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1. 发明授权

US06887662B1 Oligonucleotides and assemblies thereof useful in the detection of the presence or absence of target nucleic acid sequences in a sample 有权
标题翻译：用于检测样品中靶核酸序列的存在或不存在的寡核苷酸及其组装体
公开(公告)号：US06887662B1
公开(公告)日：2005-05-03
申请号：US09727480
申请日：2000-12-04
申请人： Sara Alajem , Avraham Reinhartz , Michal Waksman
发明人： Sara Alajem , Avraham Reinhartz , Michal Waksman
IPC分类号： G01N33/53 , C12N15/09 , C12Q1/68 , G01N21/78 , G01N33/566 , C07H21/02 , C12P19/34
CPC分类号： C12Q1/6823 , C12Q2525/301 , C12Q2525/131
摘要： Oligonucleotides useful in the detection of a nucleic acid target sequence in a sample.
摘要翻译：用于检测样品中核酸靶序列的寡核苷酸。

2. 发明授权

US08507260B2 Multistep reaction lateral flow capillary 有权
标题翻译：多步反应侧流毛细管
公开(公告)号：US08507260B2
公开(公告)日：2013-08-13
申请号：US12791944
申请日：2010-06-02
申请人： Sara Alajem , Avraham Reinhartz
发明人： Sara Alajem , Avraham Reinhartz
IPC分类号： C12M1/34
CPC分类号： B01L3/5023 , B01L3/5027 , B01L2200/026 , B01L2200/10 , B01L2200/12 , B01L2200/16 , B01L2300/069 , B01L2300/0809 , B01L2300/0825 , B01L2300/0864 , B01L2300/12 , B01L2300/123 , B01L2300/161 , B01L2400/0406 , G01N33/5302 , G01N33/5306
摘要： Disclosed is a lateral flow capillary device and uses thereof comprising a unipath bibulous capillary flow matrix and at least two reservoirs each in fluid communication with the capillary flow matrix wherein a reservoir contacts the capillary flow matrix through a passage having a rim pressing the matrix. The pressure that the rim applies on the matrix prevents leakage of liquids out of the capillary flow matrix at the reservoir/ matrix interface, allowing accurate sequential draining of liquid from the reservoirs. During use of the disclosed lateral flow capillary device a static interface is formed between the first liquid and the second liquid in an interface creation zone inside the capillary flow matrix wherein the first amount and second amount are such that first liquid substantially remains in the first reservoir and the second liquid substantially remains in the second reservoir subsequent to the formation of the static interface and wherein the interface begins to move only subsequent to exhaustion of a liquid from a reservoir.
摘要翻译：公开了一种侧流毛细管装置及其使用，其包括单通道吸水毛细管流动基质和至少两个与毛细管流动基质流体连通的储存器，其中储存器通过具有压制基质的边缘的通道与毛细管流动基质接触。边缘施加在基体上的压力可防止液体在储存器/基质界面处从毛细管流动基质中泄漏出来，从而可以准确地从储存器排出液体。在公开的侧流毛细管装置的使用期间，在毛细管流动基质内部的界面产生区域中在第一液体和第二液体之间形成静态界面，其中第一量和第二量使得第一液体基本上保留在第一储存器并且第二液体在形成静态界面之后基本上保留在第二储存器中，并且其中界面仅在液体从储存器耗尽之后开始移动。

3. 发明授权

US5807751A Apparatus and method for detection of analytes in a sample 失效
标题翻译：用于检测样品中分析物的装置和方法
公开(公告)号：US5807751A
公开(公告)日：1998-09-15
申请号：US653733
申请日：1996-05-23
申请人： Sara Alajem , Menachem Ritterband , Avraham Reinhartz
发明人： Sara Alajem , Menachem Ritterband , Avraham Reinhartz
IPC分类号： B01L3/00 , G01N33/543 , G01N33/76 , C12Q1/68
CPC分类号： B01L3/5085 , G01N33/54366 , G01N33/76 , G01N2333/59 , Y10S436/809
摘要： Apparatus for detection one or more analyte in a fluid sample. The apparatus includes one or more fluid including the fluid sample to be tested for the analyte(s) and one or more vessels for holding the fluid(s). The vessel includes a base at a first end, side walls extending generally perpendicularly from the base to a second end, an opening in the vessel defined by the side walls and the second end and a central axis extending from the center of the base to the center of vessel opening. The apparatus further includes a single matrix sheet including at least one capture site for capturing a specific analyte which is inserted in vessel and spaced from the central axis opposite the side walls and at least one apparatus for detection of a captured specific analyte.
摘要翻译：用于检测流体样品中的一种或多种分析物的装置。该装置包括一种或多种流体，包括待测试的待分析物的流体样品和用于保持流体的一个或多个容器。容器包括在第一端处的基部，大体上垂直于基部延伸到第二端的侧壁，由侧壁和第二端限定的容器中的开口，以及从基部的中心延伸到第二端的中心轴线船舶开放中心。该装置还包括单个基质片，其包括至少一个捕获位点，用于捕获插入在容器中并与中心轴线相对侧壁隔开的特定分析物，以及用于检测捕获的特定分析物的至少一个装置。

4. 发明授权

US5698395A Apparatus for separation, concentration and detection of target molecules in a liquid sample 失效
标题翻译：用于液体样品中靶分子的分离，浓缩和检测的装置
公开(公告)号：US5698395A
公开(公告)日：1997-12-16
申请号：US297805
申请日：1994-08-30
申请人： Menachem Ritterband , Sara Alajem , Michal Schrift , Ileana Rusu , Avraham Reinhartz
发明人： Menachem Ritterband , Sara Alajem , Michal Schrift , Ileana Rusu , Avraham Reinhartz
IPC分类号： G01N33/543 , C12Q1/68 , G01N33/558 , G01N37/00 , G01N33/548 , G01N33/552
CPC分类号： C12Q1/6834 , G01N33/558 , Y10S435/805 , Y10S435/81 , Y10S436/805
摘要： This disclosure describes an apparatus for separation and detection of target molecules in a liquid sample containing the target molecules and non-target molecules comprising at least one absorption area, a bibulous carrier defining a first liquid transport path in fluid contact with at least one absorption area including at least one reaction area upstream of the at least one absorption area wherein the reaction area includes a capture reagent and a sample area upstream of the reaction area wherein the liquid sample when applied to sample area is transported by capillary action past the reaction area where at least a portion of the target molecules may be bound to the capture reagent to permit detection of the target molecules. The liquid sample is then transported by capillary action on to the absorption area. A second liquid transport path is in fluid communication with the reaction area of the bibulous carrier for transporting a washing solution applied to the reaction area to the at least one absorption area thereby removing interfering substances from the reaction area. Means are also provided for alternatively selecting between the first and second liquid transport path during capillary transport of the liquid sample.
摘要翻译：本公开描述了一种用于分离和检测含有目标分子和非靶分子的液体样品中的靶分子的装置，所述靶分子和非靶分子包含至少一个吸收区域，限定与至少一个吸收区域流体接触的第一液体输送路径的吸水性载体包括在至少一个吸收区域上游的至少一个反应区域，其中反应区域包括捕获试剂和反应区域上游的样品区域，其中当应用于样品区域时的液体样品通过毛细管作用传送通过反应区域，目标分子的至少一部分可以与捕获试剂结合以允许检测目标分子。然后将液体样品通过毛细作用运送到吸收区域。第二液体输送路径与吸水性载体的反应区域流体连通，用于将施加到反应区域的洗涤溶液输送到至少一个吸收区域，从而从反应区域除去干扰物质。还提供了用于在液体样品的毛细管输送期间在第一和第二液体输送路径之间交替选择的装置。

5. 发明授权

US09952211B2 Liquid-transfer device particularly useful as a capturing device in a biological assay process 有权
公开(公告)号：US09952211B2
公开(公告)日：2018-04-24
申请号：US12999408
申请日：2009-06-29
申请人： Avraham Reinhartz , Sara Alajem
发明人： Avraham Reinhartz , Sara Alajem
IPC分类号： G01N33/543 , B01L3/00
CPC分类号： G01N33/54386 , B01L3/5023 , B01L2300/069 , B01L2300/0825 , B01L2300/0887 , B01L2300/161 , B01L2400/0406
摘要： A capturing device (20) and method for use in capturing a substance in a liquid, by feeding the liquid through a capturing device (20) including: a lateral capillary flow matrix (13) and a capturing matrix (26) in fluid communication with the lateral capillary flow matrix (13) such as to produce a lateral capillary flow in the capturing matrix having a lower velocity than that in the lateral capillary flow matrix. This produces by the Bernoulli effect, a lower pressure with respect to the two lateral flows sufficient to impart transverse oscillations to the lateral flow in the capturing matrix, such oscillations driving the liquid into the interior of the capturing matrix thereby exposing its interior, rather than merely a surface thereof, to the liquid. In the described preferred embodiments, the capturing device is a biological assay device, and each substance in the liquid to be captured in the capture zone of the capturing matrix is a biological substance.

6. 发明申请

US20080145835A1 Multistep Reaction Lateral Flow Capillary Device 有权
标题翻译：多步反应侧流毛细管装置
公开(公告)号：US20080145835A1
公开(公告)日：2008-06-19
申请号：US11883329
申请日：2006-01-31
申请人： Sara Alajem , Avraham Reinhartz
发明人： Sara Alajem , Avraham Reinhartz
IPC分类号： C12Q1/00 , C12M1/34
CPC分类号： B01L3/5023 , B01L3/5027 , B01L2200/026 , B01L2200/10 , B01L2200/12 , B01L2200/16 , B01L2300/069 , B01L2300/0809 , B01L2300/0825 , B01L2300/0864 , B01L2300/12 , B01L2300/123 , B01L2300/161 , B01L2400/0406 , G01N33/5302 , G01N33/5306
摘要： Disclosed is a lateral flow capillary device and uses thereof comprising a unipath bibulous capillary flow matrix and at least two reservoirs each in fluid communication with the capillary flow matrix wherein a reservoir contacts the capillary flow matrix through a passage having a rim pressing the matrix. The pressure that the rim applies on the matrix prevents leakage of liquids out of the capillary flow matrix at the reservoir/matrix interface, allowing accurate sequential draining of liquid from the reservoirs. During use of the disclosed lateral flow capillary device a static interface is formed between the first liquid and the second liquid in an interface creation zone inside the capillary flow matrix wherein the first amount and second amount are such that first liquid substantially remains in the first reservoir and the second liquid substantially remains in the second reservoir subsequent to the formation of the static interface and wherein the interface begins to move only subsequent to exhaustion of a liquid from a reservoir.
摘要翻译：公开了一种侧流毛细管装置及其使用，其包括单通吸管毛细管流动基质和至少两个与毛细管流动基质流体连通的储存器，其中储存器通过具有压制基质的边缘的通道接触毛细管流动基质。边缘施加在基体上的压力可防止液体在储存器/基质界面处从毛细管流动基质中泄漏出来，从而可以准确地从储存器排出液体。在公开的侧流毛细管装置的使用期间，在毛细管流动基质内部的界面产生区域中在第一液体和第二液体之间形成静态界面，其中第一量和第二量使得第一液体基本上保留在第一储存器并且第二液体在形成静态界面之后基本上保留在第二储存器中，并且其中界面仅在液体从储存器耗尽之后开始移动。

7. 发明授权

US09101927B2 Multistep reaction lateral flow capillary device 有权
标题翻译：多步反应侧流毛细管装置
公开(公告)号：US09101927B2
公开(公告)日：2015-08-11
申请号：US11883329
申请日：2006-01-31
申请人： Sara Alajem , Avraham Reinhartz
发明人： Sara Alajem , Avraham Reinhartz
IPC分类号： B01L3/00 , G01N33/53
CPC分类号： B01L3/5023 , B01L3/5027 , B01L2200/026 , B01L2200/10 , B01L2200/12 , B01L2200/16 , B01L2300/069 , B01L2300/0809 , B01L2300/0825 , B01L2300/0864 , B01L2300/12 , B01L2300/123 , B01L2300/161 , B01L2400/0406 , G01N33/5302 , G01N33/5306
摘要： Disclosed is a lateral flow capillary device and uses thereof comprising a unipath bibulous capillary flow matrix and at least two reservoirs each in fluid communication with the capillary flow matrix wherein a reservoir contacts the capillary flow matrix through a passage having a rim pressing the matrix. The pressure that the rim applies on the matrix prevents leakage of liquids out of the capillary flow matrix at the reservoir/matrix interface, allowing accurate sequential draining of liquid from the reservoirs. During use of the disclosed lateral flow capillary device a static interface is formed between the first liquid and the second liquid in an interface creation zone inside the capillary flow matrix wherein the first amount and second amount are such that first liquid substantially remains in the first reservoir and the second liquid substantially remains in the second reservoir subsequent to the formation of the static interface and wherein the interface begins to move only subsequent to exhaustion of a liquid from a reservoir.
摘要翻译：公开了一种侧流毛细管装置及其使用，其包括单通吸管毛细管流动基质和至少两个与毛细管流动基质流体连通的储存器，其中储存器通过具有压制基质的边缘的通道接触毛细管流动基质。边缘施加在基体上的压力可防止液体在储存器/基质界面处从毛细管流动基质中泄漏出来，从而可以准确地从储存器排出液体。在公开的侧流毛细管装置的使用期间，在毛细管流动基质内部的界面产生区域中在第一液体和第二液体之间形成静态界面，其中第一量和第二量使得第一液体基本上保留在第一储存器并且第二液体在形成静态界面之后基本上保留在第二储存器中，并且其中界面仅在液体从储存器耗尽之后开始移动。

8. 发明申请

US20110189792A1 LIQUID-TRANSFER DEVICE PARTICULARLY USEFUL AS A CAPTURING DEVICE IN A BIOLOGICAL ASSAY PROCESS 有权
标题翻译：液体转移装置特别适用于生物测定过程中的捕获装置
公开(公告)号：US20110189792A1
公开(公告)日：2011-08-04
申请号：US12999408
申请日：2009-06-29
申请人： Avraham Reinhartz , Sara Alajem
发明人： Avraham Reinhartz , Sara Alajem
IPC分类号： G01N33/50 , G01N33/48 , C12M1/34
CPC分类号： G01N33/54386 , B01L3/5023 , B01L2300/069 , B01L2300/0825 , B01L2300/0887 , B01L2300/161 , B01L2400/0406
摘要： A capturing device (20) and method for use in capturing a substance in a liquid, by feeding the liquid through a capturing device (20) including: a lateral capillary flow matrix (13) and a capturing matrix (26) in fluid communication with the lateral capillary flow matrix (13) such as to produce a lateral capillary flow in the capturing matrix having a lower velocity than that in the lateral capillary flow matrix. This produces by the Bernoulli effect, a lower pressure with respect to the two lateral flows sufficient to impart transverse oscillations to the lateral flow in the capturing matrix, such oscillations driving the liquid into the interior of the capturing matrix thereby exposing its interior, rather than merely a surface thereof, to the liquid. In the described preferred embodiments, the capturing device is a biological assay device, and each substance in the liquid to be captured in the capture zone of the capturing matrix is a biological substance.
摘要翻译：一种捕获装置（20）和用于捕获液体中的物质的方法，所述捕获装置（20）通过将所述液体供给通过捕获装置（20）而进行捕获，所述捕获装置包括：侧向毛细管流动矩阵（13）和捕获基质（26），其与横向毛细管流动基质（13），例如在捕获基质中产生比侧向毛细管流动基质中低的速度的侧向毛细管流动。这通过伯努利效应产生，相对于足以赋予捕获矩阵中的横向流动的横向振荡的两个横向流动的较低压力，这种振荡将液体驱动到捕获基质的内部，从而暴露其内部，而不是仅仅是其表面。在所述优选实施方案中，捕获装置是生物测定装置，并且捕获基质的捕获区域中待捕获的液体中的每种物质是生物物质。

9. 发明申请

US20100239459A1 Multistep Reaction Lateral Flow Capillary 有权
标题翻译：多步反应侧流毛细管
公开(公告)号：US20100239459A1
公开(公告)日：2010-09-23
申请号：US12791944
申请日：2010-06-02
申请人： Sara Alajem , Avraham Reinhartz
发明人： Sara Alajem , Avraham Reinhartz
IPC分类号： G01N33/53 , B01L3/00
CPC分类号： B01L3/5023 , B01L3/5027 , B01L2200/026 , B01L2200/10 , B01L2200/12 , B01L2200/16 , B01L2300/069 , B01L2300/0809 , B01L2300/0825 , B01L2300/0864 , B01L2300/12 , B01L2300/123 , B01L2300/161 , B01L2400/0406 , G01N33/5302 , G01N33/5306
摘要： Disclosed is a lateral flow capillary device and uses thereof comprising a unipath bibulous capillary flow matrix and at least two reservoirs each in fluid communication with the capillary flow matrix wherein a reservoir contacts the capillary flow matrix through a passage having a rim pressing the matrix. The pressure that the rim applies on the matrix prevents leakage of liquids out of the capillary flow matrix at the reservoir/matrix interface, allowing accurate sequential draining of liquid from the reservoirs. During use of the disclosed lateral flow capillary device a static interface is formed between the first liquid and the second liquid in an interface creation zone inside the capillary flow matrix wherein the first amount and second amount are such that first liquid substantially remains in the first reservoir and the second liquid substantially remains in the second reservoir subsequent to the formation of the static interface and wherein the interface begins to move only subsequent to exhaustion of a liquid from a reservoir.
摘要翻译：公开了一种侧流毛细管装置及其使用，其包括单通吸管毛细管流动基质和至少两个与毛细管流动基质流体连通的储存器，其中储存器通过具有压制基质的边缘的通道接触毛细管流动基质。边缘施加在基体上的压力可防止液体在储存器/基质界面处从毛细管流动基质中泄漏出来，从而可以准确地从储存器排出液体。在公开的侧流毛细管装置的使用期间，在毛细管流动基质内部的界面产生区域中在第一液体和第二液体之间形成静态界面，其中第一量和第二量使得第一液体基本上保留在第一储存器并且第二液体在形成静态界面之后基本上保留在第二储存器中，并且其中界面仅在液体从储存器耗尽之后开始移动。

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