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1. 发明授权

US5698395A Apparatus for separation, concentration and detection of target molecules in a liquid sample 失效
标题翻译：用于液体样品中靶分子的分离，浓缩和检测的装置
公开(公告)号：US5698395A
公开(公告)日：1997-12-16
申请号：US297805
申请日：1994-08-30
申请人： Menachem Ritterband , Sara Alajem , Michal Schrift , Ileana Rusu , Avraham Reinhartz
发明人： Menachem Ritterband , Sara Alajem , Michal Schrift , Ileana Rusu , Avraham Reinhartz
IPC分类号： G01N33/543 , C12Q1/68 , G01N33/558 , G01N37/00 , G01N33/548 , G01N33/552
CPC分类号： C12Q1/6834 , G01N33/558 , Y10S435/805 , Y10S435/81 , Y10S436/805
摘要： This disclosure describes an apparatus for separation and detection of target molecules in a liquid sample containing the target molecules and non-target molecules comprising at least one absorption area, a bibulous carrier defining a first liquid transport path in fluid contact with at least one absorption area including at least one reaction area upstream of the at least one absorption area wherein the reaction area includes a capture reagent and a sample area upstream of the reaction area wherein the liquid sample when applied to sample area is transported by capillary action past the reaction area where at least a portion of the target molecules may be bound to the capture reagent to permit detection of the target molecules. The liquid sample is then transported by capillary action on to the absorption area. A second liquid transport path is in fluid communication with the reaction area of the bibulous carrier for transporting a washing solution applied to the reaction area to the at least one absorption area thereby removing interfering substances from the reaction area. Means are also provided for alternatively selecting between the first and second liquid transport path during capillary transport of the liquid sample.
摘要翻译：本公开描述了一种用于分离和检测含有目标分子和非靶分子的液体样品中的靶分子的装置，所述靶分子和非靶分子包含至少一个吸收区域，限定与至少一个吸收区域流体接触的第一液体输送路径的吸水性载体包括在至少一个吸收区域上游的至少一个反应区域，其中反应区域包括捕获试剂和反应区域上游的样品区域，其中当应用于样品区域时的液体样品通过毛细管作用传送通过反应区域，目标分子的至少一部分可以与捕获试剂结合以允许检测目标分子。然后将液体样品通过毛细作用运送到吸收区域。第二液体输送路径与吸水性载体的反应区域流体连通，用于将施加到反应区域的洗涤溶液输送到至少一个吸收区域，从而从反应区域除去干扰物质。还提供了用于在液体样品的毛细管输送期间在第一和第二液体输送路径之间交替选择的装置。

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