专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO1996034870A1 AZACYCLOALCANE DERIVATIVES, PREPARATION THEREOF AND THEIR APPLICATIONS IN THERAPY 审中-公开
标题翻译：亚卡环素衍生物，其制剂及其在治疗中的应用
公开(公告)号：WO1996034870A1
公开(公告)日：1996-11-07
申请号：PCT/FR1996000555
申请日：1996-04-12
申请人： SYNTHELABO , BEDOYA ZURITA, Manuel , DIAZ MARTIN, Juan Antonio , DEL SOL MORENO, Gregorio , MARTIN ESCUDERO PEREZ, Ulpiano , JIMENEZ BARGUENO, Maria Dolores , ROMANACH FERRER, Magali
发明人： SYNTHELABO
IPC分类号： C07D495/04
CPC分类号： C07D491/04 , C07D209/44 , C07D217/06 , C07D495/04
摘要： Azacycloalcane derivatives having general formula (I) wherein R1 and R2 represent a hydrogen atom, an alkyl group or a phenyl group, or R1 and R2 form together an oxo group, R3 is a hydrogen atom or an alkyl group, or R3 forms a methylene group, R4 is an aromatic group or, when R3 forms a methylene group, R4 is a phenylene group of which a carbon atom is bound to Y and another carbon atom adjacent to the former carbon atom is bound to said methylene group, R5 is either a group OR7 where R7 is a hydrogen atom or a benzyl group, or a group N4-methyl-piperazinyl, or else a group NHR8 wherein R8 is a hydroxyl, pyridinylmethyl or phenylmethyl group, A is an optionally substituted aromatic cycle, n is 1 or 2, X is CH, O or N, and Y is CH2, O or S, their preparation process and their applications in therapy.
摘要翻译：通式（I）的氮杂环烷烃衍生物，其中R 1和R 2表示氢原子，烷基或苯基，或者R 1和R 2一起形成氧代基，R 3是氢原子或烷基，或者R 3形成亚甲基基团，R 4为芳基，或者，当R 3为亚甲基时，R 4为碳原子与Y结合的亚苯基，与前述碳原子相邻的另一碳原子与所述亚甲基结合，R 5为 OR 7，其中R 7为氢原子或苄基或N 4 - 甲基 - 哌嗪基，或其中R 8为羟基，吡啶基甲基或苯甲基的基团NHR 8，A为任选取代的芳环，n为1 或2，X为CH，O或N，Y为CH2，O或S，其制备方法及其在治疗中的应用。

2. 发明申请

WO1998004546A1 BENZIMIDAZOLE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTICAL USES THEREOF 审中-公开
标题翻译：苯并咪唑衍生物，其制备方法及其治疗用途
公开(公告)号：WO1998004546A1
公开(公告)日：1998-02-05
申请号：PCT/FR1997001364
申请日：1997-07-23
申请人： SYNTHELABO , COURTEMANCHE, Gilles , EVEN, Luc , DEFOSSE, Gérard , BERTIN, Jean , BOVY, Philippe
发明人： SYNTHELABO
IPC分类号： C07D401/12
CPC分类号： C07D401/12 , C07D471/04
摘要： Compounds of formula (I), wherein A is a nitrogen atom or a CH group; B is a C4-8 cycloalkyl group, a naphthyl group or a group of formula (Y), where n is 0 or 1; X is an oxygen or sulphur atom; Z is a nitrogen atom or a CH group; R2 is a hydrogen atom, a C1-4 alkyl group or a phenyl group; R3 is a C3-6 cycloalkyl group, a phenyl group, benzyl, a furyl group, thienyl, pyrrolyl, pyrazolyl, isoxazolyl, thioazolyl, pyridyl, imidazolyl or benzimidazolyl; and R7 is a hydrogen atom or a straight or branched C1-4 alkyl group; and the therapeutical uses thereof, are disclosed.
摘要翻译：式（I）的化合物，其中A是氮原子或CH基团; B是C 4-8环烷基，萘基或式（Y）的基团，其中n是0或1; X是氧或硫原子; Z是氮原子或CH基团; R2是氢原子，C1-4烷基或苯基; R3是C3-6环烷基，苯基，苄基，呋喃基，噻吩基，吡咯基，吡唑基，异恶唑基，硫代唑基，吡啶基，咪唑基或苯并咪唑基; 且R 7为氢原子或直链或支链C 1-4烷基; 及其治疗用途。

3. 发明申请

WO1997017347A1 COMPOUNDS DERIVED FROM OXAZOLIDIN-2-ONE AND PREPARATION AND THERAPEUTICAL USE THEREOF 审中-公开
标题翻译：衍生自奥沙星2-ONE的化合物及其制备及其治疗用途
公开(公告)号：WO1997017347A1
公开(公告)日：1997-05-15
申请号：PCT/FR1996001732
申请日：1996-11-05
申请人： SYNTHELABO , JEGHAM, Samir , PUECH, Frédéric , BURNIER, Philippe , BERTHON, Danielle
发明人： SYNTHELABO
IPC分类号： C07D413/04
CPC分类号： C07D413/04
摘要： Oxazolidin-2-one derivatives of general formula (I), wherein n is 0 or 1, R1 is a cyano, alkyl or fluoroalkyl group, R2 is a hydrogen atom or a hydroxyl group, and R3 is a hydrogen atom or a methyl group, and the therapeutical use thereof, are disclosed.
摘要翻译：通式（I）的恶唑烷-2-酮衍生物，其中n为0或1，R1为氰基，烷基或氟代烷基，R2为氢原子或羟基，R3为氢原子或甲基，及其治疗用途。

4. 发明申请

WO1997017346A1 COMPOUNDS DERIVED FROM 3-(BENZOFURAN-5-YL)OXAZOLIDIN-2-ONE, PREPARATION METHOD THEREFOR AND THERAPEUTICAL USE THEREOF 审中-公开
标题翻译：衍生自3-（苯并呋喃-5-基）氧杂环丁烷-2-酮的化合物，其制备方法及其治疗用途
公开(公告)号：WO1997017346A1
公开(公告)日：1997-05-15
申请号：PCT/FR1996001731
申请日：1996-11-05
申请人： SYNTHELABO , JEGHAM, Samir , PUECH, Frédéric , BURNIER, Philippe , BERTHON, Danielle
发明人： SYNTHELABO
IPC分类号： C07D413/04
CPC分类号： C07D413/04
摘要： Compounds derived from 3-(benzofuran-5-yl)oxazolidin-2-one, having general formula (I), wherein R1 is a phenyl, phenylmethyl, alkyl or fluoroalkyl group and R2 is a hydrogen atom or a methyl group, and the therapeutical use thereof, are disclosed.
摘要翻译：衍生自具有通式（I）的3-（苯并呋喃-5-基）恶唑烷-2-酮的化合物，其中R 1是苯基，苯基甲基，烷基或氟烷基，R 2是氢原子或甲基，公开了其治疗用途。

5. 发明申请

WO1997009310A1 1-PHENYL-3-4-[BENZYLPIPERIDINYL-1]-PROPANOL-1 DERIVATIVES, PREPARATION THEREOF AND THERAPEUTICAL APPLICATION THEREOF 审中-公开
标题翻译： 1-苯基-3,4- - [苄基]吡啶-2-基] - 丙醇1衍生物，其制备方法及其应用
公开(公告)号：WO1997009310A1
公开(公告)日：1997-03-13
申请号：PCT/FR1996001361
申请日：1996-09-05
申请人： SYNTHELABO , FROST, Jonathan , GAUDILLIERE, Bernard , ROUSSEAU, Jean
发明人： SYNTHELABO
IPC分类号： C07D211/14
CPC分类号： C07D211/18 , C07D211/14
摘要： Compounds of general formula (I), wherein R1 is a hydrogen or halogen atom or a methyl or methoxy group, R2 is a hydrogen atom or a methyl group, and R3 is a hydrogen or halogen atom, are useful for therapeutical applications.
摘要翻译：通式（I）的化合物，其中R 1为氢或卤素原子或甲基或甲氧基，R 2为氢原子或甲基，R 3为氢或卤素原子，可用于治疗用途。

6. 发明申请

WO1998022443A1 N-(IMIDAZOLYLBUTYL) BENZENESULPHONAMIDE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC APPLICATION 审中-公开
标题翻译： N-（咪唑啉基）苯并噻吩衍生物及其制备和治疗应用
公开(公告)号：WO1998022443A1
公开(公告)日：1998-05-28
申请号：PCT/FR1997002079
申请日：1997-11-19
申请人： SYNTHELABO , ALTENBURGER, Jean-Michel , LASSALLE, Gilbert , MARTIN, Valérie , GALTIER, Daniel
发明人： SYNTHELABO
IPC分类号： C07D233/54
CPC分类号： C07D233/64 , C07D233/68 , C07D401/06 , C07D401/12 , C07D409/12 , C07D409/14
摘要： The invention concerns compounds of formula (I) in which R1 and R'1 represent hydrogen, halogen or (C1-C4) alkyl, R2 represents a piperidin-1-yl group, 1, 2, 3, 6-tetrahydropyridin-1-yl optionally substituted, hexahydro-1H-azepin-1-yl, heptahydroazocin-1-yl, octahydro-1H-azonin-1-yl, (a) (A-B = -CONR", m = 1 to 2 and p = 1 to 2), (b) (Q = carbon or nitrogen, D = (C1-C4) alkyl or -CH2CF3, and r = 1 to 3, R3 represents (C1-C5) alkyl, -COR5 [R5 being (C1-C4) alkyl, -(CH2)nOCH3, -CH2O(C2H4O)nCH3, -(CH2)nCF3, -(CH2)nOH (n = 1 to 4)], -SO2R6, -CONHR6, -SO2N(R6)2 (R6 being (C1-C4) alkyl), R4 represents hydrogen or halogen and A represents phenyl or heterocycle optionally substituted or cyclo (C5-C8) alkyl. The invention is applicable in therapeutics.
摘要翻译：本发明涉及式（I）化合物，其中R 1和R 1表示氢，卤素或（C 1 -C 4）烷基，R 2表示哌啶-1-基，1,2,3,6-六氢吡啶-1-基，（a）（AB = -CONR“，m = 1〜2，p = 1〜2， 2），（b）（Q =碳或氮，D =（C 1 -C 4）烷基或-CH 2 CF 3，r = 1至3，R 3表示（C 1 -C 5）烷基，-COR 5 [ ）（CH 2）n CF 3， - （CH 2）n OH（n = 1-4）]，-SO 2 R 6，-CONHR 6，-SO 2 N（R 6）2 （C 1 -C 4）烷基），R 4表示氢或卤素，A代表苯基或任选取代的杂环或环（C 5 -C 8）烷基。

7. 发明申请

WO1997038998A1 3-[(1,2,3,4-TETRAHYDROISOQUINOLINE-2-YL)METHYL]-8-AZABICYCLO[3.2.1]OCTANE DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPEUTICS 审中-公开
标题翻译： 3 - [（1,2,3,4-四氢喹啉-2-基）甲基] -8-亚氨基] [3.2.1]月桂衍生物，其制备及其在治疗中的应用
公开(公告)号：WO1997038998A1
公开(公告)日：1997-10-23
申请号：PCT/FR1997000634
申请日：1997-04-10
申请人： SYNTHELABO , SEVRIN, Mireille , MARABOUT, Benoit , GEORGE, Pascal , MERLY, Jean-Pierre
发明人： SYNTHELABO
IPC分类号： C07D451/02
CPC分类号： C07D451/02
摘要： Compounds of general formula (I) in which each of R1, R2 and R3 represents a hydrogen or halogen atom or a hydroxy, alkyl or alkoxy group, R4 represents a hydrogen or halogen atom or an alkyl, 2-methoxyethoxy, alkoxy, cycloalkylmethoxy or phenylmethoxy group, or R3 and R4 together form a methylenedioxy group, Z represents oxygen or two hydrogen atoms and R represents an ethoxy group when Z represents oxygen, or represents a phenyl group optionally substituted by one or more halogen atoms or alkyl, alkoxy or amino groups. The compounds have a strong affinity for dopamine receptors of D2 and D3 type and for serotonin receptors of 5-HT1A and 5-HT2 type and are mixed ligands. Other compounds have a strong affinity for the dopamine receptors of D3 type and a weak affinity for the dopamine receptors of D2 type and serotonin receptors of 5-HT1A and 5-HT2 and are therefore selective and specific ligands.
摘要翻译： R 1，R 2和R 3各自表示氢或卤素原子或羟基，烷基或烷氧基的通式（I）的化合物，R 4表示氢或卤素原子或烷基，2-甲氧基乙氧基，烷氧基，环烷基甲氧基或苯基甲氧基或R3和R4一起形成亚甲二氧基，Z表示氧或两个氢原子，当Z表示氧时R表示乙氧基，或表示任选被一个或多个卤素原子取代的苯基或烷基，烷氧基或氨基组。这些化合物对D2和D3型的多巴胺受体和5-HT1A和5-HT2型的血清素受体具有强烈的亲合力，并且是混合配体。其他化合物对D3型多巴胺受体具有强亲和力，对5型HT1A和5-HT2的D2型和5-羟色胺受体的多巴胺受体具有弱亲和性，因此是选择性和特异性配体。

8. 发明申请

WO1997032584A1 SLOW-RELEASE PHARMACEUTICAL FORMULATIONS CONTAINING MIZOLASTIN 审中-公开
标题翻译：含有MIZOLASTIN的缓释药物制剂
公开(公告)号：WO1997032584A1
公开(公告)日：1997-09-12
申请号：PCT/FR1997000355
申请日：1997-02-28
申请人： SYNTHELABO , CHARIOT, Maryvonne , LEWIS, Gareth , MONTEL, Jean
发明人： SYNTHELABO
IPC分类号： A61K31/495
CPC分类号： A61K31/506 , A61K9/2013 , A61K9/2866
摘要： A slow-release pharmaceutical formulation containing mizolastin and characterised in that it comprises a core consisting of a slow-release tablet comprising mizolastin combined with a fatty matrix and an organic acid, said tablet being coated, is disclosed.
摘要翻译：含有咪唑斯汀的缓释药物制剂，其特征在于其包含由包含与脂肪基质组合的咪唑斯汀和有机酸的缓释片组成的核心，所述片剂被包被。

9. 发明申请

WO1997013768A1 OXAZOLIDIN-2-ONE DERIVATIVES, PREPARATION METHOD THEREFOR AND THERAPEUTICAL USE THEREOF 审中-公开
标题翻译：氧杂环丁二烯-2-酮衍生物，其制备方法及其治疗用途
公开(公告)号：WO1997013768A1
公开(公告)日：1997-04-17
申请号：PCT/FR1996001511
申请日：1996-10-08
申请人： SYNTHELABO , JEGHAM, Samir , PUECH, Frédéric , BURNIER, Philippe , BERTHON, Danielle , LECLERC, Odile
发明人： SYNTHELABO
IPC分类号： C07D413/04
CPC分类号： C07D413/04
摘要： Oxazolidin-2-one derivatives of general formula (I), wherein R1 is a hydrogen atom, an alkyl, hydroxyalkyl, fluoroalkyl, hydroxyfluoroalkyl, cyanoalkyl, optionally substituted phenyl or optionally substituted phenylmethyl group, or a group R3A- where R3 is a cycloalkyl or cyclooxyalkyl group optionally substituted by a hydroxy group, and A is a -CH2 or -CH2-CH2 radical, R2 is a hydrogen atom or a methyl group, X is an oxygen or sulphur atom or a group NR4 where R4 is an alkyl group, and Z is an oxygen atom or a group -CH=CH or -CH2-CH2, a method for preparing said derivatives, and the therapeutical uses thereof, are disclosed.
摘要翻译：通式（I）的恶唑烷-2-酮衍生物，其中R 1是氢原子，烷基，羟基烷基，氟代烷基，羟基氟烷基，氰基烷基，任选取代的苯基或任选取代的苯基甲基，或基团R 3 -A，其中R 3是环烷基或任选被羟基取代的环氧烷基，A是-CH 2或-CH 2 -CH 2基，R 2是氢原子或甲基，X是氧或硫原子或基团R 4，其中R 4是烷基，Z为氧原子或-CH = CH或-CH 2 -CH 2基，制备所述衍生物的方法及其治疗用途。

10. 发明申请

WO1990016061A1 ULTRASONIC SCANNING SENSOR 审中-公开
标题翻译：超声波扫描传感器
公开(公告)号：WO1990016061A1
公开(公告)日：1990-12-27
申请号：PCT/FR1990000408
申请日：1990-06-11
申请人： SYNTHELABO , FLEURY, Gérard , NORMAND, Gérard
发明人： SYNTHELABO
IPC分类号： G10K11/00
CPC分类号： G10K11/355
摘要： An ultrasonic scanning sensor (2), comprising a casing (30, 31), a head (4) mounted near the end of said casing (30) and near the organ to be explored, said head (4) comprising a cell for transmitting and receiving a wave beam, a first shaft (11), rotating around a first axis (X-X) and driven by a drive unit (6) located in said casing (31) and linking means of said head connected to said shaft, in order to allow said wave beam to scan the organ to be explored. According to the invention, said head is mounted in a body (30) which is removably connected to a handle (5) comprising a driving motor (6) for said head (4).

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式