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1. 发明授权

KR790000506B1 METHOD OF PREPARING ARYLOXYALKYL DIKETONES 失效
公开(公告)号：KR790000506B1
公开(公告)日：1979-05-29
申请号：KR740003136
申请日：1974-07-23
申请人： STERLING DRUG INC
发明人： DIANA G , COLLINS J
摘要： The ketons (I) were prepd. wherein Alk. is an alkylene of 3 to 10 carbon atoms and having 3 to 7 carbon atoms intervening between the terminal bonds, R is an alkanoyl of 2 to 6 carbon atoms, R' is an alkanoyl of 2 to 6 carbon atoms or carboalkoxy of 2 to 6 carbon atoms, and Ar is phenyl substituted by 3, 4-methylenedioxy. I were useful as virucides and insecticides (no data).

2. 发明授权

US3708473A 3,3-dichloro-2-oxopolymethylenimines 失效
标题翻译： 3,3-二氯-2-氧代乙酰亚胺
公开(公告)号：US3708473A
公开(公告)日：1973-01-02
申请号：US3708473D
申请日：1971-02-08
申请人： STERLING DRUG INC
发明人： COLLINS J
IPC分类号： C07D207/50 , C07D211/02 , C07D211/76 , C07D213/75 , C07D41/06
CPC分类号： C07D213/75 , C07D207/50 , C07D211/02 , C07D211/76
摘要： THE INVENTION RELATES TO 3,3-DICHLORO-2-OXOPOLYMETHYLENIMINES AND BIS(3,3 - DICHLORO - 2 - OXOPOLYMETHYLENEIMINES) HAVING USEFUL ANTI-INFLAMMATORY PROPERTIES AS DETERMINED BY THEIR INHIBITION OF CARRAGEENAN INDUCED EDEMA IN RATS.

3. 发明授权

US3829475A 2-(carboxyphenyl)ethyl and 2-(carboxyphenyl)vinyl cyclopropyl carbinols 失效
标题翻译： 2-（羧基苯基）乙基和2-（羧基苯基）乙烯基环丙基碳二亚胺
公开(公告)号：US3829475A
公开(公告)日：1974-08-13
申请号：US26533372
申请日：1972-06-22
申请人： STERLING DRUG INC
发明人： COLLINS J
IPC分类号： C07C69/738 , C07C17/00 , C07C17/16 , C07C17/20 , C07C17/354 , C07C33/34 , C07C33/50 , C07C37/055 , C07C45/00 , C07C45/62 , C07C45/67 , C07C45/68 , C07C45/74 , C07C49/20 , C07C49/213 , C07C49/215 , C07C49/217 , C07C49/223 , C07C49/233 , C07C49/235 , C07C49/245 , C07C49/255 , C07C49/563 , C07C49/567 , C07C49/573 , C07C49/577 , C07C59/66 , C07C67/00 , C07C225/00 , C07C231/00 , C07C231/12 , C07C233/33 , C07D317/54 , C07D317/60 , C07C65/02
CPC分类号： C07C17/208 , C07C17/16 , C07C17/354 , C07C33/34 , C07C33/50 , C07C45/62 , C07C45/673 , C07C45/68 , C07C45/74 , C07C59/66 , C07D317/54 , C07D317/60 , C07C25/13 , C07C25/02 , C07C25/24 , C07C22/04 , C07C49/255 , C07C49/245 , C07C49/217 , C07C49/573 , C07C49/563
摘要： ARYL SUBSTITUTED DIKETONES AND KETO-ESTERS, USEFUL AS ANTIVIRAL AGENTS AND INSECTICIDES, ARE PREPARED BY REACTING AN ARYLALKYL OR ARYLALKENYL IODIDE WITH A METAL SALT OF THE APPROPRIATE DIKETONE OR KETO-ESTER.

4. 发明授权

US3764612A Preparation of 1-aminoalkylamino-9-orothioxanthene-4-carbox-aldehydes 失效
标题翻译： 1-氨基甲酰氨基-9-异二氢-4-羧酸 - 醛酸的制备
公开(公告)号：US3764612A
公开(公告)日：1973-10-09
申请号：US3764612D
申请日：1970-10-05
申请人： STERLING DRUG INC
发明人： COLLINS J , ROSI D
IPC分类号： C07D335/16 , A61K27/00 , C07D65/18
CPC分类号： C07D335/16
摘要： 1-(R1R2N-Y-NH)-9-oxothioxanthene-4-carboxaldehydes, intermediates for the preparation of the corresponding 4hydroxymethyl compounds, are prepared by heating 1-chlorothioxanthen-9-one with R1R2N-Y-NHCH3 to yield 1-(R1R2N-Y-NH(CH3)) thioxanthen-9-one, reacting the latter compound with phosphorus oxyhalide and dimethylformamide to yield 1-(R1R2N-Y-N(CH3))-9oxothioxanthene-4-carboxaldehyde and reacting said aldehyde with pyridine hydrochloride to produce 1-(R1R2N-Y-NH)-9oxothioxanthene-4-carboxaldehyde, where R1 and R2 are each loweralkyl and Y is lower-alkylene having from two to four carbon atoms and having its two connecting linkages on different carbon atoms. The novel intermediates, 1-(R1R2N-Y-N(CH3))thioxanthen-9ones, also have antibacterial activity.
摘要翻译：通过用R1R2N-Y-NHCH3加热1-氯 - 噻吨-9-酮，制备1-（R1R2N-Y-NH）-9-氧代噻吨-4-甲醛，制备相应的4-羟甲基化合物的中间体，得到1- [R 1 R 2 N -Y-NH（CH 3）]噻吨-9-酮，使后一化合物与磷酰卤和二甲基甲酰胺反应，得到1- [R 1 R 2 N -YN（CH 3）] - 9-氧代噻吨-4-甲醛，所述醛与吡啶盐酸盐反应，得到1-（R1R2N-Y-NH）-9-氧代噻吨-4-甲醛，其中R 1和R 2各自为低级烷基，Y为具有2至4个碳原子的低级亚烷基，两个不同碳原子上的连接键。新型中间体1- [R1R2N-Y-N（CH3）]噻吨-9-酮也具有抗菌活性。

5. 发明授权

US3745172A 1-(di-(lower-alkyl)aminoalkylamino)-9-oxothioxanthenes 失效
标题翻译： 1-（DI-（低级 - 烷基）氨基亚氨基）-9-氧代二甲基
公开(公告)号：US3745172A
公开(公告)日：1973-07-10
申请号：US3745172D
申请日：1970-10-05
申请人： STERLING DRUG INC
发明人： COLLINS J , ROSI D
IPC分类号： C07D335/16 , A61K27/00 , C07D65/18
CPC分类号： C07D335/16
摘要： A PROCESS WHICH COMPRISES REACTING 1-(DI(LOWER-ALKYL) AMINO - Y - AMINO)-9-OXOTHIOXANTHENE-4-CARBOXALDEHYDE ALDOXIME, WHERE Y IS LOWER-ALKYLENE, WITH A LOWER-ALKANOYLATING AGENT TO PRODUCE 1-(DI-(LOWER-ALKYL)-AMINO-YAMINO) - 9 - OXOTHIOXANTHENE - 4-CARBOXALDEHYDE (LOWERALKANOYL)ALDOXIME, HEATING SAID (LOWER-ALKANOYL)ALDOXIME TO PRODUCE 1 - (DI - (LOWER-ALKYL)AMINO-Y-AMINO)-9OXOTHIOXANTHENE-4-CARBONITRILE, HEATING SAID 4-CARBONITRILE IN AN AQUEOUS ACIDIC MEDIUM TO PRODUCE 1-(DI-(LOWERALKYL) - AMINO-Y-AMINO)THIOXANTHEN-9-ONE, INTERMEDIATES IN THE SYNTHESIS OF KNOW SCHISTOSOMACIDAL AGENTS.

6. 发明授权

US3711512A Preparation of 1-(aminoalkylamino)-4-hydroxymethylthioxanthen-9-ones 失效
标题翻译： 1-（氨基亚氨基）-4-羟基甲基硫代吗啉-9-酮的制备
公开(公告)号：US3711512A
公开(公告)日：1973-01-16
申请号：US3711512D
申请日：1970-10-05
申请人： STERLING DRUG INC
发明人： ROSI D , COLLINS J , MILLER T
IPC分类号： C07D335/16 , A61K27/00 , C07D65/18
CPC分类号： C07D335/16
摘要： A PROCESS FOR THE PREPARATION OF 1-(R1R2N-Y-N (R)-4-HYDROXYMETHYLTHIOXANETHEN-9 - ONE, SCHISTOSOMACIDAL AGENT, WHICH COMPRISES REACTING 1-(R1R2N-Y-N 8R)THIOXANTHEN-9-ONE WITH EXCESS FORMALDEHYDE AT AN ACIDIC PH WHERE R IS HYDROGEN OR METHYL, R1 AND R2 ARE EACH LOWER-ALKYL, AND Y IS LOWER-ALKYLENE HAVING FROM TWO TO FOUR CARBON ATOMS AND HAVING ITS TWO CONNECTING LINKAGES ON DIFFERENT CARBON ATOMS.

7. 发明专利

ZA716590B PROCESS FOR PREPARING THIOXANTHENES AND INTERMEDIATES 未知
公开(公告)号：ZA716590B
公开(公告)日：1972-06-28
申请号：ZA716590
申请日：1971-10-01
申请人： STERLING DRUG INC
发明人： COLLINS J , ROSI D , MILLER T
IPC分类号： C07D335/16 , C07D
摘要： 1-(R1R2N-Y-NH)-9-oxothioxanthene-4-carboxaldehydes, intermediates for the preparation of the corresponding 4-hydroxymethyl compounds, are prepared by heating 1-chloro-thioxanthen-9-one with R1R2N-Y-NHCH3 to yield 1-[R1R2N-Y-NH(CH3)] thioxanthen-9-one, reacting the latter compound with phosphorus oxyhalide and dimethylformamide to yield 1-[R1R2N-Y-N(CH3)]-9-oxothioxanthene-4-carboxaldehyde and reacting said aldehyde with pyridine hydrochloride to produce 1-(R1R2N-Y-NH)-9-oxothioxanthene-4-carboxaldehyde, where R1 and R2 are each lower-alkyl and Y is lower-alkylene having from two to four carbon atoms and having its two connecting linkages on different carbon atoms. The novel intermediates, 1-[R1R2N-Y-N(CH3)]thioxanthen-9-ones, also have antibacterial activity.

8. 发明专利

ZA8007781B SUBSTITUTED-PHENYLPYRIDINES AND PREPARATION 未知
公开(公告)号：ZA8007781B
公开(公告)日：1981-12-30
申请号：ZA8007781
申请日：1980-12-12
申请人： STERLING DRUG INC
发明人： SINGH B , COLLINS J , LESHER G
IPC分类号： A61K31/44 , A61K31/4406 , A61K31/4409 , A61K31/4418 , A61P9/04 , C07D213/30 , C07D
CPC分类号： C07D213/30

10. 发明专利

PH12019A ARYLOXYALKYL DIKETONES AND KETO ESTERS AND PHARMACEUTICAL COMPOSITION CONTAINING THEM 未知
公开(公告)号：PH12019A
公开(公告)日：1978-10-06
申请号：PH16085
申请日：1974-07-23
申请人： STERLING DRUG INC
发明人： COLLINS J , DIANA G
IPC分类号： C07C69/035 , A01N31/02 , A01N31/14 , A01N33/02 , A01N35/02 , A01N37/06 , A01N37/40 , A61K31/12 , A61K31/135 , A61K31/235 , A61K31/335 , A61K31/357 , A61K31/36 , A61P31/12 , C07C41/00 , C07C43/225 , C07C45/00 , C07C45/64 , C07C45/67 , C07C45/68 , C07C45/70 , C07C49/16 , C07C49/175 , C07C49/255 , C07C51/00 , C07C51/097 , C07C51/36 , C07C67/00 , C07C69/712 , C07C69/732 , C07C69/92 , C07C201/00 , C07C205/37 , C07C205/57 , C07C213/00 , C07C217/20 , C07C217/84 , C07C313/00 , C07C319/20 , C07C323/20 , C07D317/64 , C07C91/00
摘要： Aryloxyalkyl diketones and keto-esters, having pesticidal and anti-viral activity, are prepared from an aryloxyalkyl halide and an alkali metal enolate salt of a diketone or keto-ester.

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