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1. 发明申请

WO1997020928A1 NOVEL SEMAPHORIN Z AND GENE ENCODING THE SAME 审中-公开
标题翻译：新的印度尼西亚Z和基因编码它们
公开(公告)号：WO1997020928A1
公开(公告)日：1997-06-12
申请号：PCT/JP1996003517
申请日：1996-12-02
申请人： SUMITOMO PHARMACEUTICALS COMPANY, LIMITED , KIMURA, Toru , KIKUCHI, Kaoru
发明人： SUMITOMO PHARMACEUTICALS COMPANY, LIMITED
IPC分类号： C12N15/12
CPC分类号： C07K14/4703
摘要： Novel semaphorin Z; a gene thereof; a partial peptide of the semaphorin Z; an antibody; a DNA or an RNA complementary to the semaphorin Z gene; a method for screening a semaphorin Z inhibitor by using the semaphorin Z; the semaphorin Z inhibitor obtained by the screening; and a central nerve regeneration promoter comprising the inhibitor.
摘要翻译：新的信号素Z; 其基因; 信号素Z的部分肽; 抗体; 与semaphorin Z基因互补的DNA或RNA; 通过使用信号素Z筛选信号素Z抑制剂的方法; 通过筛选获得的semaphorin Z抑制剂; 和包含该抑制剂的中枢神经再生启动子。

2. 发明申请

WO1995018150A1 NOVEL HUMAN CILIARY NEUROTROPHIC FACTOR 审中-公开
标题翻译：新人类神经营养因子
公开(公告)号：WO1995018150A1
公开(公告)日：1995-07-06
申请号：PCT/JP1994002269
申请日：1994-12-27
申请人： SUMITOMO PHARMACEUTICALS COMPANY, LIMITED , INOUE, Makoto , KIKUCHI, Kaoru , ISHIGE, Yoko , ITO, Akira , KIMURA, Toru , NAKAYAMA, Chikao , NOGUCHI, Hiroshi
发明人： SUMITOMO PHARMACEUTICALS COMPANY, LIMITED
IPC分类号： C07K14/475
CPC分类号： C07K14/475
摘要： A modification of a human ciliary neurotrophic factor (human CNTF) wherein the amino acid residue of the amino acid sequence corresponding to at least the 153rd amino acid residue of the amino acid sequence of a natural human CNTF has been replaced by another amino acid residue has an activity equal or superior to that of a natural human CNTF. Hence it is expected as a useful therapeuticc agent reduced in the side effects such as the occurrence of autoantibodies caused by ample administration thereof, body weight decrease, anorexia, dry cough, and boredom. The invention also provides a D1 cap region modification of alpha -helix-rich cytokines analogous to human CNTF, such as GH, PRL, EPC, G-CSF, LIF, IL-6, IL-2, IL-4, and GM-CSF.
摘要翻译：人类睫状神经营养因子（人CNTF）的修饰，其中对应于天然人CNTF的氨基酸序列的至少153个氨基酸残基的氨基酸序列的氨基酸残基已经被另一个氨基酸残基替代，与天然人类CNTF相当或优于其他活性的活性。因此，预期作为减少副作用的有用的治疗剂，例如由其充分施用，体重减轻，厌食，干咳和无聊引起的自身抗体的发生。本发明还提供类似于人CNTF的例如GH，PRL，EPC，G-CSF，LIF，IL-6，IL-2，IL-4和GM-1的富含α-螺旋的细胞因子的D1帽区修饰， CSF。

3. 发明申请

WO1998011216A1 NOVEL SEMAPHORIN GENE: SEMAPHORIN Y 审中-公开
标题翻译：新葡萄糖基因：SEMAPHORIN Y
公开(公告)号：WO1998011216A1
公开(公告)日：1998-03-19
申请号：PCT/JP1997003167
申请日：1997-09-09
申请人： SUMITOMO PHARMACEUTICALS COMPANY, LIMITED , KIMURA, Toru , KIKUCHI, Kaoru
发明人： SUMITOMO PHARMACEUTICALS COMPANY, LIMITED
IPC分类号： C12N15/12
CPC分类号： C07K14/4703 , A01K2217/05 , A61K38/00
摘要： Semaphorin Y showing an inhibitory effect on the nerve extension; its gene; another semaphorin hybridizable with the semaphorin Y gene; modified proteins and partial peptides of the semaphorin Y; an antibody against the semaphorin Y; the antisense nucleotide of the semaphorin Y gene; the uses of these substances as drugs, diagnostic agents or experimental reagents; a method for screening semaphorin Y antagonists with the use of the semaphorin Y; the semaphorin Y antagonists obtained by this screening method; drugs containing these antagonists; and transgenic animals relating to the semaphorin Y.
摘要翻译：信号素Y显示对神经延伸的抑制作用; 其基因; 另一个可与信号素Y基因杂交的信号素; 改变的蛋白质和semaphorin Y的部分肽; 针对信号素Y的抗体; 信号素Y基因的反义核苷酸; 这些物质用作药物，诊断剂或实验试剂; 使用semaphorin Y筛选信号素Y拮抗剂的方法; 通过该筛选方法获得的信号素Y拮抗剂; 含有这些拮抗剂的药物; 和与semaphorin Y相关的转基因动物。

4. 发明申请

WO1998015628A1 NOVEL SEMAPHORIN GENE: SEMAPHORIN W 审中-公开
标题翻译：新葡萄糖基因：SEMAPHORIN W
公开(公告)号：WO1998015628A1
公开(公告)日：1998-04-16
申请号：PCT/JP1997003549
申请日：1997-10-03
申请人： SUMITOMO PHARMACEUTICALS COMPANY, LIMITED , KIMURA, Toru , KIKUCHI, Kaoru
发明人： SUMITOMO PHARMACEUTICALS COMPANY, LIMITED
IPC分类号： C12N15/12
CPC分类号： C07K14/4703 , A01K2217/05 , A61K38/00
摘要： Semaphorin W having an inhibitory effect on nerve extension and its gene; other semaphorins hybridizable with the semaphorin W gene; modified proteins and partial peptides of the semaphorin W; an antibody against the semaphorin W; an antisense nucleotide of the semaphorin W gene; the use of these substances as medicines, diagnostic drugs or research reagents; a method for screening semaphorin W antagonists with the use of the semaphorin W; semaphorin W antagonists obtained by this screening method; medicines containing these antagonists; and transgenic animals, etc. relative to the semaphorin W.
摘要翻译：对神经延伸具有抑制作用的信号素W及其基因; 其他信号素可与信号素W基因杂交; 改变的蛋白质和semaphorin W的部分肽; 针对信号素W的抗体; 信号素W基因的反义核苷酸; 使用这些物质作为药物，诊断药物或研究试剂; 使用信号素W筛选信号素W拮抗剂的方法; 通过该筛选方法获得的信号素W拮抗剂; 含有这些拮抗剂的药物; 和转基因动物等相对于semaphorin W.

5. 发明申请

WO1997004806A1 REMEDY FOR NEUROLOGICAL DISORDERS 审中-公开
标题翻译：补救神经病
公开(公告)号：WO1997004806A1
公开(公告)日：1997-02-13
申请号：PCT/JP1996002080
申请日：1996-07-25
申请人： SUMITOMO PHARMACEUTICALS COMPANY, LIMITED , OKAJIMA, Kenji , TAOKA, Yuji
发明人： SUMITOMO PHARMACEUTICALS COMPANY, LIMITED
IPC分类号： A61K39/395
CPC分类号： C07K16/2854 , A61K38/00
摘要： A remedy for neurological disorders, such as spinal injury, neurological disorders following ischemic reflow, and inflammatory central nervous system disorders, which comprises as the active ingredient a P-selectin binding inhibitor such as an anti-P-selectin antibody.
摘要翻译：包括作为活性成分的选择蛋白结合抑制剂如抗P-选择蛋白抗体的神经障碍如脊髓损伤，缺血性回流后的神经障碍和炎性中枢神经系统疾病的补救措施。

6. 发明申请

WO1994016689A1 ANALGESIC MEDICINAL COMPOSITION 审中-公开
标题翻译：化学药物组合物
公开(公告)号：WO1994016689A1
公开(公告)日：1994-08-04
申请号：PCT/JP1994000120
申请日：1994-01-28
申请人： SUMITOMO PHARMACEUTICALS COMPANY, LIMITED , TAKAGI, Hiroshi
发明人： SUMITOMO PHARMACEUTICALS COMPANY, LIMITED
IPC分类号： A61K31/195
CPC分类号： A61K31/195 , A61K31/15 , A61K2300/00
摘要： Threo-3-(3,4-Dihydroxyphenyl)serine has an excellent analgesic effect against acute, chronic or continuous pain and hence is remarkably efficacious as a remedy for pains and diseases such as postoperative pain, headache, migraine, rheumatic pain, postherpetic neuralgia, cancerous pain, neck-shoulder-arm syndrome, frozen shoulder, spinal sprain and spondylosis deformans.
摘要翻译：苏氨酸-3-（3,4-二羟基苯基）丝氨酸对急性，慢性或连续性疼痛具有极佳的镇痛作用，因此作为疼痛和疾病如术后疼痛，头痛，偏头痛，风湿性疼痛，带状疱疹后神经痛等疾病的疗效显着有效，癌性疼痛，颈肩臂综合症，肩关节炎，脊髓扭伤和椎关节僵硬症。

7. 发明申请

WO1994005788A1 NEUROTROPHIC PEPTIDE 审中-公开
标题翻译：神经营养肽
公开(公告)号：WO1994005788A1
公开(公告)日：1994-03-17
申请号：PCT/JP1993001214
申请日：1993-08-27
申请人： SUMITOMO PHARMACEUTICALS COMPANY, LIMITED , YAMAMOTO, Masahiko , OJIKA, Kosei , TOHDOH, Naoki , TOJO, Shin-Ichiro , KOJIMA, Shin-Ichi , FUKUSHIMA, Nobuyuki , IRIE, Tsunemasa , ONO, Keiichi , AGUI, Hideo , UEKI, Yasuyuki , NISHIHARA, Toshio , KAMIKAWA, Yumiko , TAIJI, Mutsuo
发明人： SUMITOMO PHARMACEUTICALS COMPANY, LIMITED , YAMAMOTO, Masahiko
IPC分类号： C12N15/12
CPC分类号： C07K7/06 , A61K38/00 , C07K14/475
摘要： A neurotrophic peptide derived from man or rat or a derivative thereof, useful as a medicine; a peptide comprising a precursor thereof or a part thereof; a gene coding for these; a transformant containing a recombinant expression vector containing said gene; and a remedy for nervous degeneration containing as the active ingredient the neurotrophic peptide, the derivative thereof, or the peptide comprising a precursor thereof or a part thereof.
摘要翻译：衍生自人或大鼠的神经营养肽或其衍生物，可用作药物; 包含其前体或其部分的肽; 编码这些的基因; 含有含有该基因的重组表达载体的转化体; 以及包含作为活性成分的神经营养肽，其衍生物或包含其前体或其部分的肽的神经变性的补救措施。

8. 发明申请

WO1998022504A1 NOVEL SEMAPHORIN GENES (I) 审中-公开
标题翻译：新闻稿（一）
公开(公告)号：WO1998022504A1
公开(公告)日：1998-05-28
申请号：PCT/JP1997004111
申请日：1997-11-12
申请人： SUMITOMO PHARMACEUTICALS COMPANY, LIMITED , INAGAKI, Shinobu , FURUYAMA, Tatsuo
发明人： SUMITOMO PHARMACEUTICALS COMPANY, LIMITED
IPC分类号： C07K14/475
CPC分类号： C07K14/4703 , A01K2217/05 , A61K38/00
摘要： A novel semaphorin which is useful mainly in diagnosing, treating or studying nervous diseases and proteins analogous thereto; peptide fragments of these proteins; antibodies against the same; genes encoding these proteins; expression vectors of these genes; transformed cells having these expression vectors transferred thereinto; a process for producing recombinant proteins by using these transformed cells; antisense nucleotides of the above-mentioned genes; transgenic animals relative to the insertion and deletion of the above-mentioned genes; a method for screening antagonists of the above-mentioned proteins; and the use of the above-mentioned proteins, peptides, antibodies, genes or antisense nucleotides as medicines, diagnostic drugs or research reagents.
摘要翻译：一种新颖的信号素，主要用于诊断，治疗或研究类似于其的神经疾病和蛋白质; 这些蛋白质的肽片段; 针对相同的抗体; 编码这些蛋白质的基因; 这些基因的表达载体; 将这些表达载体转移到其中的转化细胞; 通过使用这些转化细胞产生重组蛋白的方法; 上述基因的反义核苷酸; 转基因动物相对于上述基因的插入和缺失; 筛选上述蛋白质拮抗剂的方法; 以及使用上述蛋白质，肽，抗体，基因或反义核苷酸作为药物，诊断药物或研究试剂。

9. 发明申请

WO1997038992A1 PIPERIDINYLPYRAMIDINE DERIVATIVES 审中-公开
标题翻译：哌啶衍生物衍生物
公开(公告)号：WO1997038992A1
公开(公告)日：1997-10-23
申请号：PCT/JP1997001240
申请日：1997-04-10
申请人： SUMITOMO PHARMACEUTICALS COMPANY, LIMITED
发明人： SUMITOMO PHARMACEUTICALS COMPANY, LIMITED , FUJIWARA, Norio , UEDA, Yutaka , MURATA, Shinobu , HIROTA, Fumiyo , KAWAKAMI, Hajime , FUJITA, Hitoshi
IPC分类号： C07D401/04
CPC分类号： C07D401/04 , A61K31/506 , A61K31/517 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14 , Y02A50/411
摘要： A compound of formula (1) wherein; X is amino or hydroxyl, X is carbonyl and the like, R is an alkyl, an aryl and the like, R is hydrogen and the like, and R is an alkyl and the like, or a pharmaceutical acceptable salt thereof, is effective for inhibiting the production and/or secretion of tumor necrosis factor in a patient in need of such inhibition.
摘要翻译：式（1）的化合物，其中： X 1是氨基或羟基，X 2是羰基等，R 1是烷基，芳基等，R 2是氢等，R 3是烷基等或其药学上可接受的盐在需要这种抑制的患者中有效抑制肿瘤坏死因子的产生和/或分泌。

10. 发明申请

WO1997002047A1 GENE PREPARATIONS 审中-公开
标题翻译：基因制备
公开(公告)号：WO1997002047A1
公开(公告)日：1997-01-23
申请号：PCT/JP1996001824
申请日：1996-07-02
申请人： KOKEN CO., LTD. , SUMITOMO PHARMACEUTICALS COMPANY, LIMITED , TERADA, Masaaki , OCHIYA, Takahiro , MIYATA, Teruo , ITOH, Hiroshi
发明人： KOKEN CO., LTD. , SUMITOMO PHARMACEUTICALS COMPANY, LIMITED
IPC分类号： A61K48/00
CPC分类号： A61K48/00
摘要： Gene preparations comprising desired genes or vectors containing desired genes integrated thereinto and carriers for supporting the same.
摘要翻译：包含所需基因或包含所需基因的载体的基因制备物和用于支持其的载体。

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