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1. 发明授权

US08858882B2 Automatic analysis device 有权
标题翻译：自动分析装置
公开(公告)号：US08858882B2
公开(公告)日：2014-10-14
申请号：US13577963
申请日：2011-02-24
申请人： Sakuichiro Adachi , Terumi Tamura , Hajime Yamazaki , Akihisa Makino , Takeshi Yogi
发明人： Sakuichiro Adachi , Terumi Tamura , Hajime Yamazaki , Akihisa Makino , Takeshi Yogi
IPC分类号： G01N21/75 , G01N21/51 , G01N35/02 , G01N21/53
CPC分类号： G01N21/51 , G01N21/532 , G01N35/025 , Y10T436/113332
摘要： There is provided a data processing method that reduces influences of air bubbles and dirt while maintaining changes in light amounts. Two scattering light photoreceivers are disposed in the forward direction. A photoreceiver 33a closer to the optical axis is taken to be a main angle photoreceiver, and a photoreceiver 33b further from the optical axis is taken to be a sub-angle photoreceiver. Noise is estimated based on the reaction process data of the sub-angle photoreceiver, and noise is reduced by subtracting the estimated noise from the reaction process data of the main angle photoreceiver.
摘要翻译：提供了一种在保持光量变化的同时减少气泡和污物的影响的数据处理方法。两个散射光接收器沿向前方向设置。靠近光轴的光接收器33a被认为是主角光接收器，并且从光轴进一步的光接收器33b被认为是副角光接收器。基于副角光接收器的反应过程数据估计噪声，并且通过从主角光接收器的反应过程数据中减去估计的噪声来降低噪声。

2. 发明申请

US20120315190A1 AUTOMATIC ANALYSIS DEVICE 有权
标题翻译：自动分析装置
公开(公告)号：US20120315190A1
公开(公告)日：2012-12-13
申请号：US13577963
申请日：2011-02-24
申请人： Sakuichiro Adachi , Terumi Tamura , Hajime Yamazaki , Akihisa Makino , Takeshi Yogi
发明人： Sakuichiro Adachi , Terumi Tamura , Hajime Yamazaki , Akihisa Makino , Takeshi Yogi
IPC分类号： G01N21/75
CPC分类号： G01N21/51 , G01N21/532 , G01N35/025 , Y10T436/113332
摘要： There is provided a data processing method that reduces influences of air bubbles and dirt while maintaining changes in light amounts. Two scattering light photoreceivers are disposed in the forward direction. A photoreceiver 33a closer to the optical axis is taken to be a main angle photoreceiver, and a photoreceiver 33b further from the optical axis is taken to be a sub-angle photoreceiver. Noise is estimated based on the reaction process data of the sub-angle photoreceiver, and noise is reduced by subtracting the estimated noise from the reaction process data of the main angle photoreceiver.
摘要翻译：提供了一种在保持光量变化的同时减少气泡和污物的影响的数据处理方法。两个散射光接收器沿向前方向设置。靠近光轴的光接收器33a被认为是主角光接收器，并且从光轴进一步的光接收器33b被认为是副角光接收器。基于副角光接收器的反应过程数据估计噪声，并且通过从主角光接收器的反应过程数据中减去估计的噪声来降低噪声。

3. 发明申请

US20120282139A1 BLOOD COAGULATION ANALYZER 有权
标题翻译：血液凝聚分析仪
公开(公告)号：US20120282139A1
公开(公告)日：2012-11-08
申请号：US13509661
申请日：2010-11-19
申请人： Akihisa Makino , Tomonori Mimura , Terumi Tamura , Sakuichiro Adachi
发明人： Akihisa Makino , Tomonori Mimura , Terumi Tamura , Sakuichiro Adachi
IPC分类号： G01N21/75
CPC分类号： G01N21/51 , G01N21/532 , G01N21/82 , G01N33/18 , G01N33/1826 , G01N33/4905 , G01N33/86 , G01N2021/4711 , G01N2021/825
摘要： A blood coagulation analyzer that realizes both securement of a wide dynamic range and enhancement of sensitivity in blood coagulation analysis by selecting an appropriate angle of detection depending on the intensity of scattered light from each specimen without causing complexity of the analyzer. The analyzer has a reaction container. A storage unit is provided which takes in and stores multiple pieces of chronological light intensity variation data acquired from detectors arranged around a reaction container. A judgment unit selects light intensity variation data to be used for calculation of a blood coagulation time from the multiple pieces of light intensity variation data stored in the storage unit based on the amount of light intensity variation. A calculation unit calculates the blood coagulation time from the light intensity variation data selected by the judgment unit.
摘要翻译：一种血液凝固分析仪，其通过根据来自每个样本的散射光的强度选择适当的检测角度，而不会导致分析仪的复杂性，实现了动态范围的确定和凝固分析中的灵敏度的提高。分析仪具有反应容器。提供一种存储单元，其存储并存储从设置在反应容器周围的检测器获取的多个按时间顺序的光强度变化数据。判断单元基于光强度变化量从存储在存储单元中的多个光强度变化数据中选择要用于计算凝血时间的光强度变化数据。计算单元根据由判断单元选择的光强度变化数据计算凝血时间。

4. 发明授权

US09395298B2 Blood coagulation analyzer 有权
标题翻译：凝血分析仪
公开(公告)号：US09395298B2
公开(公告)日：2016-07-19
申请号：US13509661
申请日：2010-11-19
申请人： Akihisa Makino , Tomonori Mimura , Terumi Tamura , Sakuichiro Adachi
发明人： Akihisa Makino , Tomonori Mimura , Terumi Tamura , Sakuichiro Adachi
IPC分类号： G01N33/50 , G01N21/00 , G01N21/51 , G01N33/49 , G01N33/86 , G01N21/53 , G01N21/82 , G01N33/18
CPC分类号： G01N21/51 , G01N21/532 , G01N21/82 , G01N33/18 , G01N33/1826 , G01N33/4905 , G01N33/86 , G01N2021/4711 , G01N2021/825
摘要： A blood coagulation analyzer that realizes both securement of a wide dynamic range and enhancement of sensitivity in blood coagulation analysis by selecting an appropriate angle of detection depending on the intensity of scattered light from each specimen without causing complexity of the analyzer. The analyzer has a reaction container. A storage unit is provided which takes in and stores multiple pieces of chronological light intensity variation data acquired from detectors arranged around a reaction container. A judgment unit selects light intensity variation data to be used for calculation of a blood coagulation time from the multiple pieces of light intensity variation data stored in the storage unit based on the amount of light intensity variation. A calculation unit calculates the blood coagulation time from the light intensity variation data selected by the judgment unit.
摘要翻译：一种血液凝固分析仪，其通过根据来自每个样本的散射光的强度选择适当的检测角度，而不会导致分析仪的复杂性，实现了动态范围的确定和凝固分析中的灵敏度的提高。分析仪具有反应容器。提供一种存储单元，其存储并存储从设置在反应容器周围的检测器获取的多个按时间顺序的光强度变化数据。判断单元基于光强度变化量从存储在存储单元中的多个光强度变化数据中选择要用于计算凝血时间的光强度变化数据。计算单元根据由判断单元选择的光强度变化数据计算凝血时间。

5. 发明授权

US09664678B2 Automated analyzer and analyzing method 有权
公开(公告)号：US09664678B2
公开(公告)日：2017-05-30
申请号：US14238060
申请日：2012-09-03
申请人： Takeshi Yogi , Sakuichiro Adachi , Tomonori Mimura , Hajime Yamazaki
发明人： Takeshi Yogi , Sakuichiro Adachi , Tomonori Mimura , Hajime Yamazaki
IPC分类号： G01N21/51 , G01N33/543 , G01N21/82 , G01N35/02 , G01N21/47 , G01N35/04
CPC分类号： G01N33/54366 , G01N21/47 , G01N21/51 , G01N21/82 , G01N33/54313 , G01N35/025 , G01N2021/825 , G01N2035/0441 , G01N2035/0443 , G01N2035/0444 , G01N2800/24
摘要： An analyzer provides conditions suitable for a reagent for performing latex immunoassay with a high sensitivity using a method of measuring scattered light. Irradiation light having a wavelength in the range of 0.65 to 0.75 μm is used, and scattered light generated from a reaction solution is received at a light-receiving angle of 15° to 35° with respect to the irradiation direction during the rotational movement of the reaction container. The reagent contains latex particles the average peak particle diameter of which ranges from 0.3 μm to 0.43 μm and to which antibodies are sensitized. The reaction solution contains latex particles at a concentration at which the absorbance to irradiation light having a wavelength of 0.7 μm is 0.25 abs to 1.10 abs, and a change in the amount of scattered light caused by the aggregation of the latex particles through antigens in a sample is measured and quantified.

6. 发明申请

US20140220705A1 AUTOMATED ANALYZER AND ANALYZING METHOD 有权
标题翻译：自动分析仪和分析方法
公开(公告)号：US20140220705A1
公开(公告)日：2014-08-07
申请号：US14238060
申请日：2012-09-03
申请人： Takeshi Yogi , Sakuichiro Adachi , Tomonori Mimura , Hajime Yamazaki
发明人： Takeshi Yogi , Sakuichiro Adachi , Tomonori Mimura , Hajime Yamazaki
IPC分类号： G01N33/543
CPC分类号： G01N33/54366 , G01N21/47 , G01N21/51 , G01N21/82 , G01N33/54313 , G01N35/025 , G01N2021/825 , G01N2035/0441 , G01N2035/0443 , G01N2035/0444 , G01N2800/24
摘要： An analyzer provides conditions suitable for a reagent for performing latex immunoassay with a high sensitivity using a method of measuring scattered light. Irradiation light having a wavelength in the range of 0.65 to 0.75 μm is used, and scattered light generated from a reaction solution is received at a light-receiving angle of 15° to 35° with respect to the irradiation direction during the rotational movement of the reaction container. The reagent contains latex particles the average peak particle diameter of which ranges from 0.3 μm to 0.43 μm and to which antibodies are sensitized. The reaction solution contains latex particles at a concentration at which the absorbance to irradiation light having a wavelength of 0.7 μm is 0.25 abs to 1.10 abs, and a change in the amount of scattered light caused by the aggregation of the latex particles through antigens in a sample is measured and quantified.
摘要翻译：使用测量散射光的方法，分析仪提供适合于使用高灵敏度进行乳胶免疫测定的试剂的条件。使用波长在0.65〜0.75μm范围内的照射光，从反应溶液产生的散射光以相对于照射方向为15°〜35°的受光角度被接受反应容器该试剂含有平均峰值粒径为0.3μm〜0.43μm的胶乳粒子，抗体被致敏。反应溶液含有胶乳颗粒，其浓度为具有0.7μm波长的照射光的吸光度为0.25atm至1.10abs，以及由胶乳颗粒通过抗原凝集而引起的散射光量的变化样品被测量和量化。

7. 发明申请

US20120288409A1 ANALYSIS DEVICE 审中-公开
标题翻译：分析装置
公开(公告)号：US20120288409A1
公开(公告)日：2012-11-15
申请号：US13517170
申请日：2011-01-27
申请人： Toshiyuki Inabe , Akihisa Makino , Sakuichiro Adachi
发明人： Toshiyuki Inabe , Akihisa Makino , Sakuichiro Adachi
IPC分类号： G01N21/49
CPC分类号： G01N21/51 , G01N2021/4707
摘要： An analysis device using scattering light is provided capable of, when a foreign substance such as a bubble is mixed in a measurement target or is attached in a reaction container, reducing the influence by the foreign substance while improving the S/N ratio characteristics. Two or more detectors are disposed on a plane orthogonal to an optical axis of light applied to the measurement target and on a circumference around the optical axis. A change in outputs from the detectors is observed, and a detector influenced by noise due to a foreign substance such as a bubble is specified for rejection, and outputs from the detectors are averaged.
摘要翻译：提供了一种使用散射光的分析装置，当在测定对象物中混入异物等气泡或附着在反应容器中时，能够在提高S / N比特性的同时降低异物的影响。两个或更多个检测器设置在与施加到测量目标的光的光轴正交并且在围绕光轴的圆周上的平面上。观察到来自检测器的输出变化，并且由于诸如气泡的异物而被噪声影响的检测器被规定为拒绝，并且来自检测器的输出被平均。

8. 发明授权

US09080972B2 Automatic analyzer 有权
标题翻译：自动分析仪
公开(公告)号：US09080972B2
公开(公告)日：2015-07-14
申请号：US13979668
申请日：2012-01-10
申请人： Akihisa Makino , Sakuichiro Adachi
发明人： Akihisa Makino , Sakuichiro Adachi
IPC分类号： G01N21/53 , G01N21/49 , G01N21/51 , G01N35/00
CPC分类号： G01N21/49 , G01N21/51 , G01N35/00693 , G01N2201/0415 , G01N2201/1211
摘要： The scattered light from the measurement target substance passes through a light receiving window, and is received by a detector for +θ scattered light and a detector for −θ scattered light which are arranged symmetrically to each other across an optical axis at an equal angle or an equal interval in a vertical direction. A light source is fixed by a light-source holder (that is a base member on which the light source is arranged), and the detectors are arranged on and fixed to a detector holder (that is a base member on which the detectors are arranged). In this manner, drift of the light quantity data caused by the thermal deformation of the optical system can be corrected by comparing values of the light quantity data of the detectors.
摘要翻译：来自测量对象物质的散射光通过光接收窗口，并被检测器接收+ 散射光和检测器 - ＆thetas; 散射光在垂直方向上以等角度或等间隔的光轴彼此对称地布置。光源由光源保持器（即配置有光源的基底部件）固定，检测器被配置在检测器支架（作为检测器布置在其上的基底部件）上并固定）。以这种方式，可以通过比较检测器的光量数据的值来校正由光学系统的热变形引起的光量数据的漂移。

9. 发明授权

US08709345B2 Sample analyzing device 有权
标题翻译：样品分析仪
公开(公告)号：US08709345B2
公开(公告)日：2014-04-29
申请号：US13147809
申请日：2010-03-01
申请人： Sakuichiro Adachi , Akihisa Makino
发明人： Sakuichiro Adachi , Akihisa Makino
IPC分类号： G01N35/02 , G01N21/27 , G01N21/25
CPC分类号： G01N35/025 , G01N21/253 , G01N21/272 , G01N21/274 , G01N2201/127 , Y10T436/113332 , Y10T436/114998
摘要： To reduce measurement time, it may be considered to quicken reaction or speed up analytic determination. In existing analyzing devices, photometry is performed, typically, about every 15 seconds, so that it has not been possible to secure satisfactory reproducibility. Namely, reducing the measurement time and securing reproducibility have not been compatible. It has therefore been desired to increase the number of times of measurements performed in a short period of time. A cell disk is controlled to stop at a position for photometry during the time after a sample and a reagent are mixed and before measurement is finished and, while the cell disk is stopped, photometry is performed once or plural times thereby increasing the total number of times of measurements.
摘要翻译：为了减少测量时间，可以考虑加快反应或加速分析测定。在现有的分析装置中，通常每隔15秒进行测光，因此不可能确保令人满意的再现性。也就是说，减少测量时间和确保再现性不兼容。因此，期望在短时间内增加测量次数。控制细胞盘在样品和试剂混合之后并在测量结束之前的时间点停止在测光位置，并且在细胞盘停止时，测光一次或多次，从而增加总数测量次数。

10. 发明申请

US20120039748A1 AUTOMATIC ANALYSIS APPARATUS 审中-公开
标题翻译：自动分析仪
公开(公告)号：US20120039748A1
公开(公告)日：2012-02-16
申请号：US13202337
申请日：2010-02-24
申请人： Tomonori Mimura , Akihisa Makino , Sakuichiro Adachi
发明人： Tomonori Mimura , Akihisa Makino , Sakuichiro Adachi
IPC分类号： G01N33/00
CPC分类号： G01N35/025 , G01N2035/0455
摘要： An automatic analysis apparatus capable of testing a plurality of items with high accuracy and at low cost without increasing the size of the apparatus is provided. An automatic analysis apparatus 1 having test mechanisms for a plurality of items including a photometric mechanism 70 and flow analysis mechanisms 40a and 40b is provided with a common disk (disk for reaction and pretreatment) 20. In the common disk 20, fixed containers 21 fixed to the common disk 20 and detachably-provided disposable containers 22 are disposed. Therefore, while achieving the downsizing of the apparatus, the containers to be used can be selected in accordance with the test items in such a manner that the fixed containers 21 are used as high-accuracy containers to be cleaned and reused and the disposable containers 22 are used as low-cost disposable containers.
摘要翻译：提供了一种能够在不增加设备尺寸的情况下以高精度和低成本测试多个项目的自动分析装置。具有包括测光机构70和流量分析机构40a，40b的多个项目的测试机构的自动分析装置1设置有公共盘（反应和预处理盘）20。在普通盘20中，固定容器21固定配置在普通盘20上，可拆卸地设置一次性容器22。因此，在实现装置的小型化的同时，可以根据试验项目来选择要使用的容器，使得固定容器21用作待清洁和重复使用的高精度容器，并且一次性容器22 被用作低成本的一次性容器。

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