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    • 1. 发明申请
    • PLATELET-DERIVED MICROPARTICLES AS A NOVEL DIAGNOSIS MAKER FOR A CARDIOVASCULAR DISEASE
    • 作为心血管疾病的新型诊断药物的平板传代微量元素
    • WO2006087597A1
    • 2006-08-24
    • PCT/IB2005/000422
    • 2005-02-21
    • SAGA UNIVERSITYNODE, KoichiINOUE, Teruo
    • NODE, KoichiINOUE, Teruo
    • G01N33/50A61B5/00
    • G01N33/86
    • The present invention relates to a diagnosis maker for a cardiovascular disease comprising platelet-derived microparticles. The present invention also relates to a method for diagnosing a cardiovascular disease in a subject with symptoms of cardiovascular disease or suspected of having cardiovascular disease, wherein said method comprises: (a) obtaining a sample from said subject; (b) reacting an antibody to platelet-derived microparticles or a fragment thereof with a biological sample; (c) detecting a presence or an absence of the platelet-derived microparticles or a fragment thereof in said sample; and (d) diagnosing cardiovascular disease in said subject having said symptoms when said platelet-derived microparticles or a fragment thereof are detected in said sample.
    • 本发明涉及包含血小板衍生的微粒的心血管疾病的诊断制造者。 本发明还涉及一种用于诊断具有心血管疾病症状或疑似患有心血管疾病的受试者的心血管疾病的方法,其中所述方法包括:(a)从所述受试者获得样品; (b)将抗体与血小板衍生的微粒或其片段与生物样品反应; (c)检测所述样品中血小板衍生的微粒或其片段的存在或不存在; 和(d)在所述样品中检测到所述血小板衍生的微粒或其片段时,在所述具有所述症状的受试者中诊断心血管疾病。