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1. 发明申请

US20050058821A1 Microporous PVDF films and method of manufacturing 有权
标题翻译：微孔PVDF薄膜及其制造方法
公开(公告)号：US20050058821A1
公开(公告)日：2005-03-17
申请号：US10661908
申请日：2003-09-12
申请人： Samantha Smith , Gene Shipman , Robert Floyd , Harold Freemyer , Steven Hamrock , Michael Yandrasits , David Walton
发明人： Samantha Smith , Gene Shipman , Robert Floyd , Harold Freemyer , Steven Hamrock , Michael Yandrasits , David Walton
IPC分类号： B01D67/00 , B01D71/34 , B29C55/00 , B32B3/26 , B32B5/14 , B32B9/00 , C08J5/22 , C08J9/28 , H01M4/02 , H01M8/10 , B32B35/00
CPC分类号： H01M8/1044 , B01D67/0009 , B01D67/0011 , B01D67/0016 , B01D67/0027 , B01D69/141 , B01D71/34 , B01D2323/46 , B01D2325/022 , B01D2325/20 , B01D2325/24 , C08J5/2281 , C08J2327/16 , H01M8/1023 , H01M8/1039 , H01M8/1048 , H01M8/106 , H01M8/1079 , H01M8/1083 , Y02E60/521 , Y02P70/56 , Y10T428/1352 , Y10T428/139 , Y10T428/249953 , Y10T428/249958 , Y10T428/249959 , Y10T428/249978 , Y10T428/249987 , Y10T428/3154
摘要： Shaped microporous articles are produced from polyvinylidene fluoride (PVDF) and nucleating agents using thermally induced phase separation (TIPS) processes. The shaped microporous article is oriented in at least one direction at a stretch ratio of at least approximately 1.1 to 1.0. The shaped article may also comprise a diluent, glyceryl triacetate. The shaped microporous article may also have the micropores filled with a sufficient quantity of ion conducting electrolyte to allow the membrane to function as an ion conductive membrane. The method of making a microporous article comprises the steps of melt blending polyvinylidene fluoride, nucleating agent and glyceryl triacetate; forming a shaped article of the mixture; cooling the shaped article to cause crystallization of the polyvinylidene fluoride and phase separation of the polyvinylidene fluoride and glyceryl triacetate; and stretching the shaped article in at least one direction at a stretch ratio of at least approximately 1.1 to 1.0.
摘要翻译：成型微孔制品由聚偏氟乙烯（PVDF）和使用热诱导相分离（TIPS）工艺的成核剂制备。成形的微孔制品以至少约1.1至1.0的拉伸比在至少一个方向上取向。成型制品还可以包含稀释剂，三乙酸甘油酯。成形的微孔制品也可以具有填充足量的离子导电电解质的微孔，以允许膜用作离子导电膜。制造微孔制品的方法包括熔融共混聚偏二氟乙烯，成核剂和三乙酸甘油酯的步骤; 形成混合物的成型制品; 冷却成型制品以引起聚偏二氟乙烯的结晶和聚偏二氟乙烯和甘油三乙酸酯的相分离; 并且以至少约1.1至1.0的拉伸比在至少一个方向上拉伸成形制品。

2. 发明申请

US20080113242A1 MICROPOROUS PVDF FILMS 有权
标题翻译： MICROPOROUS PVDF膜
公开(公告)号：US20080113242A1
公开(公告)日：2008-05-15
申请号：US12014435
申请日：2008-01-15
申请人： Samantha Smith , Gene Shipman , Robert Floyd , Harold Feemyer , Steven Hamrock , Michael Yandrasits , David Walton
发明人： Samantha Smith , Gene Shipman , Robert Floyd , Harold Feemyer , Steven Hamrock , Michael Yandrasits , David Walton
IPC分类号： H01M8/10 , H01M4/00 , H01M14/00 , H01M2/16
CPC分类号： H01M8/1044 , B01D67/0009 , B01D67/0011 , B01D67/0016 , B01D67/0027 , B01D69/141 , B01D71/34 , B01D2323/46 , B01D2325/022 , B01D2325/20 , B01D2325/24 , C08J5/2281 , C08J2327/16 , H01M8/1023 , H01M8/1039 , H01M8/1048 , H01M8/106 , H01M8/1079 , H01M8/1083 , Y02E60/521 , Y02P70/56 , Y10T428/1352 , Y10T428/139 , Y10T428/249953 , Y10T428/249958 , Y10T428/249959 , Y10T428/249978 , Y10T428/249987 , Y10T428/3154
摘要： Shaped microporous articles are produced from polyvinylidene fluoride (PVDF) and nucleating agents using thermally induced phase separation (TIPS) processes. The shaped microporous article is oriented in at least one direction at a stretch ratio of at least approximately 1.1 to 1.0. The shaped article may also comprise a diluent, glyceryl triacetate. The shaped microporous article may also have the micropores filled with a sufficient quantity of ion conducting electrolyte to allow the membrane to function as an ion conductive membrane. The method of making a microporous article comprises the steps of melt blending polyvinylidene fluoride, nucleating agent and glyceryl triacetate; forming a shaped article of the mixture; cooling the shaped article to cause crystallization of the polyvinylidene fluoride and phase separation of the polyvinylidene fluoride and glyceryl triacetate; and stretching the shaped article in at least one direction at a stretch ratio of at least approximately 1.1 to 1.0.
摘要翻译：成型微孔制品由聚偏氟乙烯（PVDF）和使用热诱导相分离（TIPS）工艺的成核剂制备。成形的微孔制品以至少约1.1至1.0的拉伸比在至少一个方向上取向。成型制品还可以包含稀释剂，三乙酸甘油酯。成形的微孔制品也可以具有填充足量的离子导电电解质的微孔，以允许膜用作离子导电膜。制造微孔制品的方法包括熔融共混聚偏二氟乙烯，成核剂和三乙酸甘油酯的步骤; 形成混合物的成型制品; 冷却成型制品以引起聚偏二氟乙烯的结晶和聚偏二氟乙烯和甘油三乙酸酯的相分离; 并且以至少约1.1至1.0的拉伸比在至少一个方向上拉伸成形制品。

3. 发明申请

US20070032453A1 ADJUVANT CHEMOTHERAPY FOR ANAPLASTIC GLIOMAS 审中-公开
标题翻译：用于解剖胶囊的ADJUVANT CHEMOTHERAPY
公开(公告)号：US20070032453A1
公开(公告)日：2007-02-08
申请号：US11460866
申请日：2006-07-28
申请人： Rheal Towner , Yashige Kotake , Robert Floyd
发明人： Rheal Towner , Yashige Kotake , Robert Floyd
IPC分类号： A61K31/7008 , A61K31/13
CPC分类号： A61K31/13 , A61K31/70 , A61K31/7008 , A61K41/00 , A61K45/06 , A61K2300/00
摘要： The present invention involves the use of nitrone free radical trapping agents in the treatment and prevention of gliomas. The agents may be used alone or combined with other traditional chemo- and radiotherapies and surgery, to treat or prevent glioma occurrence, recurrence, spread, growth, metastasis, or vascularization.
摘要翻译：本发明涉及使用硝酮自由基捕获剂来治疗和预防胶质瘤。这些药物可以单独使用或与其他传统的化学和放射治疗和手术组合使用，以治疗或预防胶质瘤发生，复发，扩散，生长，转移或血管化。

4. 发明申请

US20070065655A1 Flame retardant porous film 审中-公开
标题翻译：阻燃多孔膜
公开(公告)号：US20070065655A1
公开(公告)日：2007-03-22
申请号：US11229963
申请日：2005-09-19
申请人： Robert Floyd , James Mrozinski
发明人： Robert Floyd , James Mrozinski
IPC分类号： B32B5/22 , C08J9/26
CPC分类号： C08J5/18 , C08J2323/06 , C08J2323/12 , C08K5/0041 , C08K5/0066 , Y10T428/249986 , C08L23/10
摘要： The present invention is a microporous film that includes a crystallizable polymer, a melting flame retardant additive, a non-melting nucleating agent, and a diluent.
摘要翻译：本发明是一种微孔膜，其包括可结晶聚合物，熔融阻燃添加剂，非熔化成核剂和稀释剂。

5. 发明申请

US20050272724A1 Spin trapping pharmaceutical compositions and methods for use thereof 审中-公开
公开(公告)号：US20050272724A1
公开(公告)日：2005-12-08
申请号：US11053747
申请日：2005-02-08
申请人： John Carney , Robert Floyd
发明人： John Carney , Robert Floyd
IPC分类号： A61K31/13 , A61K31/135 , A61K31/15 , A61K31/165 , A61K31/167 , A61K31/195 , A61K31/40 , A61K31/4172 , A61K31/44 , A61K31/445 , A61K31/5415 , C07C291/02
CPC分类号： C07C291/02 , A61K31/13 , A61K31/135 , A61K31/15 , A61K31/165 , A61K31/167 , A61K31/195 , A61K31/40 , A61K31/4172 , A61K31/44 , A61K31/445 , A61K31/5415
摘要： Spin trapping compositions in general have now been discovered to be effective in treating a variety of disorders, including disorders such as those arising from ischemia, infection, inflammation, exposure to radiation or cytotoxic compounds, not just of the central and peripheral nervous systems but of peripheral organ disease having a wide variety of etiologies. In the preferred embodiment, the compositions for treating tissue damage from ischemia contain PBN, or active derivatives thereof, in a suitable pharmaceutical carrier for intravenous oral, topical, or nasal/pulmonary administration. Other preferred spin-trapping agents include 5,5-dimethyl pyrrolidine N-oxide (DMPO), α-(4-pyridyl-1-oxide)-N-tert-butylnitrone (POBN), and (TEMPO) and spin-trapping derivatives, conjugates with drugs or targeting molecules, dimmers and cyclodextran polymers of PBN. Many different disorders can be treated using these compounds, including diseases or disorders of the central and peripheral nervous systems, and disorders arising from ischemia, infection, inflammation, oxidation from exposure to radiation or cytotoxic compounds, as well as due to naturally occurring processes such as aging.

6. 发明申请

US20070292453A1 RNA virus vaccines and methods 有权
标题翻译： RNA病毒疫苗和方法
公开(公告)号：US20070292453A1
公开(公告)日：2007-12-20
申请号：US11639023
申请日：2006-12-14
申请人： Robert Floyd , Dirk Dittmer
发明人： Robert Floyd , Dirk Dittmer
IPC分类号： A61K39/00 , A61P43/00
CPC分类号： A61K39/12 , A61K2039/5252 , C12N7/00 , C12N2770/24134 , C12N2770/24163 , Y02A50/394
摘要： The invention is a vaccine, and method of vaccination, against RNA viruses, including RNA viruses in the family Flaviviridae, which includes for example West Nile Virus, Yellow fever virus, Dengue fever virus, Hepatitis C virus, Pestiviruses, Bovine viral diarrhea virus, and Classical Swine fever virus, wherein the vaccine comprises the RNA virus or immunogenic portions thereof, which have been treated with and rendered non-pathogenic by a phenothiazine dye and visible light, the phenothiazine dyes, including, but not limited to, Methylene Blue (MB), Methylene Green, 1-methyl MB, 1,9-dimethyl MB, Azure A, Azure B, Azure C, thionine, and toluidine blue, or by squalene. The invention includes novel strains of WNV for use in producing a vaccine, and novel primers and their use in recognizing and amplifying all of or portions of the WNV genome for diagnosing WNV infections, for quality control of the vaccine, or for identifying the presence of WNV in blood or blood products.
摘要翻译：本发明是一种针对RNA病毒的疫苗和疫苗接种方法，包括黄病毒科中的RNA病毒，其包括例如西尼罗河病毒，黄热病毒，登革热病毒，丙型肝炎病毒，瘟病毒，牛病毒性腹泻病毒，和经典猪瘟病毒，其中疫苗包括已经用吩噻嗪染料和可见光处理并由其引起非致病性的RNA病毒或其免疫原性部分，吩噻嗪染料，包括但不限于亚甲蓝（ MB），亚甲基绿，1-甲基MB，1,9-二甲基MB，Azure A，Azure B，Azure C，硫堇和甲苯胺蓝，或角鲨烯。本发明包括用于生产疫苗的新型WNV菌株，以及新型引物及其用于识别和扩增WNV基因组的全部或部分用于诊断WNV感染，用于质量控制疫苗或用于鉴定血液或血液制品中的WNV。

7. 发明申请

US20050107366A1 Spin trapping pharmaceutical compositions and methods for use thereof 审中-公开
标题翻译：旋转捕获药物组合物及其使用方法
公开(公告)号：US20050107366A1
公开(公告)日：2005-05-19
申请号：US10937804
申请日：2004-09-10
申请人： John Carney , Robert Floyd
发明人： John Carney , Robert Floyd
IPC分类号： A61K31/13 , A61K31/135 , A61K31/15 , A61K31/165 , A61K31/167 , A61K31/195 , A61K31/40 , A61K31/4172 , A61K31/44 , A61K31/445 , A61K31/5415 , C07C291/02
CPC分类号： C07C291/02 , A61K31/13 , A61K31/135 , A61K31/15 , A61K31/165 , A61K31/167 , A61K31/195 , A61K31/40 , A61K31/4172 , A61K31/44 , A61K31/445 , A61K31/5415
摘要： Spin trapping compositions in general have now been discovered to be effective in treating a variety of disorders, including disorders such as those arising from ischemia, infection, inflammation, exposure to radiation or cytotoxic compounds, not just of the central and peripheral nervous systems but of peripheral organ disease having a wide variety of etiologies. In the preferred embodiment, the compositions for treating tissue damage from ischemia contain PBN, or active derivatives thereof, in a suitable pharmaceutical carrier for intravenous oral, topical, or nasal/pulmonary administration. Other preferred spin-trapping agents include 5,5-dimethyl pyrrolidine N-oxide (DMPO), α-(4-pyridyl-1-oxide)-N-tert-butylnitrone (POBN), and (TEMPO) and spin-trapping derivatives, conjugates with drugs or targeting molecules, dimmers and cyclodextran polymers of PBN. Many different disorders can be treated using these compounds, including diseases or disorders of the central and peripheral nervous systems, and disorders arising from ischemia, infection, inflammation, oxidation from exposure to radiation or cytotoxic compounds, as well as due to naturally occurring processes such as aging.
摘要翻译：现在已经发现旋转捕获组合物现在已被发现有效地治疗各种疾病，包括诸如由局部缺血，感染，炎症，暴露于辐射或细胞毒性化合物引起的疾病，不仅仅是中枢和周围神经系统，而是外周器官疾病具有多种病因。在优选的实施方案中，用于治疗来自局部缺血的组织损伤的组合物在用于静脉内口服，局部或鼻/肺部施用的合适的药物载体中含有PBN或其活性衍生物。其他优选的自旋捕获剂包括5,5-二甲基吡咯烷N-氧化物（DMPO），α-（4-吡啶基-1-氧化物）-N-叔丁基硝酮（POBN）和（TEMPO）和自旋捕获衍生物与PBN的药物或靶向分子，二聚体和环糊精聚合物缀合。可以使用这些化合物治疗许多不同的病症，包括中枢和周围神经系统的疾病或病症，以及由缺血，感染，炎症，暴露于辐射或细胞毒性化合物的氧化引起的疾病，以及由于天然存在的过程作为老化。

8. 发明申请

US20060148915A1 Microporous materials and methods of making 审中-公开
标题翻译：微孔材料及制作方法
公开(公告)号：US20060148915A1
公开(公告)日：2006-07-06
申请号：US11026852
申请日：2004-12-30
申请人： Robert Floyd , Randall Swenson , James Mrozinski
发明人： Robert Floyd , Randall Swenson , James Mrozinski
IPC分类号： B32B27/00 , C08J9/26
CPC分类号： B01D67/0018 , B01D67/0027 , B01D71/26 , B01D2323/08 , B01D2323/12 , B29C55/005 , B29C67/20 , B29K2023/00 , B29K2105/04 , B29K2105/16 , C08K5/0083 , C08L23/06 , C08L91/06 , C08L2203/14 , C08L2205/02 , C08L2205/025 , C08L2205/16 , Y10T428/249986 , Y10T428/249991 , Y10T428/249992 , C08L2666/02 , C08L2666/06
摘要： Microporous materials and articles are disclosed. The microporous materials contain a polyolefin or olefinic polymer and a solid diluent in which the polymer is soluble at a temperature above the melting temperature of the polymer and that phase separates from the polymer at a temperature below the polymer crystallization temperature. The resulting material is a microporous material having a polymeric matrix with solid diluent present throughout. The invention is also directed to methods of forming the microporous material using thermally induced phase separation and subsequent processing.
摘要翻译：公开了微孔材料和制品。微孔材料包含聚烯烃或烯烃聚合物和固体稀释剂，其中聚合物在高于聚合物熔融温度的温度下可溶，并且该相在低于聚合物结晶温度的温度下与聚合物分离。所得材料是具有聚合物基质的微孔材料，其中存在固体稀释剂。本发明还涉及使用热致相分离和后续处理形成微孔材料的方法。

9. 发明申请

US20060147503A1 Oil absorbent wipe with high crumpability 审中-公开
标题翻译：吸油性擦拭具有很高的可膨胀性
公开(公告)号：US20060147503A1
公开(公告)日：2006-07-06
申请号：US11026853
申请日：2004-12-30
申请人： Robert Floyd
发明人： Robert Floyd
IPC分类号： A61K9/70
CPC分类号： A61K8/0208 , A61K8/8111 , A61K8/92 , A61Q19/10
摘要： There is provided an oil absorbing wipe material suitable for wiping a users' skin or hair and a method for their manufacture. The wipes comprise at least an oil absorbing porous coextruded film of a crystalline thermoplastic material with a solid diluant containing crumpable layer and a generally nontacky layer. Generally, the wipe changes transparency or color when loaded with oil to provide an oil absorption indication functionality. The wipe is capable of forming a compact ball by crumpling a 10 cm by 10 cm sample to a diameter of 3.0 cm or less.
摘要翻译：提供了适于擦拭使用者的皮肤或头发的吸油擦拭材料及其制造方法。擦拭物至少包含结晶热塑性材料的吸油多孔共挤出膜，其中含有可膨胀层的固体稀释剂和一般非粘性层。通常，当装载油时，擦拭物改变透明度或颜色以提供吸油指示功能。擦拭物能够通过将10cm×10cm的样品弄皱到3.0cm以下的直径来形成紧凑的球。

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