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1. 发明授权

US08324290B2 Polyisobutylene urethane, urea and urethane/urea copolymers and medical devices containing the same 有权
标题翻译：聚异丁烯聚氨酯，尿素和氨基甲酸酯/尿素共聚物以及含有它们的医疗装置
公开(公告)号：US08324290B2
公开(公告)日：2012-12-04
申请号：US12492483
申请日：2009-06-26
申请人： Shrojalkumar Desai , Marlene C. Schwarz , Mark Boden , Mohan Krishnan , Michael C. Smith , Frederick H. Strickler , Daniel J. Cooke
发明人： Shrojalkumar Desai , Marlene C. Schwarz , Mark Boden , Mohan Krishnan , Michael C. Smith , Frederick H. Strickler , Daniel J. Cooke
IPC分类号： A61N1/05
CPC分类号： C08G18/6204 , A61L27/18 , A61L31/06 , C08G18/10 , C08G18/12 , C08G18/4063 , C08G18/4854 , C08G18/4858 , C08G18/6511 , C08G18/7657 , C08L75/00 , C08G18/3206
摘要： The present invention pertains to polyisobutylene urethane, urea and urethane/urea copolymers, to methods of making such copolymers and to medical devices that contain such polymers. According to certain aspects of the invention, polyisobutylene urethane, urea and urethane/urea copolymers are provided, which comprise a polyisobutylene segment, an additional polymeric segment that is not a polyisobutylene segment, and a segment comprising a residue of a diisocyanate. According to other aspects of the invention, polyisobutylene urethane, urea and urethane/urea copolymers are provided, which comprise a polyisobutylene segment and end groups that comprise alkyl-, alkenyl- or alkynyl-chain-containing end groups.
摘要翻译：本发明涉及聚异丁烯氨基甲酸酯，脲和氨基甲酸酯/尿素共聚物，涉及制备这种共聚物的方法和含有这种聚合物的医疗装置。根据本发明的某些方面，提供聚异丁烯氨基甲酸酯，脲和氨基甲酸酯/脲共聚物，其包含聚异丁烯链段，不是聚异丁烯链段的另外的聚合链段和包含二异氰酸酯残基的链段。根据本发明的其它方面，提供聚异丁烯氨基甲酸酯，脲和氨基甲酸酯/脲共聚物，其包含聚异丁烯链段和包含含有烷基，链烯基或炔基链的端基的端基。

2. 发明申请

US20100023104A1 POLYISOBUTYLENE URETHANE, UREA AND URETHANE/UREA COPOLYMERS AND MEDICAL DEVICES CONTAINING THE SAME 有权
标题翻译：聚异丁烯尿素，尿素和尿素/尿素共聚物和含有它的医疗装置
公开(公告)号：US20100023104A1
公开(公告)日：2010-01-28
申请号：US12492483
申请日：2009-06-26
申请人： Shrojalkumar Desai , Marlene C. Schwarz , Mark Boden , Mohan Krishnan , Michael C. Smith , Frederick H. Strickler , Daniel J. Cooke
发明人： Shrojalkumar Desai , Marlene C. Schwarz , Mark Boden , Mohan Krishnan , Michael C. Smith , Frederick H. Strickler , Daniel J. Cooke
IPC分类号： A61N1/05 , C08F136/14 , C08F8/30 , A61L27/34
CPC分类号： C08G18/6204 , A61L27/18 , A61L31/06 , C08G18/10 , C08G18/12 , C08G18/4063 , C08G18/4854 , C08G18/4858 , C08G18/6511 , C08G18/7657 , C08L75/00 , C08G18/3206
摘要： The present invention pertains to polyisobutylene urethane, urea and urethane/urea copolymers, to methods of making such copolymers and to medical devices that contain such polymers. According to certain aspects of the invention, polyisobutylene urethane, urea and urethane/urea copolymers are provided, which comprise a polyisobutylene segment, an additional polymeric segment that is not a polyisobutylene segment, and a segment comprising a residue of a diisocyanate. According to other aspects of the invention, polyisobutylene urethane, urea and urethane/urea copolymers are provided, which comprise a polyisobutylene segment and end groups that comprise alkyl-, alkenyl- or alkynyl-chain-containing end groups.
摘要翻译：本发明涉及聚异丁烯氨基甲酸酯，脲和氨基甲酸酯/尿素共聚物，涉及制备这种共聚物的方法和含有这种聚合物的医疗装置。根据本发明的某些方面，提供聚异丁烯氨基甲酸酯，脲和氨基甲酸酯/脲共聚物，其包含聚异丁烯链段，不是聚异丁烯链段的另外的聚合链段和包含二异氰酸酯残基的链段。根据本发明的其它方面，提供聚异丁烯氨基甲酸酯，脲和氨基甲酸酯/脲共聚物，其包含聚异丁烯链段和包含含有烷基，链烯基或炔基链的端基的端基。

3. 发明授权

US08501831B2 Polyisobutylene urethane, urea and urethane/urea copolymers and medical devices containing the same 有权
标题翻译：聚异丁烯聚氨酯，尿素和氨基甲酸酯/尿素共聚物以及含有它们的医疗装置
公开(公告)号：US08501831B2
公开(公告)日：2013-08-06
申请号：US13618148
申请日：2012-09-14
申请人： Shrojalkumar Desai , Marlene C. Schwarz , Mark Boden , Mohan Krishnan , Michael C. Smith , Frederick H. Strickler , Daniel J. Cooke
发明人： Shrojalkumar Desai , Marlene C. Schwarz , Mark Boden , Mohan Krishnan , Michael C. Smith , Frederick H. Strickler , Daniel J. Cooke
IPC分类号： A61N1/05
CPC分类号： C08G18/6204 , A61L27/18 , A61L31/06 , C08G18/10 , C08G18/12 , C08G18/4063 , C08G18/4854 , C08G18/4858 , C08G18/6511 , C08G18/7657 , C08L75/00 , C08G18/3206
摘要： The present invention pertains to polyisobutylene urethane, urea and urethane/urea copolymers, to methods of making such copolymers and to medical devices that contain such polymers. According to certain aspects of the invention, polyisobutylene urethane, urea and urethane/urea copolymers are provided, which comprise a polyisobutylene segment, an additional polymeric segment that is not a polyisobutylene segment, and a segment comprising a residue of a diisocyanate. According to other aspects of the invention, polyisobutylene urethane, urea and urethane/urea copolymers are provided, which comprise a polyisobutylene segment and end groups that comprise alkyl-, alkenyl- or alkynyl-chain-containing end groups.
摘要翻译：本发明涉及聚异丁烯氨基甲酸酯，脲和氨基甲酸酯/尿素共聚物，涉及制备这种共聚物的方法和含有这种聚合物的医疗装置。根据本发明的某些方面，提供聚异丁烯氨基甲酸酯，脲和氨基甲酸酯/脲共聚物，其包含聚异丁烯链段，不是聚异丁烯链段的另外的聚合链段和包含二异氰酸酯残基的链段。根据本发明的其它方面，提供聚异丁烯氨基甲酸酯，脲和氨基甲酸酯/脲共聚物，其包含聚异丁烯链段和包含含有烷基，链烯基或炔基链的端基的端基。

4. 发明申请

US20130013040A1 POLYISOBUTYLENE URETHANE, UREA AND URETHANE/UREA COPOLYMERS AND MEDICAL DEVICES CONTAINING THE SAME 有权
公开(公告)号：US20130013040A1
公开(公告)日：2013-01-10
申请号：US13618148
申请日：2012-09-14
申请人： Shrojalkumar Desai , Marlene C. Schwarz , Mark Boden , Mohan Krishnan , Michael C. Smith , Frederick H. Strickler , Daniel J. Cooke
发明人： Shrojalkumar Desai , Marlene C. Schwarz , Mark Boden , Mohan Krishnan , Michael C. Smith , Frederick H. Strickler , Daniel J. Cooke
IPC分类号： C08G73/00 , A61N1/05
CPC分类号： C08G18/6204 , A61L27/18 , A61L31/06 , C08G18/10 , C08G18/12 , C08G18/4063 , C08G18/4854 , C08G18/4858 , C08G18/6511 , C08G18/7657 , C08L75/00 , C08G18/3206
摘要： The present invention pertains to polyisobutylene urethane, urea and urethane/urea copolymers, to methods of making such copolymers and to medical devices that contain such polymers. According to certain aspects of the invention, polyisobutylene urethane, urea and urethane/urea copolymers are provided, which comprise a polyisobutylene segment, an additional polymeric segment that is not a polyisobutylene segment, and a segment comprising a residue of a diisocyanate. According to other aspects of the invention, polyisobutylene urethane, urea and urethane/urea copolymers are provided, which comprise a polyisobutylene segment and end groups that comprise alkyl-, alkenyl- or alkynyl-chain-containing end groups.

5. 发明申请

US20090326077A1 POLYISOBUTYLENE URETHANE, UREA AND URETHANE/UREA COPOLYMERS AND MEDICAL DEVICES CONTAINING THE SAME 审中-公开
标题翻译：聚异丁烯尿素，尿素和尿素/尿素共聚物和含有它的医疗装置
公开(公告)号：US20090326077A1
公开(公告)日：2009-12-31
申请号：US12492440
申请日：2009-06-26
申请人： Shrojalkumar Desai , Marlene C. Schwarz , Mark Boden , Mohan Krishnan , Michael C. Smith , Frederick H. Strickler , Daniel J. Cooke
发明人： Shrojalkumar Desai , Marlene C. Schwarz , Mark Boden , Mohan Krishnan , Michael C. Smith , Frederick H. Strickler , Daniel J. Cooke
IPC分类号： A61K8/87 , C08F8/30 , A61K8/72 , A61N1/05 , A61N1/39 , A61N1/375
CPC分类号： C08G18/6204 , A61L27/18 , A61L31/06 , C08G18/10 , C08G18/12 , C08G18/4063 , C08G18/4854 , C08G18/4858 , C08G18/6511 , C08G18/7657 , C08L75/00 , C08G18/3206
摘要： The present invention pertains to polyisobutylene urethane, urea and urethane/urea copolymers, to methods of making such copolymers and to medical devices that contain such polymers. According to certain aspects of the invention, polyisobutylene urethane, urea and urethane/urea copolymers are provided, which comprise a polyisobutylene segment, an additional polymeric segment that is not a polyisobutylene segment, and a segment comprising a residue of a diisocyanate. According to other aspects of the invention, polyisobutylene urethane, urea and urethane/urea copolymers are provided, which comprise a polyisobutylene segment and end groups that comprise alkyl-, alkenyl- or alkynyl-chain-containing end groups.
摘要翻译：本发明涉及聚异丁烯氨基甲酸酯，脲和氨基甲酸酯/尿素共聚物，涉及制备这种共聚物的方法和含有这种聚合物的医疗装置。根据本发明的某些方面，提供聚异丁烯氨基甲酸酯，脲和氨基甲酸酯/脲共聚物，其包含聚异丁烯链段，不是聚异丁烯链段的另外的聚合链段和包含二异氰酸酯残基的链段。根据本发明的其它方面，提供聚异丁烯氨基甲酸酯，脲和氨基甲酸酯/脲共聚物，其包含聚异丁烯链段和包含含有烷基，链烯基或炔基链的端基的端基。

6. 发明授权

US09205271B2 Styrene-isobutylene copolymers and medical devices containing the same 有权
标题翻译：苯乙烯 - 异丁烯共聚物和含有它们的医疗装置
公开(公告)号：US09205271B2
公开(公告)日：2015-12-08
申请号：US12563733
申请日：2009-09-21
申请人： Shrojalkumar Desai , Daniel J. Cooke , G. Shantanu Reddy , Mohan Krishnan , Michael C. Smith
发明人： Shrojalkumar Desai , Daniel J. Cooke , G. Shantanu Reddy , Mohan Krishnan , Michael C. Smith
IPC分类号： A61N1/05 , A61N1/375 , C08L53/00 , C08L75/08
CPC分类号： A61N1/375 , A61N1/05 , C08L53/00 , C08L75/08 , C08L2666/04 , C08L2666/02
摘要： In accordance with various aspects of the invention, copolymers comprising styrene and isobutylene monomers are used in the construction of implantable and insertable medical devices for electrical stimulation, including, for example, electronic signal generating components and electrical leads for such devices.
摘要翻译：根据本发明的各个方面，包含苯乙烯和异丁烯单体的共聚物用于构建用于电刺激的可植入和可插入的医疗装置，包括例如电子信号产生组件和用于这种装置的电引线。

7. 发明申请

US20100076538A1 STYRENE-ISOBUTYLENE COPOLYMERS AND MEDICAL DEVICES CONTAINING THE SAME 有权
标题翻译：苯乙烯 - 异丁烯共聚物和含有它们的医疗装置
公开(公告)号：US20100076538A1
公开(公告)日：2010-03-25
申请号：US12563733
申请日：2009-09-21
申请人： Shrojalkumar Desai , Daniel J. Cooke , G. Shantanu Reddy , Mohan Krishnan , Michael C. Smith
发明人： Shrojalkumar Desai , Daniel J. Cooke , G. Shantanu Reddy , Mohan Krishnan , Michael C. Smith
IPC分类号： A61N1/05
CPC分类号： A61N1/375 , A61N1/05 , C08L53/00 , C08L75/08 , C08L2666/04 , C08L2666/02
摘要： In accordance with various aspects of the invention, copolymers comprising styrene and isobutylene monomers are used in the construction of implantable and insertable medical devices for electrical stimulation, including, for example, electronic signal generating components and electrical leads for such devices.
摘要翻译：根据本发明的各个方面，包含苯乙烯和异丁烯单体的共聚物用于构建用于电刺激的可植入和可插入的医疗装置，包括例如电子信号产生组件和用于这种装置的电引线。

8. 发明授权

US08160721B2 Implantable lead with flexible tip features 有权
标题翻译：可植入导线，具有灵活的尖端特征
公开(公告)号：US08160721B2
公开(公告)日：2012-04-17
申请号：US12508322
申请日：2009-07-23
申请人： Daniel J. Cooke , Leslie J. Carion , Shrojalkumar Desai , Brendan E. Koop , Ronald W. Heil, Jr. , Harshad M. Borgaonkar , Matthew S. Finlay
发明人： Daniel J. Cooke , Leslie J. Carion , Shrojalkumar Desai , Brendan E. Koop , Ronald W. Heil, Jr. , Harshad M. Borgaonkar , Matthew S. Finlay
IPC分类号： A61N1/00
CPC分类号： A61N1/057 , A61N1/0568
摘要： A medical electrical lead comprises a flexible, elongate lead body extending along a longitudinal axis and having a proximal end and a distal end. A protective distal tip structure is disposed on the distal end of the lead body. The tip structure includes a plurality of compliant projections each extending distally from the distal end of the body in the direction of the longitudinal axis. The projections are configured to contact and bear against cardiac tissue when the lead is implanted, and are deformable under the action of an axially or radially directed force. The projections optionally include a coating over a substrate. The coating can include a hydrogel material and/or a pharmaceutical agent such as a steroid for reducing inflammation at the implantation site.
摘要翻译：医疗电引线包括沿着纵向轴线延伸并且具有近端和远端的柔性细长引线体。保护性的顶端结构设置在引线体的远端。尖端结构包括多个顺从突起，每个突起从纵向轴线的方向远离主体的远端延伸。突起被配置为当铅被植入时与心脏组织接触并承受，并且在轴向或径向力的作用下可变形。突起任选地包括在基底上的涂层。涂层可以包括水凝胶材料和/或药剂，例如类固醇，用于在植入部位减少炎症。

9. 发明申请

US20100042195A1 IMPLANTABLE LEAD WITH FLEXIBLE TIP FEATURES 有权
标题翻译：具有灵活提示功能的可伸缩引线
公开(公告)号：US20100042195A1
公开(公告)日：2010-02-18
申请号：US12508322
申请日：2009-07-23
申请人： Daniel J. Cooke , Leslie L. Carion , Shrojalkumar Desai , Brendan E. Koop , Ronald W. Heil, JR. , Harshad M. Borgaonkar , Matthew S. Finlay
发明人： Daniel J. Cooke , Leslie L. Carion , Shrojalkumar Desai , Brendan E. Koop , Ronald W. Heil, JR. , Harshad M. Borgaonkar , Matthew S. Finlay
IPC分类号： A61N1/05
CPC分类号： A61N1/057 , A61N1/0568
摘要： A medical electrical lead comprises a flexible, elongate lead body extending along a longitudinal axis and having a proximal end and a distal end. A protective distal tip structure is disposed on the distal end of the lead body. The tip structure includes a plurality of compliant projections each extending distally from the distal end of the body in the direction of the longitudinal axis. The projections are configured to contact and bear against cardiac tissue when the lead is implanted, and are deformable under the action of an axially or radially directed force. The projections optionally include a coating over a substrate. The coating can include a hydrogel material and/or a pharmaceutical agent such as a steroid for reducing inflammation at the implantation site.
摘要翻译：医疗电引线包括沿着纵向轴线延伸并且具有近端和远端的柔性细长引线体。保护性的顶端结构设置在引线体的远端。尖端结构包括多个顺从突起，每个突起从纵向轴线的方向远离主体的远端延伸。突起被配置为当铅被植入时与心脏组织接触并承受，并且在轴向或径向力的作用下可变形。突起任选地包括在基底上的涂层。涂层可以包括水凝胶材料和/或药剂，例如类固醇，用于在植入部位减少炎症。

10. 发明申请

US20080046059A1 LEAD INCLUDING A HEAT FUSED OR FORMED LEAD BODY 审中-公开
标题翻译：引导包括热熔或形成的铅体
公开(公告)号：US20080046059A1
公开(公告)日：2008-02-21
申请号：US11462479
申请日：2006-08-04
申请人： Paul E. Zarembo , Mohan Krishnan , David Durand , Donna Osterkamp , Daniel J. Cooke
发明人： Paul E. Zarembo , Mohan Krishnan , David Durand , Donna Osterkamp , Daniel J. Cooke
IPC分类号： A61N1/00
CPC分类号： A61N1/056 , A61N1/057
摘要： An implantable lead comprises a lead body extending from a lead proximal end portion to a lead distal end portion. In one example, the lead body may comprise a heat-formed bias portion. In another example, an outer insulator is fused to the lead body. In such an example, a lead body fusable plug may be disposed distal to at least one conductor. In another example, the lead comprises an inner boot and an outer boot fused to one another. In another example, the lead includes an atraumatic tip fused to the lead distal end portion. In another example, the lead body is reducable in size using heat shrink tubing. In yet another example, two or more lead sections may be interconnected using an outer insulator fused to the respective lead bodies. In a further example, a stiffener member is fused to the lead body adjacent a lead component.
摘要翻译：可植入引线包括从引线近端部分延伸到引线远端部分的引线体。在一个示例中，引线体可以包括加热成形的偏压部分。在另一示例中，外绝缘体熔合到引线体。在这种示例中，引线本体可熔插塞可以设置在至少一个导体的远侧。在另一个示例中，引线包括彼此融合的内靴和外靴。在另一示例中，引线包括熔合到引线远端部分的无创尖端。在另一个例子中，使用热缩管可以使引线体尺寸减小。在又一示例中，两个或更多个引线部分可以使用融合到相应引线体的外绝缘体互连。在另一个例子中，加强件与引线部件相邻地被引导体熔合。

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