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1. 发明申请

US20120282139A1 BLOOD COAGULATION ANALYZER 有权
标题翻译：血液凝聚分析仪
公开(公告)号：US20120282139A1
公开(公告)日：2012-11-08
申请号：US13509661
申请日：2010-11-19
申请人： Akihisa Makino , Tomonori Mimura , Terumi Tamura , Sakuichiro Adachi
发明人： Akihisa Makino , Tomonori Mimura , Terumi Tamura , Sakuichiro Adachi
IPC分类号： G01N21/75
CPC分类号： G01N21/51 , G01N21/532 , G01N21/82 , G01N33/18 , G01N33/1826 , G01N33/4905 , G01N33/86 , G01N2021/4711 , G01N2021/825
摘要： A blood coagulation analyzer that realizes both securement of a wide dynamic range and enhancement of sensitivity in blood coagulation analysis by selecting an appropriate angle of detection depending on the intensity of scattered light from each specimen without causing complexity of the analyzer. The analyzer has a reaction container. A storage unit is provided which takes in and stores multiple pieces of chronological light intensity variation data acquired from detectors arranged around a reaction container. A judgment unit selects light intensity variation data to be used for calculation of a blood coagulation time from the multiple pieces of light intensity variation data stored in the storage unit based on the amount of light intensity variation. A calculation unit calculates the blood coagulation time from the light intensity variation data selected by the judgment unit.
摘要翻译：一种血液凝固分析仪，其通过根据来自每个样本的散射光的强度选择适当的检测角度，而不会导致分析仪的复杂性，实现了动态范围的确定和凝固分析中的灵敏度的提高。分析仪具有反应容器。提供一种存储单元，其存储并存储从设置在反应容器周围的检测器获取的多个按时间顺序的光强度变化数据。判断单元基于光强度变化量从存储在存储单元中的多个光强度变化数据中选择要用于计算凝血时间的光强度变化数据。计算单元根据由判断单元选择的光强度变化数据计算凝血时间。

2. 发明授权

US09395298B2 Blood coagulation analyzer 有权
标题翻译：凝血分析仪
公开(公告)号：US09395298B2
公开(公告)日：2016-07-19
申请号：US13509661
申请日：2010-11-19
申请人： Akihisa Makino , Tomonori Mimura , Terumi Tamura , Sakuichiro Adachi
发明人： Akihisa Makino , Tomonori Mimura , Terumi Tamura , Sakuichiro Adachi
IPC分类号： G01N33/50 , G01N21/00 , G01N21/51 , G01N33/49 , G01N33/86 , G01N21/53 , G01N21/82 , G01N33/18
CPC分类号： G01N21/51 , G01N21/532 , G01N21/82 , G01N33/18 , G01N33/1826 , G01N33/4905 , G01N33/86 , G01N2021/4711 , G01N2021/825
摘要： A blood coagulation analyzer that realizes both securement of a wide dynamic range and enhancement of sensitivity in blood coagulation analysis by selecting an appropriate angle of detection depending on the intensity of scattered light from each specimen without causing complexity of the analyzer. The analyzer has a reaction container. A storage unit is provided which takes in and stores multiple pieces of chronological light intensity variation data acquired from detectors arranged around a reaction container. A judgment unit selects light intensity variation data to be used for calculation of a blood coagulation time from the multiple pieces of light intensity variation data stored in the storage unit based on the amount of light intensity variation. A calculation unit calculates the blood coagulation time from the light intensity variation data selected by the judgment unit.
摘要翻译：一种血液凝固分析仪，其通过根据来自每个样本的散射光的强度选择适当的检测角度，而不会导致分析仪的复杂性，实现了动态范围的确定和凝固分析中的灵敏度的提高。分析仪具有反应容器。提供一种存储单元，其存储并存储从设置在反应容器周围的检测器获取的多个按时间顺序的光强度变化数据。判断单元基于光强度变化量从存储在存储单元中的多个光强度变化数据中选择要用于计算凝血时间的光强度变化数据。计算单元根据由判断单元选择的光强度变化数据计算凝血时间。

3. 发明申请

US20120039748A1 AUTOMATIC ANALYSIS APPARATUS 审中-公开
标题翻译：自动分析仪
公开(公告)号：US20120039748A1
公开(公告)日：2012-02-16
申请号：US13202337
申请日：2010-02-24
申请人： Tomonori Mimura , Akihisa Makino , Sakuichiro Adachi
发明人： Tomonori Mimura , Akihisa Makino , Sakuichiro Adachi
IPC分类号： G01N33/00
CPC分类号： G01N35/025 , G01N2035/0455
摘要： An automatic analysis apparatus capable of testing a plurality of items with high accuracy and at low cost without increasing the size of the apparatus is provided. An automatic analysis apparatus 1 having test mechanisms for a plurality of items including a photometric mechanism 70 and flow analysis mechanisms 40a and 40b is provided with a common disk (disk for reaction and pretreatment) 20. In the common disk 20, fixed containers 21 fixed to the common disk 20 and detachably-provided disposable containers 22 are disposed. Therefore, while achieving the downsizing of the apparatus, the containers to be used can be selected in accordance with the test items in such a manner that the fixed containers 21 are used as high-accuracy containers to be cleaned and reused and the disposable containers 22 are used as low-cost disposable containers.
摘要翻译：提供了一种能够在不增加设备尺寸的情况下以高精度和低成本测试多个项目的自动分析装置。具有包括测光机构70和流量分析机构40a，40b的多个项目的测试机构的自动分析装置1设置有公共盘（反应和预处理盘）20。在普通盘20中，固定容器21固定配置在普通盘20上，可拆卸地设置一次性容器22。因此，在实现装置的小型化的同时，可以根据试验项目来选择要使用的容器，使得固定容器21用作待清洁和重复使用的高精度容器，并且一次性容器22 被用作低成本的一次性容器。

4. 发明申请

US20120048036A1 AUTOMATIC ANALYSIS APPARATUS 审中-公开
标题翻译：自动分析仪
公开(公告)号：US20120048036A1
公开(公告)日：2012-03-01
申请号：US13262671
申请日：2010-04-08
申请人： Tomonori Mimura , Akihisa Makino , Sakuichiro Adachi
发明人： Tomonori Mimura , Akihisa Makino , Sakuichiro Adachi
IPC分类号： G01N1/22
CPC分类号： G01N35/025 , G01N35/0092
摘要： An automatic analysis apparatus that is capable of aligning the timing of sample dispensing and efficiently carrying out tests of a plurality of items. An intermediate disk (disk) is set so that an A-cycle for carrying out an operation for pretreatment and B-cycles for carrying out operations for dispensing a sample to a reaction disk and a flow analysis mechanism serving as test mechanisms are combined to use n-units of the B-cycles as a dispensing operation cycle time period of the sample. Therefore, the timing of sampling can be efficiently aligned so that the test of an item having a short analysis cycle can be carried out during the test of an item having a long analysis cycle, and so that the tests of an item having a large number of requests can be carried out during the test of the item having a small number of requests.
摘要翻译：一种自动分析装置，其能够对准样品分配的定时并且有效地进行多个项目的测试。中间盘（盘）被设置为使得用于执行用于预处理的操作的A循环和用于将用于将样品分配到反应盘的操作的B循环和用作测试机构的流量分析机构组合使用 B个循环的n个单位作为样品的分配操作循环时间段。因此，可以有效地对准采样的定时，使得在具有长分析周期的项目的测试期间可以执行具有短分析周期的项目的测试，并且使得具有大数量的项目的测试可以在具有少量请求的项目的测试期间执行请求。

5. 发明申请

US20120020838A1 AUTOMATIC ANALYSIS DEVICE AND DISPENSING DEVICE 审中-公开
标题翻译：自动分析装置和分配装置
公开(公告)号：US20120020838A1
公开(公告)日：2012-01-26
申请号：US13263454
申请日：2010-04-08
申请人： Tomonori Mimura , Akihisa Makino , Sakuichiro Adachi
发明人： Tomonori Mimura , Akihisa Makino , Sakuichiro Adachi
IPC分类号： G01N33/50
CPC分类号： G01N35/025 , G01N2035/0453
摘要： An automatic analysis device 1a includes: an intermediate disk (intermediate unit) 20 on which a disposable container (intermediate container) 21 for carrying out a pretreatment by pretreatment liquid for a sample dispensed from a sample container 11 or a reaction with a reagent is arranged; a reaction disk (main analysis unit) 60 for carrying out a test of an item having a relatively large number of test requests, on which a reaction vessel 61 for carrying out a reaction of a reagent with the sample obtained after the pretreatment is arranged; and flow-based analysis mechanisms (sub analysis units) 30a to 30c for carrying out a test for the sample obtained after the reaction with the reagent in the disposable container 21, which is the item having a relatively small number of test requests.
摘要翻译：自动分析装置1a包括：中间盘（中间单元）20，其上设置有用于对从样品容器11分配的样品的预处理液进行预处理或与试剂反应的一次性容器（中间容器）21 ; 反应盘（主分析单元）60，用于执行具有相对较多测试请求的项目的测试，其上布置用于进行试剂与预处理之后获得的样品的反应的反应容器61; 以及用于对作为具有相对少的测试要求的项目的一次性容器21中的试剂进行反应后获得的样品进行试验的基于流的分析机构（子分析单元）30a至30c。

6. 发明授权

US08852511B2 Automatic analyzer 有权
标题翻译：自动分析仪
公开(公告)号：US08852511B2
公开(公告)日：2014-10-07
申请号：US13382316
申请日：2010-07-05
申请人： Sakuichiro Adachi , Muneo Maeshima , Isao Yamazaki , Tomonori Mimura
发明人： Sakuichiro Adachi , Muneo Maeshima , Isao Yamazaki , Tomonori Mimura
IPC分类号： G01N33/00 , G01N21/51
CPC分类号： G01N21/51 , G01N15/0205 , G01N21/253 , G01N2015/0065 , G01N2035/00396 , G01N2035/0453
摘要： To be adapted to various types of latex reagents for detecting scattered light and thereby measuring agglutination reactions with high sensitivity while sufficiently ensuring integration time. To be adapted to various types of latex particles of different particle sizes, a plurality of light receivers are arranged in a plane perpendicular to the direction of cell movement by rotation of a cell disk. To ensure sufficient integration time, the angle between the optical axis of the irradiation light and each of a plurality of optical axes of scattered light viewed from above the cell is made equal to or less than 17.7° including a mounting error.
摘要翻译：适用于各种类型的用于检测散射光的乳胶试剂，从而以高灵敏度测量凝集反应，同时充分确保积分时间。为了适应于各种类型的不同粒度的胶乳颗粒，多个光接收器通过旋转细胞盘而布置在垂直于细胞移动方向的平面中。为了确保足够的积分时间，使得照射光的光轴与从电池单元的上方观察的散射光的多个光轴中的每一个之间的角度等于或小于包括安装误差的17.7°。

7. 发明申请

US20060039823A1 Chemical analysis apparatus 审中-公开
标题翻译：化学分析仪
公开(公告)号：US20060039823A1
公开(公告)日：2006-02-23
申请号：US11204344
申请日：2005-08-16
申请人： Hironobu Yamakawa , Hideo Enoki , Kunio Harada , Sakuichiro Adachi , Tomonori Mimura
发明人： Hironobu Yamakawa , Hideo Enoki , Kunio Harada , Sakuichiro Adachi , Tomonori Mimura
IPC分类号： G01N35/00
CPC分类号： G01N35/1016 , B01F11/0071 , B01F13/0071 , B01F13/0076 , B01L3/502746 , B01L3/502784 , B01L2200/0605 , B01L2300/0654 , B01L2300/0867 , B01L2300/089 , B01L2400/0427 , F04B19/006 , G01N2035/00158 , G01N2035/00237 , G01N2035/102
摘要： A chemical analysis apparatus is equipped with analysis sections having openings, means for supplying samples or reagents from the openings, means for combining and mixing samples with reagents to obtain droplets as liquids to be measured, and means for measuring the physical properties of the liquids to be measured during reaction or after completion of reaction. Furthermore, plate members are provided facing each other in analysis sections and a plurality of electrodes are provided on the plate member faces that face each other. Voltage is applied from the plurality of electrodes to the droplets of the samples and the reagents.
摘要翻译：化学分析装置配备有具有开口的分析部分，用于从开口供应样品或试剂的装置，用于将样品与试剂混合并混合以获得待测量液体的液滴的装置，以及用于测量液体的物理性质的装置在反应期间或反应完成后测量。此外，在分析部分中彼此面对地设置板构件，并且在彼此相对的板构件面上设置多个电极。电压从多个电极施加到样品和试剂的液滴。

8. 发明申请

US20060097155A1 Substrate for transporting liquid, a system for analysis and a method for analysis 有权
标题翻译：用于输送液体的基材，分析系统和分析方法
公开(公告)号：US20060097155A1
公开(公告)日：2006-05-11
申请号：US11258230
申请日：2005-10-26
申请人： Sakuichiro Adachi , Kunio Harada , Hideo Enoki , Hironobu Yamakawa , Tomonori Mimura
发明人： Sakuichiro Adachi , Kunio Harada , Hideo Enoki , Hironobu Yamakawa , Tomonori Mimura
IPC分类号： H01J49/00
CPC分类号： G01N21/253 , B01L3/502784 , B01L2200/027 , B01L2200/0673 , B01L2300/0654 , B01L2300/0816 , B01L2300/0845 , B01L2300/089 , B01L2400/0427 , G01N35/08 , Y10T436/2575
摘要： Conventional liquid transport substrates having a fluid channel formed along an array of electrodes have a problem in which throughput decreases, depending on driving conditions. In order to avoid two-way passage in a fluid channel from the inlet to a measuring section and a fluid channel from the measuring section to the outlet, the measuring section is located in the middle of the fluid channel connecting the inlet and the outlet, so that manipulation from the inlet to the outlet takes place in one direction on the substrate. Even when analyzing a large number of sample droplets, by transport of the droplets substantially in one direction, it is possible to complete measurement in a short time.
摘要翻译：具有沿着电极阵列形成的流体通道的常规液体输送基板具有根据驱动条件的生产率下降的问题。为了避免从入口到测量部分的流体通道和从测量部分到出口的流体通道的双向通道，测量部分位于连接入口和出口的流体通道的中间，使得从入口到出口的操作在基板上沿一个方向发生。即使当分析大量的样品液滴时，通过基本上沿一个方向输送液滴，可以在短时间内完成测量。

9. 发明授权

US07342662B2 Sample analyzer 失效
标题翻译：样品分析仪
公开(公告)号：US07342662B2
公开(公告)日：2008-03-11
申请号：US11132291
申请日：2005-05-19
申请人： Kunio Harada , Sakuichiro Adachi , Hideo Enoki , Hironobu Yamakawa , Tomonori Mimura
发明人： Kunio Harada , Sakuichiro Adachi , Hideo Enoki , Hironobu Yamakawa , Tomonori Mimura
IPC分类号： G01N21/00
CPC分类号： G01N21/3151 , G01N21/5907
摘要： The adverse effect on measurement accuracy brought about by the transmission of light beams through portions of a liquid sample with different concentrations, i.e., a concentration distribution in the vertical direction of a container, is prevented by using semiconductor light sources of two different types with different wavelengths. The semiconductor light sources (2, 4) of two different types are housed in the same package (5) such that a detector (9) can capture the light beams emitted by the light sources after their optical axes have intersected with one another. The multiple light beams can be thus caused to pass through portions with substantially the same concentration and therefore can be detected without being influenced by the difference in concentration of the sample in the container.
摘要翻译：通过使用具有不同浓度的液体样品的一部分（即，容器的垂直方向上的浓度分布），通过使用具有不同浓度的两种不同类型的半导体光源来传输光束所产生的对测量精度的不利影响波长。两种不同类型的半导体光源（2,4）被容纳在相同的封装（5）中，使得检测器（9）在光轴彼此相交之后能够捕获由光源发射的光束。因此，可以使多个光束通过具有基本相同浓度的部分，因此可以不受样品在容器中的浓度差的影响而被检测。

10. 发明授权

US09664678B2 Automated analyzer and analyzing method 有权
公开(公告)号：US09664678B2
公开(公告)日：2017-05-30
申请号：US14238060
申请日：2012-09-03
申请人： Takeshi Yogi , Sakuichiro Adachi , Tomonori Mimura , Hajime Yamazaki
发明人： Takeshi Yogi , Sakuichiro Adachi , Tomonori Mimura , Hajime Yamazaki
IPC分类号： G01N21/51 , G01N33/543 , G01N21/82 , G01N35/02 , G01N21/47 , G01N35/04
CPC分类号： G01N33/54366 , G01N21/47 , G01N21/51 , G01N21/82 , G01N33/54313 , G01N35/025 , G01N2021/825 , G01N2035/0441 , G01N2035/0443 , G01N2035/0444 , G01N2800/24
摘要： An analyzer provides conditions suitable for a reagent for performing latex immunoassay with a high sensitivity using a method of measuring scattered light. Irradiation light having a wavelength in the range of 0.65 to 0.75 μm is used, and scattered light generated from a reaction solution is received at a light-receiving angle of 15° to 35° with respect to the irradiation direction during the rotational movement of the reaction container. The reagent contains latex particles the average peak particle diameter of which ranges from 0.3 μm to 0.43 μm and to which antibodies are sensitized. The reaction solution contains latex particles at a concentration at which the absorbance to irradiation light having a wavelength of 0.7 μm is 0.25 abs to 1.10 abs, and a change in the amount of scattered light caused by the aggregation of the latex particles through antigens in a sample is measured and quantified.

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