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1. 发明授权

US5049375A Oral compositions containing colloidal fluoride 失效
标题翻译：含有胶态氟化物的口服组合物
公开(公告)号：US5049375A
公开(公告)日：1991-09-17
申请号：US527776
申请日：1990-05-24
申请人： Satoshi Tsujita , Manabu Tonomura , Shigeto Kayane , Takashi Imamura
发明人： Satoshi Tsujita , Manabu Tonomura , Shigeto Kayane , Takashi Imamura
IPC分类号： A61K8/21 , A61K33/16 , A61Q11/00
CPC分类号： A61Q11/00 , A61K8/21 , B82Y5/00 , A61K2800/413
摘要： A colloidal solution comprises a fluoride(s) being difficultiy soluble in water comprises colloidal particles of the fluoride having a particle size of 0.005 to 1 micron, said fluoride having a fluoride ion concentration of 1 to 10,000 ppm in the state of saturation.

2. 发明授权

US5130146A Fluoride colloid and oral composition 失效
标题翻译：氟化物胶体和口服组合物
公开(公告)号：US5130146A
公开(公告)日：1992-07-14
申请号：US712742
申请日：1991-06-10
申请人： Satoshi Tsujita , Manabu Tonomura , Shigeto Kayane , Takashi Imamura
发明人： Satoshi Tsujita , Manabu Tonomura , Shigeto Kayane , Takashi Imamura
IPC分类号： A61K8/21 , A61K33/16 , A61Q11/00
CPC分类号： A61Q11/00 , A61K8/21 , B82Y5/00 , A61K2800/413
摘要： A colloidal solution comprises a fluoride(s) being difficultly soluble in water comprises colloidal particles of the fluoride having a particle size of 0.005 to 1 micron, said fluoride having a fluoride ion concentration of 1 to 10,000 ppm in the state of saturation.

3. 发明授权

US4787940A Method for purifying sugar phosphates or their salts 失效
标题翻译：糖精磷酸盐或其盐的净化方法
公开(公告)号：US4787940A
公开(公告)日：1988-11-29
申请号：US12496
申请日：1987-02-09
申请人： Shigeto Kayane , Mitsugu Morishita , Takashi Imamura , Masanobu Tanigaki , Tomihiro Kurosaki
发明人： Shigeto Kayane , Mitsugu Morishita , Takashi Imamura , Masanobu Tanigaki , Tomihiro Kurosaki
IPC分类号： C07H1/06 , C07H11/04 , C13D3/18 , B01D17/06
CPC分类号： C07H1/06 , C07H11/04
摘要： A novel method for purifying a sugar phosphate or its salt, in which a sugar-containing mixture of a sugar phosphate or its salt and phosphoric acid or its salt is subjected to electrodialysis to remove the phosphoric acid or its salt from the mixture.According to this method, the phosphoric acid or its salt can be readily obtained in a reusable form. The method is thus quite advantageous in view of the economy.
摘要翻译：一种纯化糖磷酸盐或其盐的新方法，其中糖磷酸盐或其盐的含糖混合物和磷酸或其盐进行电渗析以从混合物中除去磷酸或其盐。根据该方法，可以容易地以可重复使用的形式获得磷酸或其盐。鉴于经济，该方法是非常有利的。

4. 发明授权

US4983582A Preventive and therapeutic method for hypertension 失效
标题翻译：高血压预防和治疗方法
公开(公告)号：US4983582A
公开(公告)日：1991-01-08
申请号：US155509
申请日：1988-02-12
申请人： Masakazu Murata , Yoshinao Nagashima , Kenji Hara , Shigeto Kayane , Takashi Imamura
发明人： Masakazu Murata , Yoshinao Nagashima , Kenji Hara , Shigeto Kayane , Takashi Imamura
IPC分类号： C07H11/04 , A61K31/70 , A61P9/10 , A61P9/12
CPC分类号： A61K31/7004
摘要： A preventive and therapeutic method for hypertension by dosing hexose phosphate calcium which produces an immediate effect without having any undesirable side-effects to control a rise in the blood pressure, and is efficacious also for various diseases of which onset can be ascribed to hypertension, such as myocardial infarction, cerebral apoplexy, cirrhosis of livers, billiary stasis, and others.
摘要翻译：通过给予磷酸钙钙的高血压的预防和治疗方法，其产生立即效果，而不产生任何不希望的副作用来控制血压升高，并且对于起始可以归因于高血压的各种疾病也是有效的，作为心肌梗死，脑中风，肝硬化，肚脐淤滞等。

5. 发明授权

US5543310A Immobilized phosphorylase 失效
标题翻译：固定磷酸化酶
公开(公告)号：US5543310A
公开(公告)日：1996-08-06
申请号：US113743
申请日：1993-08-31
申请人： Shigeto Kayane , Takashi Kawai , Masaru Sakata , Takashi Imamura , Masanobu Tanigaki , Tomihiro Kurosaki
发明人： Shigeto Kayane , Takashi Kawai , Masaru Sakata , Takashi Imamura , Masanobu Tanigaki , Tomihiro Kurosaki
IPC分类号： C07H11/04 , C07H1/02 , C12N11/08 , C12P19/02 , C12N9/10
CPC分类号： C12N11/08 , C12P19/02
摘要： A process for preparing glucose-1-phosphate from an .alpha.-glucan and orthophosphate using a phosphorylase immobilized onto an anion-exchange resin is disclosed. The anion-exchange resin used is a synthetic polymer resin into which an anion exchange group; a primary to quarternary ammonium group, a phosphonium group, or a sulfonium group, is introduced. This type of immobilized phosphorylase ensures (i) an effective utilization of phosphorylase, (ii) a higher reactivity of a higher absorbance of the phosphorylase to the resin, (iii) an excellent phosphorylase activity retention performance, and (iv) a higher physical strength of the resin.
摘要翻译：公开了使用固定在阴离子交换树脂上的磷酸化酶从α-葡聚糖和正磷酸盐制备葡萄糖-1-磷酸的方法。使用的阴离子交换树脂是合成聚合物树脂，其中阴离子交换基团; 引入了主要到季铵基，鏻基或锍基。这种固定的磷酸化酶可确保（i）磷酸化酶的有效利用，（ii）磷酸化酶对树脂的较高吸光度的较高反应性，（iii）优异的磷酸化酶活性保持性能，和（iv）较高的物理强度的树脂。

6. 发明授权

US4650862A Sugar phosphates 失效
标题翻译：糖磷酸盐
公开(公告)号：US4650862A
公开(公告)日：1987-03-17
申请号：US753058
申请日：1985-07-09
申请人： Takashi Imamura , Shigeto Kayane , Tomihiro Kurosaki
发明人： Takashi Imamura , Shigeto Kayane , Tomihiro Kurosaki
IPC分类号： A61K8/00 , A61K8/60 , A61Q5/00 , A61Q5/02 , C07H11/04
CPC分类号： A61Q5/02 , A61K8/60 , C07H11/04
摘要： Sugar phosphate of the following general formula (I): ##STR1## is prepared by reaction between a phosphoric monoester and a glycidyltriammonium salt.The sugar phosphate according to the invention has good moisture retention and good adsorptivity on hair, and can be used in shampoos, rinses and cosmetics.
摘要翻译：以下通式（I）的磷酸盐：通过磷酸单酯和缩水甘油基三铵盐之间的反应制备。根据本发明的糖磷酸盐具有良好的保湿性和对头发的良好的吸附性，并且可用于洗发剂，漂洗剂和化妆品中。

7. 发明申请

US20080255058A1 Composition for Oral Cavity 审中-公开
标题翻译：口腔组成
公开(公告)号：US20080255058A1
公开(公告)日：2008-10-16
申请号：US11576114
申请日：2005-09-28
申请人： Morihide Itano , Shigeto Kayane , Katsuya Ueno , Hiromoto Mizushima
发明人： Morihide Itano , Shigeto Kayane , Katsuya Ueno , Hiromoto Mizushima
IPC分类号： A61K31/7028 , C07H15/04
CPC分类号： A61Q17/005 , A61K8/34 , A61K8/39 , A61K8/602 , A61K8/604 , A61K8/608 , A61K8/73 , A61K31/7028 , A61K31/7032 , A61Q11/00
摘要： The present invention relates to an oral care composition, which contains a compound represented by the formula (A): (wherein, R represents a substituted or unsubstituted, linear or branched alkyl group having from 6 to 18 carbon atoms, G represents a galactose residue, m stands for an integer of from 0 to 200, and n stands for an integer of from 1 to 30); and a coaggregation inhibitor of bacteria of the genus Fusobacterium and cariogenic bacteria, which contains the compound as an effective ingredient. The composition for oral cavity according to the present invention inhibits coaggregation of bacteria of the genus Fusobacterium with cariogenic bacteria so that it has an excellent caries preventive effect.
摘要翻译：本发明涉及一种口腔护理组合物，其含有式（A）表示的化合物：（其中，R表示具有6至18个碳原子的取代或未取代的直链或支链烷基，G表示半乳糖残基 m表示0〜200的整数，n表示1〜30的整数）表示。以及含有该化合物作为有效成分的Fusobacterium属和致龋细菌属细菌的共聚抑制剂。根据本发明的口腔用组合物抑制Fusobacterium属细菌与致龋细菌的共聚，使其具有优异的防龋效果。

8. 发明授权

US6048913A Coating composition for teeth 失效
标题翻译：牙齿涂层组成
公开(公告)号：US6048913A
公开(公告)日：2000-04-11
申请号：US125420
申请日：1998-08-17
申请人： Atsushi Yamagishi , Akira Oshima , Shigeto Kayane , Yukihiro Nakano
发明人： Atsushi Yamagishi , Akira Oshima , Shigeto Kayane , Yukihiro Nakano
IPC分类号： A61K6/00 , A61K6/02 , A61K6/083 , A61K7/16
CPC分类号： A61K6/0017
摘要： The present invention relates to a dental coating composition comprising a polymer which has in its molecule one or more phosphorus series acid residues selected from the group consisting of phosphoric acid, phosphonic acid and phosphinic acid and halides and salts thereof and has a weight-average molecular weight of 10,000 to 5,000,000, and water or a lower alcohol. The composition is a dental coating agent which does not easily peel off when drinking or eating, can be removed easily if necessary and does not have a safety problem.
摘要翻译： PCT No.PCT / JP97 / 04533 Sec。 371日期1998年8月17日第 102（e）日期1998年8月17日PCT 1997年12月10日PCT公布。第WO98 / 26749号公报日期1998年6月25日本发明涉及一种牙科用涂料组合物，其包含在其分子中具有选自磷酸，膦酸和次膦酸及其卤化物及其盐中的一种或多种磷系酸残基的聚合物，并且具有重均分子量为10,000至5,000,000，以及水或低级醇。该组合物是在饮用或饮食时不容易剥离的牙科涂剂，如果需要，可以容易地除去并且没有安全问题。

9. 发明授权

US08834852B2 Composition for oral cavity 有权
标题翻译：口腔成分
公开(公告)号：US08834852B2
公开(公告)日：2014-09-16
申请号：US12772492
申请日：2010-05-03
申请人： Morihide Itano , Shigeto Kayane , Katsuya Ueno , Hiromoto Mizushima
发明人： Morihide Itano , Shigeto Kayane , Katsuya Ueno , Hiromoto Mizushima
IPC分类号： A61K8/00 , A61K8/18 , A61Q11/00 , A01N43/04 , A61K31/70 , A61Q17/00 , A61K8/60 , A61K8/34 , A61K8/39 , A61K8/73 , A61K31/7028 , A61K31/7032
CPC分类号： A61Q17/005 , A61K8/34 , A61K8/39 , A61K8/602 , A61K8/604 , A61K8/608 , A61K8/73 , A61K31/7028 , A61K31/7032 , A61Q11/00
摘要： The present invention relates to an oral care composition, which contains a compound represented by the formula (A): (wherein, R represents a substituted or unsubstituted, linear or branched alkyl group having from 6 to 18 carbon atoms, G represents a galactose residue, m stands for an integer of from 0 to 200, and n stands for an integer of from 1 to 30); and a coaggregation inhibitor of bacteria of the genus Fusobacterium and cariogenic bacteria, which contains the compound as an effective ingredient. The composition for oral cavity according to the present invention inhibits coaggregation of bacteria of the genus Fusobacterium with cariogenic bacteria so that it has an excellent caries preventive effect.
摘要翻译：本发明涉及一种口腔护理组合物，其含有式（A）表示的化合物：（其中，R表示具有6至18个碳原子的取代或未取代的直链或支链烷基，G表示半乳糖残基 m表示0〜200的整数，n表示1〜30的整数）表示。以及含有该化合物作为有效成分的Fusobacterium属和致龋细菌属细菌的共聚抑制剂。根据本发明的口腔用组合物抑制Fusobacterium属细菌与致龋细菌的共聚，使其具有优异的防龋效果。

10. 发明申请

US20120269741A1 Liquid Compositions for Oral Cavity 审中-公开
标题翻译：口腔液体组合物
公开(公告)号：US20120269741A1
公开(公告)日：2012-10-25
申请号：US13537887
申请日：2012-06-29
申请人： Yoshitaka YANO , Shigeto Kayane , Takahisa Yamashiro
发明人： Yoshitaka YANO , Shigeto Kayane , Takahisa Yamashiro
IPC分类号： A61K8/60 , A61P31/04 , A61K8/92 , A61Q11/00
CPC分类号： A61K8/37 , A61K8/24 , A61K8/39 , A61K8/41 , A61K8/60 , A61Q11/00
摘要： The present invention relates to a liquid composition for the oral cavity, which contains the following components (A), (B), (C) and (D): (A) an oil-soluble flavor, (B) a cationic bactericide, (C) a sugar fatty acid ester, and (D) one or more compounds selected from the group consisting of polyglycerol fatty acid esters, polyoxyethylene hydrogenated castor oils, and sorbitan fatty acid esters. The present invention also pertains to a liquid composition for the oral cavity, which contains the following components (A), (B), (E) and (F): (A) an oil-soluble flavor, (B) a cationic bactericide, (E) a polyphosphoric acid or salt thereof, and (F) a polyglycerol fatty acid ester. The liquid composition for the oral cavity according to the present invention is excellent in the adsorption of the bactericide to teeth and the like, barely causes unpleasant odor, and is excellent in stability.
摘要翻译：本发明涉及口腔用液体组合物，其含有以下成分（A），（B），（C），（D））：（A）油溶性香料，（B）阳离子性杀菌剂，（C）糖脂肪酸酯，和（D）一种或多种选自聚甘油脂肪酸酯，聚氧乙烯氢化蓖麻油和脱水山梨糖醇脂肪酸酯的化合物。本发明还涉及口腔用液体组合物，其含有以下组分（A），（B），（E）和（F））：（A）油溶性风味剂，（B）阳离子杀菌剂，（E）多磷酸或其盐，和（F）聚甘油脂肪酸酯。根据本发明的用于口腔的液体组合物在杀菌剂对牙齿等的吸附方面优异，几乎不引起令人不愉快的气味，并且稳定性优异。

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