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1. 发明申请

US20060294608A1 Novel haemopoietin receptor and genetic sequences encoding same 审中-公开
标题翻译：新型造血素受体和编码相同的遗传序列
公开(公告)号：US20060294608A1
公开(公告)日：2006-12-28
申请号：US11509410
申请日：2006-08-24
申请人： Douglas Hilton , Nicos Nicola , Alison Farley , Tracy Willson , Jian-Guo Zhang , Warren Alexander , Steven Rakar , Louis Fabri , Tetsuo Kojima , Masatsugu Maeda , Yasufumi Kikuchi , Andrew Nash
发明人： Douglas Hilton , Nicos Nicola , Alison Farley , Tracy Willson , Jian-Guo Zhang , Warren Alexander , Steven Rakar , Louis Fabri , Tetsuo Kojima , Masatsugu Maeda , Yasufumi Kikuchi , Andrew Nash
IPC分类号： A01K67/027 , C07H21/04 , C12P21/06 , C07K14/71 , C07K16/28
CPC分类号： C07K14/715 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/0381 , C07K16/2866 , C12N15/8509
摘要： The present invention relates generally to a novel haemopoietin receptor or derivatives thereof and to genetic sequences encoding same. Interaction between the novel receptor of the present invention and a cytokine ligand facilitates proliferation, differentiation and survival of a wide variety of cells. The novel receptor and its derivatives and the genetic sequences encoding same of the present invention are useful in the development of a wide range of agonists, antagonists, therapeutics and diagnostic reagents based on ligand interaction with its receptor.
摘要翻译：本发明一般涉及一种新型促血细胞生成素受体或其衍生物和编码该基因的遗传序列。本发明的新型受体与细胞因子配体之间的相互作用促进多种细胞的增殖，分化和存活。本发明的新受体及其衍生物和编码本发明的遗传序列可用于开发基于配体与其受体相互作用的广泛范围的激动剂，拮抗剂，治疗剂和诊断试剂。

2. 发明授权

US07220828B2 Haemopoietin receptor and genetic sequence encoding same 失效
标题翻译：促血细胞生成素受体和编码相同的遗传序列
公开(公告)号：US07220828B2
公开(公告)日：2007-05-22
申请号：US09037657
申请日：1998-03-10
申请人： Tracy Willson , Nicos A. Nicola , Douglas J. Hilton , Jian-Guo Zhang , Alison Farley , Warren Alexander , Steven Rakar , Yasufumi Kikuchi , Tetsuo Kojima , Masatsugu Maeda , Louis Fabri , Andrew Nash
发明人： Tracy Willson , Nicos A. Nicola , Douglas J. Hilton , Jian-Guo Zhang , Alison Farley , Warren Alexander , Steven Rakar , Yasufumi Kikuchi , Tetsuo Kojima , Masatsugu Maeda , Louis Fabri , Andrew Nash
IPC分类号： C07K14/715 , C12N15/09 , A61K38/00
CPC分类号： C07K14/7155 , A61K38/00 , C07K2319/00
摘要： The present invention relates generally to a novel haemopoietin receptor or derivatives thereof and to genetic sequences encoding same. Interaction between the novel receptor of the present invention and a cytokine ligand facilitates proliferation, differentiation and survival of a wide variety of cells. The novel receptor and its derivatives and the genetic sequences encoding same of the present invention are useful in the development of a wide range of agonists, antagonists, therapeutics and diagnostic reagents based on ligand interaction with its receptor.
摘要翻译：本发明一般涉及一种新型促血细胞生成素受体或其衍生物和编码该基因的遗传序列。本发明的新型受体与细胞因子配体之间的相互作用促进多种细胞的增殖，分化和存活。本发明的新受体及其衍生物和编码本发明的遗传序列可用于开发基于配体与其受体相互作用的广泛范围的激动剂，拮抗剂，治疗剂和诊断试剂。

3. 发明申请

US20060242718A1 SOCS-box containing peptides 审中-公开
标题翻译：含有SOCS盒的肽
公开(公告)号：US20060242718A1
公开(公告)日：2006-10-26
申请号：US11400964
申请日：2006-04-10
申请人： Tracy Willson , Richard Simpson , Alison Farley , Sandra Nicholson , Jian Zhang , Manuel Baca , Nicos Nicola , Douglas Hilton , Warren Alexander , Donald Metcalf
发明人： Tracy Willson , Richard Simpson , Alison Farley , Sandra Nicholson , Jian Zhang , Manuel Baca , Nicos Nicola , Douglas Hilton , Warren Alexander , Donald Metcalf
IPC分类号： A01K67/00 , A61K38/22
CPC分类号： C07K14/4703 , A01K2217/05 , A61K38/00
摘要： The present invention relates generally to amino acid sequences obtainable from SOCS proteins and which are capable of interacting with intracellular molecules. The present invention further relates to nucleic acid molecules encoding said amino acid sequences. The amino acid sequences and the nucleic acid molecules encoding same of the present invention are useful in modulating degradation of proteinaceous molecules such as but not limited to SOCS proteins and proteinaceous molecules associate therewith. The present invention provides a mechanism for modulating cytokine or cytokine-like molecule signaling by modulating the degradation of activated signal transduction molecules or their negative regulators, i.e. the SOCS proteins.
摘要翻译：本发明一般涉及可从SOCS蛋白获得并且能够与细胞内分子相互作用的氨基酸序列。本发明还涉及编码所述氨基酸序列的核酸分子。编码本发明的氨基酸序列和核酸分子可用于调节蛋白质分子的降解，例如但不限于与其缔合的SOCS蛋白和蛋白质分子。本发明提供了通过调节活化的信号转导分子或其负调节物（即SOCS蛋白）的降解来调节细胞因子或细胞因子样分子信号传导的机制。

4. 发明申请

US20050004015A1 NOVEL HAEMOPOIETIN RECEPTOR AND GENETIC SEQUENCES ENCODING SAME 失效
标题翻译：新型海马素受体和编码序列的遗传序列
公开(公告)号：US20050004015A1
公开(公告)日：2005-01-06
申请号：US10014156
申请日：2001-12-07
申请人： Douglas Hilton , Tracy Willson , Timothy Gainsford , Warren Alexander , Donald Metcalf , Ashley Ng , Nicos Nicola
发明人： Douglas Hilton , Tracy Willson , Timothy Gainsford , Warren Alexander , Donald Metcalf , Ashley Ng , Nicos Nicola
IPC分类号： C12N15/02 , A61K31/00 , A61K38/00 , A61K45/00 , A61P9/00 , A61P9/10 , A61P25/00 , A61P25/02 , A61P25/16 , C07K14/575 , C07K14/715 , C07K14/72 , C07K16/28 , C12N5/00 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12R1/91 , A61K38/17
CPC分类号： C07K14/72 , C07K14/715
摘要： The present invention is directed to a novel haemopoietin receptor or a derivative thereof and to genetic sequences encoding same. The receptor molecule and its derivatives and the genetic sequences encoding same of the present invention are useful in the development of a wide range of agonists, antagonists, therapeutics and diagnostic reagents based on ligand interaction with its receptor. The present invention particularly relates to a receptor for leptin.
摘要翻译：本发明涉及一种新型促血细胞生成素受体或其衍生物和编码该基因的遗传序列。受体分子及其衍生物和本发明编码相同基因的序列可用于开发基于配体与其受体相互作用的广泛范围的激动剂，拮抗剂，治疗剂和诊断试剂。本发明特别涉及瘦素受体。

5. 发明申请

US20060003377A1 Therapeutic and diagnostic proteins comprising a SOCS box 审中-公开
标题翻译：包括SOCS盒的治疗和诊断蛋白质
公开(公告)号：US20060003377A1
公开(公告)日：2006-01-05
申请号：US11214199
申请日：2005-08-29
申请人： Douglas Hilton , Warren Alexander , Elizabeth Viney , Tracy Willson , Rachael Richardson , Robyn Starr , Sandra Nicholson , Donald Metcalf , Nicos Nicola
发明人： Douglas Hilton , Warren Alexander , Elizabeth Viney , Tracy Willson , Rachael Richardson , Robyn Starr , Sandra Nicholson , Donald Metcalf , Nicos Nicola
IPC分类号： C12Q1/68 , G01N33/53 , C07K14/47 , C07H21/04
CPC分类号： A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/03 , A61K38/00 , C07K14/47 , C07K14/4703 , C07K2319/00 , C07K2319/43 , C07K2319/60 , C12N15/8509 , G01N33/6863
摘要： The present invention relates generally to therapeutic and diagnostic agents. More particularly, the present invention provides therapeutic molecules capable of modulating signal transduction such as but not limited to cytokine-mediated signal transduction. The molecules of the present invention are useful, therefore, in modulating cellular responsiveness to cytokines as well as other mediators of signal transduction such as endogenous or exogenous molecules, antigens, microbes and microbial products, viruses or components thereof, ions, hormones and parasites.
摘要翻译：本发明一般涉及治疗和诊断剂。更具体地，本发明提供能够调节信号转导的治疗分子，例如但不限于细胞因子介导的信号转导。因此，本发明的分子可用于调节对细胞因子以及信号转导的其它介质如内源性或外源性分子，抗原，微生物和微生物产物，病毒或其组分，离子，激素和寄生虫的细胞反应性。

6. 发明申请

US20050208521A1 Therapeutic and diagnostic agents 失效
标题翻译：治疗和诊断剂
公开(公告)号：US20050208521A1
公开(公告)日：2005-09-22
申请号：US10991181
申请日：2004-11-17
申请人： Douglas Hilton , Warren Alexander , Elizabeth Viney , Tracy Willson , Rachael Richardson , Robyn Starr , Sandra Nicholson , Donald Metcalf , Nicos Nicola
发明人： Douglas Hilton , Warren Alexander , Elizabeth Viney , Tracy Willson , Rachael Richardson , Robyn Starr , Sandra Nicholson , Donald Metcalf , Nicos Nicola
IPC分类号： A61K38/00 , C07H21/04 , C07K14/47 , C12N15/09 , C12P21/06 , C12Q1/68 , G01N33/53 , G01N33/564 , G01N33/574 , G01N33/68
CPC分类号： G01N33/564 , A61K38/00 , C07K14/4703 , G01N33/574 , G01N33/6863
摘要： The present invention relates generally to therapeutic and diagnostic agents. More particularly, the present invention provides therapeutic molecules capable of modulating signal transduction such as but not limited to cytokine-mediated signal transduction. The molecules of the present invention are useful, therefore, in modulating cellular responsiveness to cytokines as well as other mediators of signal transduction such as endogenous or exogenous molecules, antigens, microbes and microbial products, viruses or components thereof, ions, hormones and parasites.
摘要翻译：本发明一般涉及治疗和诊断剂。更具体地，本发明提供能够调节信号转导的治疗分子，例如但不限于细胞因子介导的信号转导。因此，本发明的分子可用于调节对细胞因子以及信号转导的其它介质如内源性或外源性分子，抗原，微生物和微生物产物，病毒或其组分，离子，激素和寄生虫的细胞反应性。

7. 发明申请

US20070275916A1 Methods of Identifying Compounds Which Modulate Granulocite-Colony Stimulating Factor (G-Csf) Dependent Processes by Modulation of the Levels of Suppressor of Cytokine Signaling (Socs) 审中-公开
标题翻译：通过调节细胞因子信号抑制因子水平鉴定化合物的方法，调节粒细胞集落刺激因子（G-Csf）依赖过程
公开(公告)号：US20070275916A1
公开(公告)日：2007-11-29
申请号：US10559711
申请日：2004-06-04
申请人： Ben Croker , Andrew Roberts , Don Metcalf , Warren Alexander , Doug Hilton , Nicos Nicola
发明人： Ben Croker , Andrew Roberts , Don Metcalf , Warren Alexander , Doug Hilton , Nicos Nicola
IPC分类号： A61K48/00 , A01K67/00 , C07H21/04 , C07K1/00
CPC分类号： A01K67/0276 , A01K2217/075 , A01K2267/0381 , C07K14/4703 , C12N2800/30 , C12N2830/008
摘要： The present invention relates generally to compounds which modulate cytokine-dependent processes. More particularly, the compounds of the present invention modulate responses to a colony stimulating factor and even more particularly to granulocyte-colony stimulating factor (G-CSF) by modulating the levels of molecules which inhibit G-CSF such as but not limited to a suppressor of cytokine signaling (SOCS) and in particular SOCS-3. The present invention further contemplates methods for regulating G-CSF-dependent processes by contacting cells in vitro with or administering to a subject a compound which up- or down-regulates the level of activity of G-CSF by modulating the level or activity of a SOCS molecule such as SOCS-3. The instant compounds are further useful for modulating a range of G-CSF-induced cellular responses including neutrophil recovery after chemotherapy or radiotherapy, mobilizing stem and progenitor cells, treating infection and treating inflammatory conditions.
摘要翻译：本发明一般涉及调节细胞因子依赖性过程的化合物。更具体地，本发明的化合物通过调节抑制G-CSF的分子的水平来调节对集落刺激因子的反应，甚至更特别地调节粒细胞集落刺激因子（G-CSF），例如但不限于抑制因子的细胞因子信号（SOCS），特别是SOCS-3。本发明进一步考虑了通过使细胞在体外与受试者接触的方法来调节G-CSF依赖性过程的方法，所述化合物通过调节G-CSF的水平或活性来上调或下调G-CSF的活性水平 SOCS分子如SOCS-3。本发明化合物还可用于调节一系列G-CSF诱导的细胞反应，包括化疗或放疗后的嗜中性粒细胞回收，动员干细胞和祖细胞，治疗感染和治疗炎性病症。

8. 发明申请

US20060069023A1 Animal model for studying hormone signalling and method of modulating the signalling 审中-公开
标题翻译：用于研究激素信号的动物模型和调节信号的方法
公开(公告)号：US20060069023A1
公开(公告)日：2006-03-30
申请号：US11231101
申请日：2005-09-19
申请人： Warren Alexander , Donald Metcalf , Christopher Greenhalgh
发明人： Warren Alexander , Donald Metcalf , Christopher Greenhalgh
IPC分类号： A61K38/17
CPC分类号： C12N15/8509 , A01K67/0276 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A01K2267/02 , A01K2267/03 , A61K38/1709 , A61K48/00 , C12N2800/30
摘要： The present invention relates generally to a method for the treatment and/or prophylaxis of conditions arising from or otherwise associated with aberrations in hormone signalling. The present invention further provides an animal model useful for screening for agents capable of agonizing or antagonizing hormone signalling. More particularly, the present invention contemplates a method for the treatment and/or prophylaxis of conditions arising from or otherwise associated with aberrations in growth hormone signalling. The present invention further comprises a genetically modified animal. More particularly, the animals are genetically modified such that they have altered growth hormone signalling. The genetically modified animals of the present invention range from laboratory animals useful inter alia for animal models for studying hormone regulation and for the development of therapeutic protocols predicated, in part, on modulating hormone signalling to livestock animals. The latter may be manipulated for improved food production.
摘要翻译：本发明一般涉及用于治疗和/或预防由激素信号传导中的异常引起或以其他方式与激素信号传导相关的病症的方法。本发明还提供了可用于筛选能够激动或拮抗激素信号传导的药剂的动物模型。更具体地说，本发明考虑了用于治疗和/或预防由生长激素信号传导中的异常引起或以其他方式与生物激素信号传导相关的病症的方法。本发明还包括转基因动物。更具体地，动物被遗传修饰，使得它们具有改变的生长激素信号传导。本发明的转基因动物的范围从实验动物特别是用于研究激素调节的动物模型和用于开发部分地调节对家畜动物的激素信号传导的治疗方案的实验动物。后者可能被操纵以改善粮食生产。

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