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    • 6. 发明授权
    • Method and apparatus for characterizing materials by using a mechanical resonator
    • 通过使用机械谐振器表征材料的方法和装置
    • US06393895B1
    • 2002-05-28
    • US09133171
    • 1998-08-12
    • Leonid MatsievJames BennettEric McFarland
    • Leonid MatsievJames BennettEric McFarland
    • G01N2902
    • G01N29/4418B01J2219/00704G01H13/00G01N5/04G01N9/002G01N11/16G01N29/022G01N29/036G01N29/348G01N29/42G01N2009/006G01N2291/014G01N2291/0224G01N2291/0255G01N2291/02818G01N2291/02863G01N2291/0422G01N2291/0423G01N2291/0426G01N2291/0427
    • A method and apparatus for measuring properties of a liquid composition includes a mechanical resonator, such as a thickness shear mode resonator or a tuning fork resonator, connected to a measurement circuit. The measurement circuit provides a variable frequency input signal to the tuning fork, causing the mechanical resonator to oscillate. To test the properties of a liquid composition, the mechanical resonator is placed inside a sample well containing a small amount of the liquid. The input signal is then sent to the mechanical resonator and swept over a selected frequency range, preferably less than 1 MHz to prevent the liquid being tested from exhibiting gel-like characteristics and causing false readings. The mechanical resonator's response over the frequency range depends on various characteristics of the liquid being tested, such as the temperature, viscosity, and other physical properties. Particular mechanical resonators, such as tuning fork resonators, can also be used to measure a liquid composition's electrical properties, such as the dielectric constant and conductivity, because the tuning fork's structure allows a high degree of electrical coupling between the tuning fork and the surrounding liquid. The mechanical resonator can be covered with a coating to impart additional special detection properties to the resonator, and multiple resonators can be attached together as a single sensor to obtain multiple frequency responses. The invention is particularly suitable for combinatorial chemistry applications, which require rapid analysis of chemical properties for screening.
    • 用于测量液体组合物性质的方法和装置包括连接到测量电路的机械谐振器,例如厚度剪切模式谐振器或音叉谐振器。 测量电路向音叉提供可变频率输入信号,使机械谐振器振荡。 为了测试液体组合物的性质,将机械谐振器放置在含有少量液体的样品孔内。 然后将输入信号发送到机械谐振器并扫过选定的频率范围,优选小于1MHz,以防止被测试的液体表现出凝胶状特征并导致错误的读数。 机械谐振器在频率范围内的响应取决于待测液体的各种特性,例如温度,粘度和其他物理性质。 由于音叉的结构允许音叉和周围液体之间的高度电耦合,所以诸如音叉谐振器的特殊的机械谐振器也可用于测量液体组合物的电性能,例如介电常数和导电性 。 可以用涂层覆盖机械谐振器以赋予谐振器附加的特殊检测特性,并且多个谐振器可以作为单个传感器附接在一起以获得多个频率响应。 本发明特别适用于组合化学应用,需要快速分析筛选的化学性质。
    • 8. 发明申请
    • Graphic design of combinatorial material libraries
    • 组合材料库的平面设计
    • US20070185657A1
    • 2007-08-09
    • US11732408
    • 2007-04-02
    • Steven LacyEric McFarlandAdam SafirStephen TurnerLynn ErdenPei Wang
    • Steven LacyEric McFarlandAdam SafirStephen TurnerLynn ErdenPei Wang
    • C40B30/02
    • G16C20/60G16B35/00
    • Computer-implemented methods, programs and apparatus for generating a library design for a combinatorial library of materials. A library design includes a set of sources representing components to be used in preparing the combinatorial library, destinations representing arrangements of cells and mappings, defining one or more distribution patterns for assigning components to cells in the destination arrangement or arrangements. Mappings include gradients and sets of user-defined equations, and are used to calculate the amount of one or more components to be assigned to a cell or cells in an arrangement. A library design can also include one or more process parameters defined to vary over time or across a plurality of destination cells. The invention outputs a data file defining the library design, including electronic data representing the sources, the destinations and the mapping, in a format suitable for implementing manually or using automated material handling apparatus.
    • 用于生成材料组合库的图书馆设计的计算机实现的方法,程序和装置。 图书馆设计包括一组代表用于准备组合库的组件的源,表示单元格和映射的目的的目的地,定义用于将组件分配给目的地布置或布置中的单元的一个或多个分布模式。 映射包括梯度和用户定义方程组,并且用于计算要分配给单元或单元的一个或多个组件的数量。 库设计还可以包括一个或多个过程参数,其定义为随时间变化或跨多个目的地小区而变化。 本发明以适合手动实现或使用自动化材料处理装置的格式输出定义库设计的数据文件,包括表示源,目的地和映射的电子数据。