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1. 发明申请

WO2009128944A3 COATING SYSTEMS FOR THE CONTROLLED DELIVERY OF HYDROPHILIC BIOACTIVE AGENTS 审中-公开
标题翻译：用于控制输送水解生物剂的涂料体系
公开(公告)号：WO2009128944A3
公开(公告)日：2010-08-05
申请号：PCT/US2009002418
申请日：2009-04-17
申请人： SURMODICS INC , CHAPPA RALPH A , HERGENROTHER ROBERT , WADMAN SHANNON A , WORMUTH KLAUS R
发明人： CHAPPA RALPH A , HERGENROTHER ROBERT , WADMAN SHANNON A , WORMUTH KLAUS R
IPC分类号： A61L27/34 , A61L27/54
CPC分类号： A61L27/54 , A61L27/34 , A61L2300/232 , A61L2300/252 , A61L2300/256 , A61L2300/258 , A61L2300/608 , A61L2420/08 , C08L31/04
摘要： Described are coating systems for the controlled delivery of hydrophilic bioactive agents, for example, from implantable medical devices. The coating systems of the invention comprise (a) a polymeric basecoat layer containing one or more hydrophilic bioactive agents; and (b) an elution-controlling topcoat layer that comprises a poly(ethylene-co-vinyl acetate) copolymer. The elution rate of the hydrophilic bioactive agent can be controlled by varying the vinyl acetate concentration in the elution-controlling topcoat layer.
摘要翻译：描述了用于例如从可植入医疗装置控制递送亲水生物活性剂的涂层系统。本发明的涂层体系包括（a）含有一种或多种亲水性生物活性剂的聚合物底涂层; 和（b）包含聚（乙烯 - 共 - 乙酸乙烯酯）共聚物的洗脱控制面漆层。亲水性生物活性剂的洗脱速度可以通过改变洗脱控制面漆层中的乙酸乙烯酯浓度来控制。

2. 发明申请

WO2004098565A3 IMPLANTABLE CONTROLLED RELEASE BIOACTIVE AGENT DELIVERY DEVICE 审中-公开
标题翻译：可植入控制释放生物体递送装置
公开(公告)号：WO2004098565A3
公开(公告)日：2005-03-03
申请号：PCT/US2004013327
申请日：2004-04-29
申请人： SURMODICS INC , ANDERSON ARON B , LAWIN LAURIE R , SHEN BYRON C , DE JUAN EUGENE , VARNER SIGNE E , CHAPPA RALPH A
发明人： ANDERSON ARON B , LAWIN LAURIE R , SHEN BYRON C , DE JUAN EUGENE , VARNER SIGNE E , CHAPPA RALPH A
IPC分类号： A61K9/00 , A61K31/58
CPC分类号： A61K31/58 , A61F2310/00353 , A61K9/0051
摘要： The invention provides a controlled release bioactive agent delivery device that includes a body member having a direction of extension, a longitudinal axis along the direction of extension, and a proximal end and a distal end, wherein at least a portion of the body member deviates from the direction of extension, and a polymeric coated composition in contact with the body member, the polymeric coated composition including a first polymer, a second polymer, and a bioactive agent, wherein the first polymer comprises polyalkyl(meth)acrylate, aromatic poly(meth)acrylate, or a combination of polyalkyl(meth)acrylate and aromatic poly(meth)acrylate, and wherein the second polymer comprises poly(ethylene-co-vinyl acetate). The invention also provides the use of said composition for the manufacture of a medicament for delivering a bioactive agent to a patient in a controlled release manner, as well as methods of making a controlled release bioactive agent delivery device.
摘要翻译：本发明提供一种控制释放的生物活性剂递送装置，其包括具有延伸方向的本体构件，沿着延伸方向的纵向轴线，以及近端和远端，其中，身体构件的至少一部分偏离所述聚合物涂覆组合物包括第一聚合物，第二聚合物和生物活性剂，其中所述第一聚合物包含（甲基）丙烯酸烷基酯，（甲基）丙烯酸烷基酯，芳族聚（甲基）丙烯酸酯，）丙烯酸酯或聚（甲基）丙烯酸烷基酯和芳族聚（甲基）丙烯酸酯的组合，其中第二聚合物包括聚（乙烯 - 共 - 乙酸乙烯酯）。本发明还提供了所述组合物用于制备用于以控制释放方式将生物活性剂递送至患者的药物以及制备受控释放生物活性剂递送装置的方法的用途。

3. 发明申请

WO2012092421A3 COMPOSITION FOR INTRAVASCULAR DELIVERY OF THERAPEUTIC COMPOSITION 审中-公开
标题翻译：用于治疗组合物的血管内输送的组合物
公开(公告)号：WO2012092421A3
公开(公告)日：2012-09-07
申请号：PCT/US2011067717
申请日：2011-12-29
申请人： SURMODICS INC , CHAPPA RALPH A
发明人： CHAPPA RALPH A
IPC分类号： A61F2/958 , A61K47/22 , A61K9/00 , A61K31/337 , A61M25/00
CPC分类号： A61K47/22 , A61K9/0019 , A61K31/337 , A61K31/436 , A61L29/16 , A61L2300/416 , A61M25/0009 , A61M25/0026 , A61M25/0045 , A61M25/1011 , A61M25/1029 , A61M2025/1004 , A61M2025/1013 , A61M2025/105 , A61M2025/1088
摘要： The present invention relates to a pharmaceutical composition for intravascular delivery of a therapeutic agent, such as paclitaxel, rapamycin, or an analog thereof. The composition includes the therapeutic agent and a biocompatible solvent, such as glycofurol. The composition can aid tissue penetration by the therapeutic agent. A catheter assembly that protects the pharmaceutical composition from the surroundings can be used for its intravascular delivery.
摘要翻译：本发明涉及治疗剂如紫杉醇，雷帕霉素或其类似物的血管内递送的药物组合物。组合物包括治疗剂和生物相容性溶剂，例如糖醇。该组合物可以帮助组织穿透治疗剂。将药物组合物与周围环境保护的导管组件可用于其血管内递送。

4. 发明申请

WO2012058274A3 COATINGS AND METHODS FOR CONTROLLED ELUTION OF HYDROPHILIC ACTIVE AGENTS 审中-公开
标题翻译：水解活性剂的控制涂层和方法
公开(公告)号：WO2012058274A3
公开(公告)日：2012-06-21
申请号：PCT/US2011057826
申请日：2011-10-26
申请人： CHAPPA RALPH A , BURKSTRAND MICHAEL J , BABCOCK DAVID E , SURMODICS INC
发明人： CHAPPA RALPH A , BURKSTRAND MICHAEL J , BABCOCK DAVID E
IPC分类号： A61L27/34 , A61L27/54 , A61L31/10 , A61L31/16
CPC分类号： A61L31/10 , A61L27/34 , A61L27/54 , A61L31/16 , A61L2420/02 , C08L31/04
摘要： Embodiments of the invention include multi-layer coatings and methods for controlling the elution of hydrophilic active agents. In an embodiment, the invention includes a medical device including a substrate, a primer polymer layer disposed on the substrate, an expandable layer disposed on the primer polymer layer, and a hydrophilic active agent dispersed within the expandable layer. In an embodiment, the invention includes a method of forming a medical device including depositing a primer layer onto a substrate, the primer layer comprising a primer polymer. The method can further include depositing an expandable layer onto the primer layer, the expandable layer including an expandable polymer, and a hydrophilic active agent. The expandable layer can be deposited with a solvent that is effective to solvate both the expandable polymer and the primer polymer. Other embodiments are also included herein.
摘要翻译：本发明的实施方案包括多层涂层和用于控制亲水性活性剂洗脱的方法。在一个实施方案中，本发明包括医疗装置，其包括基材，设置在基材上的底漆聚合物层，设置在底漆聚合物层上的可膨胀层，以及分散在可膨胀层内的亲水性活性剂。在一个实施方案中，本发明包括形成医疗装置的方法，包括将底漆层沉积在基底上，底层包含底漆聚合物。该方法还可以包括将可膨胀层沉积到底漆层上，该可膨胀层包括可膨胀聚合物和亲水性活性剂。可膨胀层可以用有效溶剂化可发性聚合物和底漆聚合物的溶剂沉积。本文还包括其它实施例。

5. 发明申请

WO2006031532A3 METHODS, DEVICES, AND COATINGS FOR CONTROLLED ACTIVE AGENT RELEASE 审中-公开
标题翻译：用于控制活性剂释放的方法，装置和涂料
公开(公告)号：WO2006031532A3
公开(公告)日：2006-06-08
申请号：PCT/US2005031763
申请日：2005-09-09
申请人： SURMODICS INC , CHAPPA RALPH A
发明人： CHAPPA RALPH A
IPC分类号： A61L27/34 , A61L27/54 , A61L31/10 , A61L31/16
CPC分类号： A61L27/54 , A61L27/34 , A61L31/10 , A61L31/16 , A61L2300/602
摘要： The present invention relates to methods, devices, and coatings, wherein active agent release is determined by deposition rate of a coating or material. In an embodiment, the invention includes a method for coating a medical device, including identifying active agent elution rates for a coating composition applied to substrates at a plurality of coating deposition rates, selecting one of the coating deposition rates, and applying the coating composition to the medical device at the selected deposition rate. In an embodiment, the invention includes a combination including a medical device and a composition for coating the surface of a medical device, with an active agent in a manner that permits the coated surface to release the active agent over time when implanted in vivo.
摘要翻译：本发明涉及方法，装置和涂层，其中通过涂层或材料的沉积速率确定活性剂释放。在一个实施方案中，本发明包括用于涂覆医疗装置的方法，包括鉴定以多种涂布沉积速率施加到基材上的涂料组合物的活性剂洗脱速率，选择一种涂布沉积速率，以及将涂料组合物施用于医疗器械以选定的沉积速率。在一个实施方案中，本发明包括包含医疗装置和用于涂覆医疗装置的表面的组合物的组合，其中活性剂以允许涂覆的表面随着时间植入体内而释放活性剂的方式。

6. 发明申请

WO2008088593A3 ADDITIVES AND METHODS FOR ENHANCING ACTIVE AGENT ELUTION KINETICS 审中-公开
标题翻译：添加剂和增强活性剂溶液动力学的方法
公开(公告)号：WO2008088593A3
公开(公告)日：2009-04-02
申请号：PCT/US2007079704
申请日：2007-09-27
申请人： SURMODICS INC , CHAPPA RALPH A
发明人： CHAPPA RALPH A
IPC分类号： A61K31/56
CPC分类号： A61K31/56 , A61K9/0024 , A61K9/0048 , A61K47/32 , A61L31/10 , A61L31/16 , A61L2300/222 , A61L2300/602 , C08L39/06 , C08L33/10 , C08L29/04
摘要： The present invention relates to methods and additives for increasing active agent elution control coatings and 'elution control coatings including the same. In an embodiment the invention includes an elution control coating comprising a polymeric matrix and at least about 0.1 wt. % of an additive dispersed in the polymeric matrix. The additive can include polyvinylpyrrolidone or a copolymer thereof. An active agent can be dispersed within the polymeric matrix, the active agent having limited solubility in water. Embodiments of the invention also include a method of forming an elution control coating comprising estradiol, ployethylene-co-vinyl acetate copolymer (PEVA), poly-n-butylmethacrylate (PBMA) and polyvinylpyrrolidone (PVP).
摘要翻译：本发明涉及用于增加活性剂洗脱控制涂层和“洗脱控制涂层”的方法和添加剂。在一个实施方案中，本发明包括洗脱控制涂层，其包含聚合物基质和至少约0.1wt。分散在聚合物基质中的添加剂的％。添加剂可以包括聚乙烯吡咯烷酮或其共聚物。活性剂可以分散在聚合物基质内，活性剂在水中的溶解度有限。本发明的实施方案还包括形成包含雌二醇，聚乙烯 - 共 - 乙酸乙烯酯共聚物（PEVA），聚甲基丙烯酸正丁酯（PBMA）和聚乙烯吡咯烷酮（PVP））的洗脱控制涂层的方法。

7. 发明申请

WO2008003043A3 COMBINATION DEGRADABLE AND NON-DEGRADABLE MATRICES FOR ACTIVE AGENT DELIVERY 审中-公开
标题翻译：组合可降解和不可降解的主动代理交付矩阵
公开(公告)号：WO2008003043A3
公开(公告)日：2009-02-12
申请号：PCT/US2007072357
申请日：2007-06-28
申请人： SURMODICS INC , CHAPPA RALPH A , HERGENROTHER ROBERT W , BUSHENDORF PAULA , SLAGER JORAM
发明人： CHAPPA RALPH A , HERGENROTHER ROBERT W , BUSHENDORF PAULA , SLAGER JORAM
IPC分类号： A61L27/26 , A61L27/34 , A61L27/48 , A61L31/04 , A61L31/12
CPC分类号： A61L27/58 , A61L27/48 , A61L27/54 , A61L2300/252 , A61L2300/256 , A61L2300/604 , C08L23/0853 , C08L23/0869 , C08L33/08 , C08L71/02 , C08L2201/06 , C08L2666/22
摘要： The present invention relates to combination degradable and non- degradable matrices and related methods. In an embodiment, the invention includes an active agent delivery matrix including a degradable polymer network, a non-degradable polymer network, the non-degradable polymer network interspersed within the degradable polymer network, and an active agent. In an embodiment, the invention includes an active agent elution control matrix including a degradable polymer; and a non-degradable polymer interspersed with the degradable polymer. In an embodiment, the invention includes a method of making an active agent delivery matrix including mixing a degradable polymer with a first solvent to form a degradable polymer solution; mixing a non-degradable polymer with a second solvent to form a non-degradable polymer solution; and simultaneously depositing the degradable polymer solution and the non-degradable polymer solution onto a substrate.
摘要翻译：本发明涉及可降解和不可降解的组合和相关方法。在一个实施方案中，本发明包括活性剂递送基质，其包括可降解聚合物网络，不可降解聚合物网络，散布在可降解聚合物网络内的不可降解聚合物网络和活性剂。在一个实施方案中，本发明包括包含可降解聚合物的活性剂洗脱控制基质; 和散布有可降解聚合物的不可降解聚合物。在一个实施方案中，本发明包括制备活性剂递送基质的方法，包括将可降解聚合物与第一溶剂混合以形成可降解聚合物溶液; 将不可降解的聚合物与第二溶剂混合以形成不可降解的聚合物溶液; 同时将可降解聚合物溶液和不可降解聚合物溶液沉积在基材上。

8. 发明申请

WO2008022258A3 METHODS AND MATERIALS FOR INCREASING THE ADHESION OF ELUTION CONTROL MATRICES TO SUBSTRATES 审中-公开
标题翻译：用于增加基质控制基质粘附的方法和材料
公开(公告)号：WO2008022258A3
公开(公告)日：2008-07-24
申请号：PCT/US2007076096
申请日：2007-08-16
申请人： SURMODICS INC , CHAPPA RALPH A , FINLEY MICHAEL J
发明人： CHAPPA RALPH A , FINLEY MICHAEL J
IPC分类号： A61L27/34 , A61F2/06 , A61L29/08 , A61L29/16 , A61L31/10 , A61L31/16
CPC分类号： A61L29/085 , A61L29/06 , A61L29/16 , A61L31/06 , A61L31/10 , A61L31/16 , A61L2300/608 , A61L2420/08 , C08L83/04 , C08L65/04
摘要： The present invention relates to methods and components for increasing adhesion of an elution control matrix to a polymeric substrate, and medical devices including such components. In an embodiment, the invention includes a medical device including a substrate having a surface, the substrate comprising a polysiloxane, a parylene layer contacting the surface of the substrate, and an elution control matrix contacting the parylene layer, the elution control matrix comprising a polymeric matrix and an active agent dispersed within the polymeric matrix. Other embodiments are included herein.
摘要翻译：本发明涉及用于增加洗脱控制基质与聚合物基质的粘附性的方法和组分以及包含这些组分的医疗装置。在一个实施方案中，本发明包括医疗装置，所述医疗装置包括具有表面的基材，所述基材包含聚硅氧烷，接触所述基材表面的聚对二甲苯层和接触所述聚对亚苯基二甲基层的洗脱控制基质，所述洗脱控制基质包含聚合物基质和分散在聚合物基质内的活性剂。其他实施例在此包括。

9. 发明申请

WO2008039749A2 MULTI-LAYERED COATINGS AND METHODS FOR CONTROLLING ELUTION OF ACTIVE AGENTS 审中-公开
标题翻译：多层涂料和控制活性剂溶液的方法
公开(公告)号：WO2008039749A2
公开(公告)日：2008-04-03
申请号：PCT/US2007079379
申请日：2007-09-25
申请人： SURMODICS INC , CHAPPA RALPH A
发明人： CHAPPA RALPH A
IPC分类号： A61L27/34 , A61L27/54 , A61L31/10 , A61L31/16
CPC分类号： A61L31/16 , A61L27/34 , A61L27/54 , A61L31/10 , A61L2300/608 , A61L2420/08 , C08L65/04
摘要： Embodiments of the invention include multi-layered coatings for controlling the elution rates of active agents and methods. In an embodiment, the invention includes a method of applying an elution control coating to a substrate. The method can include depositing a coating solution onto the substrate to form a base layer. The method can also include selecting a desired concentration of the solvent based on a desired elution rate. The method can further include removing solvent from the base layer to reach a desired concentration of the solvent and depositing a layer of parylene on the base layer. In an embodiment, the invention can include a medical device including a substrate, a base layer, and a porous layer. The base layer can include a polymeric matrix and an active agent dispersed within the polymeric matrix. The porous layer can include parylene. Other embodiments are also included herein.
摘要翻译：本发明的实施方案包括用于控制活性剂的洗脱速率的多层涂层和方法。在一个实施方案中，本发明包括将洗脱控制涂层施加到基底上的方法。该方法可以包括将涂覆溶液沉积到基底上以形成基底层。该方法还可以包括基于所需的洗脱速率来选择所需浓度的溶剂。该方法还可以包括从基层去除溶剂以达到所需浓度的溶剂并在基层上沉积聚对二甲苯层。在一个实施例中，本发明可以包括包括基底，基底层和多孔层的医疗装置。基层可以包括分散在聚合物基质内的聚合物基质和活性剂。多孔层可以包括聚对二甲苯。本文还包括其它实施例。

10. 发明申请

WO2004028699A3 ADVANCED COATING APPARATUS AND METHOD 审中-公开
标题翻译：高级涂料设备及方法
公开(公告)号：WO2004028699A3
公开(公告)日：2004-05-27
申请号：PCT/US0322632
申请日：2003-07-17
申请人： SURMODICS INC , CHAPPA RALPH A , CARLSON MARK F
发明人： CHAPPA RALPH A , CARLSON MARK F
IPC分类号： B05B13/02 , B05B13/04
CPC分类号： B05B7/0807 , B05B7/0861 , B05B7/0869 , B05B13/0207 , B05B13/0228 , B05B13/0436 , B05B13/0442 , B05D1/002 , B05D1/02
摘要： A coating apparatus for coating a rollable device including a device rotator having a pair of rollers and spray nozzle is described. The spray nozzle produces a spray of coating material that is directed towards a gap that is between the rollers of the pair. The majority of any spray not deposited on the rollable device during a coating process passes through the gap between the rollers.
摘要翻译：描述了一种用于涂覆可卷绕装置的涂覆装置，其包括具有一对辊和喷嘴的装置旋转体。喷嘴产生喷涂的涂料，该喷涂材料指向一对间的间隙。在涂布过程中，大部分没有沉积在可滚动装置上的喷雾通过辊之间的间隙。

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