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1. 发明授权

US07831300B2 Extrapolating ICA knowledge from one epoch to another for improved fetal ECG separation 有权
标题翻译：将ICA知识从一个时代推广到另一个时代，以改善胎儿心电图分离
公开(公告)号：US07831300B2
公开(公告)日：2010-11-09
申请号：US12034129
申请日：2008-02-20
申请人： Sai Kolluri , Bruce A. Friedman , Lawrence T. Hersh , Rush Winslow Hood, Jr.
发明人： Sai Kolluri , Bruce A. Friedman , Lawrence T. Hersh , Rush Winslow Hood, Jr.
IPC分类号： A61B5/0245
CPC分类号： A61B5/0444 , A61B5/4362
摘要： A method of utilizing a maternal-fetal monitoring system to monitor the physiological properties of both a maternal patient and a fetus. A series of ECG electrodes are placed across the maternal patient's abdomen and receives ECG input waveforms across sixteen separate channels. The sixteen channels of information are processed using an ICA algorithm to generate a series of ICA output waveforms and a transfer matrix. Following the current epoch, the transfer matrix is applied to the input waveforms on a continuous basis. The conditioned input waveforms are displayed immediately following the first epoch and prior to the expiration of a subsequent epoch. The transfer matrix for the second epoch is combined with the transfer matrix for the first epoch to generate an updated transfer matrix. Various filtering operations on the transfer matrix coefficients may be used to find the updated transfer matrix before the end of the current epoch.
摘要翻译：一种利用母胎监测系统来监测母亲患者和胎儿的生理特性的方法。一系列ECG电极放置在母亲患者的腹部，并接收跨16个独立通道的ECG输入波形。使用ICA算法处理16个信道的信道，以生成一系列ICA输出波形和传送矩阵。在当前时代之后，传输矩阵连续地应用于输入波形。条件输入波形显示在第一纪元之后，并在随后的时期到期之前。将第二纪元的传递矩阵与第一纪元的传输矩阵组合以生成更新的传送矩阵。可以使用传递矩阵系数上的各种滤波操作来在当前时期结束之前找到更新的传输矩阵。

2. 发明申请

US20090209874A1 EXTRAPOLATING ICA KNOWLEDGE FROM ONE EPOCH TO ANOTHER FOR IMPROVED FETAL ECG SEPARATION 有权
标题翻译：将一个EPOCH的ICA知识扩展到另一个改进的FET心电图分离
公开(公告)号：US20090209874A1
公开(公告)日：2009-08-20
申请号：US12034129
申请日：2008-02-20
申请人： Sai Kolluri , Bruce A. Friedman , Lawrence T. Hersh , Rush Winslow Hood, JR.
发明人： Sai Kolluri , Bruce A. Friedman , Lawrence T. Hersh , Rush Winslow Hood, JR.
IPC分类号： A61B5/0448
CPC分类号： A61B5/0444 , A61B5/4362
摘要： A method of utilizing a maternal-fetal monitoring system to monitor the physiological properties of both a maternal patient and a fetus. A series of ECG electrodes are placed across the maternal patient's abdomen and receives ECG input waveforms across sixteen separate channels. The sixteen channels of information are processed using an ICA algorithm to generate a series of ICA output waveforms and a transfer matrix. Following the current epoch, the transfer matrix is applied to the input waveforms on a continuous basis. The conditioned input waveforms are displayed immediately following the first epoch and prior to the expiration of a subsequent epoch. The transfer matrix for the second epoch is combined with the transfer matrix for the first epoch to generate an updated transfer matrix. Various filtering operations on the transfer matrix coefficients may be used to find the updated transfer matrix before the end of the current epoch.
摘要翻译：一种利用母胎监测系统来监测母亲患者和胎儿的生理特性的方法。一系列ECG电极放置在母亲患者的腹部，并接收跨16个独立通道的ECG输入波形。使用ICA算法处理16个信道的信道，以生成一系列ICA输出波形和传送矩阵。在当前时代之后，传输矩阵连续地应用于输入波形。条件输入波形显示在第一纪元之后，并在随后的时期到期之前。将第二纪元的传递矩阵与第一纪元的传输矩阵组合以生成更新的传送矩阵。可以使用传递矩阵系数上的各种滤波操作来在当前时期结束之前找到更新的传输矩阵。

3. 发明申请

US20100174202A1 METHOD AND SYSTEM FOR COMBINING OSCILLOMETRIC BLOOD PRESSURE ENVELOPE DATA OBTAINED FROM DIFFERENT SIGNAL PROCESSING PATHS 审中-公开
标题翻译：用于组合来自不同信号处理程序的OSCILOMETRIC BLOOD压力包数据的方法和系统
公开(公告)号：US20100174202A1
公开(公告)日：2010-07-08
申请号：US12350412
申请日：2009-01-08
申请人： Lawrence T. Hersh , Sai Kolluri , Bruce A. Friedman , Richard Medero
发明人： Lawrence T. Hersh , Sai Kolluri , Bruce A. Friedman , Richard Medero
IPC分类号： A61B5/0225
CPC分类号： A61B5/0225 , A61B5/02225 , A61B5/0402 , A61B5/1455
摘要： A blood pressure measurement system that utilizes a non-invasive blood pressure (NIBP) monitor having a blood pressure cuff and pressure transducer. The measurement system provides a plurality of separate processing techniques that each receive a plurality of oscillometric waveform sample values generated using the pressure transducer. Each of the processing techniques separately generates a set of envelope points based upon the oscillometric data values. The sets of envelope points are appropriately scaled such that the sets of scaled envelope points are combined with each other to create a set of combined, scaled envelope points. Various different methods can be used to scale the sets of envelope points prior to the combination of the scaled envelope points. Based upon the combination of scaled envelope points, the blood pressure is calculated and displayed by the NIBP monitor.
摘要翻译：一种血压测量系统，其利用具有血压袖带和压力换能器的非侵入性血压（NIBP）监测器。测量系统提供多个单独的处理技术，每个处理技术接收使用压力传感器产生的多个示波波形采样值。每个处理技术基于示波器数据值分别产生一组包络点。适当地缩放包络点集合，使得缩放包络点的集合彼此组合以创建一组组合的，缩放的包络点。可以使用各种不同的方法在缩放的包络点的组合之前缩放包络点集合。根据缩放的包络点的组合，由NIBP监视器计算和显示血压。

4. 发明授权

US06648828B2 Continuous, non-invasive technique for measuring blood pressure using impedance plethysmography 有权
标题翻译：使用阻抗体积描记法测量血压的连续，非侵入性技术
公开(公告)号：US06648828B2
公开(公告)日：2003-11-18
申请号：US09683916
申请日：2002-03-01
申请人： Bruce A. Friedman , Richard Medero , Lawrence T. Hersh , Sai Kolluri
发明人： Bruce A. Friedman , Richard Medero , Lawrence T. Hersh , Sai Kolluri
IPC分类号： A61B502
CPC分类号： A61B5/0285 , A61B5/021 , A61B5/02125 , A61B5/0295
摘要： Blood pressure is measured using the pulse transit time required for the blood volume pulse to propagate between two locations in an animal. Impedance plethysmography is employed to detect when the blood volume pulse occurs at one location. The plethysmograph may detect thoracic impedance to determine when the aortic heart valve opens or it may detect impedance at one location on a limb of the animal. Occurrence of the blood volume pulse at another location can be determined by impedance plethysmography or another technique, such as pulse oximetry. The calculation of cardiac stroke volume can be employed to compensate the derivation of the blood pressure for effects due to blood vessel compliance. A nonblood pressure monitor may periodically provide a reference blood pressure measurement that is used calibrate derivation of the blood pressure based on the pulse transit time.
摘要翻译：使用血液体积脉冲在动物的两个位置之间传播所需的脉搏传播时间来测量血压。采用阻抗体积描记法检测血液体积脉搏何时出现在一个位置。体积描记器可以检测胸部阻抗以确定主动脉瓣心脏瓣膜何时打开，或者可以在动物肢体的一个位置处检测阻抗。可以通过阻抗体积描记法或其他技术（例如脉搏血氧测定法）来确定另一位置处的血容量脉冲的发生。心脏搏动量的计算可用于补偿由于血管依从性引起的血压的推导。非血压监视器可以周期性地提供参考血压测量，其用于基于脉冲传播时间来校准血压的推导。

5. 发明授权

US08064991B2 Method of fetal and maternal ECG identification across multiple EPOCHS 失效
标题翻译：胎儿和母亲心电图识别多个EPOCHS的方法
公开(公告)号：US08064991B2
公开(公告)日：2011-11-22
申请号：US11970553
申请日：2008-01-08
申请人： Lawrence T. Hersh , Sai Kolluri , Bruce A. Friedman
发明人： Lawrence T. Hersh , Sai Kolluri , Bruce A. Friedman
IPC分类号： A61B5/0444
CPC分类号： A61B5/0444 , A61B5/04017 , A61B5/0472 , A61B5/04882 , A61B5/4362 , A61B5/7257 , G06F19/00 , G06K9/00536
摘要： A method of utilizing maternal-fetal monitoring system to monitor the physiological properties of both a maternal patient and a fetus. The method places a series of ECG electrodes across the maternal patient's abdomen and receives ECG input waveforms across a plurality of separate channels. The method processes the channels using an ICA algorithm to generate a series of ICA output waveforms. The ICA output waveforms are analyzed for each individual epoch to determine which of the channels include a maternal signal or a fetal signal source. Based upon the determination of which channel includes the fetal and maternal signals, further processing is carried out on the ICA output waveform on the identified channel to obtain physiological properties for the patient and the fetus. During the next epoch, the same signal processing occurs, such that the system can identify the fetal and maternal signals even as the fetal and maternal jump channels from one epoch to another.
摘要翻译：一种利用母胎监测系统监测母亲患者和胎儿生理特性的方法。该方法将一系列ECG电极放置在母亲患者的腹部上，并在多个单独的通道中接收ECG输入波形。该方法使用ICA算法处理信道以产生一系列ICA输出波形。分析每个独立时期的ICA输出波形，以确定哪些通道包括母体信号或胎儿信号源。基于哪个信道包括胎儿和母体信号的确定，对所识别的信道上的ICA输出波形进行进一步处理，以获得患者和胎儿的生理特性。在下一个时代，发生相同的信号处理，使得系统可以识别胎儿和母亲信号，即使胎儿和母亲的跳跃信道从一个时期到另一个时代。

6. 发明申请

US20080235058A1 VITAL SIGN MONITOR UTILIZING HISTORIC PATIENT DATA 审中-公开
标题翻译： VITAL SIGN MONITOR使用历史患者数据
公开(公告)号：US20080235058A1
公开(公告)日：2008-09-25
申请号：US12133922
申请日：2008-06-05
申请人： Bruce A. Friedman , John W. Booth , Richard Medero , Lawrence T. Hersh , Sai Kolluri
发明人： Bruce A. Friedman , John W. Booth , Richard Medero , Lawrence T. Hersh , Sai Kolluri
IPC分类号： G06Q50/00
CPC分类号： A61B5/022 , A61B5/0205 , A61B5/02225 , A61B5/0225 , A61B5/024 , G06Q50/24
摘要： A vital sign monitoring system that can be used with multiple patients and utilizes historic patient data information for the patient to optimize the process of obtaining current vital sign measurements. Each patient is identified with a unique patient identification device that is automatically detected by the vital sign monitor. The vital sign monitor communicates with a medical records database and obtains historic patient data information and previously diagnosed characteristics for the patient identified by the patient identification device. The historic patient data information and previously diagnosed characteristics of the patient can be utilized by the vital sign monitor to set alarm limits for the vital sign measurements and automatically adjust the blood pressure estimation algorithm of the NIBP monitor.
摘要翻译：一个生命体征监测系统，可与多个患者一起使用，并利用患者的历史患者数据信息来优化获取当前生命体征测量的过程。每个患者都有一个唯一的患者识别装置，由生命体征监测器自动检测。生命体征监测器与医疗记录数据库进行通信，并获得由患者识别装置识别的患者的历史患者数据信息和先前诊断的特征。患者的历史患者数据信息和先前诊断的特征可由生命体征监测器用于设置生命体征测量的报警限值，并自动调整NIBP监测器的血压估计算法。

7. 发明授权

US07186218B2 Method and system for cuff pressure reversions 有权
标题翻译：袖带压力逆转的方法和系统
公开(公告)号：US07186218B2
公开(公告)日：2007-03-06
申请号：US10375409
申请日：2003-02-27
申请人： Lawrence T. Hersh , Richard Medero , Bruce A. Friedman , Sai Kolluri
发明人： Lawrence T. Hersh , Richard Medero , Bruce A. Friedman , Sai Kolluri
IPC分类号： A61B5/02
CPC分类号： A61B5/02225 , A61B5/0225 , A61B5/7207 , G06F19/00
摘要： A method and system for determining when to make a reversion to smaller cuff pressure steps during an oscillometric blood pressure measurement is disclosed. The method and system comprise comparing conformance of oscillometric envelope blood pressure data with previous blood pressure data, including measuring a shift between the oscillometric envelope blood pressure data and an oscillometric envelope derived from the previous blood pressure data. In addition, the method and system include making a reversion decision based on whether the shift exceeds an allowable threshold. Once a reversion decision is made a subsequent decision may be made as to the need for increasing the cuff pressure level.
摘要翻译：公开了一种用于在示波器血压测量期间确定何时进行更小的袖带压力步骤的方法和系统。所述方法和系统包括比较示波包络血压数据与先前血压数据的一致性，包括测量示波包络血压数据与从先前血压数据得出的示波包络之间的偏移。此外，所述方法和系统包括基于所述偏移是否超过允许阈值来进行回归决定。一旦进行回归决定，可以随后作出关于增加袖带压力水平的需要的决定。

8. 发明授权

US08047998B2 Non-invasive blood pressure determination method 有权
标题翻译：无创血压测定方法
公开(公告)号：US08047998B2
公开(公告)日：2011-11-01
申请号：US11736276
申请日：2007-04-17
申请人： Sai Kolluri , Lawrence T. Hersh , Bruce A. Friedman
发明人： Sai Kolluri , Lawrence T. Hersh , Bruce A. Friedman
IPC分类号： A61B5/022
CPC分类号： A61B5/022 , A61B5/02125 , A61B5/0285 , A61B5/14551
摘要： A method for estimating systolic and diastolic pressure is disclosed herein. The method includes obtaining a predetermined type of blood pressure data from a patient, and providing previously acquired blood pressure data obtained from a plurality of different subjects. The method also includes implementing the previously acquired blood pressure data to select systolic and diastolic amplitude ratios that most closely correlate with the predetermined type of blood pressure data obtained from the patient. The selected systolic and diastolic amplitude ratios are adapted to compensate for the effects of arterial compliance. The method also includes implementing the selected systolic and diastolic amplitude ratios to generate a systolic and diastolic blood pressure estimates.
摘要翻译：本文公开了一种估计收缩压和舒张压的方法。该方法包括从患者获得预定类型的血压数据，并提供从多个不同主体获得的先前获得的血压数据。该方法还包括实施先前获得的血压数据，以选择与从患者获得的预定类型的血压数据最紧密相关的收缩和舒张振幅比。选择的收缩期和舒张期振幅比适应于补偿动脉顺应性的影响。该方法还包括实施选择的收缩和舒张振幅比以产生收缩压和舒张压。

9. 发明授权

US07775987B2 Computation of blood pressure using different signal processing channels 有权
标题翻译：使用不同的信号处理通道计算血压
公开(公告)号：US07775987B2
公开(公告)日：2010-08-17
申请号：US11284206
申请日：2005-11-21
申请人： Lawrence T. Hersh , Sai Kolluri , Bruce A. Friedman , Richard Medero
发明人： Lawrence T. Hersh , Sai Kolluri , Bruce A. Friedman , Richard Medero
IPC分类号： A61B5/02
CPC分类号： A61B5/022 , A61B5/02225 , A61B5/7207
摘要： A blood pressure measurement system that utilizes a non-invasive blood pressure (NIBP) monitor having a blood pressure cuff and pressure transducer. The measurement system provides a plurality of separate processing techniques that each receive a plurality of oscillometric data values from the pressure transducer. Each of the processing techniques separately constructs an oscillometric envelope based upon the oscillometric data values. Based upon the plurality of separate oscillometric envelopes, the system compares the envelopes and develops a calculated blood pressure from the plurality of envelopes. The calculated blood pressure is then displayed by the NIBP system. The plurality of oscillometric envelopes can be compared and combined in different manners to calculate the patient's blood pressure from the plurality of different processing techniques.
摘要翻译：一种血压测量系统，其利用具有血压袖带和压力换能器的非侵入性血压（NIBP）监测器。测量系统提供多个单独的处理技术，每个处理技术从压力传感器接收多个示波数据值。每个处理技术基于示波数据值分别构建示波包络。基于多个单独的示波包络，系统比较信封并从多个信封形成计算出的血压。然后计算的血压由NIBP系统显示。多个示波包络可以以不同的方式进行比较和组合，以从多种不同的处理技术计算出患者的血压。

10. 发明授权

US07678059B2 Non-invasive blood pressure monitor with improved performance 有权
标题翻译：非侵入性血压计，性能提升
公开(公告)号：US07678059B2
公开(公告)日：2010-03-16
申请号：US11248099
申请日：2005-10-12
申请人： Bruce A. Friedman , Sai Kolluri , Lawrence T. Hersh
发明人： Bruce A. Friedman , Sai Kolluri , Lawrence T. Hersh
IPC分类号： A61B5/02
CPC分类号： A61B5/02225 , A61B5/02125 , A61B5/02255 , A61B5/0402 , A61B5/0535 , A61B5/145
摘要： A blood pressure measurement system that utilizes both a non-invasive blood pressure (NIBP) monitor having a blood pressure cuff and a continuous non-invasive blood pressure (CNIBP) monitor. During operation of the NIBP monitor, the blood pressure cuff is inflated to an initial inflation pressure greater than the systolic blood pressure for the patient being monitored. The CNIBP monitor calculates an estimated blood pressure that is supplied to the NIBP monitor. The NIBP monitor utilizes the continuous, estimated blood pressure to select a target inflation pressure for the blood pressure cuff. During operation of the NIBP monitor, the size of the pressure steps from the initial inflation pressure to a final pressure can be varied based upon the continuous blood pressure estimate from the NIBP monitor.
摘要翻译：一种血压测量系统，其利用具有血压袖带的无创血压（NIBP）监测器和连续非侵入性血压（CNIBP）监测器。在NIBP监测器的操作期间，血压袖带膨胀至初始充气压力大于被监测患者的收缩压。 CNIBP监视器计算提供给NIBP监视器的估计血压。 NIBP监测器利用连续的估计血压来选择血压袖带的目标充气压力。在NIBP监视器的操作期间，从初始充气压力到最终压力的压力步长的大小可以基于来自NIBP监视器的连续血压估计而改变。

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