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1. 发明公开

EP2974751A1 CARDIAC OR VASCULAR TISSUE SPHEROID 审中-公开
标题翻译：心脏或血管组织球状体
公开(公告)号：EP2974751A1
公开(公告)日：2016-01-20
申请号：EP13878105.9
申请日：2013-10-24
申请人： Saga University , Cyfuse Biomedical K. K.
发明人： NOGUCHI, Ryo , TAMURA, Tadashi , NAKAYAMA, Koichi , MORITA, Shigeki , NODE, Koichi
IPC分类号： A61L27/00 , C12N5/071 , C12N5/077
CPC分类号： A61L27/3625 , A61K35/33 , A61K35/34 , A61K35/44 , A61L27/3804 , A61L27/3886 , A61L27/507 , A61L2300/64 , A61L2430/20 , C12N5/0691 , C12N5/0697 , C12N2502/1323 , C12N2502/1329 , C12N2502/28
摘要： Provided is a method for producing a cardiac tissue spheroid or vascular tissue spheroid formed from a mixture of a myocardial cell or smooth muscle cell and at least one type of cell selected from a vascular endothelial cell and fibroblast, and a three dimensional cardiac tissue structure or three dimensional vascular tissue structure which are characterized by combining or laminating said spheroid.
摘要翻译：提供一种由心肌细胞或平滑肌细胞与选自血管内皮细胞和成纤维细胞中的至少一种细胞和三维心脏组织结构的混合物形成的心脏组织球体或血管组织球体的制造方法，或者三维维管组织结构，其特征在于组合或层压所述球体。

2. 发明申请

WO2006087597A1 PLATELET-DERIVED MICROPARTICLES AS A NOVEL DIAGNOSIS MAKER FOR A CARDIOVASCULAR DISEASE 审中-公开
标题翻译：作为心血管疾病的新型诊断药物的平板传代微量元素
公开(公告)号：WO2006087597A1
公开(公告)日：2006-08-24
申请号：PCT/IB2005/000422
申请日：2005-02-21
申请人： SAGA UNIVERSITY , NODE, Koichi , INOUE, Teruo
发明人： NODE, Koichi , INOUE, Teruo
IPC分类号： G01N33/50 , A61B5/00
CPC分类号： G01N33/86
摘要： The present invention relates to a diagnosis maker for a cardiovascular disease comprising platelet-derived microparticles. The present invention also relates to a method for diagnosing a cardiovascular disease in a subject with symptoms of cardiovascular disease or suspected of having cardiovascular disease, wherein said method comprises: (a) obtaining a sample from said subject; (b) reacting an antibody to platelet-derived microparticles or a fragment thereof with a biological sample; (c) detecting a presence or an absence of the platelet-derived microparticles or a fragment thereof in said sample; and (d) diagnosing cardiovascular disease in said subject having said symptoms when said platelet-derived microparticles or a fragment thereof are detected in said sample.
摘要翻译：本发明涉及包含血小板衍生的微粒的心血管疾病的诊断制造者。本发明还涉及一种用于诊断具有心血管疾病症状或疑似患有心血管疾病的受试者的心血管疾病的方法，其中所述方法包括：（a）从所述受试者获得样品; （b）将抗体与血小板衍生的微粒或其片段与生物样品反应; （c）检测所述样品中血小板衍生的微粒或其片段的存在或不存在; 和（d）在所述样品中检测到所述血小板衍生的微粒或其片段时，在所述具有所述症状的受试者中诊断心血管疾病。

3. 发明公开

EP1851541A1 PLATELET-DERIVED MICROPARTICLES AS A NOVEL DIAGNOSIS MAKER FOR A CARDIOVASCULAR DISEASE 有权
标题翻译：从血小板WON微粒作为一种新的诊断标志物的心血管疾病
公开(公告)号：EP1851541A1
公开(公告)日：2007-11-07
申请号：EP05708556.5
申请日：2005-02-21
申请人： SAGA UNIVERSITY
发明人： NODE, Koichi , INOUE, Teruo
IPC分类号： G01N33/50 , A61B5/00
CPC分类号： G01N33/86
摘要： The present invention relates to a diagnosis maker for a cardiovascular disease comprising platelet-derived microparticles. The present invention also relates to a method for diagnosing a cardiovascular disease in a subject with symptoms of cardiovascular disease or suspected of having cardiovascular disease, wherein said method comprises: (a) obtaining a sample from said subject; (b) reacting an antibody to platelet-derived microparticles or a fragment thereof with a biological sample; (c) detecting a presence or an absence of the platelet-derived microparticles or a fragment thereof in said sample; and (d) diagnosing cardiovascular disease in said subject having said symptoms when said platelet-derived microparticles or a fragment thereof are detected in said sample.

4. 发明授权

EP1851541B1 PLATELET-DERIVED MICROPARTICLES AS A NOVEL DIAGNOSIS MAKER FOR A CARDIOVASCULAR DISEASE 有权
标题翻译：从血小板WON微粒作为一种新的诊断标志物的心血管疾病
公开(公告)号：EP1851541B1
公开(公告)日：2011-05-11
申请号：EP05708556.5
申请日：2005-02-21
申请人： SAGA UNIVERSITY
发明人： NODE, Koichi , INOUE, Teruo
IPC分类号： G01N33/50 , A61B5/00
CPC分类号： G01N33/86
摘要： The present invention relates to a diagnosis maker for a cardiovascular disease comprising platelet-derived microparticles. The present invention also relates to a method for diagnosing a cardiovascular disease in a subject with symptoms of cardiovascular disease or suspected of having cardiovascular disease, wherein said method comprises: (a) obtaining a sample from said subject; (b) reacting an antibody to platelet-derived microparticles or a fragment thereof with a biological sample; (c) detecting a presence or an absence of the platelet-derived microparticles or a fragment thereof in said sample; and (d) diagnosing cardiovascular disease in said subject having said symptoms when said platelet-derived microparticles or a fragment thereof are detected in said sample.

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