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1. 发明授权

US4911862A Optically active carboxylic acid derivatives and liquid crystalline compositions comprising them 失效
标题翻译：包含它们的光学活性羧酸衍生物和液晶组合物
公开(公告)号：US4911862A
公开(公告)日：1990-03-27
申请号：US210375
申请日：1988-06-23
申请人： Tadao Shoji , Sadao Takehara , Toru Fujisawa , Masashi Osawa , Hiroshi Ogawa , Yoshi Arai , Jitsuo Kurokawa
发明人： Tadao Shoji , Sadao Takehara , Toru Fujisawa , Masashi Osawa , Hiroshi Ogawa , Yoshi Arai , Jitsuo Kurokawa
IPC分类号： C07C69/773 , C09K19/12 , C09K19/20
CPC分类号： C09K19/12 , C09K19/2021
摘要： An optically active carboxylic acid derivative represented by the general formula ##STR1## wherein R represents a normal alkyl group having 1 to 20 carbon atoms, m and n represent 0 or 1 but are not 1 at the same time, X represents a hydrogen or halogen atom, Y represents a hydrogen or fluorine atom, provided that when Y is a hydrogen atom, X is a halogen atom, and that when n is 0, Y is a hydrogen atom, and Q* represents an optically active alkyl or 1-alkoxyethyl group having an asymmetric carbon atom.
摘要翻译：由通式（I）表示的光学活性羧酸衍生物，其中R表示具有1至20个碳原子的正烷基，m和n表示0或1，但不同时为1，X表示氢或卤素原子，Y表示氢或氟原子，条件是当Y为氢原子时，X为卤素原子，当n为0时，Y为氢原子，Q *为光学活性烷基或具有不对称碳原子的1-烷氧基乙基。

2. 发明授权

US4914224A Optically active carboxylic acid derivatives and liquid crystalline compositions comprising them 失效
标题翻译：包含它们的光学活性羧酸衍生物和液晶组合物
公开(公告)号：US4914224A
公开(公告)日：1990-04-03
申请号：US7612
申请日：1987-01-28
申请人： Tadao Shoji , Sadao Takehara , Toru Fujisawa , Masashi Osawa , Hiroshi Ogawa , Yoshi Arai , Jitsuo Kurokawa
发明人： Tadao Shoji , Sadao Takehara , Toru Fujisawa , Masashi Osawa , Hiroshi Ogawa , Yoshi Arai , Jitsuo Kurokawa
IPC分类号： C07C69/773 , C09K19/12 , C09K19/20
CPC分类号： C09K19/12 , C09K19/2021
摘要： An optically active carboxylic acid derivative represented by the general formula ##STR1## wherein R represents a normal alkyl group having 1 to 20 carbon atoms, m and n represent 0 or 1 but are not 1 at the same time, X represents a hydrogen or halogen atom, Y represents a hydrogen or fluorine atom, provided that when Y is a hydrogen atom, X is a halogen atom, and that when n is 0, Y is ahydrogen atom, and Q* represents an optically active alkyl or 1-alkoxyethyl group having an asymmetric carbon atom.

3. 发明授权

US5324451A Lactic acid derivatives and liquid crystal compositions containing the same 失效
标题翻译：乳酸衍生物和含有它的液晶组合物
公开(公告)号：US5324451A
公开(公告)日：1994-06-28
申请号：US870743
申请日：1992-04-20
申请人： Sadao Takehara , Tadao Shoji , Hiroshi Ogawa , Toru Fujisawa , Masashi Osawa
发明人： Sadao Takehara , Tadao Shoji , Hiroshi Ogawa , Toru Fujisawa , Masashi Osawa
IPC分类号： C07C69/773 , C09K19/12 , C09K19/20 , C07C69/76
CPC分类号： C09K19/126 , C09K19/2021
摘要： A compound represented by formula (I): ##STR1## wherein R.sub.1 represents an alkyl group having from 1 to 18 carbon atoms; R.sub.2 represents an alkyl group having from 2 to 16 carbon atoms; rings A, B, C, and D each represents a 1,4-phenylene group or a 1,4-phenylene group having one or two halogen atoms; Y represents a single bond, ##STR2## m and n each represents 0 or 1; p represents 0, 1, or 2; q represents 0 or an integer of from 1 to 6; and C* and C** each represents an asymmetric carbon atom in an (S)- or (R)-configuration, and a liquid crystal composition containing the compound of formula (I). The compound of formula (I) is a chiral liquid crystal compound exhibiting large spontaneous polarization, a long helical pitch, an SC* phase in a broad temperature range including room temperature, satisfactory orientation, and a high rate of response.
摘要翻译：由式（I）表示的化合物：其中R 1表示具有1至18个碳原子的烷基; R2表示具有2至16个碳原子的烷基; 环A，B，C和D各自表示具有一个或两个卤素原子的1,4-亚苯基或1,4-亚苯基; Y表示单键， m，n表示0或1; p表示0,1或2; q表示0或1至6的整数; 和C *和C **各自表示（S） - 或（R） - 构型中的不对称碳原子，和含有式（I）化合物的液晶组合物。式（I）的化合物是在包括室温，令人满意的取向和高响应速度的宽温度范围内表现出大的自发极化，长螺距，SC *相的手性液晶化合物。

4. 发明授权

US5128472A 2,5-disubstituted pyrazine derivatives, pyrimidine derivatives, and liquid crystal containing the same 失效
标题翻译： 2,5-二取代吡嗪衍生物，嘧啶衍生物和含有它们的液晶
公开(公告)号：US5128472A
公开(公告)日：1992-07-07
申请号：US606662
申请日：1990-10-31
申请人： Masashi Osawa , Tadao Shoji , Sadao Takehara , Hiroshi Ogawa , Toru Fujisawa , Takeshi Kuriyama , Kayoko Nakamura
发明人： Masashi Osawa , Tadao Shoji , Sadao Takehara , Hiroshi Ogawa , Toru Fujisawa , Takeshi Kuriyama , Kayoko Nakamura
IPC分类号： C07D239/26 , C07D241/12 , C09K19/34
CPC分类号： C07D239/26 , C07D241/12 , C09K19/3452
摘要： A 2,5-disubstituted pyrizine derivative and a 2,5-disubstituted pyrimidine derivative of the formula (I): ##STR1## wherein R.sup.1 and R.sup.2 each independently represents a straight-chain or branched alkyl group containing 1 to 20 carbon atoms;X represents a halogen atom; and ##STR2## represents a pyrazine-2,5-diyl or a pyrimidine-2,5-diyl group; each useful as an electrooptical display material are disclosed. Further a liquid crystal composition comprising said compounds as well as a ferroelectric display device wherein said liquid crystal composition is used are disclosed.
摘要翻译：式（I）的2,5-二取代吡嗪衍生物和2,5-二取代嘧啶衍生物：其中R 1和R 2各自独立地表示含有1至20个碳的直链或支链烷基原子 X表示卤原子; 并且表示吡嗪-2,5-二基或嘧啶-2,5-二基; 各自用作电光显示材料。此外，还公开了包含所述化合物的液晶组合物以及其中使用所述液晶组合物的铁电显示装置。

5. 发明授权

US4997942A 2,4-disubstituted pyrazine derivatives, pyrimidine derivatives, and liquid crystal containing the same 失效
标题翻译： 2,4-二取代吡嗪衍生物，嘧啶衍生物和含有它们的液晶
公开(公告)号：US4997942A
公开(公告)日：1991-03-05
申请号：US325813
申请日：1989-03-20
申请人： Masashi Osawa , Tadao Shoji , Sadao Takehara , Hiroshi Ogawa , Toru Fujisawa , Takeshi Kuriyama , Kayoko Nakamura
发明人： Masashi Osawa , Tadao Shoji , Sadao Takehara , Hiroshi Ogawa , Toru Fujisawa , Takeshi Kuriyama , Kayoko Nakamura
IPC分类号： C07D239/26 , C07D241/12 , C09K19/34
CPC分类号： C07D239/26 , C07D241/12 , C09K19/3452
摘要： A 2,5-disubstituted pyrazine derivative and a 2,5-disubstituted pyrimidine derivative of the formula (I): ##STR1## wherein R.sup.1 and R.sup.2 each independently represents a straight-chain or branched alkyl group containing 1 to 20 carbon atoms;X represents a halogen atom; and ##STR2## represents a pyrazine-2,5-diyl or a pyrimidine-2,5-diyl group; each useful as an electrooptical display material are disclosed. Further a liquid crystal composition comprising said compounds as well as a ferroelectric display device wherein said liquid crystal composition is used are disclosed.

6. 发明授权

US5061398A Optically active lactone derivative, intermediate therefor, process for producing the intermediate, liquid-crystal composition, and liquid-crystal display device 失效
标题翻译：光学活性衍生物，其中间体，制备中间体，液晶组合物和液晶显示装置的方法
公开(公告)号：US5061398A
公开(公告)日：1991-10-29
申请号：US515915
申请日：1990-04-27
申请人： Sadao Takehara , Takeshi Kuriyama , Kayoko Nakamura , Tadao Shoji , Toru Fujisawa , Masashi Osawa , Tamejiro Hiyama , Tetsuo Kusumoto , Akiko Nakayama , Kiyoharu Nishide
发明人： Sadao Takehara , Takeshi Kuriyama , Kayoko Nakamura , Tadao Shoji , Toru Fujisawa , Masashi Osawa , Tamejiro Hiyama , Tetsuo Kusumoto , Akiko Nakayama , Kiyoharu Nishide
IPC分类号： G02F1/13 , C07C255/37 , C07D307/33 , C09K19/34 , C09K19/54
CPC分类号： C07D307/33 , C09K19/2021 , C09K19/3405 , C09K2019/3075
摘要： An optically active lactone derivative represented by the following general formula (I): ##STR1## wherein R.sup.1 represents a straight-chain or branched alkyl, alkoxyl, alkanoyloxy, alkoxycarbonyl, alkoxyalkyl, alkoxyalkanoyloxy, or alkoxyalkoxyl group having 1 to 20 carbon atoms or an optically active group of each of the above kinds, R.sup.2 represents a straight-chain or branched alkyl group having 1 to 20 carbon atoms, ##STR2## or trans-1,4-cyclohexylene group of the formula and the asymmetric carbon atoms at the 2- and 4-positions in the lactone ring each independently is of the (S) or (R) configuration, an intermediate therefor, a process for producing the intermediate, a liquid-crystal composition, and a liquid-crystal display device.

7. 发明授权

US5498602A Oligosaccharide aromatic glycoside and sulfate thereof 失效
标题翻译：寡糖芳香糖苷及其硫酸盐
公开(公告)号：US5498602A
公开(公告)日：1996-03-12
申请号：US944077
申请日：1992-09-11
申请人： Tadao Shoji , Nahoko Takahashi , Naoya Ikushima , Toshiyuki Uryu , Takashi Yoshida , Naoki Yamamoto , Hideki Nakashima , Kaname Katsuraya , Koichiro Adachi , Fusayo Kataoka
发明人： Tadao Shoji , Nahoko Takahashi , Naoya Ikushima , Toshiyuki Uryu , Takashi Yoshida , Naoki Yamamoto , Hideki Nakashima , Kaname Katsuraya , Koichiro Adachi , Fusayo Kataoka
IPC分类号： A61K31/70 , A61K31/7028 , A61K31/7034 , A61P31/12 , A61P31/18 , C07H15/203 , C08B37/00 , C07G3/00 , C07H11/00
CPC分类号： C07H15/203 , C08B37/006
摘要： Oligosaccharide aromatic glycoside sulfates and physiologically acceptable salts thereof, are disclosed. Further, antiviral agents having these sulfate compounds as the active components, and particularly an antiviral agent, wherein the virus is one which causes AIDS (Acquired Immune Deficiency Syndrome), are disclosed. The active components or the glycoside sulfates, and the salts thereof, are characterized by an oligosaccharide aromatic glycoside sulfate in which the hydrogen of the position-1 hydroxyl group of the terminal sugar of an oligosaccharide is substituted with a specified formula having an alkyl group consisting of 1 to 18 carbons, an oxygen or no oxygen, and an allylene group. The number of constituent monosaccharides in the oligosaccharide portion is preferably within a range of 2 to 20. Further, 10% or more of the remaining hydroxyl groups of the sugar subunits are subjected to sulfated esterification. In addition the antiviral agent exhibits low toxicity and is useful in the treatment of AIDS. Furthermore, an oligosaccharide is also disclosed as described above with the exception that it is the hydrogen atom of the position 1 hydrogen group at the terminal sugar residue which is substituted with the specified formula, also described above. However, in addition the remaining hydroxyl groups of the sugar portion of this oligosaccharide are protected by acyl groups or are present in an unprotected form. Also disclosed is a method for the production of an oligosaccharide aromatic glycoside sulfate synthesized by sulfation using a sulfating agent.
摘要翻译：公开了寡糖芳香糖苷硫酸盐及其生理上可接受的盐。此外，公开了具有这些硫酸盐化合物作为活性成分的抗病毒剂，特别是其中病毒是引起AIDS（获得性免疫缺陷综合征）的抗病毒剂。活性成分或糖苷硫酸盐及其盐的特征在于寡糖芳香糖苷硫酸盐，其中寡糖末端糖的位置1羟基的氢被具有烷基的特定式所取代， 1至18个碳，氧或无氧，以及烯丙基。寡糖部分中的构成单糖的数量优选在2〜20的范围内。此外，将糖亚基的剩余羟基的10％以上进行硫酸化酯化。此外，抗病毒剂的毒性低，可用于治疗艾滋病。此外，还公开了如上所述的寡糖，不同之处在于它是上述也被指定式取代的末端糖残基上的1位氢原子的氢原子。然而，此外，该寡糖的糖部分的剩余羟基由酰基保护或以未保护的形式存在。还公开了通过使用硫酸化剂硫酸化合成的寡糖芳香族糖苷硫酸盐的制造方法。

8. 发明授权

US5179095A Piperidine derivative and pharmaceutical composition containing the same 失效
标题翻译：哌啶衍生物和含有其的药物组合物
公开(公告)号：US5179095A
公开(公告)日：1993-01-12
申请号：US798963
申请日：1991-11-26
申请人： Hitoshi Oinuma , Motosuke Yamanaka , Kazutoshi Miyake , Tomonori Hoshiko , Norio Minami , Tadao Shoji , Yoshiharu Daiku , Kohei Sawada , Kenichi Nomoto
发明人： Hitoshi Oinuma , Motosuke Yamanaka , Kazutoshi Miyake , Tomonori Hoshiko , Norio Minami , Tadao Shoji , Yoshiharu Daiku , Kohei Sawada , Kenichi Nomoto
IPC分类号： C07D211/28 , C07D401/04 , C07D401/06 , C07D401/14 , C07D405/04 , C07D409/04 , C07D417/04 , C07D471/04 , C07D473/10
CPC分类号： C07D401/04 , C07D211/28 , C07D401/06 , C07D401/14 , C07D405/04 , C07D409/04 , C07D417/04 , C07D471/04 , C07D473/10
摘要： A new piperidine compound is pharmacologically effective for treatment of the arrythmia and is defined by the formula: ##STR1## in which R.sup.1 is a lower alkyl or a tolyl, R.sup.2 is hydrogen, hydroxyl, a lower alkoxy or a lower alkyl, R.sup.3 is hydrogen, a lower alkyl, a lower alkenyl, a cycloalkyl or a cycloalkylalkyl, X is --CO--, --CH.sup.2 -- or --CHOH--, g is an integer of 1 to 3, h is an integer of 1 to 3, Y is hydrogen, a lower alkyl, a lower alkenyl, cyano, CH.sup.2 COOR, R being hydrogen or a lower alkyl, a cycloalkyl, a cycloalkylalkyl, ##STR2## 1 being 1 or 2, --A--B, A being --(CH.sub.2).sub.n --, n being an integer of 1 to 5,a straight-chain alkylene group having 1 to 5 carbon atoms which is a divalent group derived from a straight-chain alkane having lower alkyl, phenyl or hydroxyl group(s) bonded directly to one or more carbon atoms constituting said alkane by removing a hydrogen atom bonded to each of the carbon atoms placed at both ends thereof,a straight-chain alkylene group having 1 to 5 carbon atoms which is a divalent group derived from a straight-chain alkene having a double bond formed between carbon atoms adjacent to each other by removing a hydrogen atom bonded to each of the carbon atoms placed at both ends thereof,--(CH.sub.2)k--S--, k being an integer of 2 to 5, --(CH.sub.2)p--CO--, p being an integer of 1 to 4, B being cyano, --NR.sub.4 R.sub.5, a heterocyclic ring or a condensed aromatic ring.
摘要翻译：新的哌啶化合物在治疗心律失常方面是药理学有效的，并由下式定义：其中R1是低级烷基或甲苯基，R2是氢，羟基，低级烷氧基或低级烷基，R3是氢低级烷基，低级烯基，环烷基或环烷基烷基，X为-CO-，-CH 2 - 或-CHOH-，g为1〜3的整数，h为1〜3的整数，Y为氢，低级烷基，低级烯基，氰基，CH 2 COOR，R为氢或低级烷基，环烷基，环烷基烷基，A为1或2，-AB，A为 - （CH 2）n - ，n为 1至5的整数，具有1至5个碳原子的直链亚烷基，其是衍生自直接与一个或多个碳原子键合的低级烷基，苯基或羟基的直链烷烃的二价基团通过除去与位于其两端的每个碳原子键合的氢原子构成所述烷烃，具有1至5个碳原子的直链亚烷基，其是通过除去与位于其两端的每个碳原子键合的氢原子，通过除去彼此相邻的碳原子之间形成的双键的直链烯烃的二价基团， - （CH 2）k S - ，k为 2〜5的整数， - （CH 2）p -CO-，p为1〜4的整数，B为氰基，-NR 4 R 5，杂环或稠合芳环。

9. 发明授权

US5246946A Piperidine derivatives and therapeutic and preventive agents for arrhythmia containing same 失效
标题翻译：哌啶衍生物和含有其的心律不齐的治疗和预防剂
公开(公告)号：US5246946A
公开(公告)日：1993-09-21
申请号：US930727
申请日：1992-08-14
申请人： Hitoshi Oinuma , Motosuke Yamanaka , Kazutoshi Miyake , Tomonori Hoshiko , Norio Minami , Tadao Shoji , Yoshiharu Daiku , Kohei Sawada , Kenichi Nomoto
发明人： Hitoshi Oinuma , Motosuke Yamanaka , Kazutoshi Miyake , Tomonori Hoshiko , Norio Minami , Tadao Shoji , Yoshiharu Daiku , Kohei Sawada , Kenichi Nomoto
IPC分类号： C07D211/14 , C07D211/32 , C07D211/54 , C07D213/38 , C07D401/06
CPC分类号： C07D401/06 , C07D211/14 , C07D211/32 , C07D211/54 , C07D213/38
摘要： A piperidine compound has the generic formula and is useful to treat arrhythmia. ##STR1## in which R1 is a lower alkyl and W is: ##STR2## X is --S--, --SO-- or --SO2--, R2 is hydrogen or --(CH2)n--Y, n is an integer of 1 to 5, Y is an aryl, pyridyl or a substituted pyridyl, X' is --CO-- or --CH(OH)--,p is an integer of 1 to 4, R12 is hydrogen or a lower alkyl, Y' is --(CH2)m--A, m is 1 or 2, A is an aryl, a substituted aryl, pyridyl or a substituted pyridyl, R12 and Y may form a 5- or 6-membered ring or a 5- or 6-membered ring having one or more substituents andR22 is hydrogen, a halogen, a lower alkyl, a lower alkoxy or hydroxy.
摘要翻译：哌啶化合物具有通用的结构，可用于治疗心律失常。（3）X是-S-，-SO-或-SO 2 - ，R 2（R 2），其中R 1是低级烷基，W是：是氢或 - （CH 2）n Y，n是1至5的整数，Y是芳基，吡啶基或取代的吡啶基，X'是-CO-或-CH（OH） - ，p是1〜 4，R 12是氢或低级烷基，Y'是 - （CH 2）mA，m是1或2，A是芳基，取代的芳基，吡啶基或取代的吡啶基，R 12和Y可以形成5-或6 环或具有一个或多个取代基的5或6元环，R 22是氢，卤素，低级烷基，低级烷氧基或羟基。

10. 发明授权

US4977165A Piperidine derivative and therapeutic and preventive agents for arrhythmia containing same 失效
标题翻译：哌啶衍生物和含有其的心律不齐的治疗和预防剂
公开(公告)号：US4977165A
公开(公告)日：1990-12-11
申请号：US234468
申请日：1988-08-19
申请人： Hitoshi Oinuma , Motosuke Yamanaka , Kazutoshi Miyake , Tomonori Hoshiko , Norio Minami , Tadao Shoji
发明人： Hitoshi Oinuma , Motosuke Yamanaka , Kazutoshi Miyake , Tomonori Hoshiko , Norio Minami , Tadao Shoji
IPC分类号： C07D211/14 , C07D211/32 , C07D211/54 , C07D213/38 , C07D401/06
CPC分类号： C07D401/06 , C07D211/14 , C07D211/32 , C07D211/54 , C07D213/38 , Y10S514/821
摘要： A piperidine compound has the generic formula and is useful to treat arrhythmia. ##STR1## in which R.sup.1 is a lower alkyl and W is: ##STR2## X is --S--, --SO-- or --SO.sub.2 --, R.sup.2 is hydrogen or --(CH.sub.2).sub.n --Y, n is an integer of 1 to 5, Y is an aryl, pyridyl or a substituted pyridyl, X' is --CO-- or --CH(OH)--,p is an integer of 1 to 4, R.sup.12 is hydrogen or a lower alkyl, Y' is --(CH.sub.2).sub.m --A, m is 1 or 2, A is an aryl, a substituted aryl, pyridyl or a substituted pyridyl, R.sup.12 and Y may form a 5- or 6-membered ring or a 5- or 6-membered ring having one or more substituents andR.sup.22 is hydrogen, a halogen, a lower alkyl, a lower alkoxy or hydroxy.

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