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1. 发明授权

US07163933B2 Treating agent for Paget's disease of bone 失效
标题翻译：治疗佩吉特氏病的治疗剂
公开(公告)号：US07163933B2
公开(公告)日：2007-01-16
申请号：US10369752
申请日：2003-02-21
申请人： Seiichi Ishizuka , Kazuya Takenouchi , Atsushi Imaizumi , Yasuhiro Oue , Noriyoshi Kurihara , Sakamuri V. Reddy , G. David Roodman
发明人： Seiichi Ishizuka , Kazuya Takenouchi , Atsushi Imaizumi , Yasuhiro Oue , Noriyoshi Kurihara , Sakamuri V. Reddy , G. David Roodman
IPC分类号： A61K31/59
CPC分类号： A61K31/593 , A61K31/592 , A61K38/06
摘要： To obtain a treating agent for Paget's disease of bone, there is provided a method of inhibiting expression of general transcription factor of steroid hormone receptor.
摘要翻译：为了获得佩格特氏病的治疗剂，提供了抑制类固醇激素受体的一般转录因子表达的方法。

2. 发明授权

US06960573B2 Vitamin D3 derivative and treating agent for inflammatory respiratory disease using same 失效
标题翻译：维生素D3衍生物和用于炎性呼吸系统疾病的治疗剂
公开(公告)号：US06960573B2
公开(公告)日：2005-11-01
申请号：US10035217
申请日：2002-01-04
申请人： Kazuya Takenouchi , Qingzhi Gao , Kenji Manabe , Ryo Sogawa , Yasuhiro Takano , Seiichi Ishizuka
发明人： Kazuya Takenouchi , Qingzhi Gao , Kenji Manabe , Ryo Sogawa , Yasuhiro Takano , Seiichi Ishizuka
IPC分类号： A61P3/02 , A61P3/14 , A61P11/00 , C07C401/00 , C07C403/00 , C07F7/18 , C07D401/00 , C07D307/00 , A61K31/34 , A61K31/335 , A61K31/36
CPC分类号： C07C401/00 , C07F7/1804 , Y02P20/55
摘要： Compounds expressed by the following general formula (1), [wherein, R01 and R02 are each independently a hydrogen atom or a protecting group for a hydroxyl group; Z is one out of the following formulae (1-1), (1-2), (1-3), (1-4) and (1-5)]. The compounds can be used as active ingredients of treating agents for inflammatory respiratory diseases, malignant tumors, rheumatoid arthritis, osteoporosis, diabetes mellitus, hypertension, alopecia, acne, psoriasis, dermatitis, hypercalcemia, hypoparathyroidism and metabolic disorder of cartilage.
摘要翻译：由以下通式（1）表示的化合物[其中，R 01和R 02 O各自独立地为氢原子或羟基的保护基; Z为下式（1-1），（1-2），（1-3），（1-4）和（1-5）中的一个）。该化合物可用作炎性呼吸系统疾病，恶性肿瘤，类风湿性关节炎，骨质疏松症，糖尿病，高血压，脱发，痤疮，牛皮癣，皮炎，高钙血症，甲状旁腺功能低下和软骨代谢紊乱的治疗剂的活性成分。

3. 发明授权

US06548489B2 Vitamin D3 derivative and treating agent for inflammatory respiratory disease using same 失效
标题翻译：维生素D3衍生物和用于炎性呼吸系统疾病的治疗剂
公开(公告)号：US06548489B2
公开(公告)日：2003-04-15
申请号：US10035219
申请日：2002-01-04
申请人： Kazuya Takenouchi , Qingzhi Gao , Kenji Manabe , Ryo Sogawa , Yasuhiro Takano , Seiichi Ishizuka
发明人： Kazuya Takenouchi , Qingzhi Gao , Kenji Manabe , Ryo Sogawa , Yasuhiro Takano , Seiichi Ishizuka
IPC分类号： A61K31543
CPC分类号： C07C401/00 , C07F7/1804 , Y02P20/55
摘要： Compounds expressed by the following general formula (1), [wherein, R01 and R02 are each independently a hydrogen atom or a protecting group for a hydroxyl group; Z is one out of the following formulae (1-1) to (1-5)]. The compounds can be used as active ingredients of treating agents for inflammatory respiratory diseases, malignant tumors, rheumatoid arthritis, osteoporosis, diabetes mellitus, hypertension, alopecia, acne, psoriasis, dermatitis, hypercalcemia, hypoparathyroidism and metabolic disorder of cartilage.
摘要翻译：由以下通式（1）表示的化合物[其中，R 01和R 02各自独立地为氢原子或羟基的保护基; Z为下式（1-1）〜（1-5）中的1种），可用作炎性呼吸系统疾病，恶性肿瘤，类风湿性关节炎，骨质疏松症，糖尿病，高血压，脱发，痤疮，牛皮癣，皮炎，高钙血症，甲状旁腺功能低下和软骨代谢紊乱。

4. 发明申请

US20060148768A1 Vitamin d3 lactone derivatives 有权
标题翻译：维生素d3内酯衍生物
公开(公告)号：US20060148768A1
公开(公告)日：2006-07-06
申请号：US10543881
申请日：2004-01-29
申请人： Kazuya Takenouchi , Miyuki Anzai , Hiroshi Saito , Kazuhisa Okada , Seiichi Ishizuka , Daishiro Miura , Hiroaki Takayama , Atsushi Kittaka , Nozomi Saito , Toshie Fujishima
发明人： Kazuya Takenouchi , Miyuki Anzai , Hiroshi Saito , Kazuhisa Okada , Seiichi Ishizuka , Daishiro Miura , Hiroaki Takayama , Atsushi Kittaka , Nozomi Saito , Toshie Fujishima
IPC分类号： A61K31/59 , C07D307/02
CPC分类号： C07D307/58 , A61K31/593
摘要： A compound represented by the following Formula (1) that is effective for the treatment of Paget's disease of bone or hypercalcemia or a medically acceptable solvate thereof; [wherein R1 refers to hydrogen atom, C1-C6 alkyl group optionally substituted with hydrogen group or C1-C6 alkoxy group optionally substituted with hydroxyl group, R2a and R2b refer to hydrogen atom, C1-C10 alkyl group optionally substituted with hydroxyl group, C6-C10 aryl group optionally substituted with hydroxyl group or C7-C12 aralkyl group optionally substituted with a hydroxyl group, or are combined to represent ethylene group. However, a compound in which R1 is a hydrogen atom or a methyl group and R2a and R2b are hydrogen atoms is excluded].
摘要翻译：由下式（1）表示的化合物可有效治疗佩吉特氏骨或高钙血症或其医学上可接受的溶剂合物; [其中R 1是氢原子，任选被氢或C 1 -C 6烷基取代的C 1 -C 6烷基，任选被羟基取代的C 1 -C 6烷氧基，R 2a和R 2b是指氢原子，C 1〜任选被羟基取代的C 1 -C 10烷基，任选被羟基取代的C 6 -C 10芳基或C 6 - 任选被羟基取代的或者被组合以代表亚乙基的C 1 -C 12芳烷基。但是，不包括其中R 1是氢原子或甲基，R 2b和R 2b的氢原子的化合物。

5. 发明申请

US20050101574A1 Parathyroid hormone production inhibitors containing vitamin d3 derivatives 审中-公开
标题翻译：含维生素d3衍生物的甲状旁腺激素生成抑制剂
公开(公告)号：US20050101574A1
公开(公告)日：2005-05-12
申请号：US10362289
申请日：2001-08-29
申请人： Seiichi Ishizuka , Daishiro Miura , Kenji Manabe , Qingzhi Gao , Ryo Sogawa , Kazuya Takenouchi
发明人： Seiichi Ishizuka , Daishiro Miura , Kenji Manabe , Qingzhi Gao , Ryo Sogawa , Kazuya Takenouchi
IPC分类号： A61P5/18 , C07C401/00 , C07D309/32 , C07D309/38 , A61K31/59
CPC分类号： C07C401/00 , C07D309/32 , C07D309/38
摘要： An agent for suppressing the production of parathyroid hormone and a remedy for hyperparathyroidism containing a vitamin D3 derivative described by the following general formula (1) [in the formula, m is an integer of from 1 to 3, q is an integer of from 0 to 3, r is an integer of from 0 to 3 and X is carbon atom or oxygen atom, provided that 1≦q+r≦3] as an active ingredient.
摘要翻译：用于抑制甲状旁腺激素产生的药剂和含有由以下通式（1）描述的维生素D 3 N衍生物的甲状旁腺功能亢进疗法[在式中，m为1至3的整数 q为0〜3的整数，r为0〜3的整数，X为碳原子或氧原子，条件是1 <= q + r = 3]作为有效成分。

6. 发明授权

US09073885B2 Vitamin D3 lactone derivatives 有权
标题翻译：维生素D3内酯衍生物
公开(公告)号：US09073885B2
公开(公告)日：2015-07-07
申请号：US10543881
申请日：2004-01-29
申请人： Kazuya Takenouchi , Miyuki Anzai , Hiroshi Saito , Kazuhisa Okada , Seiichi Ishizuka , Daishiro Miura , Hiroaki Takayama , Atsushi Kittaka , Nozomi Saito , Toshie Fujishima
发明人： Kazuya Takenouchi , Miyuki Anzai , Hiroshi Saito , Kazuhisa Okada , Seiichi Ishizuka , Daishiro Miura , Hiroaki Takayama , Atsushi Kittaka , Nozomi Saito , Toshie Fujishima
IPC分类号： A61K31/593 , C07D307/58
CPC分类号： C07D307/58 , A61K31/593
摘要： A compound represented by the following Formula (1) that is effective for the treatment of Paget's disease of bone or hypercalcemia or a medically acceptable solvate thereof; [wherein R1 refers to hydrogen atom, C1-C6 alkyl group optionally substituted with hydrogen group or C1-C6 alkoxy group optionally substituted with hydroxyl group, R2a and R2b refer to hydrogen atom, C1-C10 alkyl group optionally substituted with hydroxyl group, C6-C10 aryl group optionally substituted with hydroxyl group or C7-C12 aralkyl group optionally substituted with a hydroxyl group, or are combined to represent ethylene group. However, a compound in which R1 is a hydrogen atom or a methyl group and R2a and R2b are hydrogen atoms is excluded].
摘要翻译：由下式（1）表示的化合物可有效治疗佩吉特氏骨或高钙血症或其医学上可接受的溶剂合物; [其中，R1表示氢原子，可以被氢原子取代的C1-C6烷基或者被羟基取代的C1-C6烷氧基，R2a和R2b表示氢原子，可以被羟基取代的C1-C10烷基，C6 任选被羟基取代的-C 10芳基或任选被羟基取代的C 7 -C 12芳烷基，或被组合以代表亚乙基。然而，除了R1是氢原子或甲基，R2a和R2b是氢原子的化合物]。

7. 发明授权

US06689766B2 Vitamin D3 derivative and treating agent for inflammatory respiratory disease using same 失效
标题翻译：维生素D3衍生物和用于炎性呼吸系统疾病的治疗剂
公开(公告)号：US06689766B2
公开(公告)日：2004-02-10
申请号：US10035211
申请日：2002-01-04
申请人： Kazuya Takenouchi , Qingzhi Gao , Kenji Manabe , Ryo Sogawa , Yasuhiro Takano , Seiichi Ishizuka
发明人： Kazuya Takenouchi , Qingzhi Gao , Kenji Manabe , Ryo Sogawa , Yasuhiro Takano , Seiichi Ishizuka
IPC分类号： A61K359
CPC分类号： C07C401/00 , C07F7/1804 , Y02P20/55
摘要： Compounds expressed by the following general formula (1), [wherein, R01 and R02 are each independently a hydrogen atom or a protecting group for a hydroxyl group; Z is one out of the following formula (1-5)]. The compounds can be used as active ingredients of treating agents for inflammatory respiratory diseases, malignant tumors, rheumatoid arthritis, osteoporosis, diabetes mellitus, hypertension, alopecia, acne, psoriasis, dermatitis, hypercalcemia, hypoparathyroidism and metabolic disorder of cartilage.
摘要翻译：由以下通式（1）表示的化合物[其中，R 01和R 02各自独立地为氢原子或羟基的保护基; Z是下列公式（1-5）中的一种），该化合物可用作炎性呼吸系统疾病，恶性肿瘤，类风湿性关节炎，骨质疏松症，糖尿病，高血压，脱发，痤疮，牛皮癣，皮炎，高钙血症，甲状旁腺功能低下和软骨代谢紊乱。

8. 发明授权

US06531460B1 Vitamin D, derivatives and remedies for inflammatory respiratory diseases containing the same 失效
标题翻译：维生素D3衍生物和含有此类炎症性呼吸道疾病的补救措施
公开(公告)号：US06531460B1
公开(公告)日：2003-03-11
申请号：US09830167
申请日：2001-04-23
申请人： Kazuya Takenouchi , Qingzhi Gao , Kenji Manabe , Ryo Sogawa , Yasuhiro Takano , Seiichi Ishizuka
发明人： Kazuya Takenouchi , Qingzhi Gao , Kenji Manabe , Ryo Sogawa , Yasuhiro Takano , Seiichi Ishizuka
IPC分类号： C07D40100
CPC分类号： C07C401/00 , C07F7/1804 , Y02P20/55
摘要： Compounds expressed by the following general formula (1), The compounds can be used as active ingredients of treating agents for inflammatory respiratory diseases, malignant tumors, rheumatoid arthritis, osteoporosis, diabetes mellitus, hypertension; alopecia, acne, psoriasis, dermatitis, hypercalcemia, hypoparathyroidism and metabolic disorder of cartilage.
摘要翻译：由以下通式（1）表示的化合物：该化合物可用作炎性呼吸系统疾病，恶性肿瘤，类风湿性关节炎，骨质疏松症，糖尿病，高血压的治疗剂的活性成分; 脱发，痤疮，牛皮癣，皮炎，高钙血症，甲状旁腺功能低下和软骨代谢紊乱。

9. 发明授权

US06867313B2 Vitamin D3 derivative and treating agent for inflammatory respiratory disease using same 失效
标题翻译：维生素D3衍生物和用于炎性呼吸系统疾病的治疗剂
公开(公告)号：US06867313B2
公开(公告)日：2005-03-15
申请号：US10035251
申请日：2002-01-04
申请人： Kazuya Takenouchi , Qingzhi Gao , Kenji Manabe , Ryo Sogawa , Yasuhiro Takano , Seiichi Ishizuka
发明人： Kazuya Takenouchi , Qingzhi Gao , Kenji Manabe , Ryo Sogawa , Yasuhiro Takano , Seiichi Ishizuka
IPC分类号： A61P3/02 , A61P3/14 , A61P11/00 , C07C401/00 , C07C403/00 , C07F7/18 , A61K31/59
CPC分类号： C07C401/00 , C07F7/1804 , Y02P20/55
摘要： Compounds expressed by the following general formula (1), [wherein, R01 and R02 are each independently a hydrogen atom or a protecting group for a hydroxyl group; Z is one out of the following formulae (1-1) to (1-5)]. The compounds can be used as active ingredients of treating agents for inflammatory respiratory diseases, malignant tumors, rheumatoid arthritis, osteoporosis, diabetes mellitus, hypertension, alopecia, acne, psoriasis, dermatitis, hypercalcemia, hypoparathyroidism and metabolic disorder of cartilage.
摘要翻译：由以下通式（1）表示的化合物[其中，R 01和R 02各自独立地为氢原子或羟基的保护基; Z为下式（1-1）〜（1-5）中的1种），可用作炎性呼吸系统疾病，恶性肿瘤，类风湿性关节炎，骨质疏松症，糖尿病，高血压，脱发，痤疮，牛皮癣，皮炎，高钙血症，甲状旁腺功能低下和软骨代谢紊乱。

10. 发明授权

US08371662B2 Wheel braking controller of vehicle 有权
标题翻译：车辆制动控制器
公开(公告)号：US08371662B2
公开(公告)日：2013-02-12
申请号：US11979060
申请日：2007-10-30
申请人： Yutaka Nishikawa , Kazuya Takenouchi , Masaie Kato
发明人： Yutaka Nishikawa , Kazuya Takenouchi , Masaie Kato
IPC分类号： B60T8/42 , B62L3/02 , B62L3/08
CPC分类号： B60T8/368 , B60T8/4031 , B60T8/4081
摘要： A wheel braking controller of a vehicle includes a brake lever operated by a rider, a master cylinder generating a hydraulic pressure according to an operation force of the brake lever, and a brake caliper braking a front wheel based on operation of the brake lever, a channel switching unit provided between the master cylinder and the brake caliper and switching channels of a brake fluid. A hydraulic pressure generator generates a hydraulic pressure based on operation of the brake lever and the driving state of the vehicle and controlling braking of the front wheel using the brake caliper by the hydraulic pressure. A braking controller including the channel switching unit and the hydraulic pressure generator is integrally provided on one body. The wheel braking controller so configured reduces the number of parts, and provides for easy mounting of the controller on the vehicle body.
摘要翻译：车辆的车轮制动控制器包括由驾驶员操作的制动杆，根据制动杆的操作力产生液压的主缸和基于制动杆的操作制动前轮的制动钳; 设置在主缸和制动钳之间的通道切换单元以及制动液的切换通道。液压发生器基于制动杆的操作和车辆的驱动状态产生液压，并通过液压控制制动钳的前轮的制动。包括通道切换单元和液压发生器的制动控制器一体地设置在一体上。如此构造的车轮制动控制器减少了部件的数量，并且将控制器容易地安装在车体上。

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