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1. 发明授权

US06861034B1 Priming mechanisms for drop ejection devices 有权
标题翻译：液滴喷射装置的启动机构
公开(公告)号：US06861034B1
公开(公告)日：2005-03-01
申请号：US09721388
申请日：2000-11-22
申请人： Scott A. Elrod , Joy Roy , Babur B. Hadimioglu , Richard H. Bruce , Jaan Noolandi , David A. Horine
发明人： Scott A. Elrod , Joy Roy , Babur B. Hadimioglu , Richard H. Bruce , Jaan Noolandi , David A. Horine
IPC分类号： C12M1/00 , B01L3/02 , B05B1/04 , B05B17/06 , B01L3/00 , B41J23/00 , B41J29/38
CPC分类号： B05B17/0607 , B01L3/0268
摘要： Provided is a priming mechanism for priming a biofluid drop ejection device having a drop ejection opening leading to an ejection reservoir. The priming mechanism includes a vacuum unit which generates a vacuum force, connected to a vacuum nozzle. The vacuum nozzle is located over the drop ejection opening. A disposable sleeve or tubing is attached to the vacuum nozzle and is placed in operational contact with the drop ejection opening. A fluid height detection sensor is positioned to sense a fluid height within at least one of the disposable tubing and the vacuum nozzle. Upon sensing a predetermined fluid height, by the fluid height detection sensor, the priming operation is completed, and the primer mechanism is removed from the operational contact with the drop ejection opening.
摘要翻译：提供了一种用于起动生物流体液滴喷射装置的起动机构，其具有通向喷射储存器的液滴喷射开口。起动机构包括产生与真空喷嘴连接的真空力的真空单元。真空喷嘴位于液滴喷射口的上方。一次性套筒或管道连接到真空喷嘴并且与液滴喷射口处于操作接触。液体高度检测传感器被定位成感测至少一个一次性管道和真空喷嘴中的流体高度。通过流体高度检测传感器感测到预定的流体高度时，完成起动操作，并且将底漆机构从与液滴喷射口的操作接触部分移开。

2. 发明授权

US06713022B1 Devices for biofluid drop ejection 有权
标题翻译：生物流体液滴喷射装置
公开(公告)号：US06713022B1
公开(公告)日：2004-03-30
申请号：US09724987
申请日：2000-11-22
申请人： Jaan Noolandi , David A. Horine , Babur B. Hadimioglu , Richard H. Bruce , Joy Roy , Scott A. Elrod
发明人： Jaan Noolandi , David A. Horine , Babur B. Hadimioglu , Richard H. Bruce , Joy Roy , Scott A. Elrod
IPC分类号： B41J2175
CPC分类号： B01L3/0268 , B01L2400/0439 , G01N35/1002 , G01N2035/102 , G01N2035/1041
摘要： A biofluid drop ejection unit for ejecting biofluid drops. A biofluid drop ejection mechanism of such a unit includes a transducer, which generates energy used to emit the biofluid drop. Further provided is a reagent cartridge or biofluid containment area which holds the biofluid. The reagent cartridge or biofluid containment area is configured to hold low volumes of biofluid and to avoid contamination of the biofluid. The reagent cartridge or biofluid containment area is in operational connection with the drop ejection mechanism such that upon operation of the drop ejection mechanism, biofluid drops are emitted. The biofluid drop ejection mechanism is a high efficiency device, and may be configured as two separate pieces or as a single disposable unit.
摘要翻译：用于喷射生物流体滴的生物流体滴落喷射单元。这种单元的生物流体液滴喷射机构包括换能器，其产生用于发射生物流体滴的能量。另外还提供了一个保持生物流体的试剂盒或生物流体容纳区域。试剂盒或生物流体容纳区域被配置为保持低体积的生物流体并避免污染生物流体。试剂盒或生物流体容纳区域与液滴喷射机构操作连接，使得在液滴喷射机构的操作时，发射生物流体液滴。生物流体液滴喷射机构是高效率的装置，并且可以被配置为两个分开的部件或者作为单个一次性部件。

3. 发明授权

US06514704B2 Quality control mechanism and process for a biofluid multi-ejector system 失效
公开(公告)号：US06514704B2
公开(公告)日：2003-02-04
申请号：US09773804
申请日：2001-02-01
申请人： Richard H. Bruce , Scott A. Elrod , Babur B. Hadimioglu , David A. Horine , Jaan Noolandi , Joy Roy , Robert A. Sprague
发明人： Richard H. Bruce , Scott A. Elrod , Babur B. Hadimioglu , David A. Horine , Jaan Noolandi , Joy Roy , Robert A. Sprague
IPC分类号： C12Q168
CPC分类号： G01N35/10 , G01N35/00712 , G01N35/1009 , G01N2035/1037 , G06F19/00
摘要： A method and mechanism for ensuring quality control in printed biological assays is provided. A multi-ejector system having a plurality of individual drop ejectors is loaded with a variety of biofluids. Biofluids include at least a carrier fluid, a biological material to be used in the testing, and markers, such as fluorescent dyes. Data regarding the biofluid loaded in each of the drop ejectors is stored along with an expected signature output of the biofluid. Particularly, the signature output represents signals from individual ones of the fluorescent markers included within the biofluid. Once a biological assay consisting of the biofluid drops has been printed, a scanner capable of detecting the markers scans the biological assay and obtains signature output signals for each of the drops of the biological assay. A comparing operation is undertaken to compare the obtained signature output through the scanning operation, with the expected signature output signals for the biofluid loaded in the corresponding drop ejector. The biological material itself may also be tagged with a marker to ensure its inclusion in the biofluid. By the comparing operation, it is possible to verify the biofluids were loaded in the proper drop ejector, including the proper biological material, and that the drop ejectors are functioning properly.

4. 发明授权

US06740530B1 Testing method and configurations for multi-ejector system 失效
标题翻译：多喷射器系统的测试方法和配置
公开(公告)号：US06740530B1
公开(公告)日：2004-05-25
申请号：US09718733
申请日：2000-11-22
申请人： Richard H. Bruce , Scott A. Elrod , Jaan Noolandi , David A. Horine , Babur B. Hadimioglu
发明人： Richard H. Bruce , Scott A. Elrod , Jaan Noolandi , David A. Horine , Babur B. Hadimioglu
IPC分类号： G01N110
CPC分类号： B01L3/0268 , B01J19/0046 , B01J2219/00378 , B01J2219/00585 , B01J2219/00596 , B01J2219/00603 , B01J2219/00659 , B01J2219/00693 , B41J2/14008 , B41J2002/14322 , C40B60/14 , Y10T436/25 , Y10T436/2575
摘要： Methods for testing proper operation of drop ejection units in a multi-ejector system are provided to determine whether the drop ejectors have been properly filled and/or the ejectors are emitting fully formed droplets. The methods include testing the ejectors prior to drop ejection. In this method, a priming system is used wherein fluid received by the priming system is ejected onto a test substrate to allow a scanner to determine the existence of the fluids at selected locations. The selected locations are correlated to the drop ejection units to determine which ejection units do not have biofluid or sufficient biofluid. A further method allows for ejection prior to printing, on a test substrate wherein testing for both the fullness of the ejector units as well as proper emission of the ejectors of droplets may be tested. The ejectors after being primed, eject the biofluids which are then scanned and correlated to each individual ejector. A further method provided is a laser scattering method wherein a laser beam is interposed between the drop emission path of the ejectors. Laser detection then determines whether a correlated drop ejector is properly emitting droplets.
摘要翻译：提供了用于测试多喷射器系统中液滴喷射单元的正确操作的方法，以确定液滴喷射器是否已经被适当地填充和/或喷射器正在发射完全形成的液滴。这些方法包括在喷射之前测试喷射器。在该方法中，使用起动系统，其中由起动系统接收的流体被喷射到测试基板上，以允许扫描仪确定在选定位置处的流体的存在。所选择的位置与液滴喷射单元相关，以确定哪些喷射单元不具有生物流体或足够的生物流体。另外的方法允许在打印之前在测试基板上进行喷射，其中可以测试喷射器单元的充满度以及液滴喷射器的适当发射。喷射器被喷涂后，喷射生物流体，然后将其扫描并与每个喷射器相关联。提供的另一种方法是激光散射方法，其中激光束插入在喷射器的液滴发射路径之间。然后，激光检测确定相关的液滴喷射器是否正确地发射液滴。

5. 发明授权

US06623700B1 Level sense and control system for biofluid drop ejection devices 失效
标题翻译：生物流体喷射装置的液位感应和控制系统
公开(公告)号：US06623700B1
公开(公告)日：2003-09-23
申请号：US09721386
申请日：2000-11-22
申请人： David A. Horine , Babur B. Hadimioglu , Richard H. Bruce , Jaan Noolandi , Scott A. Elrod
发明人： David A. Horine , Babur B. Hadimioglu , Richard H. Bruce , Jaan Noolandi , Scott A. Elrod
IPC分类号： B01L302
CPC分类号： B41J2/17566 , B41J2/1714 , Y10T436/2575
摘要： A level control mechanism is provided for a biofluid drop ejection device which ejects biofluid drops in small volumes. The biofluid drop device includes a drop ejection mechanism having a transducer which generates energy used to emit the biofluid drops. A reagent cartridge or biofluid holding area holds a biofluid, isolated from the drop ejection mechanism to avoid contamination between the biofluid drop ejection mechanism and the reagent cartridge. The reagent cartridge is connected to the drop ejection mechanism such that upon operation of the mechanism, the biofluid is emitted in controlled biofluid drops. A level sensor is positioned to sense a height of the biofluid within the cartridge. Upon sensing the height of the biofluid below a certain level, an adjustment is made to the height by providing at least one of additional biofluid to the cartridge, and raising the level of the entire reagent cartridge.
摘要翻译：为生物流体液滴喷射装置提供液面控制机构，其以小体积喷射生物流体液滴。生物流体液滴装置包括液滴喷射机构，其具有产生用于发射生物流体滴的能量的换能器。试剂盒或生物流体保持区域保持与液滴喷射机构隔离的生物流体，以避免生物流体液滴喷射机构和试剂盒之间的污染。试剂盒连接到液滴喷射机构，使得在机构操作时，生物流体在受控的生物流体滴下发射。水平传感器被定位成感测盒内的生物流体的高度。当感测到生物流体的高度低于一定水平时，通过向盒提供至少一种额外的生物流体，并提高整个试剂盒的水平来调节高度。

6. 发明授权

US06503454B1 Multi-ejector system for ejecting biofluids 有权
标题翻译：用于喷射生物流体的多喷射器系统
公开(公告)号：US06503454B1
公开(公告)日：2003-01-07
申请号：US09721389
申请日：2000-11-22
申请人： Babur B. Hadimioglu , Scott A. Elrod , Richard H. Bruce , Jaan Noolandi , David A. Horine
发明人： Babur B. Hadimioglu , Scott A. Elrod , Richard H. Bruce , Jaan Noolandi , David A. Horine
IPC分类号： B01L302
CPC分类号： B01L3/0268 , G01N2035/1039 , Y10T436/2575
摘要： A multiple-ejector system for printing arrays of biofluids include a tooling plate having a plurality of sets of tooling pins extending outward from the surface of the tooling plate. A printed circuit board is provided having pairs of power connection pins and ground return pins extending from a surface of the circuit board. A plurality of biofluid drop ejection units are provided and include alignment grooves and at least a transducer. Each of the plurality of biofluid drop ejection units are connected to a corresponding one of a set of tooling pins by connection of the tooling pins and alignment grooves. The power connection pins of the pairs are in operational connection with respective transducers and the ground return connection pins of the pairs are in operational connection with a body portion of the drop ejection units. The different drop ejection units will contain different biofluids which are to be emitted onto a substrate. Verification of drop ejection units containing biofluids, may be obtained in one embodiment through the use of an optical scanner. Detection of drops at defined locations provides a verification that validates a properly formed spot is present on a substrate, and is in the correct position.
摘要翻译：用于打印生物流体阵列的多喷射器系统包括具有从工具板的表面向外延伸的多组工具销的工具板。提供一个印刷电路板，其具有从电路板的表面延伸的成对的电源连接引脚和接地返回引脚。提供多个生物流体液滴喷射单元，并且包括对准凹槽和至少一个换能器。多个生物流体滴落喷射单元中的每一个通过工具销和对准槽的连接连接到一组加工销中的对应的一个。成对的电源连接引脚与相应的换能器操作连接，并且对的接地返回连接引脚与液滴喷射单元的主体部分操作连接。不同的液滴喷射单元将包含将被发射到基底上的不同生物流体。通过使用光学扫描仪可以在一个实施例中获得包含生物流体的液滴喷射单元的验证。在限定位置处检测液滴提供验证，验证正确形成的斑点存在于基底上，并处于正确的位置。

7. 发明授权

US08122880B2 Inhaler that uses focused acoustic waves to deliver a pharmaceutical product 有权
标题翻译：吸入器使用聚焦声波来递送药品
公开(公告)号：US08122880B2
公开(公告)日：2012-02-28
申请号：US09740209
申请日：2000-12-18
申请人： Jaan Noolandi , Babur B. Hadimioglu , Robert A. Sprague
发明人： Jaan Noolandi , Babur B. Hadimioglu , Robert A. Sprague
IPC分类号： B05B17/06 , A61M15/00 , A61M11/00
CPC分类号： B05B17/06 , A61M11/005 , A61M15/0085 , A61M15/02 , A61M15/025
摘要： An improved method and apparatus for delivering medication to the lungs is described. Acoustic ink printing technology is modified to operate as an inhaler that generates tiny droplets near a patient's nose or mouth. The tiny droplets are easily carried by air currents into the patient's lungs. The inhaler itself is preferably a battery operated portable device that can be easily carried and easily cleaned to avoid contaminating the medication.
摘要翻译：描述了用于将药物递送至肺部的改进方法和装置。声学油墨印刷技术被修改为作为在患者的鼻子或嘴部附近产生微小液滴的吸入器。微小的液滴容易被气流携带到病人的肺部。吸入器本身优选地是电池操作的便携式装置，其可以容易地携带并容易地清洁以避免污染药物。

8. 发明授权

US07121275B2 Method of using focused acoustic waves to deliver a pharmaceutical product 有权
公开(公告)号：US07121275B2
公开(公告)日：2006-10-17
申请号：US09739989
申请日：2000-12-18
申请人： Jaan Noolandi , Babur B. Hadimioglu , Robert A. Sprague
发明人： Jaan Noolandi , Babur B. Hadimioglu , Robert A. Sprague
IPC分类号： A61M11/08 , G02B3/08
CPC分类号： B05B17/0615 , A61M15/0085 , A61M15/025 , Y10S101/34
摘要： An improved method and apparatus for delivering medication to the lungs is described. Acoustic ink printing technology is modified to operate as an inhaler that generates tiny droplets near a patient's nose or mouth. The tiny droplets are easily carried by air currents into the patient's lungs. The inhaler itself is preferably a battery operated portable device that can be easily carried and easily cleaned to avoid contaminating the medication.

9. 发明授权

US6146798A Printing plate with reversible charge-controlled wetting 有权
标题翻译：印版具有可逆电荷控制润湿
公开(公告)号：US6146798A
公开(公告)日：2000-11-14
申请号：US222921
申请日：1998-12-30
申请人： Ross D Bringans , Jaan Noolandi , David K Biegelsen , David K Fork , Scott A Elrod
发明人： Ross D Bringans , Jaan Noolandi , David K Biegelsen , David K Fork , Scott A Elrod
IPC分类号： G03F7/00 , B41C1/10 , B41N1/14 , G03G13/26
CPC分类号： B41C1/1041 , B41C1/1058
摘要： The present invention is a method and system for lithographic printing by controlling the surface energy of a printing plate to affect the hydrophilic and hydrophobic properties of the printing plate. These properties enable the ink to be applied to the printing plate in an image-wise manner and provides for rapid production of images on a recording medium. The lithographic printing plate may be rewritten repeatedly between printing jobs or may even be rewritten between individual recording media.
摘要翻译：本发明是通过控制印版的表面能来影响印版的亲水性和疏水性的方法和系统。这些特性使油墨能够以图像方式施加到印版上，并且可以在记录介质上快速生成图像。平版印刷版可以在打印作业之间重复重写，或者甚至可以在各个记录介质之间重写。

10. 发明申请

US20110184513A1 Artificial corneal implant 审中-公开
标题翻译：人造角膜植入物
公开(公告)号：US20110184513A1
公开(公告)日：2011-07-28
申请号：US12928819
申请日：2010-12-20
申请人： David Myung , Jaan Noolandi , Alan J. Smith , Curtis W. Frank , Christopher N. Ta , Yin Hu , Won-Gun Koh , Michael R. Carrasco , Laura Hartmann
发明人： David Myung , Jaan Noolandi , Alan J. Smith , Curtis W. Frank , Christopher N. Ta , Yin Hu , Won-Gun Koh , Michael R. Carrasco , Laura Hartmann
IPC分类号： A61F2/14
CPC分类号： A61L27/3804 , A61F2/142 , A61L27/3813 , A61L27/3839 , A61L27/52 , A61L2430/16 , C12N5/0621 , C12N2533/30
摘要： A material that can be applied as implants designed to artificially replace or augment the cornea, such as an artificial cornea, corneal onlay, or corneal inlay (intrastromal lens) is provided. The artificial corneal implant has a double network hydrogel with a first network interpenetrated with a second network. The first network and the second network are based on biocompatible polymers. At least one of the network polymers is based on a hydrophilic polymer. The artificial cornea or implant has epithelialization promoting biomolecules that are covalently linked to the surface of the double network hydrogel using an azide-active-ester chemical linker. Corneal epithelial cells or cornea-derived cells are adhered to the biomolecules. The double network has a physiologic diffusion coefficient to allow passage of nutrients to the adhered cells.
摘要翻译：提供了可以作为植入物被应用于人造地替代或增加角膜的材料，例如人造角膜，角膜镶嵌物或角膜嵌体（体内镜片）。人造角膜植入物具有双网络水凝胶，其中第一网络与第二网络互穿。第一个网络和第二个网络是基于生物相容的聚合物。至少一种网状聚合物是基于亲水性聚合物。人造角膜或植入物具有上皮促进生物分子，其使用叠氮化物 - 活性酯化学接头共价连接到双网络水凝胶的表面。角膜上皮细胞或角膜衍生细胞粘附于生物分子。双网络具有生理扩散系数，以允许营养物质通过粘附细胞。

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