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2. 发明授权

US06569902B2 Nitrone inhibition of cancer development 有权
标题翻译：硝酸抑制癌症发展
公开(公告)号：US06569902B2
公开(公告)日：2003-05-27
申请号：US09819570
申请日：2001-03-28
申请人： Robert A. Floyd , Yashige Kotake , Kenneth L. Hensley , Dai Nakae
发明人： Robert A. Floyd , Yashige Kotake , Kenneth L. Hensley , Dai Nakae
IPC分类号： A01N3302
CPC分类号： C12N15/85 , A61K31/135 , A61K31/15 , A61K2039/53 , C07K14/005 , C12N2740/15022
摘要： PBN (&agr;-phenyl-tert-butylnitrone), and its derivatives nitrone-based free radical traps, significantly reduce preneoplastic nodule development as well as inhibit hepatocellular carcinoma (HCC) formation at very low levels. The involvement of reactive oxygen species (ROS) in cancer development has been strongly implicated for many years. The involvement of ROS has been strongly implicated in cancer development is a model system where feeding a choline deficiency (CD) diet to rats leads to hepatocellular carcinoma (HCC) development. Administering PBN in the drinking water inhibits HCC formation. Preneoplastic nodule growth in the liver is significantly suppressed by administering PBN, or some of its natural metabolites, in the diet. The effectiveness of PBN in preventing HCC development in the CD liver model is considered due to its prevention of tumor development after the target cells have already been initiated, i.e. genetically changed into tumor cells. Administration of PBN (or its potent derivatives) to humans that may already have microscopic tumor preneoplastic nodules should prevent the eventual frank tumor formation.
摘要翻译： PBN（α-苯基 - 叔丁基硝酮）及其衍生物基于硝酮的自由基捕获，显着减少肿瘤前结节发育，并以非常低的水平抑制肝细胞癌（HCC）形成。活性氧（ROS）在癌症发展中的参与已经被强烈地牵连了很多年。 ROS的参与已经强烈地涉及癌症发展是一种向大鼠喂食胆碱缺乏（CD）饮食导致肝细胞癌（HCC）发展的模型系统。在饮用水中管理PBN可抑制HCC的形成。通过在饮食中施用PBN或其一些天然代谢物，可以显着抑制肝脏中的肿瘤性结节生长。考虑到PBN在CD肝模型中预防HCC发展的有效性是由于其在靶细胞已经开始之后，即基因改变为肿瘤细胞，因此预防肿瘤发展。对可能已经具有微观肿瘤肿瘤前结节的人的PBN（或其有效衍生物）的给药应该防止最终的坦诚肿瘤形成。

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