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1. 发明申请

WO1994029313A1 NOVEL beta-LACTAM COMPOUND AND PROCESS FOR PRODUCING THE SAME 审中-公开
标题翻译：新型β--LACTAM化合物及其生产方法
公开(公告)号：WO1994029313A1
公开(公告)日：1994-12-22
申请号：PCT/JP1994000958
申请日：1994-06-14
申请人： SUMITOMO PHARMACEUTICALS COMPANY, LIMITED , SUNAGAWA, Makoto , YAMAGA, Hiroshi , SUMITA, Yoshihiro
发明人： SUMITOMO PHARMACEUTICALS COMPANY, LIMITED
IPC分类号： C07D477/00
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D477/20
摘要： A novel beta -lactam compound represented by general formula [1] and having an excellent antibacterial activity against gram-positive bacteria, in particular, methicillin-resistant staphylococci and methicillin-resistant coagulase-negative staphylococci, a pharmaceutically acceptable salt thereof, and a process for producing the same, wherein R represents lower alkyl which may be hydroxylated; R represents hydrogen or lower alkyl; X represents oxygen, sulfur or NH; Y represents nitrogen or carbon, provided n is 0 when Y represents nitrogen and n is 1 when Y represents carbon; and Z represents (each independently when n is 1) hydrogen, R (lower alkyl, etc.), A (aryl, etc.), -OH, -OR , -OA, -SR , -SA, -NH2, -NHR , -NR R (R and R being each lower alkyl, etc.), -NHA, -NR A, -CONH2, -CONHR , -CONR R , -CONHA, -CONR A, -CONHC(NH)NH2, -COOH, -COOR , -COOA, -COR , -COA, halogen, or cyano.
摘要翻译：由通式[1]表示的新颖的β-内酰胺化合物，对革兰氏阳性细菌，特别是耐甲氧西林葡萄球菌和耐甲氧西林凝固酶阴性葡萄球菌，其药学上可接受的盐具有优异的抗菌活性，制备其中R 1表示可被羟基化的低级烷基; R 2表示氢或低级烷基; X表示氧，硫或NH; Y表示氮或碳，当Y表示氮时n为0，当Y表示碳时n为1; 并且Z代表（当n为1时各自独立地为氢），R a（低级烷基等），A（芳基等），-OH，-OR a，-OA，-SR a ，-SA，-NH 2，-NHR a，-NR R c（R b和R c各自为低级烷基等），-NHA，-NR a A ，-CONH 2，-CONHR a，-CONR b，R a，-CONHA，-CONR a，-CONHC（NH）NH 2，-COOH，-COOR a，-COOA， - COR a，-COA，卤素或氰基。

2. 发明申请

WO1998009965A1 NOVEL 'beta'-LACTAM COMPOUNDS AND PROCESS FOR PREPARING THE SAME 审中-公开
标题翻译：新型β--LACTAM化合物及其制备方法
公开(公告)号：WO1998009965A1
公开(公告)日：1998-03-12
申请号：PCT/JP1997003078
申请日：1997-09-03
申请人： SUMITOMO PHARMACEUTICALS COMPANY, LIMITED , SUNAGAWA, Makoto , YAMAGA, Hiroshi , NOUDA, Hiroshi , SHINAGAWA, Hisatoshi
发明人： SUMITOMO PHARMACEUTICALS COMPANY, LIMITED
IPC分类号： C07D487/04
CPC分类号： C07D477/20
摘要： beta -Lactam compounds represented by general formula (1) and salts and esters thereof, wherein R represents a lower alkyl or an OH-substituted lower alkyl; R represents H or a lower alkyl; X represents O, S, or NH; n is 1 to 3; and R represents -C(Ra)=NH (wherein Ra represents H, a lower alkyl, or a substituted lower alkyl). The above compounds have an excellent antimicrobial activity against Gram-positive bacteria, particularly meticillin-resistant staphylococci and meticillin-resistant and coagulase-negative staphylococci.
摘要翻译：由通式（1）表示的β-内酰胺化合物及其盐和酯，其中R 1表示低级烷基或OH-取代的低级烷基; R 2表示H或低级烷基; X表示O，S或NH; n为1〜3; 并且R 3表示-C（R a）= NH（其中R a表示H，低级烷基或取代的低级烷基）。上述化合物对革兰氏阳性菌，特别是耐甲氧西林葡萄球菌和耐甲氧西林和凝固酶阴性葡萄球菌具有优异的抗菌活性。

3. 发明申请

WO1996031488A1 NOVEL PYRIMIDINE DERIVATIVES EFFICACIOUS AS PSYCHOTROPIC DRUG AND PROCESS FOR THE PRODUCTION THEREOF 审中-公开
标题翻译：新型吡咯烷酮衍生物作为心血管药物有效，其生产方法
公开(公告)号：WO1996031488A1
公开(公告)日：1996-10-10
申请号：PCT/JP1996000895
申请日：1996-04-02
申请人： SUMITOMO PHARMACEUTICALS COMPANY, LIMITED , IGARASHI, Jun-etsu , NISHIMURA, Tamiki , SUNAGAWA, Makoto
发明人： SUMITOMO PHARMACEUTICALS COMPANY, LIMITED
IPC分类号： C07D239/47
CPC分类号： C07D239/47 , C07D239/38 , C07D239/48 , C07D401/12
摘要： Compound represented by general formula (I) or pharmacologically acceptable salts thereof: wherein A represents halogeno, optionally substituted lower alkyl or optionally substituted cycloalkyl; B and B are the same or different and each represents hydrogen or optionally substituted amino; X represents sulfur or oxygen; and Y , Y , Y , Y and Y are the same or different and each represents hydrogen, halogeno, optionally substituted lower alkyl, optionally substituted cycloalkyl, optionally substituted lower alkenyl, optionally substituted lower alkynyl, optionally substituted aryl or optionally substituted heterocycle. The compounds have a potent interaction with central nervous system receptors such as dopamine or serotonin and are excellent in absorbability in vivo, stability, etc. Thus they are highly useful as a psychotropic drug with relieved side effects.
摘要翻译：由通式（I）表示的化合物或其药理学上可接受的盐：其中A 1表示卤代，任选取代的低级烷基或任选取代的环烷基; B 1和B 2相同或不同，各自表示氢或任选取代的氨基; X表示硫或氧; Y 1，Y 2，Y 3，Y 4和Y 5相同或不同，各自代表氢，卤代，任选取代的低级烷基，任选取代的环烷基，任选取代的低级烯基，任选取代的低级炔基，任选取代的芳基或任选取代的杂环。这些化合物与中枢神经系统受体如多巴胺或5-羟色胺具有强烈的相互作用，并且在体内的吸收性，稳定性等方面优异。因此，它们作为具有减轻副作用的精神药物是非常有用的。

4. 发明申请

WO1997004806A1 REMEDY FOR NEUROLOGICAL DISORDERS 审中-公开
标题翻译：补救神经病
公开(公告)号：WO1997004806A1
公开(公告)日：1997-02-13
申请号：PCT/JP1996002080
申请日：1996-07-25
申请人： SUMITOMO PHARMACEUTICALS COMPANY, LIMITED , OKAJIMA, Kenji , TAOKA, Yuji
发明人： SUMITOMO PHARMACEUTICALS COMPANY, LIMITED
IPC分类号： A61K39/395
CPC分类号： C07K16/2854 , A61K38/00
摘要： A remedy for neurological disorders, such as spinal injury, neurological disorders following ischemic reflow, and inflammatory central nervous system disorders, which comprises as the active ingredient a P-selectin binding inhibitor such as an anti-P-selectin antibody.
摘要翻译：包括作为活性成分的选择蛋白结合抑制剂如抗P-选择蛋白抗体的神经障碍如脊髓损伤，缺血性回流后的神经障碍和炎性中枢神经系统疾病的补救措施。

5. 发明申请

WO1994016689A1 ANALGESIC MEDICINAL COMPOSITION 审中-公开
标题翻译：化学药物组合物
公开(公告)号：WO1994016689A1
公开(公告)日：1994-08-04
申请号：PCT/JP1994000120
申请日：1994-01-28
申请人： SUMITOMO PHARMACEUTICALS COMPANY, LIMITED , TAKAGI, Hiroshi
发明人： SUMITOMO PHARMACEUTICALS COMPANY, LIMITED
IPC分类号： A61K31/195
CPC分类号： A61K31/195 , A61K31/15 , A61K2300/00
摘要： Threo-3-(3,4-Dihydroxyphenyl)serine has an excellent analgesic effect against acute, chronic or continuous pain and hence is remarkably efficacious as a remedy for pains and diseases such as postoperative pain, headache, migraine, rheumatic pain, postherpetic neuralgia, cancerous pain, neck-shoulder-arm syndrome, frozen shoulder, spinal sprain and spondylosis deformans.
摘要翻译：苏氨酸-3-（3,4-二羟基苯基）丝氨酸对急性，慢性或连续性疼痛具有极佳的镇痛作用，因此作为疼痛和疾病如术后疼痛，头痛，偏头痛，风湿性疼痛，带状疱疹后神经痛等疾病的疗效显着有效，癌性疼痛，颈肩臂综合症，肩关节炎，脊髓扭伤和椎关节僵硬症。

6. 发明申请

WO1994005788A1 NEUROTROPHIC PEPTIDE 审中-公开
标题翻译：神经营养肽
公开(公告)号：WO1994005788A1
公开(公告)日：1994-03-17
申请号：PCT/JP1993001214
申请日：1993-08-27
申请人： SUMITOMO PHARMACEUTICALS COMPANY, LIMITED , YAMAMOTO, Masahiko , OJIKA, Kosei , TOHDOH, Naoki , TOJO, Shin-Ichiro , KOJIMA, Shin-Ichi , FUKUSHIMA, Nobuyuki , IRIE, Tsunemasa , ONO, Keiichi , AGUI, Hideo , UEKI, Yasuyuki , NISHIHARA, Toshio , KAMIKAWA, Yumiko , TAIJI, Mutsuo
发明人： SUMITOMO PHARMACEUTICALS COMPANY, LIMITED , YAMAMOTO, Masahiko
IPC分类号： C12N15/12
CPC分类号： C07K7/06 , A61K38/00 , C07K14/475
摘要： A neurotrophic peptide derived from man or rat or a derivative thereof, useful as a medicine; a peptide comprising a precursor thereof or a part thereof; a gene coding for these; a transformant containing a recombinant expression vector containing said gene; and a remedy for nervous degeneration containing as the active ingredient the neurotrophic peptide, the derivative thereof, or the peptide comprising a precursor thereof or a part thereof.
摘要翻译：衍生自人或大鼠的神经营养肽或其衍生物，可用作药物; 包含其前体或其部分的肽; 编码这些的基因; 含有含有该基因的重组表达载体的转化体; 以及包含作为活性成分的神经营养肽，其衍生物或包含其前体或其部分的肽的神经变性的补救措施。

7. 发明申请

WO1998022504A1 NOVEL SEMAPHORIN GENES (I) 审中-公开
标题翻译：新闻稿（一）
公开(公告)号：WO1998022504A1
公开(公告)日：1998-05-28
申请号：PCT/JP1997004111
申请日：1997-11-12
申请人： SUMITOMO PHARMACEUTICALS COMPANY, LIMITED , INAGAKI, Shinobu , FURUYAMA, Tatsuo
发明人： SUMITOMO PHARMACEUTICALS COMPANY, LIMITED
IPC分类号： C07K14/475
CPC分类号： C07K14/4703 , A01K2217/05 , A61K38/00
摘要： A novel semaphorin which is useful mainly in diagnosing, treating or studying nervous diseases and proteins analogous thereto; peptide fragments of these proteins; antibodies against the same; genes encoding these proteins; expression vectors of these genes; transformed cells having these expression vectors transferred thereinto; a process for producing recombinant proteins by using these transformed cells; antisense nucleotides of the above-mentioned genes; transgenic animals relative to the insertion and deletion of the above-mentioned genes; a method for screening antagonists of the above-mentioned proteins; and the use of the above-mentioned proteins, peptides, antibodies, genes or antisense nucleotides as medicines, diagnostic drugs or research reagents.
摘要翻译：一种新颖的信号素，主要用于诊断，治疗或研究类似于其的神经疾病和蛋白质; 这些蛋白质的肽片段; 针对相同的抗体; 编码这些蛋白质的基因; 这些基因的表达载体; 将这些表达载体转移到其中的转化细胞; 通过使用这些转化细胞产生重组蛋白的方法; 上述基因的反义核苷酸; 转基因动物相对于上述基因的插入和缺失; 筛选上述蛋白质拮抗剂的方法; 以及使用上述蛋白质，肽，抗体，基因或反义核苷酸作为药物，诊断药物或研究试剂。

8. 发明申请

WO1998011216A1 NOVEL SEMAPHORIN GENE: SEMAPHORIN Y 审中-公开
标题翻译：新葡萄糖基因：SEMAPHORIN Y
公开(公告)号：WO1998011216A1
公开(公告)日：1998-03-19
申请号：PCT/JP1997003167
申请日：1997-09-09
申请人： SUMITOMO PHARMACEUTICALS COMPANY, LIMITED , KIMURA, Toru , KIKUCHI, Kaoru
发明人： SUMITOMO PHARMACEUTICALS COMPANY, LIMITED
IPC分类号： C12N15/12
CPC分类号： C07K14/4703 , A01K2217/05 , A61K38/00
摘要： Semaphorin Y showing an inhibitory effect on the nerve extension; its gene; another semaphorin hybridizable with the semaphorin Y gene; modified proteins and partial peptides of the semaphorin Y; an antibody against the semaphorin Y; the antisense nucleotide of the semaphorin Y gene; the uses of these substances as drugs, diagnostic agents or experimental reagents; a method for screening semaphorin Y antagonists with the use of the semaphorin Y; the semaphorin Y antagonists obtained by this screening method; drugs containing these antagonists; and transgenic animals relating to the semaphorin Y.
摘要翻译：信号素Y显示对神经延伸的抑制作用; 其基因; 另一个可与信号素Y基因杂交的信号素; 改变的蛋白质和semaphorin Y的部分肽; 针对信号素Y的抗体; 信号素Y基因的反义核苷酸; 这些物质用作药物，诊断剂或实验试剂; 使用semaphorin Y筛选信号素Y拮抗剂的方法; 通过该筛选方法获得的信号素Y拮抗剂; 含有这些拮抗剂的药物; 和与semaphorin Y相关的转基因动物。

9. 发明申请

WO1997038992A1 PIPERIDINYLPYRAMIDINE DERIVATIVES 审中-公开
标题翻译：哌啶衍生物衍生物
公开(公告)号：WO1997038992A1
公开(公告)日：1997-10-23
申请号：PCT/JP1997001240
申请日：1997-04-10
申请人： SUMITOMO PHARMACEUTICALS COMPANY, LIMITED
发明人： SUMITOMO PHARMACEUTICALS COMPANY, LIMITED , FUJIWARA, Norio , UEDA, Yutaka , MURATA, Shinobu , HIROTA, Fumiyo , KAWAKAMI, Hajime , FUJITA, Hitoshi
IPC分类号： C07D401/04
CPC分类号： C07D401/04 , A61K31/506 , A61K31/517 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14 , Y02A50/411
摘要： A compound of formula (1) wherein; X is amino or hydroxyl, X is carbonyl and the like, R is an alkyl, an aryl and the like, R is hydrogen and the like, and R is an alkyl and the like, or a pharmaceutical acceptable salt thereof, is effective for inhibiting the production and/or secretion of tumor necrosis factor in a patient in need of such inhibition.
摘要翻译：式（1）的化合物，其中： X 1是氨基或羟基，X 2是羰基等，R 1是烷基，芳基等，R 2是氢等，R 3是烷基等或其药学上可接受的盐在需要这种抑制的患者中有效抑制肿瘤坏死因子的产生和/或分泌。

10. 发明申请

WO1997002047A1 GENE PREPARATIONS 审中-公开
标题翻译：基因制备
公开(公告)号：WO1997002047A1
公开(公告)日：1997-01-23
申请号：PCT/JP1996001824
申请日：1996-07-02
申请人： KOKEN CO., LTD. , SUMITOMO PHARMACEUTICALS COMPANY, LIMITED , TERADA, Masaaki , OCHIYA, Takahiro , MIYATA, Teruo , ITOH, Hiroshi
发明人： KOKEN CO., LTD. , SUMITOMO PHARMACEUTICALS COMPANY, LIMITED
IPC分类号： A61K48/00
CPC分类号： A61K48/00
摘要： Gene preparations comprising desired genes or vectors containing desired genes integrated thereinto and carriers for supporting the same.
摘要翻译：包含所需基因或包含所需基因的载体的基因制备物和用于支持其的载体。

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