPC分类号： C07D207/26 , C07D207/38 , C07D211/86 , C07D409/06
摘要： The present invention is related to new 2-oxo-cyclic compound the process for preparing them and a pharmaceutical composition comprising the same. The present invention provides a pharmaceutical composition for preventing and treating the inflammatory disease comprising the pain or inflammation caused by rheumatic disease, for example, rheumatoid arthritis, spondyloarthopathies, gout, osteoarthritis, systemic lupus erythematosus and juvenile arthritis, and inflammatory syndrome for example, from myositis, gingivitis, synovitis, ankylosing spondylitis, burstitis, burns and scar, inflammatory Crohn's disease, Types I diabetes. therefore, it can be used as the therapeutics for treating and preventing inflammatory diseases.
摘要翻译：本发明涉及新的2-氧代环状化合物及其制备方法和包含其的药物组合物。本发明提供了用于预防和治疗炎性疾病的药物组合物，其包括由风湿性疾病引起的疼痛或炎症，例如类风湿性关节炎，脊椎动物病变，痛风，骨关节炎，系统性红斑狼疮和幼年关节炎以及炎性综合征，例如，肌炎，牙龈炎，滑膜炎，强直性脊柱炎，爆发性炎症，烧伤和瘢痕，炎性克罗恩病，I型糖尿病。因此，它可以用作治疗和预防炎性疾病的治疗剂。

7. 发明授权

US07723376B2 2-oxo-heterocyclic compounds and pharmaceutical compositions 失效
标题翻译： 2-氧杂环化合物和药物组合物
公开(公告)号：US07723376B2
公开(公告)日：2010-05-25
申请号：US10564653
申请日：2004-07-15
申请人： Hwan Mook Kim , Gyoon Hee Han , Song Kyu Park , Chang Woo Lee , Sang Bae Han , Ki Hoon Lee , Yung Hee Kho , Jin Hyuk Yang , Bum Woo Park , Hyang Woo Lee , Jeung Whan Han , Dong Kyu Ryu , Jin Ha Lee , Tae Gyu Chun , Yong Kee Kim , Hee Yoon Lee , Bong Yong Lee , Jeom Yong Kim , Ji Duck Kim , Kyunga Yu , Sun Young Kim
发明人： Hwan Mook Kim , Gyoon Hee Han , Song Kyu Park , Chang Woo Lee , Sang Bae Han , Ki Hoon Lee , Yung Hee Kho , Jin Hyuk Yang , Bum Woo Park , Hyang Woo Lee , Jeung Whan Han , Dong Kyu Ryu , Jin Ha Lee , Tae Gyu Chun , Yong Kee Kim , Hee Yoon Lee , Bong Yong Lee , Jeom Yong Kim , Ji Duck Kim , Kyunga Yu , Sun Young Kim
IPC分类号： A01N43/36
CPC分类号： A61K31/454 , A61K31/4015 , A61K31/4545 , C07D207/38 , C07D211/86 , C07D223/10 , C07D417/06
摘要： The present invention is related to novel use of 2-oxo-heterocyclic compounds having anticancer activity and the process for preparing them and a pharmaceutical composition comprising the same. The present invention provides a pharmaceutical composition for preventing and treating the cancer disease comprising lung cancer, bone cancer, pancreatic cancer, skin cancer, cancer of the head and neck, cutaneous or intraocular melanoma, uterine cancer, ovarian cancer, rectal cancer or cancer of the anal region, stomach cancer, colon cancer, breast cancer, gynecologic tumors, Hodgkin's disease, cancer of the esophagus, cancer of the small intestine, cancer of the endocrine system, sarcomas of soft tissues, cancer of the urethra, cancer of the penis, prostate cancer, chronic or acute leukemia, solid tumors of childhood, lymphocytic lymphonas, cancer of the bladder, cancer of the kidney or ureter, or neoplasms of the central nervous system, therefore, it can be used as the therapeutics for treating and preventing cancer diseases.
摘要翻译：本发明涉及具有抗癌活性的2-氧代杂环化合物及其制备方法的新用途以及包含其的药物组合物。本发明提供了用于预防和治疗包括肺癌，骨癌，胰腺癌，皮肤癌，头颈癌，皮肤或眼内黑素瘤，子宫癌，卵巢癌，直肠癌或癌症的癌症疾病的药物组合物肛门区域，胃癌，结肠癌，乳腺癌，妇科肿瘤，霍奇金病，食道癌，小肠癌，内分泌系统癌，软组织肉瘤，尿道癌，阴茎癌，前列腺癌，慢性或急性白血病，儿童实体瘤，淋巴细胞淋巴管，膀胱癌，肾或输尿管癌，或中枢神经系统肿瘤，因此可用作治疗和预防的治疗剂癌症疾病

8. 发明授权

US07462739B2 Ceramide derivatives, method for preparing the same, and therapeutic agent for treating atopic dermatitis comprising the ceramide derivatives 失效
标题翻译：神经酰胺衍生物，其制备方法以及治疗特应性皮炎的治疗剂，其包含所述神经酰胺衍生物
公开(公告)号：US07462739B2
公开(公告)日：2008-12-09
申请号：US12005226
申请日：2007-12-26
申请人： Byeong-Deog Park , Jong-Kyung Youm , Hyung-Sub Gwak , Mi-Jung Kwon , Hwan-Mook Kim , Jong-Soon Kang , Sang-Bae Han
发明人： Byeong-Deog Park , Jong-Kyung Youm , Hyung-Sub Gwak , Mi-Jung Kwon , Hwan-Mook Kim , Jong-Soon Kang , Sang-Bae Han
IPC分类号： C07F9/22 , C07F9/28
CPC分类号： A61K8/68 , A61Q19/00 , C07F9/091
摘要： Disclosed are ceramide derivatives represented by the following formula 1 or 2, a method for preparing the same, and a therapeutic agent for treating atopic dermatitis including the ceramide derivatives as active ingredients: wherein, R1 and R2 are each independently straight or branched alkyl groups having 4 to 22 carbon atoms. The therapeutic agent for treating atopic dermatitis including the ceramide derivatives as active ingredients according to the present invention may be useful to treat atopic dermatitis, or treat other skin diseases that are required for improving skin inflammations or suppressing epidermal proliferation, by suppressing or improving inflammatory conditions in the atopic dermatitis in addition to giving immunoregulatory functions, and suppressing or improving skin disorders, for example epidermal proliferation that is generally observed in the atopic dermatitis.
摘要翻译：公开了由下式1或2表示的神经酰胺衍生物，其制备方法和用于治疗特应性皮炎的治疗剂，其包括神经酰胺衍生物作为活性成分：其中，R 1和R 2各自独立地为具有 4至22个碳原子。用于治疗特应性皮炎的治疗剂，包括根据本发明的神经酰胺衍生物作为活性成分，可用于治疗特应性皮炎或治疗改善皮肤炎症或抑制表皮增生所需的其它皮肤病，抑制或改善炎性病症在特应性皮炎中除了给予免疫调节功能外，还抑制或改善皮肤病，例如通常在特应性皮炎中观察到的表皮增生。

9. 发明授权

US06444125B2 Method of treating waste water for removing nitrogen and phosphorus and apparatus therefor 有权
标题翻译：处理废水去除氮磷的方法及其设备
公开(公告)号：US06444125B2
公开(公告)日：2002-09-03
申请号：US09842173
申请日：2001-04-26
申请人： Sang Bae Han
发明人： Sang Bae Han
IPC分类号： C02F330
CPC分类号： C02F3/308 , C02F3/301 , Y10S210/903 , Y10S210/906
摘要： A method of treating sewage or waste water for removing nitrogen and phosphorus as well as organic materials in the sewage or waste water, and an apparatus therefor are provided. The method applies intermittent aeration and dynamic flow to an equipment having at least a pair of reaction basins with intermittent aeration means, a clarifier with sludge transfer means, and a filter for passing liquid without passing solid between the reaction basins. According to the method, the efficiency of removing nutrient salts is excellent and stable even in the treatment of waste water having low content of influent organisms and low C/N ratio.
摘要翻译：提供了一种处理污水或废水以除去污水或废水中的氮，磷以及有机物质的方法及其设备。该方法对具有间歇曝气装置的至少一对反应池的设备进行间歇曝气和动态流动，具有污泥转移装置的澄清器和用于在不在反应池之间通过固体的液体的过滤器。根据该方法，即使在处理含水量低且流入物质含量低的废水时，除去营养盐的效率也优异且稳定。

10. 发明申请

US20090048328A1 Compound Comprising Prodigiosin From Serratia Macescence B-1231 Kctc 0386Bp for Prevention and Treatment of Acute Graft-Versus-Host Disease 审中-公开
标题翻译：化合物包括来自沙雷氏菌Mstique的Prodigiosin B-1231 Kctc 0386Bp用于预防和治疗急性移植物抗宿主病
公开(公告)号：US20090048328A1
公开(公告)日：2009-02-19
申请号：US11988561
申请日：2006-07-10
申请人： Hwan Mook Kim , Sang-Bae Han , Chang-Woo Lee , Ki-Hoon Lee , Sung-Kyu Park , Ki-Ho Lee , Jong-Soon Kang , Won-Kee Yoon , Young-Kook Kim
发明人： Hwan Mook Kim , Sang-Bae Han , Chang-Woo Lee , Ki-Hoon Lee , Sung-Kyu Park , Ki-Ho Lee , Jong-Soon Kang , Won-Kee Yoon , Young-Kook Kim
IPC分类号： A61K31/4155 , A61P37/06
CPC分类号： C12P17/10
摘要： This invention relates to a composition for the prevention and treatment of acute graft-versus-host disease comprising prodigiosin isolated from Serratia marcescence B-1231 KCTC 0386BP, as an effective ingredient. The prodigiosin is immunosup-pressive by selectively suppressing the proliferation of T-cells through the suppression of the expression of IL-2 receptors, which is needed for the activation of T-cells. Prodigiosin can be used either alone or in conjunction with cyclosporin A for greater effect, since the two substances have different mode of actions. These make prodigiosin effective for the prevention and treatment of acute graft-versus-host disease.
摘要翻译：本发明涉及用于预防和治疗急性移植物抗宿主病的组合物，其包括从沙雷氏菌属B-1231 KCTC 0386BP分离的天竺葵素作为有效成分。通过抑制T细胞活化所需的IL-2受体的表达，通过选择性抑制T细胞的增殖，产生免疫抑制作用。由于两种物质具有不同的作用模式，因此可以单独使用或与环孢菌素A联合使用。这些使癌细胞生成素有效预防和治疗急性移植物抗宿主病。

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