专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20080057517A1 Methods of regulating cytokine signalling 审中-公开
标题翻译：调节细胞因子信号传导的方法
公开(公告)号：US20080057517A1
公开(公告)日：2008-03-06
申请号：US11818589
申请日：2007-06-15
申请人： Sandra Nicholson , Manuel Baca , Nicos Nicola , Douglas Hilton , Jian Zhang , Louis Fabri , Andrew Nash
发明人： Sandra Nicholson , Manuel Baca , Nicos Nicola , Douglas Hilton , Jian Zhang , Louis Fabri , Andrew Nash
IPC分类号： G01N33/53
CPC分类号： G01N33/6863
摘要： The present invention relates generally to a method for regulating cytokine signalling and agents useful for same. The method of the present invention is predicated in part on the identification of the molecular target of suppressor of cytokine signalling (SOCS) interaction in controlling cytokine signalling. The identification of the molecular target permits the development of assays to screen for a range of agonists and antagonists useful in modulating cytokine function. The present invention further provides, therefore, screening assays and more particularly high through-put screening assays for agonists and antagonists of SOCS-receptor interaction. Such agonists and antagonists are useful in the manufacture of medicaments for controlling cytokine signalling. Control of cytokine signalling is important for the treatment of a range of conditions including cancer, inflammatory conditions, immunological disorders and any other conditions involving aberrations of signal transduction.
摘要翻译：本发明一般涉及用于调节细胞因子信号传导的方法和可用于其的试剂。本发明的方法部分地基于在控制细胞因子信号传导中识别细胞因子信号传导抑制剂（SOCS）相互作用的分子靶标。分子靶标的鉴定允许开发测定以筛选可用于调节细胞因子功能的一系列激动剂和拮抗剂。因此，本发明进一步提供用于SOCS-受体相互作用的激动剂和拮抗剂的筛选测定和更特别的高通量筛选测定。这样的激动剂和拮抗剂可用于制备用于控制细胞因子信号传导的药物。细胞因子信号传导的控制对于治疗一系列病症（包括癌症，炎性病症，免疫学障碍和涉及信号转导异常的任何其他病症）是重要的。

2. 发明申请

US20050058645A1 Monoclonal antibody against Interleukin-13 receptor alpha 1 (IL-13Ralpha1) 有权
标题翻译：白细胞介素-13受体α1单克隆抗体（IL-13Rα1）
公开(公告)号：US20050058645A1
公开(公告)日：2005-03-17
申请号：US10850270
申请日：2004-05-20
申请人： Felicity Dunlop , Manuel Baca , Andrew Nash , Louis Fabri , Douglas Hilton , Nicos Nicola
发明人： Felicity Dunlop , Manuel Baca , Andrew Nash , Louis Fabri , Douglas Hilton , Nicos Nicola
IPC分类号： C07K16/28 , C12N5/20 , A61K39/395 , C07K16/24
CPC分类号： C07K16/2866 , C07K2317/24 , C07K2317/55 , C07K2319/00
摘要： The present invention relates generally to antibodies that bind to the Interleukin-13 receptor α1 chain (IL-13Rα1) and antagonize IL-13 receptor-mediated signaling by IL-13 and/or IL-4. More particularly, the present invention provides humanized or human antibodies to mammalian and in particular IL-13Rα1. These antibodies have uses in the treatment or prevention of IL-13- and/or IL-4-mediated diseases or conditions. The present invention further contemplates a method of modulating IL-13- and/or IL-4-mediated diseases or conditions by the administration of the subject antibodies. The present invention further provides an assay system useful for identifying antibodies or other agents which modulate IL-13 and/or IL-4 signaling through an IL-13 receptor complex. Accordingly, a method of screening for modulators of IL-13Rα1/ligand interaction is also provided.
摘要翻译：本发明一般涉及结合白细胞介素-13受体α1链（IL-13Rα1）并通过IL-13和/或IL-4拮抗IL-13受体介导的信号传导的抗体。更具体地说，本发明为哺乳动物，特别是IL-13Rα1提供人源化或人抗体。这些抗体在治疗或预防IL-13和/或IL-4介导的疾病或病症中具有应用。本发明进一步考虑通过施用受试者抗体调节IL-13和/或IL-4介导的疾病或病症的方法。本发明还提供了可用于鉴定通过IL-13受体复合物调节IL-13和/或IL-4信号传导的抗体或其它试剂的测定系统。因此，还提供了筛选IL-13Rα1/配体相互作用的调节剂的方法。

3. 发明申请

US20060242718A1 SOCS-box containing peptides 审中-公开
标题翻译：含有SOCS盒的肽
公开(公告)号：US20060242718A1
公开(公告)日：2006-10-26
申请号：US11400964
申请日：2006-04-10
申请人： Tracy Willson , Richard Simpson , Alison Farley , Sandra Nicholson , Jian Zhang , Manuel Baca , Nicos Nicola , Douglas Hilton , Warren Alexander , Donald Metcalf
发明人： Tracy Willson , Richard Simpson , Alison Farley , Sandra Nicholson , Jian Zhang , Manuel Baca , Nicos Nicola , Douglas Hilton , Warren Alexander , Donald Metcalf
IPC分类号： A01K67/00 , A61K38/22
CPC分类号： C07K14/4703 , A01K2217/05 , A61K38/00
摘要： The present invention relates generally to amino acid sequences obtainable from SOCS proteins and which are capable of interacting with intracellular molecules. The present invention further relates to nucleic acid molecules encoding said amino acid sequences. The amino acid sequences and the nucleic acid molecules encoding same of the present invention are useful in modulating degradation of proteinaceous molecules such as but not limited to SOCS proteins and proteinaceous molecules associate therewith. The present invention provides a mechanism for modulating cytokine or cytokine-like molecule signaling by modulating the degradation of activated signal transduction molecules or their negative regulators, i.e. the SOCS proteins.
摘要翻译：本发明一般涉及可从SOCS蛋白获得并且能够与细胞内分子相互作用的氨基酸序列。本发明还涉及编码所述氨基酸序列的核酸分子。编码本发明的氨基酸序列和核酸分子可用于调节蛋白质分子的降解，例如但不限于与其缔合的SOCS蛋白和蛋白质分子。本发明提供了通过调节活化的信号转导分子或其负调节物（即SOCS蛋白）的降解来调节细胞因子或细胞因子样分子信号传导的机制。

4. 发明申请

US20060294608A1 Novel haemopoietin receptor and genetic sequences encoding same 审中-公开
标题翻译：新型造血素受体和编码相同的遗传序列
公开(公告)号：US20060294608A1
公开(公告)日：2006-12-28
申请号：US11509410
申请日：2006-08-24
申请人： Douglas Hilton , Nicos Nicola , Alison Farley , Tracy Willson , Jian-Guo Zhang , Warren Alexander , Steven Rakar , Louis Fabri , Tetsuo Kojima , Masatsugu Maeda , Yasufumi Kikuchi , Andrew Nash
发明人： Douglas Hilton , Nicos Nicola , Alison Farley , Tracy Willson , Jian-Guo Zhang , Warren Alexander , Steven Rakar , Louis Fabri , Tetsuo Kojima , Masatsugu Maeda , Yasufumi Kikuchi , Andrew Nash
IPC分类号： A01K67/027 , C07H21/04 , C12P21/06 , C07K14/71 , C07K16/28
CPC分类号： C07K14/715 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/0381 , C07K16/2866 , C12N15/8509
摘要： The present invention relates generally to a novel haemopoietin receptor or derivatives thereof and to genetic sequences encoding same. Interaction between the novel receptor of the present invention and a cytokine ligand facilitates proliferation, differentiation and survival of a wide variety of cells. The novel receptor and its derivatives and the genetic sequences encoding same of the present invention are useful in the development of a wide range of agonists, antagonists, therapeutics and diagnostic reagents based on ligand interaction with its receptor.
摘要翻译：本发明一般涉及一种新型促血细胞生成素受体或其衍生物和编码该基因的遗传序列。本发明的新型受体与细胞因子配体之间的相互作用促进多种细胞的增殖，分化和存活。本发明的新受体及其衍生物和编码本发明的遗传序列可用于开发基于配体与其受体相互作用的广泛范围的激动剂，拮抗剂，治疗剂和诊断试剂。

5. 发明申请

US20070179089A1 Structure of SOCS and uses thereof 有权
标题翻译： SOCS的结构及其用途
公开(公告)号：US20070179089A1
公开(公告)日：2007-08-02
申请号：US11598212
申请日：2006-11-09
申请人： Raymond Norton , Jeffrey Babon , Sandra Nicholson , Nicos Nicola , Edward McManus , Manuel Baca , Shenggen Yao
发明人： Raymond Norton , Jeffrey Babon , Sandra Nicholson , Nicos Nicola , Edward McManus , Manuel Baca , Shenggen Yao
IPC分类号： A61K48/00 , C07K14/705 , A61K38/17 , C07H21/04 , C12P21/06
CPC分类号： C07K14/4703 , A61K38/17
摘要： The present invention relates to the identification of a PEST motif in Suppressor of Cytokine Signalling (SOCS) proteins, the deletion/inactivation of which has been found to increase the stability of the protein whilst maintaining at least one biological activity of the protein. Such SOCS proteins with deleted/inactivated PEST motifs can be used in gene and protein therapy procedures to provide a more stable SOCS protein when compared to the native protein. The present invention also relates to the characterization of the structure of SOCS proteins, and methods of using this structural information to identify compounds which modulate the activity of SOCS.
摘要翻译：本发明涉及鉴定细胞因子信号传导抑制因子（SOCS）蛋白质的抑制因子的PEST基序，已经发现其缺失/失活增加了蛋白质的稳定性，同时保持蛋白质的至少一种生物学活性。具有缺失/失活的PEST基序的这种SOCS蛋白质可用于基因和蛋白质治疗程序，以便与天然蛋白质相比提供更稳定的SOCS蛋白质。本发明还涉及SOCS蛋白质结构的表征，以及使用该结构信息鉴定调节SOCS活性的化合物的方法。

6. 发明申请

US20060003377A1 Therapeutic and diagnostic proteins comprising a SOCS box 审中-公开
标题翻译：包括SOCS盒的治疗和诊断蛋白质
公开(公告)号：US20060003377A1
公开(公告)日：2006-01-05
申请号：US11214199
申请日：2005-08-29
申请人： Douglas Hilton , Warren Alexander , Elizabeth Viney , Tracy Willson , Rachael Richardson , Robyn Starr , Sandra Nicholson , Donald Metcalf , Nicos Nicola
发明人： Douglas Hilton , Warren Alexander , Elizabeth Viney , Tracy Willson , Rachael Richardson , Robyn Starr , Sandra Nicholson , Donald Metcalf , Nicos Nicola
IPC分类号： C12Q1/68 , G01N33/53 , C07K14/47 , C07H21/04
CPC分类号： A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/03 , A61K38/00 , C07K14/47 , C07K14/4703 , C07K2319/00 , C07K2319/43 , C07K2319/60 , C12N15/8509 , G01N33/6863
摘要： The present invention relates generally to therapeutic and diagnostic agents. More particularly, the present invention provides therapeutic molecules capable of modulating signal transduction such as but not limited to cytokine-mediated signal transduction. The molecules of the present invention are useful, therefore, in modulating cellular responsiveness to cytokines as well as other mediators of signal transduction such as endogenous or exogenous molecules, antigens, microbes and microbial products, viruses or components thereof, ions, hormones and parasites.
摘要翻译：本发明一般涉及治疗和诊断剂。更具体地，本发明提供能够调节信号转导的治疗分子，例如但不限于细胞因子介导的信号转导。因此，本发明的分子可用于调节对细胞因子以及信号转导的其它介质如内源性或外源性分子，抗原，微生物和微生物产物，病毒或其组分，离子，激素和寄生虫的细胞反应性。

7. 发明申请

US20050208521A1 Therapeutic and diagnostic agents 失效
标题翻译：治疗和诊断剂
公开(公告)号：US20050208521A1
公开(公告)日：2005-09-22
申请号：US10991181
申请日：2004-11-17
申请人： Douglas Hilton , Warren Alexander , Elizabeth Viney , Tracy Willson , Rachael Richardson , Robyn Starr , Sandra Nicholson , Donald Metcalf , Nicos Nicola
发明人： Douglas Hilton , Warren Alexander , Elizabeth Viney , Tracy Willson , Rachael Richardson , Robyn Starr , Sandra Nicholson , Donald Metcalf , Nicos Nicola
IPC分类号： A61K38/00 , C07H21/04 , C07K14/47 , C12N15/09 , C12P21/06 , C12Q1/68 , G01N33/53 , G01N33/564 , G01N33/574 , G01N33/68
CPC分类号： G01N33/564 , A61K38/00 , C07K14/4703 , G01N33/574 , G01N33/6863
摘要： The present invention relates generally to therapeutic and diagnostic agents. More particularly, the present invention provides therapeutic molecules capable of modulating signal transduction such as but not limited to cytokine-mediated signal transduction. The molecules of the present invention are useful, therefore, in modulating cellular responsiveness to cytokines as well as other mediators of signal transduction such as endogenous or exogenous molecules, antigens, microbes and microbial products, viruses or components thereof, ions, hormones and parasites.
摘要翻译：本发明一般涉及治疗和诊断剂。更具体地，本发明提供能够调节信号转导的治疗分子，例如但不限于细胞因子介导的信号转导。因此，本发明的分子可用于调节对细胞因子以及信号转导的其它介质如内源性或外源性分子，抗原，微生物和微生物产物，病毒或其组分，离子，激素和寄生虫的细胞反应性。

8. 发明申请

US20050004015A1 NOVEL HAEMOPOIETIN RECEPTOR AND GENETIC SEQUENCES ENCODING SAME 失效
标题翻译：新型海马素受体和编码序列的遗传序列
公开(公告)号：US20050004015A1
公开(公告)日：2005-01-06
申请号：US10014156
申请日：2001-12-07
申请人： Douglas Hilton , Tracy Willson , Timothy Gainsford , Warren Alexander , Donald Metcalf , Ashley Ng , Nicos Nicola
发明人： Douglas Hilton , Tracy Willson , Timothy Gainsford , Warren Alexander , Donald Metcalf , Ashley Ng , Nicos Nicola
IPC分类号： C12N15/02 , A61K31/00 , A61K38/00 , A61K45/00 , A61P9/00 , A61P9/10 , A61P25/00 , A61P25/02 , A61P25/16 , C07K14/575 , C07K14/715 , C07K14/72 , C07K16/28 , C12N5/00 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12R1/91 , A61K38/17
CPC分类号： C07K14/72 , C07K14/715
摘要： The present invention is directed to a novel haemopoietin receptor or a derivative thereof and to genetic sequences encoding same. The receptor molecule and its derivatives and the genetic sequences encoding same of the present invention are useful in the development of a wide range of agonists, antagonists, therapeutics and diagnostic reagents based on ligand interaction with its receptor. The present invention particularly relates to a receptor for leptin.
摘要翻译：本发明涉及一种新型促血细胞生成素受体或其衍生物和编码该基因的遗传序列。受体分子及其衍生物和本发明编码相同基因的序列可用于开发基于配体与其受体相互作用的广泛范围的激动剂，拮抗剂，治疗剂和诊断试剂。本发明特别涉及瘦素受体。

9. 发明申请

US20070275916A1 Methods of Identifying Compounds Which Modulate Granulocite-Colony Stimulating Factor (G-Csf) Dependent Processes by Modulation of the Levels of Suppressor of Cytokine Signaling (Socs) 审中-公开
标题翻译：通过调节细胞因子信号抑制因子水平鉴定化合物的方法，调节粒细胞集落刺激因子（G-Csf）依赖过程
公开(公告)号：US20070275916A1
公开(公告)日：2007-11-29
申请号：US10559711
申请日：2004-06-04
申请人： Ben Croker , Andrew Roberts , Don Metcalf , Warren Alexander , Doug Hilton , Nicos Nicola
发明人： Ben Croker , Andrew Roberts , Don Metcalf , Warren Alexander , Doug Hilton , Nicos Nicola
IPC分类号： A61K48/00 , A01K67/00 , C07H21/04 , C07K1/00
CPC分类号： A01K67/0276 , A01K2217/075 , A01K2267/0381 , C07K14/4703 , C12N2800/30 , C12N2830/008
摘要： The present invention relates generally to compounds which modulate cytokine-dependent processes. More particularly, the compounds of the present invention modulate responses to a colony stimulating factor and even more particularly to granulocyte-colony stimulating factor (G-CSF) by modulating the levels of molecules which inhibit G-CSF such as but not limited to a suppressor of cytokine signaling (SOCS) and in particular SOCS-3. The present invention further contemplates methods for regulating G-CSF-dependent processes by contacting cells in vitro with or administering to a subject a compound which up- or down-regulates the level of activity of G-CSF by modulating the level or activity of a SOCS molecule such as SOCS-3. The instant compounds are further useful for modulating a range of G-CSF-induced cellular responses including neutrophil recovery after chemotherapy or radiotherapy, mobilizing stem and progenitor cells, treating infection and treating inflammatory conditions.
摘要翻译：本发明一般涉及调节细胞因子依赖性过程的化合物。更具体地，本发明的化合物通过调节抑制G-CSF的分子的水平来调节对集落刺激因子的反应，甚至更特别地调节粒细胞集落刺激因子（G-CSF），例如但不限于抑制因子的细胞因子信号（SOCS），特别是SOCS-3。本发明进一步考虑了通过使细胞在体外与受试者接触的方法来调节G-CSF依赖性过程的方法，所述化合物通过调节G-CSF的水平或活性来上调或下调G-CSF的活性水平 SOCS分子如SOCS-3。本发明化合物还可用于调节一系列G-CSF诱导的细胞反应，包括化疗或放疗后的嗜中性粒细胞回收，动员干细胞和祖细胞，治疗感染和治疗炎性病症。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式