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1. 发明授权

US06555118B1 Pharmaceutical preparation for the treatment of topical wounds and ulcers 失效
标题翻译：用于治疗局部创面和溃疡的药物制剂
公开(公告)号：US06555118B1
公开(公告)日：2003-04-29
申请号：US09681207
申请日：2001-02-22
申请人： Sarfaraz K Niazi
发明人： Sarfaraz K Niazi
IPC分类号： A61K3578
CPC分类号： A61Q19/00 , A61K8/63 , A61K8/922 , A61K8/97 , A61K36/31 , A61K36/33 , A61K36/48 , A61K36/539 , A61K36/756 , A61K2800/75 , A61L26/0057 , A61L26/0066 , A61L2300/222 , A61L2300/30 , A61L2300/412 , A61Q17/00 , A61Q19/001 , Y10S424/13 , Y10S514/844 , Y10S514/944 , Y10S514/945 , A61K2300/00
摘要： A pharmaceutical preparation for the treatment of wounds and ulcers in humans and animals and a method of preparation of the same are provided here. The composition consists of an alcoholic extract of Huangqin, Huanglian, Huangbai, Opuntia, Dilong, and &bgr;-sitosterol (from Soybean extract), in a vegetable oil-wax base, from where the alcohol is essentially removed by evaporation. The composition is used as a topical ointment for the treatment of wounds in its preferred embodiment. Wounds, in particular those occurring in the skin as second and third degree burns, stasis ulcers, trophic lesions, such as decubitus ulcers, diabetic ulcers, surgical wounds, severe cuts, diaper rash, cracked nipples and abrasions which are commonly resistant to the natural healing process, may be treated with this composition. The application of this combination to wounds greatly accelerates the rate of healing and reduces scarring as the mechanism of action proposed here involves regeneration of skin through stimulation of stem cells that allows healing without substantial scar formation.
摘要翻译：本发明提供了用于治疗人和动物中的伤口和溃疡的药物制剂及其制备方法。该组合物由植物油蜡基中的黄琴，黄连，黄柏，仙人掌，迪龙和β-谷甾醇的醇提物组成，其中醇通过蒸发基本上被除去。该组合物在其优选实施方案中用作治疗伤口的局部软膏。伤口，特别是皮肤中发生的第二和第三度烧伤，溃疡，营养性损伤，如褥疮性溃疡，糖尿病性溃疡，手术伤口，严重切口，尿布疹，裂纹乳头和擦伤，这些伤口通常对天然抗性治疗过程中，可以用这种组合物治疗。这种组合对伤口的应用极大地加快了愈合速度并减少了瘢痕形成，因为这里提出的作用机制涉及通过刺激干细胞来再生皮肤，其允许在没有实质性瘢痕形成的情况下愈合。

2. 发明授权

US06447820B1 Pharmaceutical composition for the prevention and treatment of scar tissue 失效
标题翻译：用于预防和治疗疤痕组织的药物组合物
公开(公告)号：US06447820B1
公开(公告)日：2002-09-10
申请号：US09681137
申请日：2001-01-22
申请人： Sarfaraz K Niazi
发明人： Sarfaraz K Niazi
IPC分类号： A61K3578
CPC分类号： A61K36/33 , A61K35/644 , A61K36/63 , A61K36/756 , Y10S514/946 , Y10S514/947 , A61K2300/00
摘要： The disclosed is a treatment of existing and prevention of new skin scars in humans and animals using a topical application containing alcoholic extracts of Cortex Phellodendri and Opuntia ficus indica in a specific combination.
摘要翻译：所公开的是使用包含Cortex Phellodendri和Factus indica的酒精提取物的局部应用来特异性组合的治疗现有和预防人和动物中的新皮肤瘢痕。

3. 发明授权

US06419963B1 Composition and method for the treatment of diaper rash using natural products 有权
标题翻译：使用天然产物治疗尿布疹的组合物和方法
公开(公告)号：US06419963B1
公开(公告)日：2002-07-16
申请号：US09681520
申请日：2001-04-22
申请人： Sarfaraz K Niazi
发明人： Sarfaraz K Niazi
IPC分类号： A61K3578
CPC分类号： A61K9/0014 , A61K31/56 , A61K36/63 , A61K36/718 , A61K45/06 , A61K47/44 , A61K2300/00
摘要： Provided here is a pharmaceutical composition containing beeswax, olive oil, &bgr;-sitosterol and the herb Coptis chinesis Franch for safe and quick treatment for infant and adult diaper rash. Also provided here is a methodology for the treatment of diaper rash wherein the treatment consists of compositions that contain naturally derived anti-inflammatory agents, an antimicrobial agents and such components that they provide an occlusive coating when applied to the afflicted surface.
摘要翻译：这里提供了一种含有蜂蜡，橄榄油，β-谷甾醇和草本黄连黄连的药物组合物，用于婴儿和成人尿布疹的安全和快速治疗。这里还提供了一种治疗尿布疹的方法，其中治疗由含有天然衍生抗炎剂的组合物，抗微生物剂和这些组分组成，当它们施用于受影响的表面时，它们提供闭塞性涂层。

4. 发明授权

US06338862B1 Composition and method of use in treating sexual dysfunction using cGMP-specific phosphodiesterase type 5 inhibitors 有权
标题翻译：使用cGMP特异性磷酸二酯酶5型抑制剂治疗性功能障碍的组合物和方法
公开(公告)号：US06338862B1
公开(公告)日：2002-01-15
申请号：US09681362
申请日：2001-03-26
申请人： Sarfaraz K Niazi
发明人： Sarfaraz K Niazi
IPC分类号： A61K3578
CPC分类号： A61K31/714 , A61K31/4415 , A61K31/519 , A61K36/258 , A61K45/06 , A61K2300/00
摘要： The inhibitors of cyclic guanosine monophosphate (cGMP) phosphodiesterases type 5 (cGMP-PDE5) such as sildenafil citrate (Viagra®) act by increasing the level of cGMP in sexual organs to produce enhanced blood flow and an erectile response of sexual organs. Though sildenafil citrate is a specific inhibitor of cGMP-PDE5, its effects on other body organs produce many side effects including fatalities. Described here is a method of combining cGMP-PDE5 inhibitors with natural sources of nutrients that instantly enhance the levels of endogenous cGMP and thus reduce the therapeutic dose and therefore the side effects of cGMP-PDE5 inhibitors. We have discovered that if sildenafil citrate, as a prototype of cGMP-PDE5, is combined with L-arginine, ginseng, vitamin B6, vitamin B12, and folic acid, all natural and safe ingredients, the dose requirements for sildenafil citrate can be reduced substantially. The specific composition described here assists in the action of sildenafil primarily by increasing the production of cGMP through modulation of nitric oxide pathway (L-arginine→nitric oxide→cGMP) and secondarily by having its own effect on improving blood circulation to sexual organs.
摘要翻译： 5型（cGMP）磷酸二酯酶（cGMP-PDE5）如柠檬酸西地那非（Viagra）的抑制剂通过增加性器官中cGMP的水平来产生增强的血流量和性器官的勃起反应。虽然西地那非柠檬酸盐是cGMP-PDE5的特异性抑制剂，但其对其他身体器官的作用也会产生许多副作用，包括死亡。这里描述了一种将cGMP-PDE5抑制剂与天然营养来源组合的方法，其立即增强内源性cGMP的水平，从而降低治疗剂量，从而降低cGMP-PDE5抑制剂的副作用。我们已经发现，如果西地那非柠檬酸盐作为cGMP-PDE5的原型与L-精氨酸，人参，维生素B6，维生素B12和叶酸，所有天然和安全的成分组合，可以减少柠檬酸西地那非的剂量要求实质上这里描述的具体组合主要通过调节一氧化氮途径（L-精氨酸 - >一氧化氮 - > cGMP）来增加cGMP的产生，其次通过对改善对性器官的血液循环的效果来辅助西地那非的作用。

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