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1. 发明授权

US08987242B2 Morpholinone compounds as factor IXA inhibitors 有权
标题翻译：吗啉酮化合物作为因子IXA抑制剂
公开(公告)号：US08987242B2
公开(公告)日：2015-03-24
申请号：US12791464
申请日：2010-06-01
申请人： Samuel Chackalamannil , Tin-Yau Chan , Mariappan V. Chelliah , Martin C. Clasby , Michael Dwyer , William J. Greenlee , Tomokazu Hirabayashi , Santhosh Neelamkavil , Hidemitsu Nishida , Fumihiko Saitoh , Unmesh Shah , Yan Xia
发明人： Samuel Chackalamannil , Tin-Yau Chan , Mariappan V. Chelliah , Martin C. Clasby , Michael Dwyer , William J. Greenlee , Tomokazu Hirabayashi , Santhosh Neelamkavil , Hidemitsu Nishida , Fumihiko Saitoh , Unmesh Shah , Yan Xia
IPC分类号： A61K31/535 , A01N43/00 , A61K31/33 , C07D413/12 , A61K31/397 , A61K31/496 , A61K31/5375 , A61K31/5377 , A61K31/54 , A61K31/7088 , A61K39/395 , A61K45/06 , C07D265/32 , C07D413/10 , C07D413/14 , C07D417/10
CPC分类号： C07D413/12 , A61K31/397 , A61K31/496 , A61K31/5375 , A61K31/5377 , A61K31/54 , A61K31/7088 , A61K39/395 , A61K45/06 , C07D265/32 , C07D413/10 , C07D413/14 , C07D417/10 , A61K2300/00
摘要： The present invention provides a compound of Formula (I) as described herein, or a pharmaceutically acceptable salt or a solvate thereof. The present invention also provides pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing a thromboses, embolisms, hypercoagulability or fibrotic changes.
摘要翻译：本发明提供本文所述的式（I）化合物或其药学上可接受的盐或溶剂合物。本发明还提供包含一种或多种所述化合物的药物组合物，以及使用所述化合物治疗或预防血栓形成，栓塞，高凝状态或纤维化改变的方法。

2. 发明申请

US20110059958A1 MORPHOLINONE COMPOUNDS AS FACTOR IXA INHIBITORS 有权
公开(公告)号：US20110059958A1
公开(公告)日：2011-03-10
申请号：US12744736
申请日：2009-12-03
申请人： Hidemitsu Nishida , Fumihiko Saitoh , Tomokazu Hirabayashi , Samuel Chackalamannil , Tin-Yau Chan , Mariappan V. Chelliah , Martin C. Clasby , Michael Dwyer , William J. Greenlee , Yan Xia
发明人： Hidemitsu Nishida , Fumihiko Saitoh , Tomokazu Hirabayashi , Samuel Chackalamannil , Tin-Yau Chan , Mariappan V. Chelliah , Martin C. Clasby , Michael Dwyer , William J. Greenlee , Yan Xia
IPC分类号： A61K31/5377 , C07D413/12 , A61P7/02 , A61P9/10 , A61P9/12 , C07D265/32 , C07D413/10
CPC分类号： C07D401/12 , C07D265/30 , C07D265/32 , C07D267/10 , C07D279/06 , C07D413/12 , C07D413/14 , C07D417/04
摘要： The present invention provides a compound of Formula (I) as described herein, or a pharmaceutically acceptable salt or a solvate thereof. The present invention also provides pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing a thromboses, embolisms, hypercoagulability or fibrotic changes.

3. 发明授权

US08642582B2 Morpholinone compounds as factor IXa inhibitors 有权
标题翻译：吗啉酮化合物作为因子IXa抑制剂
公开(公告)号：US08642582B2
公开(公告)日：2014-02-04
申请号：US12744736
申请日：2009-12-03
申请人： Hidemitsu Nishida , Fumihiko Saitoh , Tomokazu Hirabayashi , Samuel Chackalamannil , Tin-Yau Chan , Mariappan V. Chelliah , Martin C. Clasby , Michael Dwyer , William J. Greenlee , Yan Xia
发明人： Hidemitsu Nishida , Fumihiko Saitoh , Tomokazu Hirabayashi , Samuel Chackalamannil , Tin-Yau Chan , Mariappan V. Chelliah , Martin C. Clasby , Michael Dwyer , William J. Greenlee , Yan Xia
IPC分类号： A61K31/535
CPC分类号： C07D401/12 , C07D265/30 , C07D265/32 , C07D267/10 , C07D279/06 , C07D413/12 , C07D413/14 , C07D417/04
摘要： The present invention provides a compound of Formula (I) as described herein, or a pharmaceutically acceptable salt or a solvate thereof. The present invention also provides pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing a thromboses, embolisms, hypercoagulability or fibrotic changes.
摘要翻译：本发明提供本文所述的式（I）化合物或其药学上可接受的盐或溶剂合物。本发明还提供包含一种或多种所述化合物的药物组合物，以及使用所述化合物治疗或预防血栓形成，栓塞，高凝状态或纤维化改变的方法。

4. 发明授权

US09695198B2 Factor IXa inhibitors 有权
公开(公告)号：US09695198B2
公开(公告)日：2017-07-04
申请号：US14652150
申请日：2013-12-16
申请人： Cameron James Smith , Edward Sherer , Louis-Charles Campeau , James Balkovec , William John Greenlee , Derun Li , Liangqin Guo , Tin-Yau Chan , Yi-Heng Chen , Yili Chen , Samuel Chackalamannil , John Qiang Tan , Tomokazu Hirabayashi , Mika Sekioka , MERCK SHARP & DOHME CORP. , MOCHIDA PHARMACEUTICAL CO., LTD.
发明人： Cameron James Smith , Edward Sherer , Louis-Charles Campeau , James Balkovec , William John Greenlee , Derun Li , Liangqin Guo , Tin-Yau Chan , Yi-Heng Chen , Yili Chen , Samuel Chackalamannil , John Qiang Tan , Tomokazu Hirabayashi , Mika Sekioka
IPC分类号： C07D413/14 , C07D417/06 , C07D498/04 , C07D513/04 , C07D413/12 , C07D471/04 , C07D413/06
CPC分类号： C07D513/04 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/06 , C07D471/04 , C07D498/04
摘要： The present invention provides a compound of Formula (I) where A is a heterocycle ring system and B is a heterocycle ring system or aryl ring system, and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes.

5. 发明申请

US20150368269A1 Factor IXa Inhibitors 有权
标题翻译：因子IXa抑制剂
公开(公告)号：US20150368269A1
公开(公告)日：2015-12-24
申请号：US14652150
申请日：2013-12-16
申请人： Tomokazu HIRABAYASHI , Mika KATSUNO , Cameron James SMITH , Edward SHERER , Louis-Charles CAMPEAU , James BALKOVEC , William John GREENLEE , Derun LI , Liangqin GUO , Tin Yan CHAN , Yi-Heng CHEN , Yili CHEN , Samuel CHACKALAMANNIL , John Qiang TAN , MERCH SHARP & DOHME CORP. , MOCHIDA PHARMACEUTICAL CO., LTD.
发明人： Cameron James Smith , Edward Sherer , Louis-Charles Campeau , James Balkovec , William John Greenlee , Derun Li , Liangqin Guo , Tin-Yau Chan , Yi-Heng Chen , Yili Chen , Samuel Chackalamannil , John Qiang Tan , Tomokazu Hirabayashi , Mika Sekioka
IPC分类号： C07D513/04 , C07D417/06 , C07D413/06 , C07D498/04 , C07D471/04
CPC分类号： C07D513/04 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/06 , C07D471/04 , C07D498/04
摘要： The present invention provides a compound of Formula (I) where A is a heterocycle ring system and B is a heterocycle ring system or aryl ring system, and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes.
摘要翻译：本发明提供式（I）化合物，其中A为杂环环系，B为杂环环系或芳环系，以及包含一种或多种所述化合物的药物组合物，以及使用所述化合物治疗或预防的方法血栓形成，栓塞，高凝状态或纤维化变化。

6. 发明授权

US07284998B2 Robot control device and robot system 有权
标题翻译：机器人控制装置和机器人系统
公开(公告)号：US07284998B2
公开(公告)日：2007-10-23
申请号：US11605494
申请日：2006-11-28
申请人： Tomokazu Hirabayashi
发明人： Tomokazu Hirabayashi
IPC分类号： H01R3/00
CPC分类号： H05K7/1471
摘要： A robot control device is connected to an industrial robot through a connection cable. The robot control device has a casing that accommodates an actuator controller. A side surface of the casing has a stepped portion. The stepped portion includes a connecting portion located in such a manner that the connection cable extends along the side surface while arranged on the side surface. The connection cable is connected to the connecting portion. This configuration saves space of the robot control device.
摘要翻译：机器人控制装置通过连接电缆连接到工业机器人。机器人控制装置具有容纳致动器控制器的壳体。壳体的侧面具有阶梯部。台阶部分包括连接部分，该连接部分设置成使得连接电缆沿着侧表面延伸，同时设置在侧面上。连接电缆连接到连接部分。该配置节省了机器人控制装置的空间。

7. 发明申请

US20060206284A1 Acceleration/deceleration control method and apparatus as well as program of acceleration/deceleration control method 有权
标题翻译：加速/减速控制方法和装置以及加减速控制方法程序
公开(公告)号：US20060206284A1
公开(公告)日：2006-09-14
申请号：US11374614
申请日：2006-03-13
申请人： Tomokazu Hirabayashi
发明人： Tomokazu Hirabayashi
IPC分类号： G01P15/00
CPC分类号： B25J9/1651 , B25J9/1633 , B25J9/1638
摘要： To provide an acceleration/deceleration control method, apparatus and the like for determining the acceleration/decelerations of motors according to, for example, the drive directions, acceleration and deceleration of the motors by a simple algorism. A gravity torque calculation unit 1A calculates gravity torque acting on a joint drive motors for operating a manipulator 100 as a machine having joints, and an acceleration/deceleration calculation unit 1D calculates an acceleration speed and/or a deceleration speed of the joint drive motor based on an acceleration/deceleration correction coefficient and a set basic acceleration/deceleration, wherein the acceleration/deceleration correction coefficient is calculated by an acceleration/deceleration correction coefficient calculation unit 1B based on the gravity compensation coefficient selected from a plurality of preset gravity compensation coefficients according to a drive condition affected by gravity and on the gravity torque.
摘要翻译：提供一种用于通过简单的算法来根据例如电动机的驱动方向，加速度和减速度来确定电动机的加速/减速的加速/减速控制方法，装置等。重力扭矩计算单元1A计算作用于作为具有关节的机器的操作器100的联合驱动马达的重力扭矩，并且加速/减速计算单元1D计算接合驱动器的加速度和/或减速度基于加速/减速校正系数和设定的基本加速/减速，其中，加速/减速校正系数由加速/减速校正系数计算单元1B基于从多个预设重力中选择的重力补偿系数来计算根据受重力和重力矩影响的驱动条件的补偿系数。

8. 发明授权

US09969724B2 Factor IXa inhibitors 有权
公开(公告)号：US09969724B2
公开(公告)日：2018-05-15
申请号：US15303310
申请日：2015-04-10
申请人： Isao Sakurada , Tomokazu Hirabayashi , Yoshitaka Maeda , Hiroshi Nagasue , Takashi Mizuno , Jiayi Xu , Ting Zhang , Cameron Smith , Dann Parker
发明人： Isao Sakurada , Tomokazu Hirabayashi , Yoshitaka Maeda , Hiroshi Nagasue , Takashi Mizuno , Jiayi Xu , Ting Zhang , Cameron Smith , Dann Parker
IPC分类号： A61K31/506 , C07D413/14 , C07D471/04 , C07D413/04 , C07D417/14 , C07D498/04 , C07D519/00 , A61K31/423 , A61K31/428 , A61K31/437 , A61K31/4439 , A61K31/497 , A61K31/501 , A61K31/52 , A61K45/06
CPC分类号： C07D413/14 , A61K31/423 , A61K31/428 , A61K31/437 , A61K31/4439 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/52 , A61K45/06 , C07D413/04 , C07D417/14 , C07D471/04 , C07D498/04 , C07D519/00
摘要： In its many embodiments, the present invention provides a novel class of benzamide compounds represented by Formula (I) or pharmaceutically acceptable salts or solvates thereof, or pharmaceutical compositions comprising one or more said compounds or pharmaceutically acceptable salts or solvates thereof, and methods for using said compounds or pharmaceutically acceptable salts or solvates thereof for treating or preventing a thromboses, embolisms, hypercoagulability or fibrotic changes.

9. 发明申请

US20070123081A1 Robot control device and robot system 有权
公开(公告)号：US20070123081A1
公开(公告)日：2007-05-31
申请号：US11605494
申请日：2006-11-28
申请人： Tomokazu Hirabayashi
发明人： Tomokazu Hirabayashi
IPC分类号： H01R3/00
CPC分类号： H05K7/1471
摘要： A robot control device is connected to an industrial robot through a connection cable. The robot control device has a casing that accommodates an actuator controller. A side surface of the casing has a stepped portion. The stepped portion includes a connecting portion located in such a manner that the connection cable extends along the side surface while arranged on the side surface. The connection cable is connected to the connecting portion. This configuration saves space of the robot control device.

10. 发明申请

US20170129880A1 FACTOR IXa INHIBITORS 有权
公开(公告)号：US20170129880A1
公开(公告)日：2017-05-11
申请号：US15303310
申请日：2015-04-10
申请人： Isao Sakurada , Tomokazu Hirabayashi , Yoshitaka Maeda , Hiroshi Nagasue , Takashi Mizuno , Jiayi Xu , Ting Zhang , Cameron Smith , Dann Parker
发明人： Isao Sakurada , Tomokazu Hirabayashi , Yoshitaka Maeda , Hiroshi Nagasue , Takashi Mizuno , Jiayi Xu , Ting Zhang , Cameron Smith , Dann Parker
IPC分类号： C07D413/14 , A61K45/06 , C07D417/14 , A61K31/428 , C07D471/04 , A61K31/52 , A61K31/506 , A61K31/4439 , C07D519/00 , A61K31/497 , A61K31/501 , A61K31/423 , A61K31/437
CPC分类号： C07D413/14 , A61K31/423 , A61K31/428 , A61K31/437 , A61K31/4439 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/52 , A61K45/06 , C07D413/04 , C07D417/14 , C07D471/04 , C07D498/04 , C07D519/00
摘要： In its many embodiments, the present invention provides a novel class of benzamide compounds represented by Formula (I) or pharmaceutically acceptable salts or solvates thereof, or pharmaceutical compositions comprising one or more said compounds or pharmaceutically acceptable salts or solvates thereof, and methods for using said compounds or pharmaceutically acceptable salts or solvates thereof for treating or preventing a thromboses, embolisms, hypercoagulability or fibrotic changes.

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