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1. 发明申请

US20060211678A1 Aryl-amino substituted pyrrolopyrimidine multi-kinase inhibiting compounds 失效
标题翻译：芳基 - 氨基取代的吡咯并嘧啶多激酶抑制化合物
公开(公告)号：US20060211678A1
公开(公告)日：2006-09-21
申请号：US11194158
申请日：2005-08-01
申请人： Saleh Ahmed , Oscar Barba , Jason Bloxham , Graham Dawson , Wiliam Gattrell , John Kitchin , Neil Anthony Pegg , Imaad Saba , Shazia Sadiq , Colin Peter Sambrook Smith , Don Smyth , Amo Steing , Robin Wilkes , Bijoy Panicker , Paula Tavares , Matthew Cox , An-Hu Li , Hanqing Dong , Lifu Ma , Kenneth Foreman , Qinghua Weng , Kathryn Stolz
发明人： Saleh Ahmed , Oscar Barba , Jason Bloxham , Graham Dawson , Wiliam Gattrell , John Kitchin , Neil Anthony Pegg , Imaad Saba , Shazia Sadiq , Colin Peter Sambrook Smith , Don Smyth , Amo Steing , Robin Wilkes , Bijoy Panicker , Paula Tavares , Matthew Cox , An-Hu Li , Hanqing Dong , Lifu Ma , Kenneth Foreman , Qinghua Weng , Kathryn Stolz
IPC分类号： A61K31/5377 , A61K31/519 , A61K31/496 , A61K31/4745 , C07D487/02 , C07D471/02
CPC分类号： C07D471/02 , C07D487/02 , C07D487/04
摘要： Compounds represented by Formula (I): or stereoisomers or pharmaceutically acceptable salts thereof, are inhibitors of least two of the Abl, Aurora-A, Blk, c-Raf, cSRC, Src, PRK2, FGFR3, Flt3, Lck, Mek1, PDK-1, GSK3β, EGFR, p70S6K, BMX, SGK, CaMKII, Tie-2, IGF-1R, Ron, Ret, and KDR kinases in animals, including humans, for the treatment and/or prevention of various diseases and conditions such as cancer.
摘要翻译：由式（I）表示的化合物或其立体异构体或其药学上可接受的盐是Abl，Aurora-A，Blk，c-Raf，cSRC，Src，PRK2，FGFR3，Flt3，Lck，Mek1，PDK中的至少两种的抑制剂 -1，GSK3beta，EGFR，p70S6K，BMX，SGK，CaMKII，Tie-2，IGF-1R，Ron，Ret和KDR激酶，用于治疗和/或预防各种疾病和病症，癌症。

2. 发明授权

US07465726B2 Substituted pyrrolo[2.3-B]pyridines 失效
标题翻译：取代的吡咯并[2,3-B]吡啶
公开(公告)号：US07465726B2
公开(公告)日：2008-12-16
申请号：US11194158
申请日：2005-08-01
申请人： Saleh Ahmed , Oscar Barba , Jason Bloxham , Graham Dawson , William Gattrell , John Kitchin , Neil Anthony Pegg , Imaad Saba , Shazia Sadiq , Colin Peter Sambrook Smith , Don Smyth , Amo G. Steinig , Robin Wilkes , Bijoy Panicker , Paula Tavares , Matthew Cox , An-Hu Li , Hanqing Dong , Lifu Ma , Kenneth (‘Ken’) Foreman , Qinghua (‘Felix’) Weng , Kathryn Stolz
发明人： Saleh Ahmed , Oscar Barba , Jason Bloxham , Graham Dawson , William Gattrell , John Kitchin , Neil Anthony Pegg , Imaad Saba , Shazia Sadiq , Colin Peter Sambrook Smith , Don Smyth , Amo G. Steinig , Robin Wilkes , Bijoy Panicker , Paula Tavares , Matthew Cox , An-Hu Li , Hanqing Dong , Lifu Ma , Kenneth (‘Ken’) Foreman , Qinghua (‘Felix’) Weng , Kathryn Stolz
IPC分类号： A61K31/437 , A61K31/496 , A61K31/5355 , A61K31/541 , A61K31/5513 , A61K31/551 , C07D471/04 , C07D223/04 , C07D243/08 , C07D241/04 , C07D413/10 , C07D413/06 , C07D413/08 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/14 , A61K31/04 , A61K31/519 , C07D487/04
CPC分类号： C07D471/02 , C07D487/02 , C07D487/04
摘要： Compounds represented by Formula (I): or stereoisomers or pharmaceutically acceptable salts thereof, are inhibitors of least two of the Abl, Aurora-A, Blk, c-Raf, cSRC, Src, PRK2, FGFR3, Flt3, Lck, Mek1, PDK-1, GSK3β, EGFR, p70S6K, BMX, SGK, CaMKII, Tie-2, IGF-1R, Ron, Ret, and KDR kinases in animals, including humans, for the treatment and/or prevention of various diseases and conditions such as cancer.
摘要翻译：由式（I）表示的化合物或其立体异构体或其药学上可接受的盐是Abl，Aurora-A，Blk，c-Raf，cSRC，Src，PRK2，FGFR3，Flt3，Lck，Mek1，PDK中的至少两种的抑制剂 -1，GSK3beta，EGFR，p70S6K，BMX，SGK，CaMKII，Tie-2，IGF-1R，Ron，Ret和KDR激酶，用于治疗和/或预防各种疾病和病症，癌症。

3. 发明授权

US06949563B2 (2-carboxamido)(3-amino)thiophene compounds 有权
标题翻译：（2-甲酰氨基）（3-氨基）噻吩化合物
公开(公告)号：US06949563B2
公开(公告)日：2005-09-27
申请号：US10752342
申请日：2004-01-06
申请人： Graham Michael Wynne , Kevin Doyle , Saleh Ahmed , An-Hu Li , John Fraser Keily , Chrystelle Marie Rasamison , Neil Anthony Pegg , Imaad Saba , Claire Thomas , Don Smyth , Shazia Sadiq , Gary Newton , Graham Dawson , Andrew Phillip Crew , Arlindo Lucas Castelhano
发明人： Graham Michael Wynne , Kevin Doyle , Saleh Ahmed , An-Hu Li , John Fraser Keily , Chrystelle Marie Rasamison , Neil Anthony Pegg , Imaad Saba , Claire Thomas , Don Smyth , Shazia Sadiq , Gary Newton , Graham Dawson , Andrew Phillip Crew , Arlindo Lucas Castelhano
IPC分类号： A61K31/381 , A61K31/437 , A61K31/4436 , A61K31/4709 , A61K31/4745 , A61K45/06 , C07D409/12 , C07D409/14 , C07D471/04 , C07D49/02
CPC分类号： C07D409/12 , A61K31/165 , A61K31/22 , A61K31/277 , A61K31/381 , A61K31/437 , A61K31/4436 , A61K31/444 , A61K31/4709 , A61K31/4745 , A61K45/06 , C07D409/14 , C07D471/04 , A61K2300/00
摘要： Compounds represented by Formula (I): or a pharmaceutically acceptable salt or N-oxide thereof, wherein R1 is R2 is and R3 is C0-4alkyl, are useful in the treatment of cancer.
摘要翻译：由式（I）表示的化合物或其药学上可接受的盐或N-氧化物，其中R1是R2，R3是C0-4-4烷基，可用于治疗癌症。

4. 发明申请

US20060047123A1 Mercaptoamides as histone deacetylase inhibitors 审中-公开
标题翻译：巯基乙酰胺作为组蛋白脱乙酰酶抑制剂
公开(公告)号：US20060047123A1
公开(公告)日：2006-03-02
申请号：US11218396
申请日：2005-09-02
申请人： Saleh Ahmed , Celine Combet , Scott Cuthill , Graham Dawson , William Gattrell , Mario Lobell , Neil Pegg , Imaad Saba , Simon Swain , Claire Thomas , Graham Wynne
发明人： Saleh Ahmed , Celine Combet , Scott Cuthill , Graham Dawson , William Gattrell , Mario Lobell , Neil Pegg , Imaad Saba , Simon Swain , Claire Thomas , Graham Wynne
IPC分类号： C07D333/22 , C07D277/18 , C07D263/02
CPC分类号： C07D213/40 , C07C323/32 , C07C323/60 , C07C327/32 , C07C2601/02 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07D209/08 , C07D213/74 , C07D213/75 , C07D215/38 , C07D217/06 , C07D233/54 , C07D235/30 , C07D249/08 , C07D263/10 , C07D277/04 , C07D277/46 , C07D277/62 , C07D285/135 , C07D295/088 , C07D295/135 , C07D295/185 , C07D307/52 , C07D307/81 , C07D309/12 , C07D319/18 , C07D333/20 , C07D409/04 , C07D417/04 , C07D513/04
摘要： Mercaptoamide compounds, represented by Formulas (IA), (IB), (IIA), and (IIB): or a pharmaceutically acceptable salt thereof, inhibit histone deacetylase enzyme and are useful for the treatment and/or prevention of various infections, cancerous diseases, and conditions.
摘要翻译：由式（IA），（IB），（IIA）和（IIB）表示的巯丙酰胺化合物或其药学上可接受的盐抑制组蛋白脱乙酰酶，并且可用于治疗和/或预防各种感染，癌性疾病和条件。

5. 发明授权

US07254897B2 Integrated tilt sensor 有权
标题翻译：集成式倾斜传感器
公开(公告)号：US07254897B2
公开(公告)日：2007-08-14
申请号：US11106027
申请日：2005-04-13
申请人： Saleh Ahmed , Gary Casey
发明人： Saleh Ahmed , Gary Casey
IPC分类号： G01C9/06
CPC分类号： G01C9/20 , G01C9/06 , G01C2009/062
摘要： A tilt sensor having a printed circuit board disposed in a direction normal to a reference plane for measuring a tilt angle with a pair of electrodes formed on a first surface of the printed circuit board. A cover is affixed to the printed circuit board and creates a cavity between the cover and the printed circuit board with a predetermined gap between the cover and the pair of electrodes, the cover acting as a common electrode to the pair of electrodes to create a pair of capacitors. An inert liquid is contained in the cavity, the surface level of the inert fluid varying according to the tilt angle of the reference plane. A signal processing circuit is formed on a second surface of the printed circuit board that produces an output signal corresponding to a difference in capacitance between the two capacitors as a tilt angle detection output.
摘要翻译：一种倾斜传感器，其具有布置在垂直于参考平面的方向上的印刷电路板，用于测量与印刷电路板的第一表面上形成的一对电极的倾斜角度。盖子固定在印刷电路板上，并且在盖子和印刷电路板之间形成一个空腔，在盖子和一对电极之间具有预定的间隙，盖子用作一对电极的公共电极以形成一对的电容器。惰性液体包含在空腔中，惰性流体的表面水平根据参考平面的倾斜角度而变化。信号处理电路形成在印刷电路板的第二表面上，其产生与两个电容器之间的电容差相对应的输出信号作为倾斜角度检测输出。

6. 发明申请

US20060232736A1 Integrated tilt sensor 有权
标题翻译：集成式倾斜传感器
公开(公告)号：US20060232736A1
公开(公告)日：2006-10-19
申请号：US11106027
申请日：2005-04-13
申请人： Saleh Ahmed , Gary Casey
发明人： Saleh Ahmed , Gary Casey
IPC分类号： G02F1/1337
CPC分类号： G01C9/20 , G01C9/06 , G01C2009/062
摘要： A tilt sensor having a printed circuit board disposed in a direction normal to a reference plane for measuring a tilt angle with a pair of electrodes formed on a first surface of the printed circuit board. A cover is affixed to the printed circuit board and creates a cavity between the cover and the printed circuit board with a predetermined gap between the cover and the pair of electrodes, the cover acting as a common electrode to the pair of electrodes to create a pair of capacitors. An inert liquid is contained in the cavity, the surface level of the inert fluid varying according to the tilt angle of the reference plane. A signal processing circuit is formed on a second surface of the printed circuit board that produces an output signal corresponding to a difference in capacitance between the two capacitors as a tilt angle detection output.
摘要翻译：一种倾斜传感器，其具有布置在垂直于参考平面的方向上的印刷电路板，用于测量与印刷电路板的第一表面上形成的一对电极的倾斜角度。盖子固定在印刷电路板上，并且在盖子和印刷电路板之间形成一个空腔，在盖子和一对电极之间具有预定的间隙，盖子用作一对电极的公共电极以形成一对的电容器。惰性液体包含在空腔中，惰性流体的表面水平根据参考平面的倾斜角度而变化。信号处理电路形成在印刷电路板的第二表面上，其产生与两个电容器之间的电容差相对应的输出信号作为倾斜角度检测输出。

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