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1. 发明申请

US20100120844A1 TETRAHYDROISOQUINOLINE COMPOUND 失效
标题翻译：四氢喹啉化合物
公开(公告)号：US20100120844A1
公开(公告)日：2010-05-13
申请号：US12531318
申请日：2008-04-03
申请人： Seiichi Sato , Junya Tagashira , Shunji Takemura , Yoshiharu Miyake , Tetsuya Ishikawa , Toshiharu Arai , Takahiro Ito , Takuya Hara
发明人： Seiichi Sato , Junya Tagashira , Shunji Takemura , Yoshiharu Miyake , Tetsuya Ishikawa , Toshiharu Arai , Takahiro Ito , Takuya Hara
IPC分类号： A61K31/4709 , C07D401/02 , C07D217/18 , A61K31/47 , A61P11/06 , A61P31/18 , A61P37/06 , A61P1/00
CPC分类号： C07D217/04 , A61K31/472 , A61K31/4725 , C07D217/02 , C07D217/14 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D409/14 , C07D417/12
摘要： The present invention relates a specific tetrahydroisoquinoline compound which is useful as a chemokine receptor type 3 (CCR3) antagonist, and a pharmaceutical composition comprising the same as an active ingredient. The tetrahydroisoquinoline compound of the present invention is useful for the treatment or prevention of a disease in which CCR3 participates.
摘要翻译：本发明涉及可用作3型趋化因子受体（CCR3）拮抗剂的特定四氢异喹啉化合物，以及包含其作为活性成分的药物组合物。本发明的四氢异喹啉化合物可用于治疗或预防CCR3参与的疾病。

2. 发明授权

US08273766B2 Tetrahydroisoquinoline compound 失效
标题翻译：四氢异喹啉化合物
公开(公告)号：US08273766B2
公开(公告)日：2012-09-25
申请号：US12531318
申请日：2008-04-03
申请人： Seiichi Sato , Junya Tagashira , Shunji Takemura , Yoshiharu Miyake , Tetsuya Ishikawa , Toshiharu Arai , Takahiro Ito , Takuya Hara
发明人： Seiichi Sato , Junya Tagashira , Shunji Takemura , Yoshiharu Miyake , Tetsuya Ishikawa , Toshiharu Arai , Takahiro Ito , Takuya Hara
IPC分类号： C07D217/18 , A61K31/47
CPC分类号： C07D217/04 , A61K31/472 , A61K31/4725 , C07D217/02 , C07D217/14 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D409/14 , C07D417/12
摘要： The present invention relates a specific tetrahydroisoquinoline compound which is useful as a chemokine receptor type 3 (CCR3) antagonist, and a pharmaceutical composition comprising the same as an active ingredient. The tetrahydroisoquinoline compound of the present invention is useful for the treatment or prevention of a disease in which CCR3 participates.
摘要翻译：本发明涉及可用作3型趋化因子受体（CCR3）拮抗剂的特定四氢异喹啉化合物，以及包含其作为活性成分的药物组合物。本发明的四氢异喹啉化合物可用于治疗或预防CCR3参与的疾病。

3. 发明授权

US08974610B2 High-strength welded steel pipe and method for producing the same 有权
标题翻译：高强度焊接钢管及其制造方法
公开(公告)号：US08974610B2
公开(公告)日：2015-03-10
申请号：US13575051
申请日：2011-02-04
申请人： Taishi Fujishiro , Takuya Hara , Yoshio Terada , Shinya Sakamoto , Hitoshi Asahi
发明人： Taishi Fujishiro , Takuya Hara , Yoshio Terada , Shinya Sakamoto , Hitoshi Asahi
IPC分类号： C21D9/08 , C21D8/10 , C22C38/12 , C22C38/02 , C22C38/04 , F16L31/02 , B23K35/30 , B23K31/02 , C21D9/50 , C22C38/00 , C22C38/14
CPC分类号： B23K35/3053 , B23K31/027 , B23K2101/06 , B23K2103/04 , C21D8/105 , C21D9/08 , C21D9/50 , C21D2211/002 , C22C38/001 , C22C38/002 , C22C38/02 , C22C38/04 , C22C38/12 , C22C38/14 , Y10S148/909
摘要： A high-strength welded steel pipe is obtained by welding a seam weld portion of a steel plate that are formed in a pipe shape. In the high-strength welded steel pipe, a base metal of the steel plate includes, by mass %, C: 0.010% to 0.080%, Si: 0.01% to 0.50%, Mn: 0.50% to 2.00%, S: 0.0001% to 0.0050%, Ti: 0.003% to 0.030%, Mo: 0.05% to 1.00%, B: 0.0003% to 0.0100%, O: 0.0001% to 0.0080%, N: 0.006% to 0.0118%, P: limited to 0.050% or less, Al: limited to 0.008% or less, and the balance of Fe and inevitable impurities, Ceq is 0.30 to 0.53, Pcm is 0.10 to 0.20, [N]−[Ti]/3.4 is less than 0.003, the average grain size of the prior γ grains in heat affected zones in the steel plate is 250 μm or less, and the prior γ grains include bainite and intragranular bainite.
摘要翻译：通过焊接形成管状的钢板的焊缝部分来获得高强度焊接钢管。在高强度焊接钢管中，钢板的贱金属以质量％计含有C：0.010〜0.080％，Si：0.01〜0.50％，Mn：0.50〜2.00％，S：0.0001％至0.0050％，Ti：0.003％至0.030％，Mo：0.05％至1.00％，B：0.0003％至0.0100％，O：0.0001％至0.0080％，N：0.006％至0.0118％，P：限于0.050％以下，Al：0.008％以下，Fe和不可避免的杂质余量Ceq为0.30〜0.53，Pcm为0.10〜0.20，[N] - [Ti] /3.4小于0.003，平均粒径钢板的热影响区域的现有γ晶粒的尺寸为250μm以下，原来的γ晶粒包括贝氏体和晶粒内贝氏体。

4. 发明申请

US20120291907A1 HIGH-STRENGTH WELDED STEEL PIPE AND METHOD FOR PRODUCING THE SAME 有权
标题翻译：高强度焊接钢管及其制造方法
公开(公告)号：US20120291907A1
公开(公告)日：2012-11-22
申请号：US13575051
申请日：2011-02-04
申请人： Taishi Fujishiro , Takuya Hara , Yoshio Terada , Shinya Sakamoto , Hitoshi Asahi
发明人： Taishi Fujishiro , Takuya Hara , Yoshio Terada , Shinya Sakamoto , Hitoshi Asahi
IPC分类号： F16L9/00 , B23K31/02
CPC分类号： B23K35/3053 , B23K31/027 , B23K2101/06 , B23K2103/04 , C21D8/105 , C21D9/08 , C21D9/50 , C21D2211/002 , C22C38/001 , C22C38/002 , C22C38/02 , C22C38/04 , C22C38/12 , C22C38/14 , Y10S148/909
摘要： A high-strength welded steel pipe is obtained by welding a seam weld portion of a steel plate that are formed in a pipe shape. In the high-strength welded steel pipe, a base metal of the steel plate includes, by mass %, C: 0.010% to 0.080%, Si: 0.01% to 0.50%, Mn: 0.50% to 2.00%, S: 0.0001% to 0.0050%, Ti: 0.003% to 0.030%, Mo: 0.05% to 1.00%, B: 0.0003% to 0.0100%, O: 0.0001% to 0.0080%, N: 0.006% to 0.0118%, P: limited to 0.050% or less, Al: limited to 0.008% or less, and the balance of Fe and inevitable impurities, Ceq is 0.30 to 0.53, Pcm is 0.10 to 0.20, [N]—[Ti]/3.4 is less than 0.003, the average grain size of the prior γ grains in heat affected zones in the steel plate is 250 μm or less, and the prior γ grains include bainite and intragranular bainite.
摘要翻译：通过焊接形成管状的钢板的焊缝部分来获得高强度焊接钢管。在高强度焊接钢管中，钢板的贱金属以质量％计含有C：0.010〜0.080％，Si：0.01〜0.50％，Mn：0.50〜2.00％，S：0.0001％至0.0050％，Ti：0.003％至0.030％，Mo：0.05％至1.00％，B：0.0003％至0.0100％，O：0.0001％至0.0080％，N：0.006％至0.0118％，P：限于0.050％以下，Al：0.008％以下，Fe和不可避免的杂质余量Ceq为0.30〜0.53，Pcm为0.10〜0.20，[N] - [Ti] /3.4小于0.003，平均粒径钢板的热影响区域的现有γ晶粒的尺寸为250μm以下，原来的γ晶粒包括贝氏体和晶粒内贝氏体。

5. 发明授权

US08157379B2 Perimeter and method of controlling perimeter 有权
标题翻译：周边和周边控制方法
公开(公告)号：US08157379B2
公开(公告)日：2012-04-17
申请号：US12868174
申请日：2010-08-25
申请人： Takuya Hara
发明人： Takuya Hara
IPC分类号： A61B3/02
CPC分类号： A61B3/024
摘要： In a perimeter, luminance judging means measures a sensitivity of an examinee, sensitivity deviation computing means obtains a sensitivity deviation, means for computing ratio to p value obtains a ratio to p value, and means for adding ratios to p value adds ratios to p value of respective measurement positions. The sensitivity deviation at the position where sensitivity dispersion is large is low evaluated and the sensitivity deviation at the position where the sensitivity dispersion is small is highly evaluated. Then, an element of the position where the sensitivity was changed can be also considered in a graph showing test results of perimetry periodically conducted with time.
摘要翻译：在周边，亮度判定单元测定受检者的灵敏度，灵敏度偏差运算单元取得灵敏度偏差，计算出与p值的比值取得与p值的比值的装置，以及将p值与p值的比值相加的装置的各个测量位置。灵敏度偏差大的位置的灵敏度偏差被评价低，灵敏度色散小的位置的灵敏度偏差被高度评价。然后，在表示周期性地进行的周期性测试结果的图表中也可以考虑灵敏度变化位置的元素。

6. 发明申请

US20120045194A1 Imaging apparatus 失效
公开(公告)号：US20120045194A1
公开(公告)日：2012-02-23
申请号：US13067475
申请日：2011-06-03
申请人： Masayuki Yoshii , Takuya Hara , Nobuhisa Koike
发明人： Masayuki Yoshii , Takuya Hara , Nobuhisa Koike
IPC分类号： G03B13/36
CPC分类号： G02B7/282 , G03B7/02 , G03B13/36 , G03B15/05 , G03B17/02 , G03B19/02 , G03B19/12 , G03B2215/0507
摘要： An imaging apparatus includes an apparatus body having an outer casing, at least a shutter mechanism and an imaging device placed inside the outer casing, an opening formed in the outer casing, and a storage space and a placement space defined inside the outer casing and communicating with the opening and the storage space, respectively, a strobe unit having a lid part and a light-emitting part and connected to the apparatus body so as to be movable between close and open positions, a sensor unit placed in the placement space and having an autofocus sensor and a sensor adjusting part having plural adjusting screws, and a mirror placed inside the outer casing to reflect part of incident light toward the autofocus sensor. When the strobe unit is moved to the open position, the storage space is defined as an adjustment space into which an adjustment jig can be inserted.

7. 发明授权

US07736447B2 Steel plates for ultra-high-strength linepipes and ultra-high-strength linepipes having excellent low-temperature toughness and manufacturing methods thereof 有权
标题翻译：具有优异的低温韧性的超高强度线管和超高强度线管用钢板及其制造方法
公开(公告)号：US07736447B2
公开(公告)日：2010-06-15
申请号：US10582830
申请日：2004-12-17
申请人： Hitoshi Asahi , Takuya Hara
发明人： Hitoshi Asahi , Takuya Hara
IPC分类号： C22C38/12 , C22C38/14 , C22C38/04 , C21D8/02 , C21D8/10
CPC分类号： C22C38/12 , C21D8/02 , C21D8/0205 , C21D8/0226 , C21D8/0263 , C21D8/105 , C21D9/08 , C21D9/46 , C21D2211/002 , C22C38/001 , C22C38/002 , C22C38/02 , C22C38/04 , C22C38/06 , C22C38/08 , C22C38/14 , C22C38/16 , C22C38/22 , C22C38/26 , C22C38/28 , C22C38/38 , C22C38/42 , C22C38/44 , C22C38/46 , C22C38/48 , C22C38/50 , C22C38/54 , C22C38/58
摘要： Ultra-high-strength linepipes having excellent low-temperature toughness manufactured by welding together the edges of steel plates comprising C of 0.03 to 0.07 mass %, Si of not more than 0.6 mass %, Mn of 1.5 to 2.5 mass %, P of not more than 0.015 mass %, S of not more than 0.003 mass %, Ni of 0.1 to 1.5 mass %, Mo of 0.15 to 0.60 mass %, Nb of 0.01 to 0.10 mass %, Ti of 0.005 to 0.030 mass %, Al of not more than 0.06 mass %, one or more of required amounts of B, N, V, Cu, Cr, Ca, REM (rare-earth metals) and Mg, with the remainder consisting of iron and unavoidable impurities and having a (Hv-ave)/(Hv-M) ratio between 0.8 and 0.9 at 2.5≦P≦4.0, wherein Hv-ave is the average Vickers hardness in the direction of the thickness of the base metal and Hv-M is the martensite hardness depending on C-content (Hv-M=270+1300C) and a tensile strength TS-C between 900 MPa and 1100 MPa; P=2.7C+0.4Si+Mn+0.8Cr+0.45(Ni+Cu)+(1+β)Mo−1+β (β=1 when B≧3 ppm and β=0 when B
摘要翻译：通过将包含0.03〜0.07质量％的C，不大于0.6质量％的Si，1.5〜2.5质量％的Mn，1.5〜2.5质量％的Mn，不为P的钢板的边缘焊接在一起，制造出优异的低温韧性的超高强度线管大于0.015质量％，S：0.003质量％以下，Ni：0.1〜1.5质量％，Mo：0.15〜0.60质量％，Nb：0.01〜0.10质量％，Ti：0.005〜0.030质量％大于0.06质量％，所需量的B，N，V，Cu，Cr，Ca，REM（稀土金属）和Mg中的一种或多种，其余由铁和不可避免的杂质组成，并具有（Hv- ave）/（Hv-M）在2.5和nlE下的0.8和0.9之间的比值; P＆nlE; 4.0，其中Hv-ave是贱金属厚度方向上的维氏硬度平均值，Hv-M是马氏体硬度，取决于 C含量（Hv-M = 270±1300℃），拉伸强度TS-C在900MPa〜1100MPa之间; P = 2.7C + 0.4Si + Mn + 0.8Cr + 0.45（Ni + Cu）+（1 +＆bgr）Mo-1 +＆bgr; （B≥3ppm时＆Bgr = 1，B≤3ppm时为＆bgr = 0）。

8. 发明授权

US07601231B2 High-strength steel pipe excellent in low temperature toughness and toughness at weld heat-affected zone 有权
标题翻译：焊接热影响区的低温韧性和韧性优良的高强度钢管
公开(公告)号：US07601231B2
公开(公告)日：2009-10-13
申请号：US10444743
申请日：2003-05-23
申请人： Takuya Hara , Hitoshi Asahi
发明人： Takuya Hara , Hitoshi Asahi
IPC分类号： C22C38/04 , C22C38/14 , C22C38/12
CPC分类号： C22C38/02 , C21D8/0226 , C21D8/10 , C21D8/1261 , C21D2211/002 , C21D2211/008 , C22C38/42 , C22C38/44 , C22C38/46 , C22C38/58 , Y10S148/909
摘要： A high-strength steel pipe excellent in weldability on site and a method for producing the steel pipe by improving the reliability of the low temperature toughness of a steel are provided. For example, the steel pipe includes elements to enhance hardenability for furthering high-strengthening and also improving toughness at a weld heat affected zone subjected to double or more layer welding. In the method, the steel is made to consist of a structure composed of bainite and/or martensite by containing prescribed amounts of C, Si, Mn, P, S, Ni, Mo, Nb, Ti, Al and N, and, as occasion demands, one or more of B, V, Cu, Cr, Ca, REM, and Mg, and regulating C, Si, Mn, Cr, Ni, Cu, V and Mo. Such elements enhancing hardenability, by a specific relational expression. The diameter of prior austenite grains may be regulated in a prescribed range. The method may include heating a casting to a temperature not lower than the Ac3 point, hot rolling such casting, and thereafter cooling the resulting hot-rolled steel plate at a prescribed cooling rate.
摘要翻译：提供了一种现场焊接性优异的高强度钢管和通过提高钢的低温韧性的可靠性来制造钢管的方法。例如，钢管包括提高淬火性的元素，以进一步提高强化强度，并提高经受双层或多层焊接的焊接热影响区的韧性。在该方法中，通过含有规定量的C，Si，Mn，P，S，Ni，Mo，Nb，Ti，Al和N，由贝氏体和/或马氏体构成的结构，由钢构成，作为需要B，V，Cu，Cr，Ca，REM和Mg中的一种或多种，调节C，Si，Mn，Cr，Ni，Cu，V和Mo。这些元素通过具体的关系式提高淬透性。原奥氏体晶粒的直径可以在规定的范围内调节。该方法可以包括将铸件加热到不低于Ac3点的温度，热轧这种铸造，然后以规定的冷却速度冷却所得到的热轧钢板。

9. 发明授权

US5820699A Martensitic stainless steel having excellent hot workability and sulfide stress cracking resistance 失效
标题翻译：具有优异的热加工性和耐硫化物应力开裂性的马氏体不锈钢
公开(公告)号：US5820699A
公开(公告)日：1998-10-13
申请号：US776125
申请日：1997-04-17
申请人： Hitoshi Asahi , Takuya Hara , Akira Kawakami
发明人： Hitoshi Asahi , Takuya Hara , Akira Kawakami
IPC分类号： C21D9/08 , C21D6/00 , C22C38/00 , C22C38/42 , C22C38/44 , C22C38/50
CPC分类号： C21D6/004 , C22C38/42 , C22C38/44 , C21D2211/008
摘要： A martensitic stainless steel capable of developing a tempered martensitic structure, comprising by weight C: 0.005 to 0.05%, Si.ltoreq.0.50%, Mn: 0.1 to 1.0%, P.ltoreq.0.03%, S.ltoreq.0.005%, Mo: 1.0 to 3.0%, Cu: 1.0 to 4.0%, Ni: 5 to 8%, Al.ltoreq.0.06%, Cr and Mo satisfying a requirement represented by the formula Cr+1.6Mo.gtoreq.13; and C, N, Ni, Cu, Cr, and Mo satisfying a requirement represented by the formula Ni(eq): 40C+34N+Ni+0.3Cu-1.1Cr-1.8Mo.gtoreq.-10.5, and optionally at least one member selected from the group consisting of Ti, Zr, Ca, and REM, with the balance consisting essentially of Fe. The present invention provides a martensitic stainless steel having excellent resistance to corrosion by CO.sub.2 and sulfide stress cracking and good hot workability.
摘要翻译： PCT No.PCT / JP95 / 01453 Sec。 371日期1997年04月17日 102（e）日期1997年4月17日PCT提交1995年7月21日PCT公布。出版物WO96 / 03532 日期：1996年2月8日具有显影回火马氏体组织的马氏体系不锈钢，其含量为C：0.005〜0.05％，Si≤0.50％，Mn：0.1〜1.0％，P≤0.03％ /=0.005%，Mo：1.0〜3.0％，Cu：1.0〜4.0％，Ni：5〜8％，Al：0.06％，Cr和Mo满足式Cr + 1.6Mo> 13; 和C，N，Ni，Cu，Cr和Mo满足由式Ni（eq）表示的要求：40℃+ 34N + Ni + 0.3Cu-1.1Cr-1.8Mo> = 10.5，以及任选的至少一种选自Ti，Zr，Ca和REM组成的组分，余量基本上由Fe组成。本发明提供一种马氏体不锈钢，具有优异的耐CO 2腐蚀性和耐硫化应力开裂性以及良好的热加工性。

10. 发明授权

US5716465A High-corrosion-resistant martensitic stainless steel having excellent weldability and process for producing the same 失效
标题翻译：具有优异焊接性的高耐腐蚀马氏体不锈钢及其制造方法
公开(公告)号：US5716465A
公开(公告)日：1998-02-10
申请号：US649701
申请日：1996-08-27
申请人： Takuya Hara , Asahi Hitoshi , Hiroshi Tamehiro , Taro Muraki , Akira Kawakami
发明人： Takuya Hara , Asahi Hitoshi , Hiroshi Tamehiro , Taro Muraki , Akira Kawakami
IPC分类号： C21D1/18 , C21D8/02 , C22C38/42
CPC分类号： C22C38/42 , C21D8/0205 , C21D1/18 , C21D2211/008
摘要： A high-corrosion-resistant martensitic stainless steel possessing excellent weldability and SSC resistance, having a tempered martensitic structure, characterized by comprising steel constituents satisfying by weight C: 0.005 to 0.035%, Si: not more than 0.50%, Mn: 0.1 to 1.0%, P: not more than 0.03%, S: not more than 0.005%, Mo: 1.0 to 3.0%, Cu: 1.0 to 4.0%, Ni: 1.5 to 5.0%, Al: not more than 0.06%, N: not more than 0.01%, and Cr satisfying a requirement represented by the formula 13>Cr+1.6Mo.gtoreq.8, C+N.gtoreq.0.03, 40C+34N+Ni+0.3Cu-1.1Cr-1.8 Mo.gtoreq.10, or further comprising at least one element selected from the group consisting of Ti: 0.05 to 0.1%, Zr: 0.01 to 0.2%, Ca: 0.001 to 0.02%, and REM: 0.003 to 0.4%, with the balance consisting essentially of Fe. A process for producing a martensitic stainless steel, comprising the steps of: subjecting a steel plate, produced by hot-rolling a stainless steel slab having the above composition, to austenitization at a temperature of Ac.sub.3 point to 1000.degree. C. to harden the steel plate; subjecting the hardened steel plate to final tempering at a temperature of 550.degree. C. to Ac.sub.1 point; and cold-rolling the steel plate.
摘要翻译： PCT No.PCT / JP95 / 01950 Sec。 371日期：1996年8月27日 102（e）日期1996年8月27日PCT提交1995年9月27日PCT公布。公开号WO96 / 10654 日期1996年4月11日具有回火马氏体组织的耐焊接性和耐SSC性优异的高耐腐蚀马氏体系不锈钢，其特征在于，含有C：0.005〜0.035％，Si：0.50％以下， Mn：0.1〜1.0％，P：0.03％以下S：0.005％以下，Mo：1.0〜3.0％，Cu：1.0〜4.0％，Ni：1.5〜5.0％，Al：0.06以下％，N：0.01以下，Cr满足式13> Cr + 1.6Mo> / = 8，C + N> = 0.03,40C + 34N + Ni + 0.3Cu-1.1Cr- 或者还包含选自Ti：0.05〜0.1％，Zr：0.01〜0.2％，Ca：0.001〜0.02％，REM：0.003〜0.4％的至少一种元素，与余量基本上由Fe组成。一种马氏体不锈钢的制造方法，其特征在于，包括以下步骤：将具有上述组成的不锈钢板进行热轧制成的钢板在Ac 3点〜1000℃的温度下进行奥氏体化，使钢盘子; 使淬火钢板在550℃至Ac1点的温度下进行最终回火; 并冷轧钢板。

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