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1. 发明授权

US06613560B1 PCR microreactor for amplifying DNA using microquantities of sample fluid 失效
标题翻译： PCR微反应器用于使用样品液体的微量来扩增DNA
公开(公告)号：US06613560B1
公开(公告)日：2003-09-02
申请号：US09502597
申请日：2000-02-11
申请人： Jacqueline Tso , Sally A. Swedberg , Paul K. Wolber
发明人： Jacqueline Tso , Sally A. Swedberg , Paul K. Wolber
IPC分类号： C12M140
CPC分类号： B01L3/5027 , B01L3/502707 , B01L7/52 , B01L7/54 , B01L2300/0816 , B01L2300/0883 , B01L2300/0887 , B01L2300/12 , B01L2300/163 , B01L2300/1805 , B01L2300/1822 , B01L2300/1838 , B01L2300/1872 , B01L2400/0415 , B01L2400/0418 , B01L2400/0421 , B01L2400/0442 , B01L2400/0481 , B01L2400/0487 , B29C66/549 , G01N27/44721 , G01N27/44773 , G01N27/44791 , G01N30/02 , G01N30/60 , G01N30/6052 , G01N30/606 , G01N30/6095 , G01N2030/285 , G01N2030/0035 , B29C65/00
摘要： A microanalytical device is provided for conducting chemical processes using small amounts of fluid. The devices include microstructures, e.g., microcavities, microchannels and the like, that are laser ablated or otherwise formed in a support substrate, and can be used in a variety of chemical and biochemical methods, including chromatographic, electrophoretic and electrochromatographic separations, screening and diagnostics, and chemical and biochemical synthesis. The devices are formed from a material that is thermally and chemically stable and resistant to biofouling, significantly reducing electroosmotic flow and unwanted adsorption of solute. Preferred materials are polymeric.
摘要翻译：提供了一种微量分析装置，用于使用少量流体进行化学过程。这些器件包括在支撑衬底中激光烧蚀或以其他方式形成的微结构，例如微腔，微通道等，并且可以用于各种化学和生物化学方法，包括色谱，电泳和电色谱分离，筛选和诊断，以及化学和生物化学合成。这些装置由热和化学稳定的材料形成，并且能抵抗生物污损，显着减少电渗流和不想要的溶质吸附。优选的材料是聚合物。

2. 发明授权

US06194900B1 Integrated miniaturized device for processing and NMR detection of liquid phase samples 失效
标题翻译：用于液相样品的加工和NMR检测的集成小型化装置
公开(公告)号：US06194900B1
公开(公告)日：2001-02-27
申请号：US09100495
申请日：1998-06-19
申请人： Dominique M. Freeman , Sally A. Swedberg
发明人： Dominique M. Freeman , Sally A. Swedberg
IPC分类号： G01R3320
CPC分类号： G01R33/302
摘要： A miniaturized total analysis system with an in-line NMR detection compartment and an NMR rf microcoil detector is described for use in liquid phase analysis. The device is formed by microfabrication of microstructures in novel support substrates. The NMR detector coil may be fabricated directly in the support body at the point of detection or, alternatively, may be formed as part of a modular structure that is insertable into the device at the point of detection. In addition, an integrated device for sample preparation and NMR detection is provided comprising the miniaturized total analysis system and a miniature magnet configured to accept the miniaturized total analysis system, wherein the device is capable of generating an NMR spectrum. The invention herein is used for the analysis of small and/or macromolecular and/or other solutes in the liquid phase.
摘要翻译：描述了具有串联NMR检测室和NMR rf微线圈检测器的小型化总分析系统用于液相分析。该装置通过在新型支撑基底中微细加工而形成。 NMR检测器线圈可以在检测点处直接制造在支撑体中，或者可以形成为在检测点处可插入到装置中的模块化结构的一部分。此外，提供了用于样品制备和NMR检测的集成装置，其包括小型化总分析系统和构造成接受小型化总分析系统的微型磁体，其中该装置能够产生NMR光谱。本发明用于分析液相中的小分子和/或大分子和/或其它溶质。

3. 发明授权

US5314593A Capillary tube with reversible protein interaction and method 失效
标题翻译：毛细管与可逆蛋白相互作用和方法
公开(公告)号：US5314593A
公开(公告)日：1994-05-24
申请号：US32913
申请日：1993-03-18
申请人： Sally A. Swedberg
发明人： Sally A. Swedberg
IPC分类号： C07K1/26 , G01N27/447 , G01N27/26
CPC分类号： G01N27/44752
摘要： A method for treating capillary walls exposable to protein solutes is provided that promotes reversible interactions between the protein solutes and the wall. Thus a small bore capillary tube, useful for reproducible protein electrophoretic separations, includes an interfacial phase comprising agarose that is bonded to the bore. Pretreatment of the capillary walls with silylation reagents forms an intermediate layer that provides a determinable cathodic electroosmotic flow magnitude that remains constant even if the buffer pH fluctuates between 4-7. The modified capillaries can be used repeatedly and they exhibit selectivity in protein separations.
摘要翻译：提供了一种治疗可暴露于蛋白质溶质的毛细血管壁的方法，其促进蛋白质溶质和壁之间的可逆相互作用。因此，可用于可再现的蛋白质电泳分离的小孔毛细管包括界面相，其包含结合到孔的琼脂糖。用甲硅烷基化试剂预处理毛细管壁形成中间层，其提供可确定的阴极电渗流量，即使缓冲液pH在4-7之间波动时也保持恒定。修饰的毛细管可以重复使用，并且它们在蛋白质分离中表现出选择性。

4. 发明授权

US07201834B2 Methods and compositions for modifying the surface of a polymeric substrate 失效
标题翻译：用于改性聚合物基材表面的方法和组合物
公开(公告)号：US07201834B2
公开(公告)日：2007-04-10
申请号：US10386581
申请日：2003-03-11
申请人： Sally A. Swedberg , Karla M. Robotti , Karin Caldwell
发明人： Sally A. Swedberg , Karla M. Robotti , Karin Caldwell
IPC分类号： G01N27/453
CPC分类号： C08J7/047 , C08G65/329 , C08G65/33303 , C08G65/334 , C08J2471/00 , C09D171/02 , C25D13/22
摘要： Methods and compositions for modifying the surface of a polymeric substrate are provided. In the subject methods, at least a portion of the surface of the polymeric substrate is contacted with a biofouling resistant surfactant composition. At least a portion of the surfactant molecules of the composition are end modified with a non-reactive, charged end group that is charge stable over a pH range of about 2 to 12. The subject methods and compositions find particular use with electrophoretic devices, such as capillary electrophoretic devices.
摘要翻译：提供了改性聚合物基材表面的方法和组合物。在本方法中，聚合物基材的表面的至少一部分与生物结垢的表面活性剂组合物接触。组合物的表面活性剂分子的至少一部分用在约2至12的pH范围内电荷稳定的非反应性带电端基末端修饰。本发明方法和组合物特别用于电泳装置，例如作为毛细管电泳装置。

5. 发明授权

US5645702A Low voltage miniaturized column analytical apparatus and method 失效
标题翻译：低压小型化柱分析仪和方法
公开(公告)号：US5645702A
公开(公告)日：1997-07-08
申请号：US483217
申请日：1995-06-07
申请人： Klaus E. Witt , Patrick Kaltenbach , Fritz Bek , Sally A. Swedberg , Laurie S. Mittelstadt
发明人： Klaus E. Witt , Patrick Kaltenbach , Fritz Bek , Sally A. Swedberg , Laurie S. Mittelstadt
IPC分类号： G01N27/447 , G01N30/02 , G01N30/60 , G01N27/26
CPC分类号： G01N27/44773 , G01N30/02 , G01N30/60
摘要： A miniaturized column analytical apparatus having a miniaturized column device containing a body with an elongate separation compartment is provided. Two or more sets of spaced apart antennas are positioned along the elongate separation compartment. The elongate separation compartment has first and second opposing sides along its elongate dimension. Each set of antenna contains a plurality of antennas. One antenna from each set is associated with at least one antenna from each of the other sets to form repeating sequences of antennas along the separation compartment on the opposing sides of the separation compartment. Each set of the antennas is associated with a different oscillating electrical potential to provide a plurality of oscillating electric fields along the elongate separation compartment to draw a target substance along the elongate separation compartment toward an exit end of the separation compartment. The detector can detect a target substance passing out of the elongate separation compartment.
摘要翻译：提供了一种小型化的柱分析装置，其具有包含具有细长隔离室的主体的小型化柱装置。两个或更多组间隔开的天线沿着细长分隔室定位。细长分离隔室具有沿其细长尺寸的第一和第二相对侧。每组天线包含多个天线。每组中的一个天线与至少一个其他组中的一个天线相关联，以在分隔室的相对侧上沿分隔室形成重复的天线序列。每组天线与不同的振荡电势相关联，以沿着细长分隔室提供多个振荡电场，以沿着细长隔离室将目标物质拉向分离室的出口端。检测器可以检测出从细长隔离室流出的目标物质。

6. 发明授权

US4904632A Surface-modified chromatographic separation material 失效
标题翻译：表面改性色谱分离材料
公开(公告)号：US4904632A
公开(公告)日：1990-02-27
申请号：US64329
申请日：1987-06-19
申请人： Joseph J. Pesek , Sally A. Swedberg
发明人： Joseph J. Pesek , Sally A. Swedberg
IPC分类号： B01J20/32 , B01J31/02 , B01J31/12
CPC分类号： B01J20/3246 , B01J20/286 , B01J20/3204 , B01J31/0274 , B01J31/122
摘要： A method is provided for modifying a porous chromatographic material such as silica, alumina, thoria, titania or magnesia, which involves the steps of halogenating the surface hydroxyl groups of such material, and reacting the halogenated surface with a suitable alkylation reagent. The method gives a direct surface-to-carbon linkage in a high-yield reaction.
摘要翻译：提供了一种用于改性多孔色谱材料如二氧化硅，氧化铝，氧化钍，二氧化钛或氧化镁的方法，其包括使这种材料的表面羟基卤化并使卤代表面与合适的烷基化试剂反应的步骤。该方法在高产率反应中提供直接的表面 - 碳键。

7. 发明授权

US06919162B1 Method for producing high-structure area texturing of a substrate, substrates prepared thereby and masks for use therein 失效
标题翻译：用于生产基底的高结构区域纹理的方法，由此制备的基底和用于其中的掩模
公开(公告)号：US06919162B1
公开(公告)日：2005-07-19
申请号：US09233694
申请日：1999-01-19
申请人： Reid A. Brennen , Sally A. Swedberg
发明人： Reid A. Brennen , Sally A. Swedberg
IPC分类号： B23K26/06 , B23K26/36 , G01N30/60 , B23K26/00
CPC分类号： G01N30/6095 , B23K26/066 , B23K26/355 , B23K26/361 , B23K26/40 , B23K2103/42 , B23K2103/50 , B23K2103/52 , B41M5/24 , Y10S430/146
摘要： A method is provided for preparing high-surface area texturing of a substrate using methods by which material from a substrate is subtracted from or added to the surface of the substrate. In one embodiment, the method is a subtractive lithographic method that involves exposing a laser-ablatable substrate, such as a polymeric or ceramic substrate, to laser light. A mask may be used to define the pattern of light incident on the substrate. High-surface area textured substrates, in particular, miniaturized planar analysis devices having high-surface area textured features, prepared by the methods disclosed herein are also provided. A method by which the high-surface area textured substrate or the miniaturized planar analysis device is used as a master from which replicate copies thereof may be made is also provided.
摘要翻译：提供了一种用于使用从衬底中的材料从衬底的表面减去或添加到衬底的表面的方法来制备衬底的高表面区域纹理的方法。在一个实施例中，该方法是一种减法光刻方法，其涉及将激光可烧蚀基底（例如聚合物或陶瓷基底）暴露于激光。可以使用掩模来限定入射在基板上的光的图案。还提供了通过本文公开的方法制备的高表面积织构化基材，特别是具有高表面积纹理特征的小型化平面分析装置。还提供了高表面积纹理基板或小型化平面分析装置作为可以从其制作复制副本的主体的方法。

8. 发明授权

US06375901B1 Chemico-mechanical microvalve and devices comprising the same 有权
公开(公告)号：US06375901B1
公开(公告)日：2002-04-23
申请号：US09294867
申请日：1999-04-20
申请人： Karla M. Robotti , Sally A. Swedberg , Hongfeng Yin
发明人： Karla M. Robotti , Sally A. Swedberg , Hongfeng Yin
IPC分类号： B01L1100
CPC分类号： B81B3/0035 , B01J19/0093 , B01J2219/00891 , B01J2219/00907 , B01J2219/00909 , B01L3/502738 , B01L2300/0816 , B01L2300/087 , B01L2400/0677 , F16K99/0001 , F16K99/0017 , F16K99/0025 , F16K99/0036 , F16K99/0044 , F16K2099/0074 , F16K2099/0076 , F16K2099/0078 , F16K2099/0084 , Y10T137/2082 , Y10T436/2575
摘要： Micro-fluid devices and methods for their use are provided. The subject devices are characterized by the presence of at least one micro-valve comprising a phase reversible material, e.g. a reversible gel, that reversibly changes its physical state in response to an applied stimulus, e.g. a thermoreversible gel. In using the subject device, fluid flow along a flow path of the device is modulated by applying an appropriate stimulus, e.g. changing the temperature, to the microvalve. The subject devices find use in a variety of applications, including micro-analytical applications.

9. 再颁专利

USRE36350E Fully integrated miniaturized planar liquid sample handling and analysis device 失效
标题翻译：完全集成的小型化平面液体样品处理和分析装置
公开(公告)号：USRE36350E
公开(公告)日：1999-10-26
申请号：US127556
申请日：1998-07-30
申请人： Sally A. Swedberg , Patrick Kaltenbach , Klaus E. Witt , Fritz Bek , Laurie S. Mittelstadt
发明人： Sally A. Swedberg , Patrick Kaltenbach , Klaus E. Witt , Fritz Bek , Laurie S. Mittelstadt
IPC分类号： B01L3/00 , B01L3/02 , B01L7/00 , B29C65/02 , B81B1/00 , B81C1/00 , G01N27/447 , G01N30/02 , G01N30/28 , G01N30/30 , G01N30/60 , B01D15/08
CPC分类号： G01N30/6095 , B01L3/502707 , B01L7/54 , G01N27/44708 , G01N27/44773 , G01N27/44791 , B01L2200/025 , B01L2200/027 , B01L2200/0689 , B01L2200/10 , B01L2200/12 , B01L2300/0816 , B01L2300/087 , B01L2300/0874 , B01L2300/0887 , B01L2300/1822 , B01L2400/0415 , B01L2400/0421 , B01L2400/0442 , B01L2400/0487 , B01L3/0268 , B01L3/502715 , B01L3/5055 , B29C65/02 , B29C66/54 , B29C66/549 , G01N2030/285 , G01N2030/3007 , G01N2030/3015 , G01N2030/303 , G01N27/44721 , G01N30/02 , G01N30/60 , G01N30/6047 , G01N30/6052 , G01N30/606
摘要： A miniaturized total analysis system (".mu.-TAS") comprising a miniaturized planar column device is described for use in liquid phase analysis. The .mu.-TAS comprises microstructures fabricated by laser ablation in a variety of novel support substrates. The .mu.-TAS includes associated laser-ablated features required for integrated sample analysis, such as analyte detection means and fluid communication means. .mu.-TAS constructed according to the invention is useful in any analysis system for detecting and analyzing small and/or macromolecular solutes in the liquid phase and may employ chromatographic separation means, electrophoretic separation means, electrochromatographic separation means, or combinations thereof.
摘要翻译：描述了包括小型化平面柱装置的小型化总分析系统（“mu-TAS”）用于液相分析。 mu-TAS包括通过在各种新型支撑衬底中的激光烧蚀制造的微观结构。 mu -TAS包括用于集成样品分析所需的相关激光烧蚀特征，例如分析物检测装置和流体连通装置。根据本发明构建的mu-TAS可用于检测和分析液相中的小分子和/或大分子溶质的任何分析系统，并且可以使用色谱分离装置，电泳分离装置，电色谱分离装置或其组合。

10. 发明授权

US5641400A Use of temperature control devices in miniaturized planar column devices and miniaturized total analysis systems 失效
标题翻译：在微型平面柱装置和小型化总分析系统中使用温度控制装置
公开(公告)号：US5641400A
公开(公告)日：1997-06-24
申请号：US546629
申请日：1995-10-23
申请人： Patrick Kaltenbach , Sally A. Swedberg , Klaus E. Witt , Fritz Bek , Laurie S. Mittelstadt
发明人： Patrick Kaltenbach , Sally A. Swedberg , Klaus E. Witt , Fritz Bek , Laurie S. Mittelstadt
IPC分类号： B01L3/00 , B01L7/00 , B29C65/02 , B81B1/00 , B81C1/00 , G01N27/447 , G01N30/02 , G01N30/28 , G01N30/30 , G01N30/60 , B01D15/08
CPC分类号： B01L7/54 , B01L3/5027 , B01L3/502707 , B01L7/525 , G01N27/44708 , G01N27/44773 , G01N27/44791 , G01N30/6095 , B01L2200/025 , B01L2200/0689 , B01L2200/10 , B01L2200/12 , B01L2300/0816 , B01L2300/087 , B01L2300/0874 , B01L2300/0883 , B01L2300/0887 , B01L2300/12 , B01L2300/1822 , B01L2400/0415 , B01L2400/0421 , B01L3/502715 , B01L3/5055 , B29C65/02 , B29C66/54 , B29C66/549 , G01N2030/285 , G01N2030/3007 , G01N2030/3015 , G01N2030/303 , G01N27/44721 , G01N30/02 , G01N30/60 , G01N30/6047 , G01N30/6052 , G01N30/606
摘要： Miniaturized planar column devices and miniaturized total analysis systems for liquid phase analysis are disclosed. The systems include a temperature control device for regulating temperature, preferably a thermoelectric device comprising Peltier elements.
摘要翻译：公开了用于液相分析的小型化平面柱装置和小型化总分析系统。该系统包括用于调节温度的温度控制装置，优选包括珀尔帖元件的热电装置。

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